1: SMC5 Smc5p [ Saccharomyces cerevisiae ]
GeneID: 854123 updated 08-Mar-2009 - Gene name
- SMC5
- Primary source
- SGD:S000005394
- Locus tag
- YOL034W
- Gene type
- protein coding
- RefSeq status
- Reviewed
- Organism
- Saccharomyces cerevisiae (strain: S288C)
- Lineage
- Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
- Also known as
- SMC5
[Top][Help]Genomic regions, transcripts, and products
Related Articles in PubMed
GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?
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1. |
This study presents evidence for the requirement of Nse1, a subunit of the Smc5-Smc6 complex, in Rad52-dependent postreplication repair and a role for the Nse1 and Mms21 E3 ligase activities associated with this complex in this repair mode. |
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2. |
Data show that the Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus in Saccharomyces cerevisiae. |
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3. |
The lethality of SMC5 mutations is suppressed by the rad52 mutation. |
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4. |
Smc5/6 complex is needed during replication to prevent the accumulation of branched chromosome structures. |
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5. |
The lethality of SMC5 mutations is suppressed by the rad52 mutation. |
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6. |
The Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events. |
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7. |
results further supporting the importance of Smc5-Smc6 in maintaining the integrity of the repetitive ribosomal DNA (rDNA) locus, the largest repetitive region of the budding yeast genome |
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8. |
Smc5/6-containing complexes have critical roles in both DNA repair and chromosome segregation |
[Top][Help]General gene informationGeneOntology Provided by SGD
[Top][Help]General protein information- Names
- Smc5p
- Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
[Top][Help]NCBI Reference Sequences (RefSeq)Genome Annotation
The following sections contain reference sequences that belong to a specific genome build. Explain This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.
mRNA and Protein(s)
NP_014608.1 Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; Smc5p [Saccharomyces cerevisiae]
- UniProtKB/Swiss-Prot
- Q08204
- Conserved Domains (3) summary
- COG1196
Location:42–1069 Blast Score:639
- Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
- cd03277
Location:956–1072 Blast Score:508 Location:40–224 Blast Score:422
- ABC_SMC5_euk; Eukaryotic SMC5 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...
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