Gene name

SMC5

Primary source

SGD:S000005394

Locus tag

YOL034W

Gene type

protein coding

RefSeq status

Reviewed

Organism

Saccharomyces cerevisiae (strain: S288C)

Lineage

Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Also known as

SMC5

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chromosome: XVSee SMC5 in MapViewer

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

	1.	This study presents evidence for the requirement of Nse1, a subunit of the Smc5-Smc6 complex, in Rad52-dependent postreplication repair and a role for the Nse1 and Mms21 E3 ligase activities associated with this complex in this repair mode.
	2.	Data show that the Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus in Saccharomyces cerevisiae.
	3.	The lethality of SMC5 mutations is suppressed by the rad52 mutation.
	4.	Smc5/6 complex is needed during replication to prevent the accumulation of branched chromosome structures.
	5.	The lethality of SMC5 mutations is suppressed by the rad52 mutation.
	6.	The Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.
	7.	results further supporting the importance of Smc5-Smc6 in maintaining the integrity of the repetitive ribosomal DNA (rDNA) locus, the largest repetitive region of the budding yeast genome
	8.	Smc5/6-containing complexes have critical roles in both DNA repair and chromosome segregation

GeneOntology Provided by SGD

Names

Smc5p

Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

mRNA and Protein(s)

1. NP_014608.1 Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; Smc5p [Saccharomyces cerevisiae]

   UniProtKB/Swiss-Prot

   Q08204

   Conserved Domains (3) summary

   COG1196
   Location:42–1069
   Blast Score:639

   Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]

   cd03277
   Location:956–1072
   Blast Score:508
   Location:40–224
   Blast Score:422

   ABC_SMC5_euk; Eukaryotic SMC5 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal...