Details of Element: Father
Component of Clamp

Unique Name: fathe12
Contained in the Common BLSA Data Set ? No

Data Points (as of 09/06/98) Males Females Total
Number of Data Points 22 0 22
Number of Distinct Participants 21 0 21
Year First Collected 1972 n/a -
Year Last Collected 1977 n/a -

Type of Variable: Absolute Measure
Encoding: Continuous
Units of Measure: #, Hx of Diabetes
Precision: #.
Anticipated Range: 0. thru 1.
Masterfile Index: 128-01-01
Related Data Elements: none
Specific to this Data Element:
    Descriptive history:
    The 128 file type contains data from the fasting sample obtained prior to administration of a hyperglycemic or hyperinsulinemic-euglycemic clamp procedure. The coding of Card 1 deals with factors known to influence the results of the fasting level. These factors include the BLSA participant's family history of diabetes mellitus, medications and diseases known to affect the test, and technical factors that influence the results of the test.

    Data collection methodology:
    Blood chemistry.

    Related protocols:
    Other blood chemistries.

    Investigators:
    Dr. Reubin Andres (primary investigator)
    GRC Box-24
    andresr@grc.nia.nih.gov
    (410)-558-8194

    Frequency of data collection:
    Data were collected in selected BLSA men from 1972 to 1981.

    Inclusion/exclusion rules:
    No exclusions.

    Publications using these data:

  • Andres, R., Swerdloff, R., Tobin, J. The effect of age on plasma insulin response to hyperglycemia: Studies in man with a servo-control technique. Proceedings 8th International Congress of Gerontology; 1969:36-39.
  • Andres, R., Swerdloff, R., Pozefsky, T., Coleman, D. Manual feedback technique for the control of blood glucose concentration. In: Skeegs LJ, ed. Automation in Analytical Chemistry. New York: Mediad, Inc.; 1966:486-491.
  • Andres, R., Langs, H., Pozefsky, T., Swerdloff, R., Gregerman, R. Alterations in carbohydrate metabolism with age: quantification and investigation into the underlying mechanisms. Proceedings 7th International Congress of Gerontology. Vienna, Austria: Verlag der Weiner Medizinischen Akademie; 1966:351-353.
  • Andres, R. Aging and diabetes. Med Clin North Am. 55(4): 835-46,1971.
  • Andres, R., Tobin, J. Aging, carbohydrate metabolism, and diabetes. Proceedings 9th International Congress of Gerontology; 1972:276-280.
  • Andres, R. Aging and carbohydrate metabolism. In: Carlson L, ed. Nutrition in Old Age. Symposia of the Swedish Nutrition Foundation. Sweden: Almqvist and Wiksell; 1972:24-31.
  • DeFronzo, R.A., Andres, R., Edgar, P., Walker, W.G. Carbohydrate metabolism in uremia: a review. Medicine. 52(5): 469-81,1973.
  • Insel, P.A., Kramer, K.J., Sherwin, R.S., Liljenquist, J.E., Tobin, J.D., Andres, R., Berman, M. Modeling the insulin-glucose system in man. Fed Proc. 33(7): 1865-8,1974.
  • Sherwin, R.S., Kramer, K.J., Tobin, J.D., Insel, P.A., Liljenquist, J.E., Berman, M., Andres, R. A model of the kinetics of insulin in man. J Clin Invest. 53(5): 1481-92,1974.
  • Insel, P., Lilijenquist, J., JD, T., Sherwin, R., Watkins, P., Andres, R., Berman, M. Insulin control of glucose metabolism in man: A new kinetic analysis. J. Clin. Invest. 55: 1057-1066,1975.
  • Tobin, J., Andres, R. The control of insulin and glucose metabolism in aging man. Proceedings 10th International Congress of Gerontology; 1975:183-185.
  • Andres, R., Tobin, J.D. Aging and the disposition of glucose. Adv Exp Med Biol. 61: 239-49,1975.
  • McGuire, E.A., Helderman, J.H., Tobin, J.D., Andres, R., Berman, M. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol. 41(4): 565-73,1976.
  • DeFronzo, R.A., Andres, R., Bedsoe, T.A., Boden, G., Faloona, G.A., Tobin, J.D. A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man. Diabetes. 26(5): 445-52,1977.
  • Andres, R., Tobin, J. Endocrine systems. In: Finch C, Hayflick L, eds. Handbook of the Biology of Aging. New York: Van Nostrand Reinhold Co.; 1977:357-378.
  • Vestal, R.E., McGuire, E.A., Tobin, J.D., Andres, R., Norris, A.H., Mezey, E. Aging and ethanol metabolism. Clin Pharmacol Ther. 21(3): 343-54,1977.
  • DeFronzo, R.A., Tobin, J.D., Rowe, J.W., Andres, R. Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. J Clin Invest. 62(2): 425-35,1978.
  • Andersen, D.K., Elahi, D., Brown, J.C., Tobin, J.D., Andres, R. Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels. J Clin Invest. 62(1): 152-61,1978.
  • DeFronzo, R.A., Tobin, J.D., Andres, R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237(3): E214-23,1979.
  • Elahi, D., Andersen, D.K., Brown, J.C., Debas, H.T., Hershcopf, R.J., Raizes, G.S., Tobin, J.D., Andres, R. Pancreatic alpha- and beta-cell responses to GIP infusion in normal man. Am J Physiol. 237(2): E185-91,1979.
  • McGuire, E.A., Tobin, J.D., Berman, M., Andres, R. Kinetics of native insulin in diabetic, obese, and aged men. Diabetes. 28(2): 110-20,1979.
  • Elahi, D., Andersen, D.K., Tobin, J.D., Andres, R. Discrepant performance on oral and intravenous glucose tolerance tests: the role of gastric inhibitory polypeptide. J Clin Endocrinol Metab. 52(6): 1199-203,1981.
  • Andres, R. Aging, diabetes, and obesity: standards of normality. Mt Sinai J Med. 48(6): 489-95,1981.
  • Elahi, D., Nagulesparan, M., Hershcopf, R.J., Muller, D.C., Tobin, J.D., Blix, P.M., Rubenstein, A.H., Unger, R.H., Andres, R. Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. N Engl J Med. 306(20): 1196-202,1982.
  • Elahi, D., Raizes, G.S., Andres, R., Hershcopf, R.J., Muller, D.C., Tobin, J.D., Andersen, D.K. Interaction of arginine and gastric inhibitory polypeptide on insulin release in man. Am J Physiol. 242(5): E343-51,1982.
  • Helderman, J.H., Elahi, D., Andersen, D.K., Raizes, G.S., Tobin, J.D., Shocken, D., Andres, R. Prevention of the glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes. 32(2): 106-11,1983.
  • Elahi, D., Andersen, D.K., Muller, D.C., Tobin, J.D., Brown, J.C., Andres, R. The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes. 33(10): 950-7,1984.
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