The DTP Human Tumor Cell Line Screen has checked tens of thousands of compounds for evidence of the ability to inhibit the growth of human tumor cell lines. Available here are screening results and chemical structural data on compounds that are not covered by a confidentiality agreement. We anticipate that this list will be updated at least once a year.
Searchable Results
- Standard Agent Database
- Mechanism of Action
- Chemical Structure
- Chemical indentifier (NSC number, CAS number , chemical name)
Screening Results (August 2008 Release)
The compounds submitted to the cancer screen are generally tested at five different concentrations for the ability to inhibit sixty different human tumor cell lines. The dose respose data is used to calculate three concentration parameters.
- GI50
- TGI
- LC50
The Cancer Screening Results (July 2007 Release) can be downloaded in bulk via compressed files. Caution: Each of these files is about 20MB and uncompresses to about 185 MB
Each is a gzip compressed ASCII file containing the results for ~43,000 compounds. The usual .Z (or .gz) file type was changed to .BIN to make sure Netscape doesn't try to uncompress on the fly and write the 185 MB to your screen. You should save the file to your disk and uncompress, which will result in an ASCII file with 11 comma delimited fields per record:
Please note the links for more information on the SNB-19, U251, NCI/ADR-RES, and MDA-MB-435 cell lines.
- NSC number - the NCI's internal ID number
- Concentration Unit - Either M for molar or u for µ g/ml
- log of the highest concentration tested
- panel name for the cell line
- cell line name
- panel number of the cell line (see table)
- cell number of the cell line (see table)
- -log of the result (GI50, TGI, LC50 depending on the file)
- number of tests for this NSC and cell line
- maximum number of tests for this NSC
- StdDev Standard Deviation of the Log10 of the results averaged across all tests for this NSC and cell line
Diversity Set Data
The Diversity Set Results (August 1999 Release) can be accessed as text files. Each file is approximately 5.6Mb.
Chemical Structural Data
Cancer Screen (September 2003 Release)
The 2D structures were retrieved from the DTP's Drug Information System for 42,247 compounds out of the 43,177 compounds with screening data available. The data are presented in a compressed ASCII file in MDL's SDFile format. There is one field that are included in the SD file.
- NSC - the NCI's internal ID number
Caution: The Structural Data file is over 11Mb compressed and about 107Mb uncompressed. The file is compressed with the standard Unix compress program which is widely available for all platforms (and handled correctly by most archiving programs including WinZip). The standard Netscape setting tries to uncompress the file on the fly and display it when the file has the usual .Z or .gz type, so I given it a file type .BIN to make sure Netscape asks you to write it directly to disk. You will probably have to rename the file from cans03sd.bin to cans03sd.gz . After uncompressing you should have an ASCII file in MDL SD file format.