| US 7,402,725 B2 | ||
| WIP, a WASP-associated protein | ||
| Narayanaswamy Ramesh, Wayland, Mass. (US); Miguel A. de la Fuente, Boston, Mass. (US); Ines M. Anton, Turin (Italy); and Raif S. Geha, Belmont, Mass. (US) | ||
| Assigned to The Children's Medical Center Corporation, Boston, Mass. (US) | ||
| Filed on May 20, 2005, as Appl. No. 11/134,068. | ||
| Application 11/134068 is a continuation of application No. 10/078547, filed on Feb. 19, 2002, granted, now 6,927,318. | ||
| Application 10/078547 is a continuation in part of application No. 09/599287, filed on Jun. 22, 2000, granted, now 6,635,446. | ||
| Application 09/599287 is a continuation of application No. PCT/US98/27501, filed on Dec. 22, 1998. | ||
| Claims priority of provisional application 60/101457, filed on Sep. 23, 1998. | ||
| Claims priority of provisional application 60/068533, filed on Dec. 23, 1997. | ||
| Prior Publication US 2006/0294611 A1, Dec. 28, 2006 | ||
| Int. Cl. G01N 33/00 (2006.01); A01K 60/027 (2006.01); A01N 61/00 (2006.01); A61K 31/00 (2006.01) | ||
| U.S. Cl. 800—3 [800/14; 800/18; 514/1] | 8 Claims |
| 1. A method for identifying an agent that exhibits WASP-interacting protein (WIP) activity comprising:
a) contacting a T cell isolated from a transgenic mouse whose genome comprises a homozygous disruption of the WIP gene with
the agent, wherein said T cell is deficient in WIP expression; and
b) assessing WIP activity in said cell;
wherein if the WIP activity of the T cell of (a) is about the same as the WIP activity of a T cell from a mouse that has wild-type
expression of WIP, then that the agent exhibits WIP activity.
|