Testing Information

Testing Status of Agents at NTP

Chlordecone (kepone)

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http://ntp.niehs.nih.gov/go/TS-10097-H

CASRN: 143-50-0

Related: CHLORDECONE ALCOHOL (CAS 1034-41-9)

Formula: C10-Cl10-O

Synonyms/Common Names:

  • 1,1A,3,3A,4,5,5A,5B,6-DECACHLOROOCTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA(CD)PENTALEN-2-OL (9CI)
  • KEPONE

Known Uses:

INSECTICIDE FOR FRUIT TREES; AS A FUNGICIDE; BASE MATERIAL FOR THE MANUFACTURE OF KELEVAN.

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00191) Completed 
    • NTIS No. PB264041  (Peer Review NA)
      Citation: Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CAS No. 143-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00191) Completed 
    • NTIS No. PB264041  (Peer Review NA)
      Citation: Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CAS No. 143-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00191) Report Complete 
    • TR-000 (143-50-0) (NTIS No. PB264041)  (Peer Review NA)
      Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CAS No. 143-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: FR: 0,18,26 (AVG), MR: 0,8,24 (AVG), FM: 0,20,40 (AVG), MM: 0,20,23 (AVG) PPM

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0447) Completed 
    • Citation: BUNGAY, P.M., DEDRICK, R.L., & MATTHEWS, H.B., ENTERIC TRANSPORT OF CHLORDECONE (KEPONE) IN THE RAT, J PHARM & BIOPHARM 9(3):309-341, 1981.
    • Rats: Sprague Dawley; Rats: Sprague Dawley

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (232320) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (163075) Completed 
    •  Positive 
  • Salmonella  (663576) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (795821) Completed 
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment  (NTA94020) Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • M/F Rats: F344/N

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Web page last updated on January 22, 2009