Gulminetti R, Maccabruni A, Michelone G, DeiCas A, Arlandi L; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 299 (abstract no. Tu.B.2200).
IRCCS Policlinico San Matteo, Pavia, Italy. Fax: +39-382-527976.
Introduction: High incidence of oral candidiasis is reported in HIV-infected children; although this is not a life-threatening condition, since it may impair nutrition and progress to esophagitis, specific treatment is often requested. Moreover antimicotic resistent strains have been frequently reported in adult patients. To evaluate the incidence of oral thrush and of resistent strains of candida we studied a group of HIV-infected children. Patients: We evaluated 22 HIV-infected children (age range 2-12 years), 11 with mild disease (I N or B 1-2-or C1 according to "CDC 95" classification), and 11 with severe disease (IB3- C2or3). Surveillance oral swabs from twenty-two exposed children aged less than one year, who seroreverted in the follow-up, were studied as controls. Oral swabs from children with clinically suspected oral candidiasis, observed over one year, were cultured. Sensitivity of isolated strains was tested by Kirby-Bauer test. Children with confirmed infection were treated with oral fluconazole and then retested on day 21. Multiresistent strains were those who lacked sensitivity to greater than or equal to 2 of the eight tested antimicotic drugs. Results: All cultures obtained from children of the control group were negative. Of the 133 cultures from infected children 70 were positive. Candida albicans is the only isolated species. In the group with mild disease 36/57 cultures were positive (63%), and 19 of these 36 (53%) strains multiresistent. In the group with severe disease 34/76 cultures were positive (45%) and only 5 (15%) were multiresistent. Conclusions: High incidence of oral trush is confirmed in our children, with a median of 5 infections/child/year. No species other than Candida albicans were found. Multiresistent candida strains accounted for 34% (24/70) of all isolates. Surprisinlgy, both occurrence of infection and of multiresistence are more frequent in children without severe immunodeficiency.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Adult
- Candida
- Candida albicans
- Candidiasis
- Candidiasis, Oral
- Child
- Fluconazole
- HIV Infections
- HIV Seropositivity
- Humans
- methods
Other ID:
UI: 102218304
From Meeting Abstracts