9/81 - 6/86 Graduate Teaching Assistant and Adjunct Mathematics Instructor, New York University.
9/86 - 9/89 National Research Council - National Institutes of Health Research Associate.
9/89 - 7/96 N. I. H. Senior Staff Fellow, Mathematical Research Branch, N.I.D.D.K.
7/96 - Present Research Mathematician, Mathematical Research Branch, N.I.D.D.K.
8/97 - Present Acting Lab Chief, Mathematical Research Branch/ Laboratory of Biological Modeling, N.I.D.D.K.
A. S. Sherman and C. S. Peskin. 1988. Solving the Hodgkin-Huxley equations by a random walk method. SIAM J. Sci. and Stat. Comput. 9:170--190. [Web of Science] [MathSciNet]
A. Sherman, J. Rinzel, and J. Keizer. 1988. Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing. Biophys. J. 54:411--425. [PubMed]
P. B. Carroll, A. Sherman, R. Ferrer, A. C. Boschero, J. Rinzel, and I. Atwater. 1990. Modulation of the frequency of glucose-dependent bursts of electrical activity by HCO3/CO2 in rodent pancreatic beta-cells. Experimental and theoretical results. Eur. Biophys. J. 18:71--77. [PubMed]
A. Sherman, J. Keizer, and J. Rinzel. 1990. Domain model for Ca2+ inactivation of Ca2+ channels at low channel density. Biophys. J. 58:985--995. [PubMed]
A. Sherman and J. Rinzel. 1991. Model for synchronization of pancreatic beta-cells by gap junction coupling. Biophys. J. 59:547--559. [PubMed]
A. Sherman and J. Rinzel. 1992. Rhythmogenic effects of weak electrotonic coupling in neuronal models. Proc. Natl. Acad. Sci. USA. 89:2471--2474. [PubMed]
P. Smolen, J. Rinzel, and A. Sherman. 1993. Why pancreatic islets burst but single beta-cells do not: The heterogeneity hypothesis. Biophys. J. 64:1668--1680. [PubMed]
A. Sherman. 1994. Anti-phase, asymmetric, and aperiodic oscillations in excitable cells I. Coupled bursters. Bull. Math. Biol. 56:811--835. [PubMed]
P. Smolen and A. Sherman. 1994. Phase-independent resetting in relaxation and burst oscillators. J. Theor. Biol. 169:339--348. [PubMed]
A. Sherman and M. Mascagni. 1994. A gradient random walk method for two-dimensional reaction-diffusion equations. SIAM J. Sci. Comput. 15:1280--1293. [Web of Science] [MathSciNet]
A. Sherman, L. Xu, and C. Stokes. 1995. Estimating and eliminating junctional current in coupled cell populations by leak subtraction. A computational study. J. Membr. Biol., 143:79--87. [PubMed] (Joint with experimental paper: E. Rojas, C. Stokes, D. Mears, and I. Atwater. 1995. Single micro-electrode voltage-clamp measurements of pancreatic beta-cell membrane ionic currents in intact mouse islets of Langerhans. J. Membr. Biol. 143:65--77). [PubMed]
R. Bertram, M. Butte, T. Kiemel, and A. Sherman. 1995. Topological and phenomenological classification of bursting mechanisms. Bull. Math. Biol. 57:413--439. [PubMed] [XPP File]
R. Bertram, P. Smolen, A. Sherman, D. Mears, I. Atwater, F. Martin, and B. Soria. 1995. A role for calcium-release activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells. Biophys. J. 68:2323--2332. [PubMed]
R. Bertram, A. Sherman, and E. Stanley. 1996. The single domain/bound calcium hypothesis of transmitter release and facilitation. J. Neurophysiol., 75:1919--1931. [PubMed]
D. Mears, N. F. Sheppard, Jr., I. Atwater, E. Rojas, R. Bertram, and A. Sherman. 1997. Evidence that calcium release-activated current mediates transient glucose-induced electrical activity in the pancreatic beta-cell. J. Membr. Bio., 155:47--59. [PubMed]
R. Bertram and A. Sherman. 1998. Population dynamics of synaptic release sites. SIAM J. Applied Math., 58:142-169. [The Journal] [MathSciNet]
G. de Vries, H.-R. Zhu, and A. Sherman. 1998. Diffusively coupled bursters: Effects of heterogeneity. Bull. Math. Biol., 60:1167--1200. [Science Direct] [Web of Science][Mathematica Files]
R. Bertram, G. D. Smith, and A. Sherman. 1999. A modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release. Biophys. J., 76:735--750. [PubMed]
T. A. Kinard, G. de Vries, A. Sherman, and L. S. Satin. 1999. Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances. Biophys. J., 76:1423--1435.[PubMed]
F. Van Goor, A. P. LeBeau, L. Z. Krsmanovic, A. Sherman, K. J. Catt, and S. S. Stojilkovic. 2000. Amplitude-dependent spike-broadening in immortalized GnRH neurons.Biophys. J., 79:1310--1323. [PubMed]
R. Bertram, J. Previte, A. Sherman, T. A. Kinard, and L. S. Satin. 2000. The phantom burster model for pancreatic beta-cells. Biophys. J., 79:2880--2892. [PubMed] [Flash Animation] [XPP File]
G. de Vries and A. Sherman. 2000. Channel sharing in pancreatic beta-cells revisited: Enhancement of emergent bursting by noise. J. Theor. Biol., 207:513--530. [PubMed]
A. P. LeBeau, F. Van Goor, S. S. Stojilkovic, and A. Sherman. 2000. Modeling of membrane excitability in gonadotropin-releasing hormone-secreting hypothalamic neurons regulated by Ca2+-mobilizing and adenylyl cyclase-coupled receptors. J. Neurosci., 20:9290--9297. [PubMed] [Flash Animation]
G. D. Smith, L.-X. Dai, R. Miura, and A. Sherman. 2001. Asymptotic analysis of equations for the buffered diffusion of intracellular calcium. SIAM J. Applied Math., 61:1816--1838. [Abstract] [The Journal] [Matlab Files]
G. de Vries and A. Sherman. 2001. From spikers to bursters via coupling: Help from heterogeneity, Bull. Math. Biol., 63:371--391. [PubMed]
V. Matveev, A. Sherman, and R. S. Zucker. 2002. New and Corrected Simulations of Synaptic Facilitation, Biophys. J., 83:1368--73. [PubMed] [Simulation Software] [CalC Scripts]
A. R. Sedaghat, A. Sherman, and M. J. Quon. 2002. A mathematical model of metabolic insulin signaling pathways, Am. J. Physiol. (Endocrinol. Metab.), 283:E1084--E1101. [PubMed ] [Supplementary Material: XPP/WinPP Differential Equation Files]
P. B. Goforth, R. Bertram, F. A. Khan, M. Zhang, A. Sherman, and L. S. Satin. 2002. Calcium-activated K+ channels of mouse pancreatic beta-cells are controlled by both store and cytoplasmic Ca2+. J. Gen. Physiol., 120:307--322. [PubMed] [XPP Files]
M. Zhang, P. Goforth, A. Sherman, R. Bertram, and L. S. Satin. 2003. The Ca2+ dynamics of isolated mouse beta-cells and islets: Implications for mathematical models, . Biophys. J. 84:2852--2870. [PubMed] [XPP Files]
V. Matveev, R. S. Zucker, and A. Sherman. 2004. Facilitation through buffer saturation: Constraints on endogenous buffering properties,. Biophys. J. 86:2691--2709. [PubMed] [Calcium Calculator Software] [CalC Scripts]
C. Zimliki, D. Mears, and A. Sherman. 2004. Three roads to islet bursting: Emergent oscillations in coupled phantom bursters, Biophys. J., 87:193--206. [PubMed] [XPP file]
R. Bertram and A. Sherman. 2004. A calcium based phantom bursting model for pancreatic beta-cells, Bull. Math. Biol., 66:1313-1344. [PubMed] [XPP Files and Animations]
R. Bertram, L. Satin, M. Zhang, P. Smolen, and A. Sherman. 2004. Calcium and glycolysis mediate multiple bursting modes in pancreatic islets, Biophys. J., 87:3074--3087. [PubMed] [XPP Files and Errata]
R. Bertram and A. Sherman. 2004. Filtering of calcium transients by the endoplasmic reticulum in pancreatic beta-cells, Biophys. J., 87:3775--3785. [PubMed] [XPP Files]
M. G. Pedersen, R. Bertram, and A. Sherman. 2005. Intra- and Inter-Islet Synchronization of Metabolically Driven Insulin Secretion, Biophys. J., 89:107--119. [PubMed]
C. S. Nunemaker, M. Zhang, D. H. Wasserman, O. P. McGuinness, A. C. Powers, R. Bertram, A. Sherman, and L. S. Satin, 2005. Individual mice can be distinguished by the period of their islet calcium oscillations: Is there an intrinsic islet period which is imprinted in vivo? Diabetes, 54:3517--3522 [PubMed]
K. Tsaneva-Atanasova, C. L. Zimliki, R. Bertram, and A. Sherman, 2006. Diffusion of calcium and metabolites in pancreatic islets: Killing oscillat ions with a pitchfork, Biophys. J., 90:3434--3446. [PubMed] [XPP Files]
C. S. Nunemaker, R. Bertram, A. Sherman, K. Tsaneva-Atanosova, C. R. Daniel, and L. S. Satin. 2006. Glucose modulates Ca2+ oscillations in pancreatic islets via ionic and glycolytic mechanisms, Biophys. J., 91:2082--2096. [Pubmed] [XPP Files]
R. Bertram, M. Gram Pedersen, D. S. Luciani, and A. Sherman, 2006. A simplified model for mitochondrial ATP production, J. Theor. Biol., 243(4):575-86. [Pubmed] [XPP file]
V. Matveev, R. Bertram, and A. Sherman, 2006. Residual bound Ca2+ can account for the effects of Ca2+ buffers on synaptic facilitation., J. Neurophysiol. 96(6):3389-97 [Pubmed] [CalC Scripts]
R. Bertram, L. S. Satin, M. Gram Pedersen, D. S. Luciani, and A. Sherman, 2007. Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Biophys. J., 92(5):1544-55. [Pubmed] [XPP files]
H. L. Ong, X. Liu, K. Tsaneva-Atanasova, B. B. Singh, B. C. Bandyopadhyay, W. D. Swaim, J. T. Russell, R. S. Hegde, A. Sherman, and I. S. Ambudkar. 2007. Relocalization of STIM1 for activation of store-operated Ca2+ entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca2+ store. J. Biol. Chem., 282(16):12176-85. [PubMed]
T. McLaughlin, A. Sherman, P. Tsao, O. Gonzalez, G. Yee, C. Lamendola, G. M. Reaven, and S. W. Cushman. 2007. Enhanced proportion of small adipose cells in insulin-resistant versus insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia, 50(8):1707-15. [PubMed]
K. Tsaneva-Atanasova, A. Sherman, F. van Goor, and S. S. Stojilkovic. 2007. Mechanism of spontaneous and receptor-controlled electrical activity in pituitary somatotrophs: Experiments and theory. J. Neurophysiol. 98(1):131-44. [PubMed] [XPP File]
J. V. Stern, H. M. Osinga, A. LeBeau, and A. Sherman. 2008. Resetting behavior in a model of bursting in secretory pituitary cells: Distinguishing plateaus from pseudo-plateaus. Bull. Math. Biol., 70(1):68-88. [PubMed] [XPP Files]Y. D. Chen, S. Wang, A. Sherman. 2008. Identifying the targets of the amplifying pathway for insulin secretion in pancreatic beta-cells by kinetic modeling of granule exocytosis. Biophys. J. 95(5):2226-41. [PubMed] [XPP Files]
M. Zhang, B. Fendler, B. Peercy, P. Goel, R. Bertram, A. S. Sherman, and L. S. Satin. 2008. Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets. Biophys. J., 95:4676-4688. [PubMed] T. McLaughlin, A. Deng, O. Gonzales, M. Aillaud, G. Yee, C. Lamendola, F. Abbasi, A. J. Connolly, A. Sherman, S. W. Cushman, G. Reaven, P. S. Tsao. 2008. Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women Diabetologia, 51:2303-8. [PubMed]A. Sherman. 1996. Contributions of modeling to understanding stimulus-secretion coupling in pancreatic beta-cells. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E362--E372. [PubMed]
A. Sherman and R. Bertram. 2005. Integrative Modeling of the Pancreatic beta-Cell. in "Wiley Interscience Encyclopedia of Genetics, Genomics, Proteomics, and Bioinformatics", Part 3 Proteomics, M. Dunn, ed., Section 3.8 Systems Biology, R. L. Winslow, ed., John Wiley & Sons, Ltd. DOI: 10.1002/047001153X.g308213. [On-Line Book] [XPP Files]
R. Bertram and A. Sherman. 2005. Negative Calcium Feedback: The Road from Chay-Keizer in "Bursting: The Genesis of Rhythm in the Nervous System", S. Coombes and P. Bressloff, eds., World Scientific, London, pp. 19--48. [Publisher Page]
G. de Vries and A. Sherman. 2005. Beyond Synchronization: Modulatory and Emergent Effects of Coupling in Square-Wave Bursting in "Bursting: The Genesis of Rhythm in the Nervous System", S. Coombes and P. Bressloff, eds., World Scientific, London, pp. 243--272. [Publisher Page]
R. Bertram, A. Sherman, and L. S. Satin, 2007. Metabolic and electrical oscillations: Partners in controlling pulsatile insulin secretion. Am. J. Physiol. Endocrinol. Metab. 293:890-900. [PubMed]
A. Sherman, P. Carroll, R. Santos, and I. Atwater. 1990. Glucose dose response of pancreatic beta-cells: Experimental and theoretical results, in ``Transduction in Biological Systems'', J. Bacigalupo, C. Hidalgo, E. Jaimovich, and J. Vergara, eds., Plenum Press, New York, pp. 123--141.
J. Rinzel, A. Sherman, and C. L. Stokes. 1992. Channels, coupling, and synchronized rhythmic bursting activity. in ``Analysis and Modeling of Neural Systems'', F. H. Eeckman, ed., Kluwer Academic Publishers, Boston, pp. 29--46.
A. Sherman. 1997. Calcium and membrane potential oscillations in pancreatic beta-cells, in ``Case Studies in Mathematical Modeling - Ecology, Physiology, and Cell Biology'', H. G. Othmer, F. R. Adler, M. A. Lewis, and J. C. Dallon, eds., Prentice-Hall, New Jersey, p. 199 -- 217. [The Book] [Models and Exercises]
A. Sherman and P. Smolen. 1997. Computer modeling of heterogeneous beta-cell populations, in ``Physiology and Pathophysiology of the Islets of Langerhans'', B. Soria, ed., Plenum Press, New York, pp. 275--284. [PubMed] [Abstract]
M. V. Mascagni and A. S. Sherman. 1998. Numerical methods for neuronal modeling, in "Methods in Neuronal Modeling," I. Segev and C. Koch, eds., MIT Press, Cambridge, pp.569--606. [The Book] [Supplementary Material]
R. Bertram and A. Sherman. 2000. Dynamical complexity and temporal plasticity in pancreatic beta-cells. J. Biosc., 25:197-209. [PubMed]
A. Sherman, Y.-X. Li, and J. Keizer. 2002. Whole Cell Models in "Computational Cell Biology", C. Fall, E. Marland, J. Wagner, and J. Tyson , eds., Springer-Verlag, New York, pp. 101 -- 139. [Web Site for the Book]
R. Bertram, K. Wierschem, M. Zhang, P. Goforth, A. Sherman, and L. S. Satin. 2002. Phantom bursting in pancreatic islets: A potential role for insulin feedback, in "Recent Research Developments in Biophysics", S. G. Pandalai, ed., Transworld Research Network, Vol. 1, pp. 31--51.
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Last updated 07/07/05