National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Hereditary Multiple Exostoses: Insights into Pathogenesis
November 3 – 5, 2005 • Houston, TX
Agenda
| Thursday, November 3 |
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| 9:00 a.m. | Welcome to conference Dan Wells, Ph.D. |
| 9:10 a.m. | Introduction to genetics and natural history HME Jacqueline Hecht, Ph.D. |
| Orthopedics and Clinical Genetics | |
| 9:30 a.m. | Introduction of orthopedics and defining severity of hereditary multiple exostosis Christine Alvarez, M.D. |
| 10:10 a.m. | Mutational analysis and clinical expression of disease in patients with HME Luca Sangiorgi, M.D., Ph.D. |
| 11:00 a.m. | Mutation detection strategies for molecular screening in patients with HME Wim Wuyts, Ph.D. |
| 11:30 a.m. | Clinical treatments and surgical procedures George Thompson, M.D. |
| Bone Development | |
| 1:15 p.m. | FGF binding to percelan isolated from the growth plate John R. Hassell, Ph.D. |
| 1:45 p.m. | FGF that regulate growth plate development David Ornitz, M.D., Ph.D. |
| 2:15 p.m. | Syndecans: Cell surface modulators of growth plate chondrocytes Maurizio Pacifici, M.D., Ph.D. |
| 2:45 p.m. | Delineation of regulatory networks underlying BMP action in chondrogenesis Michael Underhill, Ph.D. |
| 3:30 p.m. | How PTHrP regulates chondrocytes in the growth plate Henry Kronenberg, M.D., Ph.D. |
| 4:00 p.m. | Ihh signaling in the growth plate Andrea Vortkamp, Ph.D. |
| 4:30 p.m. | Multiple aspects of Ihh signaling in the endochondral skeleton Matthew Hilton, Ph.D. |
| Friday, November 4 |
|
| Exostosis/Development | |
| 9:00 a.m. | Analysis of human exostoses and derived cells Jacqueline Hecht, Ph.D. |
| 9:30 a.m. | Signaling defects in chondrocytes give rise to exostoses Jeffrey Esko, Ph.D. |
| 10:00 a.m. | Mice deficient in EXT2 lack heparan sulfate and develop exostoses Dominique Stickens, Ph.D. |
| 10:45 a.m. | Profiling of osteochondromas and peripheral chondrosarcomas Pancras Hogendoorn, M.D., Ph.D. |
| EXT Function and Nonmammalian Models | |
| 11:15 a.m. | EXT1 and EXT2 proteins and heparan sulfate biosynthesis Marion Kusche-Gullberg, Ph.D. |
| 11:45 a.m. | Heparan sulfate biosynthesis and sulfation Scott Selleck, M.D., Ph.D. |
| 2:00 p.m. | ES cells and the role of heparan sulphate in development and disease Catherine Merry, Ph.D. |
| 2:30 p.m. | Developmental regulation of HSPG synthesis during Drosophila development Rahul Warrior, Ph.D. |
| 3:00 p.m. | Zebrafish as a model for studies on hereditary multiple exostosis Malorzata Wiweger, Ph.D. |
| Nonbone Phenotypes | |
| 3:30 p.m. | Phenotypes of conditional EXT1-knockout mice: Nonskeletal symptoms Yu Yamaguchi, M.D., Ph.D. |
| 4:00 p.m. | Structure and biosynthesis of mouse brain heparan sulfate Jeremy Turnbull, Ph.D. |
| 4:30 p.m. | Keloid formation following surgical treatment of HME Harish Hosalkar, M.D. |
| Saturday, November 5 |
|
| HME-Related Diseases | |
| 9:00 a.m. | p53 and Rb in cartilage tumors in mice Benjamin Alman, M.D. |
| 9:30 a.m | Tibia dyschondroplasia, Ihh signaling Roland M. Leach, Ph.D. |
| 10:00 a.m. | Olliers and Mafucci Pancras Hogendoorn, M.D., Ph.D. |
| 10:30 a.m. | Malignant transformation in human chondrosarcoma cells James Martin, Ph.D. |
| 11:00 a.m. | Meeting Summary and Review |
| ABC’s of HME Workshop | |
| 1:00 p.m. | Overview of the scientific sessions of the conference Jeffrey Esko, Ph.D. and Scott Selleck, M.D., Ph.D. |
| 1:30 p.m. | Genetics of HME Wim Wuyts, Ph.D. |
| 2:00 p.m. | Presenting study results, hereditary multiple exostoses and pain Jacqueline Hecht, Ph.D. and Sandra Darilek, M.S. |
| 2:45 p.m. | Chronic pain and the need for treatment Ashish Sinha, M.D., Ph.D. |
| 3:45 p.m. | Use of fixators John E. Herzenberg, M.D., F.R.C.S.C. |
| 4:15 p.m. | Questions and discussion |
Abstract
| Hereditary Multiple Exostoses: Insights into Pathogenesis Abstract |
Summary
| Hereditary Multiple Exostoses: Insights into Pathogenesis Summary |
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