 |
Safety and Health Topics: |
|
| Acetylene Tetrabromide |
|
General Description
Synonyms: symmetrical Tetrabromoethane; 1,1,2,2-Tetrabromoethane
OSHA IMIS Code Number: 0080
Chemical Abstracts Service (CAS) Registry Number: 79-27-6
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KI8225000
Department of Transportation Regulation Number (49 CFR 172.101): 2504 159
NIOSH Pocket Guide to Chemical Hazards, Acetylene Tetrabromide: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 1 ppm, 14 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 1 ppm, 14 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1 ppm, 14 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 14 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix D - Substances With No Established RELs
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 8 ppm
Potential symptoms: Eye, skin and respiratory tract irritation; anorexia, nausea; severe headache; abdominal pain; heartburn, dizziness, CNS depression; jaundice, urobilinuria, bilirubinuria; monocytosis.
Health Effects: Cumulative liver and kidney damage (HE3); Cumulative lung damage (HE10); Central nervous system effects (HE7, HE8); Dermatitis; LD50 (oral, rabbit, guinea pig) 400 mg/kg. SKIN ABS.
Affected organs: Eyes, upper respiratory system, liver, kidney; skin, and brain.
Notes: 1) Involved in a case report of solvent-induced encephalopathy in a worker after acute exposure. 2) Induced stomach tumors in mice by repeated skin application.
Date Last Revised: 08/24/1992
Literature Basis:
- (urobilinuria, bilirubinuria, liver irritation, kidney damage…)
Reid, J.B.: Saturated methyl halogenated aliphatic hydrocarbons (Chapter 62). In: Patty's Toxicology, 5th Ed., Vol. 5, Bingham, E., Cohrssen, B., Powell, C.H. eds. New York: John Wiley & Sons, Inc., pp. 185-189, 2001.
- (encephalopathy)
Morrow, L.A., Callender, T., Lottenberg, S., Buchsbaum, M.S., Hodgson, M.J., and Robin, N.: PET and neurobehavioral evidence of tetrabromoethane encephalopathy. J. Neuropsychiatry Clin. Neurosci. 2(4) : 431-435, 1990.
- (stomach tumors in mice)
Van Duuren, B.L., Goldschmidt, B.M., Loewengart, G., Smith, A.C., Melchionne, S., Seldman, I. and Roth, D.: Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice. J. Natl. Cancer Inst. 63(6): 1433-1439, 1979.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
-
sampling media: Silica Gel Tube (150/75 mg sections)
analytical solvent: Tetrahydrofuran
maximum volume: 100 Liters maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Manual of Analytical Methods (NIOSH 2003)
method classification: Fully Validated
Wipe sampling: No.
* All Trademarks are the property of their respective owners.
|
|
|
|
 |
|
Back to Top
www.osha.gov
