Extensive resequencing is taking place on 75 candidate genes at three
Genomics Centers:
The division of labor is indicated in the table below. In each of the
three laboratories, parallel activities are proceeding with both the
resequencing of all 75 genes in the 190 cases and the identification
of ht-SNPs, based on 733 unrelated subjects genotyped by different technologies.
Common to all three centers is a common strategy for resequencing genes
identified from the 190 cases of prostate and breast cancer.
Gene Name |
Pathway |
Description |
Platform |
Breast |
Prostate |
GHR |
IGF |
GROWTH HORMONE RECEPTOR |
Illumina |
x |
x |
GHRH |
IGF |
GROWTH HORMONE-RELEASING HORMONE |
Illumina* |
x |
x |
GHRHR |
IGF |
GROWTH HORMONE-RELEASING HORMONE RECEPTOR |
Illumina* |
x |
x |
IGF1 |
IGF |
INSULIN-LIKE GROWTH FACTOR I |
Taqman |
x |
x |
IGF1R |
IGF |
INSULIN-LIKE GROWTH FACTOR I RECEPTOR |
Illumina |
x |
x |
IGF2 |
IGF |
INSULIN-LIKE GROWTH FACTOR 2 |
Illumina |
x |
x |
IGF2R |
IGF |
INSULIN-LIKE GROWTH FACTOR II RECEPTOR |
Illumina |
x |
x |
IGFALS |
IGF |
IGFBP ACID-LABILE SUBUNIT |
Illumina |
x |
x |
IGFBP1 |
IGF |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN |
Taqman |
x |
x |
IGFBP2/5 |
IGF |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN |
Illumina |
x |
x |
IGFBP3 |
IGF |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN |
Taqman |
x |
x |
IGFBP4 |
IGF |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN |
Illumina |
x |
x |
IGFBP6 |
IGF |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN |
Illumina |
x |
x |
INSR |
IGF |
INSULIN RECEPTOR |
Illumina |
x |
x |
IRS1 |
IGF |
INSULIN RECEPTOR SUBSTRATE 1 |
Illumina |
x |
x |
IRS2 |
IGF |
INSULIN RECEPTOR SUBSTRATE 2 |
Illumina |
x |
x |
POU1F1 |
IGF |
POU DOMAIN, CLASS 1, TRANSCRIPTION FACTOR 1 |
Illumina |
x |
x |
SST |
IGF |
SOMATOSTATIN |
Illumina |
x |
x |
SSTR1 |
IGF |
SOMATOSTATIN RECEPTOR 1 |
Illumina |
x |
x |
SSTR2 |
IGF |
SOMATOSTATIN RECEPTOR 2 |
Illumina |
x |
x |
SSTR3 |
IGF |
SOMATOSTATIN RECEPTOR 3 |
Illumina |
x |
x |
SSTR4 |
IGF |
SOMATOSTATIN RECEPTOR 4 |
Illumina |
x |
x |
SSTR5 |
IGF |
SOMATOSTATIN RECEPTOR 5 |
Illumina |
x |
x |
IL6 |
inflam (?) |
INTERLEUKIN 6 |
Illumina |
x |
x |
PTGS2 |
inflam (?) |
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 |
Illumina |
x |
x |
TLR4 |
inflam (?) |
TOLL-LIKE RECEPTOR |
Taqman |
x |
x |
PIK3AP1 |
PIK |
PHOSPHOINOSITIDE 3-KINASE ADAPTOR PROTEIN 1 |
Illumina |
x |
x |
PIK3C2A |
PIK |
PHOSPHATIDYLINOSITOL 3-KINASE, CLASS 2, ALPHA |
Illumina |
x |
x |
PIK3C2B |
PIK |
PHOSPHATIDYLINOSITOL 3-KINASE, CLASS 2, BETA |
Illumina |
x |
x |
PIK3CD |
PIK |
PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, DELTA |
Illumina |
x |
x |
PIK3R3 |
PIK |
PHOSPHATIDYLINOSITOL 3-KINASE, REGULATORY SUBUNIT 3 |
Illumina |
x |
x |
CASP8 |
replication |
CASPASE 8 |
Illumina |
x |
x |
CAT |
replication |
CATALASE |
Illumina |
x |
x |
DPF3 |
replication |
|
Illumina |
x |
x |
GPX1 |
replication |
GLUTATHIONE PEROXIDASE |
Illumina |
x |
x |
ICAM1 |
replication |
INTERCELLULAR ADHESION MOLECULE |
|
x |
x |
ICAM5 |
replication |
INTERCELLULAR ADHESION MOLECULE |
Illumina |
x |
x |
MC2R |
replication |
MELANOCORTIN 2 RECEPTOR |
Illumina |
x |
x |
MnSOD |
replication |
SUPEROXIDE DISMUTASE |
Taqman |
x |
x |
MPO |
replication |
MYELOPEROXIDASE |
Taqman |
x |
x |
ACTHR |
steroid |
ADRENOCORTICOTROPIC HORMONE RECEPTOR |
Taqman |
x |
x |
ACVR1 |
steroid |
ACTIVIN A RECEPTOR, TYPE I |
Illumina |
x |
x |
ACVR2 |
steroid |
ACTIVIN A RECEPTOR, TYPE II |
Illumina |
x |
x |
AKR1C3 |
steroid |
ALDO-KETO REDUCTASE FAMILY 1, MEMBER C3 |
Illumina |
x |
x |
AR |
steroid |
ANDROGEN RECEPTOR |
Taqman |
x |
x |
CGA |
steroid |
CHORIONIC GONADOTROPIN |
Illumina |
x |
x |
COMT |
steroid |
CATECHOL - O -METHYL TRANSFERASE |
Taqman |
x |
x |
CYP11A |
steroid |
|
Taqman |
x |
x |
CYP17 |
steroid |
|
Taqman |
x |
x |
CYP19 |
steroid |
|
Taqman |
x |
x |
CYP1A1 |
steroid |
|
Taqman |
x |
x |
CYP1A2 |
steroid |
|
Taqman |
x |
x |
CYP1B1 |
steroid |
|
Taqman |
x |
x |
CYP3A4 |
steroid |
|
Illumina |
x |
x |
ESR1 |
steroid |
ESTROGEN RECEPTOR ALPHA |
Illumina |
x |
x |
ESR2 |
steroid |
ESTROGEN RECEPTOR BETA |
Taqman* |
x |
x |
FSHB |
steroid |
FOLLICLE-STIMULATING HORMONE BETA UNIT |
Taqman |
x |
x |
FSHR |
steroid |
FOLLICLE-STIMULATING HORMONE RECEPTOR |
Illumina |
x |
x |
HSD17B1 |
steroid |
17-BETA-HYDROXYSTEROID DEHYDROGENASE 1 |
Taqman |
x |
x |
HSD17B2 |
steroid |
17-BETA-HYDROXYSTEROID DEHYDROGENASE 2 |
Taqman |
x |
x |
HSD17B3 |
steroid |
17-BETA-HYDROXYSTEROID DEHYDROGENASE 3 |
Illumina |
x |
x |
HSD17B4 |
steroid |
17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 |
Illumina |
x |
x |
HSD3B1/2 |
steroid |
3-BETA-HYDROXYSTEROID DEHYDROGENASE |
Illumina |
x |
x |
INHA |
steroid |
INHIBIN, ALPHA |
Illumina |
x |
x |
INHBA |
steroid |
INHIBIN, BETA A |
Illumina |
x |
x |
INHBB |
steroid |
INHIBIN, BETA B |
Illumina |
x |
x |
LHB |
steroid |
LUTEINIZING HORMONE, BETA |
Illumina |
x |
x |
LHCGR |
steroid |
LUTEINIZING HORMONE/CHORIOGONADOTROPIN RECEPTOR |
Illumina |
x |
x |
PGR |
steroid |
PROGESTERONE RECEPTOR |
Illumina* |
x |
x |
POMC |
steroid |
PROOPIOMELANOCORTIN |
Illumina |
x |
x |
PRL |
steroid |
PROLACTIN |
Illumina |
x |
x |
PRLR |
steroid |
PROLACTIN RECEPTOR |
Illumina |
x |
x |
SHBG |
steroid |
SEX HORMONE-BINDING GLOBULIN |
Illumina |
x |
x |
SRD5A1 |
steroid |
STEROID 5-ALPHA-REDUCTASE 1 |
Illumina |
x |
x |
SRD5A2 |
steroid |
STEROID 5-ALPHA-REDUCTASE 2 |
Illumina |
x |
x |
UGTB7/17 |
steroid |
URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 2, B7 |
Illumina |
x |
x |