Sarkissian NA; National Conference on Human Retroviruses and Related Infections.
Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 121.
Medical University, Varna, Bulgaria
An in vitro model of mixed infection in cell culture using HIV-I and Influenza Virus (IfV) was developed. We studied human T-lymphoblastoma cells MT4 and promonocytar U-937 cells. Both cell lines had moderate sensitivity to human IfV (A/USSR/90/77(H3N2)). Simultaneous or consequent administration of IfV in the mixed infection led to (i) reducing of speed of destructive processes in cell culture; (ii) decreasing of amount of IfV-positive cells; (iii) repeated infection with IfV does not influence upon HIV-I replication in cell culture. Ultrastructural study showed that both viruses are capable to pass a full cycle of replication in cells, which results in formation of morphologically mature virions. The developed model allowed to reveal the formation of derivative structures of rough reticulum, which found solely in Hairy cell leukemia.
Publication Types:
Keywords:
- Animals
- Cell Line
- HIV-1
- Humans
- In Vitro
- Influenza A virus
- Orthomyxoviridae
- USSR
- Virion
Other ID:
UI: 102214331
From Meeting Abstracts