Testing Status of Agents at NTP
Nitrofurantoin
CASRN: 67-20-9
Formula: C8-H6-N4-O5
Synonyms/Common Names:
- 1-(((5-NITRO-2-FURANYL)METHYLENE)AMINO)-2,4-IMIDAZOLIDINEDIONE (9CI)
Known Uses:
URINARY ANTIBACTERIAL AGENT. (TDB)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55196) Completed
- NTIS No. PB90-197930
(Peer Review 04/18/1988)
Citation: Toxicology and Carcinogenesis Studies of Nitrofurantoin (CAS No. 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB90-197930
(Peer Review 04/18/1988)
- 13-Week (Dosed-Feed)
(C55196) Completed
- NTIS No. PB90-197930
(Peer Review 04/18/1988)
Citation: Toxicology and Carcinogenesis Studies of Nitrofurantoin (CAS No. 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,600,10000, M: 0,300,5000 PPM/10 PER GROUP
- NTIS No. PB90-197930
(Peer Review 04/18/1988)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C55196) Report Complete
- TR-341 (NTIS No. PB90-197930)
(Peer Review 04/18/1988)
Toxicology and Carcinogenesis Studies of Nitrofurantoin (CAS No. 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Clear Evidence
- Dose: FR: 0,600,1300, MR&M: 0,1300,2500 PPM/50 PER GROUP
- TR-341 (NTIS No. PB90-197930)
(Peer Review 04/18/1988)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(161709) Completed
- Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(986170) Completed
- Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(922322) Completed
- Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
- Positive
- Micronucleus
(A51689) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(131452) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
- Salmonella
(133668) Completed
- Positive
- Salmonella
(451594) Completed
- Positive
- Salmonella
(626123) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
- Salmonella
(674104) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
- Salmonella
(962072) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
- Salmonella
(981362) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
Organ Systems Toxicity
- 120 DAY MINIMUM Continuous Breeding (Dosed-Feed)
(RACB89063) Completed
- NTIS No. PB93-175354
Citation: Final Report on the Reproduction and Fertility Assessment in Swiss CD-1 Mice for Nitrofurantoin when Administered via Feed - M/F Mice: Swiss
- Dose: 0,.02,.05,.1,.2,.4%; 0,.03,.06,.12%; 0,.12%; 0,.12%
- NTIS No. PB93-175354
Web page last updated on January 22, 2009