Lucchini A, Fora R, Cariti G, Sciandra M, Delli Quadri R, Sinicco A; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 284 (abstract no. PO-B01-0893).
Inst. of Infect. Dis. Univ. of Turin, Italy.
In order to evaluate the risk of developing AIDS after an episode of H.Z., we studied 134 newly HIV seroconverted patients: 108 (80.6%) men and 26 (19.4%) women (74, 55.2% IDUs; 33, 24.6% homosexual men; 26, 19.4% heterosexual and 1 professional exposure; average age: 29.7 +/- 8 years R. 18-59). The average time from last negative to first positive HIV test was 6.7 +/- 3.5 months (R.: 1-12). When first seen, 23 pts were in CDC I, 47 in stage II, and 64 in stage III. The mean follow-up time was 36.4 +/- 20.2 months (R.: 3-74). During follow-up 11 pts (8.2%) had an episode of H.Z.; no correlation was found with age. H.Z. was significantly more frequent in homosexuals (p = .002). A case-control analysis revealed a significant lower number of CD4+ cells in pts at diagnosis of H.Z. compared with pts without H.Z. at equal time from seroconversion (p = .003). Five pts with H.Z. developed AIDS later on. The estimated risk of developing H.Z. in the cohort was 22% at 62 months from seroconversion; the risk of developing AIDS after H.Z. was 52% at 31 months, 76% at 56 months from H.Z.. The risk of developing AIDS in pts who manifested an H.Z. was significantly higher than in pts with no episode of H.Z. (Log-Rank test: p = .025). The occurrence of H.Z. during the natural history of HIV infection is an important clinical predictor of progression to AIDS.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- CD4-Positive T-Lymphocytes
- Disease Progression
- Female
- HIV
- HIV Core Protein p24
- HIV Infections
- HIV Seropositivity
- Herpes Zoster
- Herpesvirus 3, Human
- Homosexuality
- Humans
- Male
- immunology
Other ID:
UI: 102203766
From Meeting Abstracts