Rossi T, Mazzilli F, D'Offizi G, Rosso R, Pinter E, Sarandrea N, Dondero F, Aiuti F; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 295 (abstract no. PC0107).
5th Medical Clinic Univ. of Rome La Sapienza.
OBJECTIVE: Semen is considered to be an important vehicle in HIV transmission. In our study we performed a longitudinal study of semen parameters in HIV infected patients and in high risk group to identify functional alterations of sperm in HIV+ patients and to establish whether these could precede seroconversion. METHODS: We selected 16 HIV+ patients (4 CDC II, 4 CDC III, 8 CDC IVC2), 36 "high risk" seronegative for HIV subjects, 30 potential semen donors. Semen analysis, the hypoosmotic swelling test, the neutral red test and seminal plasma biochemical analysis were performed according to WHO standards. RESULTS: 85% of HIV+ patient showed an alteration of the sperm kinetic properties (44% of high risk subjects). Viscosity is increased in about 50% of HIV+ patients compared to 25% of high risk subjects. In both group, HIV+ patients and high risk subjects there was a significant increase of the percentage of leukocytes and prevalence of peroxidase positive cells (high risk subjects). 44% of HIV+ (22% of high risk subjects) showed high level of spermiophage cells. DISCUSSION AND CONCLUSIONS: Physical seminal parameters in HIV-1 infected patients are modified according to CDC stage. Our preliminary data indicate: 1) increased viscosity is probably due to the phlogosys of the adnexal glands of the genital tract even in asymptomatic patients; 2) early failure of epididymal function and 3) an increased level of spermiophage cells perhaps involved in the sexual transmission of HIV-1.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- HIV
- HIV Core Protein p24
- HIV Envelope Protein gp120
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Longitudinal Studies
- Male
- Prevalence
- Semen
- Sperm Count
- Spermatozoa
- immunology
Other ID:
UI: 102208927
From Meeting Abstracts