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Commonly used P. falciparum clones This list contains information on Plasmodium falciparum clones, their origin, drug sensitivity, protein, isoenzyme, and 2D-gel profiles. Clone Origin Drug Sensitivity Protein markers Isoenzymes 2D-gel proteins 3D7A Netherlands, Clone from isolate NF54 . . . Walliker et al., 1987, Science, 236(4809): 1661-1666 CQ 10-7 Pyr 10-9 5.1 - 7.3- 9.2+ 9.5- 12.2+ 12.1- 10.4+ 9.4- 12.3- 9.21- GPI-1 ADA-1 PEP-1 A-2 C-2 D-2 E-3 F-2 G-1 K-3 . 3D7B Netherlands, . . . . 3D7A after mosquito transmission CQ 10-7 Pyr 10-9 5.1 - 7.3- 9.2+ 9.5- 12.2+ 12.1- 10.4+ 9.4- 12.3- 9.21- GPI-1 ADA-1 PEP-1 A-2 C-2 D-2 E-3 F-2 G-1 K-3 . HB3A Honduras, Clone of H-1, produced by W. Trager. (Walliker et al., 1987, Science, 236-1661-1666). CQ 10-7 Pyr 10-7 5.1+ 9.2- 12.2- 10.4- 12.3- 7.3+ 9.5- 12.1- 9.4- 9.21+ GPI-1 ADA-2 PEP-1 A-2 D-4 F-2 K-1 C-6 E-4 G-2 HB3B Honduras = HB3A after mosquito transmission CQ 10-7 Pyr 10-7 5.1+ 9.2- 12.2- 10.4- 12.3- 7.3+ 9.5- 12.1- 9.4- 9.21+ GPI-1 ADA-2 PEP-1 A-2 D-4 F-2 K-1 C-6 E-4 G-2 7G8 Brazil. Clone derived from isolate IMTM22 (Burkot et al., 1984, Trans Roy Soc Trop Med Hyg 78, 339-341) CQ10-6 Pyr10-5 5.1- 9.2- 12.2- 10.4+ 12.3+ 7.3- 9.5+ 12.1- 9.4- 9.21+ GPI-1 ADA-1 PEP-1 Not tested T9-94 Thailand. Clone from isolate T9. (Thaithong et al., 1984. Trans Roy Soc Trop Med Hyg 78, 242-245) CQ5x10-7 Pyr10-9 5.1+ 9.2- 12.2- 10.4- 12.3+ 7.3+ 9.5- 12.1- 9.4- 9.21- GPI-1 ADA-1 PEP-1 A-4 D-5 F-3 K-6 C-2 E-2 G-2 T9-96 Thailand. Clone from isolate T9. (Thaithong et al., 1984. Trans Roy Soc Trop Med Hyg 78, 242-245) CQ10-7 Pyr10-9 5.1+ 9.2+ 12.2+ 10.4+ 12.3+ 7.3- 9.5- 12.1+ 9.4- 9.21+ GPI-2 ADA-1 PEP-2 A-2 D-4 F-2 K-3 C-1 E-3 G-2 T9-98 Thailand. Clone from isolate T9 (Thaithong et al., 1984. Trans Roy Soc Trop Med Hyg 78, 242-245) CQ10-7 5x10-5 5.1+ 9.2+ 12.2+ 10.4+ 12.3+ 7.3- 9.5- 12.1+ 9.4- 9.21+ GPI-2 ADA-1 PEP-2 A-2 D-4 F-2 K-3 C-1 E-3 G-2 T9-101 Thailand. Clone from isolate T9 (Thaithong et al., 1984. Trans Roy Soc Trop Med Hyg 78, 242-245) CQ10-6 5x10-5 5.1+ 9.2+ 12.2+ 10.4+ 12.3+ 7.3- 9.5- 12.1- 9.4+ 9.21+ GPI-1 ADA-2 PEP-1 A-1 D-4 F-2 K-6 C-2 E-3 G-2 T9-102 Thailand. Clone from isolate T9. (Thaithong et al., 1984. Trans Roy Soc Trop Med Hyg 78, 242-245) CQ10-6 Pyr5x10-5 5.1- 9.2+ 12.2- 10.4+ 12.3+ 7.3- 9.5- 12.1+ 9.4+ 9.21+ GPI-1 ADA-1 PEP-1 A-1 D-5 F-2 K-6 C-2 E-3 G-2 Compiled by David Walliker, University of Edinburgh, UK Last updated: Mar 14, 2000 Disclaimer | Write to the Help Desk NCBI | NLM | NIH