BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= TDE2469
(437 letters)
Database: nr
5,470,121 sequences; 1,894,087,724 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42527969|ref|NP_973067.1| hexokinase family protein [Tre... 853 0.0
gi|15639496|ref|NP_218946.1| hexokinase (hxk) [Treponema pa... 303 2e-80
gi|156868657|gb|EDO62029.1| hypothetical protein CLOLEP_008... 251 5e-65
gi|15222973|ref|NP_175463.1| hexokinase, putative [Arabidop... 108 9e-22
gi|153809463|ref|ZP_01962131.1| hypothetical protein BACCAC... 104 1e-20
gi|45387407|gb|AAS60194.1| hexokinase 3 [Nicotiana tabacum] 100 4e-19
gi|47218712|emb|CAG05684.1| unnamed protein product [Tetrao... 99 6e-19
gi|11494010|gb|AAG35735.1|AF208543_1 hexokinase [Lycopersic... 99 6e-19
gi|11386887|sp|Q9SQ76|HXK2_SOLTU Hexokinase-2 (StHK2) >gi|6... 98 1e-18
gi|34451887|gb|AAQ72424.1| hexokinase PpHxk1 [Physcomitrell... 98 1e-18
gi|50512102|gb|AAT77513.1| hexokinase 3 [Nicotiana sylvestris] 97 2e-18
gi|74272328|gb|ABA01010.1| hexokinase [Solanum chacoense] 97 2e-18
gi|115439869|ref|NP_001044214.1| Os01g0742500 [Oryza sativa... 97 2e-18
gi|587202|emb|CAA86511.1| Human hexokinase II cDNA [Homo sa... 96 3e-18
gi|7549765|ref|NP_036867.1| hexokinase 2 [Rattus norvegicus... 96 3e-18
gi|15553127|ref|NP_000180.2| hexokinase 2 [Homo sapiens] >g... 96 3e-18
gi|150866927|ref|XP_001386689.2| Hexokinase [Pichia stipiti... 96 3e-18
gi|114578344|ref|XP_001162535.1| PREDICTED: hexokinase 2 is... 96 4e-18
gi|114578346|ref|XP_001162408.1| PREDICTED: hexokinase 2 is... 96 4e-18
gi|119390703|pdb|2NZT|A Chain A, Crystal Structure Of Human... 96 4e-18
gi|91077784|ref|XP_966410.1| PREDICTED: similar to CG3001-P... 96 4e-18
gi|5804910|emb|CAA86476.2| hexokinase II [Homo sapiens] 96 4e-18
gi|7305143|ref|NP_038848.1| hexokinase 2 [Mus musculus] >gi... 96 4e-18
gi|119620009|gb|EAW99603.1| hexokinase 2, isoform CRA_b [Ho... 96 4e-18
gi|91077786|ref|XP_975828.1| PREDICTED: similar to CG3001-P... 96 6e-18
gi|29347840|ref|NP_811343.1| hexokinase type III [Bacteroid... 95 8e-18
gi|134299664|ref|YP_001113160.1| Hexokinase [Desulfotomacul... 95 1e-17
gi|156109318|gb|EDO11063.1| hypothetical protein BACOVA_029... 94 2e-17
gi|91077818|ref|XP_970645.1| PREDICTED: similar to CG3001-P... 94 2e-17
gi|109103519|ref|XP_001111706.1| PREDICTED: similar to hexo... 94 2e-17
gi|45383696|ref|NP_989543.1| hexokinase 2 [Gallus gallus] >... 94 2e-17
gi|109103521|ref|XP_001111663.1| PREDICTED: similar to hexo... 94 2e-17
gi|91077782|ref|XP_975717.1| PREDICTED: similar to CG3001-P... 93 3e-17
gi|119903225|ref|XP_001255832.1| PREDICTED: similar to hexo... 93 3e-17
gi|11066979|gb|AAG28789.1|AF309088_1 hexokinase [Tuber borc... 93 3e-17
gi|51476140|emb|CAH18060.1| hypothetical protein [Homo sapi... 93 4e-17
gi|2689658|gb|AAB91396.1| mutant type II hexokinase [Rattus... 93 4e-17
gi|126304047|ref|XP_001381777.1| PREDICTED: similar to hexo... 92 5e-17
gi|126352418|ref|NP_001075245.1| hexokinase II [Equus cabal... 92 8e-17
gi|122134685|sp|Q1W674|HXK2_PIG Hexokinase-2 (Hexokinase ty... 92 9e-17
gi|68492091|ref|XP_710176.1| hexokinase-like protein [Candi... 91 1e-16
gi|30961939|gb|AAP40021.1| hexokinase [Nicotiana benthamiana] 91 1e-16
gi|47085787|ref|NP_998231.1| hexokinase 2 [Danio rerio] >gi... 91 1e-16
gi|68477224|ref|XP_717405.1| putative hexokinase II [Candid... 91 2e-16
gi|45387403|gb|AAS60192.1| hexokinase 1a [Nicotiana tabacum] 90 3e-16
gi|73980943|ref|XP_532991.2| PREDICTED: similar to hexokina... 89 4e-16
gi|149238644|ref|XP_001525198.1| hexokinase [Lodderomyces e... 89 5e-16
gi|38195100|gb|AAR13363.1| hexokinase [Brugia malayi] 89 7e-16
gi|47218711|emb|CAG05683.1| unnamed protein product [Tetrao... 89 8e-16
gi|11386886|sp|Q9SEK3|HXK1_SPIOL Hexokinase-1 (SoHxK1) >gi|... 88 1e-15
gi|68485995|ref|XP_713116.1| putative hexokinase [Candida a... 88 1e-15
gi|126343371|ref|XP_001380610.1| PREDICTED: similar to hexo... 88 1e-15
gi|125571979|gb|EAZ13494.1| hypothetical protein OsJ_003319... 88 1e-15
gi|66507476|ref|XP_392350.2| PREDICTED: similar to Hexokina... 87 2e-15
gi|113207858|emb|CAJ28915.1| hexokinase [Crassostrea gigas] 87 2e-15
gi|157123146|ref|XP_001660030.1| hexokinase [Aedes aegypti]... 87 2e-15
gi|23477117|emb|CAC81350.1| hexokinase [Solanum lycopersicum] 87 2e-15
gi|72082796|ref|XP_786955.1| PREDICTED: similar to hexokina... 87 3e-15
gi|53713814|ref|YP_099806.1| hexokinase type III [Bacteroid... 87 3e-15
gi|11386885|sp|Q9SEK2|HXK1_TOBAC Hexokinase-1 (NtHxK1) >gi|... 87 3e-15
gi|50346083|gb|AAT74901.1| general specificity hexokinase [... 87 3e-15
gi|157123148|ref|XP_001660031.1| hexokinase [Aedes aegypti]... 87 3e-15
gi|70984695|ref|XP_747854.1| glucokinase GlkA, putative [As... 87 3e-15
gi|50512106|gb|AAT77515.1| hexokinase 7 [Nicotiana tabacum] 86 3e-15
gi|60682032|ref|YP_212176.1| putative hexokinase [Bacteroid... 86 4e-15
gi|75061917|sp|Q5RC71|HXK1_PONPY Hexokinase-1 (Hexokinase t... 86 4e-15
gi|171735|gb|AAA34697.1| hexokinase P-II peptide >gi|224664... 86 4e-15
gi|171739|gb|AAA34699.1| hexokinase (HXK2) 86 4e-15
gi|27805797|ref|NP_776744.1| FK506 binding protein 12-rapam... 86 4e-15
gi|119467212|ref|XP_001257412.1| glucokinase GlkA, putative... 86 4e-15
gi|119113166|ref|XP_564289.2| ENSANGP00000028361 [Anopheles... 86 5e-15
gi|45198797|ref|NP_985826.1| AFR279Cp [Ashbya gossypii ATCC... 86 5e-15
gi|15991833|ref|NP_277035.1| hexokinase 1 isoform HKI-td [H... 86 6e-15
gi|109089480|ref|XP_001110227.1| PREDICTED: similar to hexo... 86 7e-15
gi|114630843|ref|XP_001169123.1| PREDICTED: hexokinase 1 is... 86 7e-15
gi|114630841|ref|XP_001169215.1| PREDICTED: hexokinase 1 is... 86 7e-15
gi|109089478|ref|XP_001110396.1| PREDICTED: similar to hexo... 85 8e-15
gi|15991827|ref|NP_277031.1| hexokinase 1 isoform HKI-R [Ho... 85 8e-15
gi|9955857|dbj|BAB12228.1| hexokinase [Aspergillus oryzae] ... 85 8e-15
gi|119574708|gb|EAW54323.1| hexokinase 1, isoform CRA_d [Ho... 85 8e-15
gi|68492364|ref|XP_710054.1| putative hexokinase [Candida a... 85 9e-15
gi|114630847|ref|XP_507830.2| PREDICTED: hexokinase 1 isofo... 85 9e-15
gi|148230649|ref|NP_001090603.1| hypothetical protein LOC10... 85 9e-15
gi|15991829|ref|NP_277032.1| hexokinase 1 isoform HKI-ta/tb... 85 9e-15
gi|62088632|dbj|BAD92763.1| hexokinase 1 isoform HKI varian... 85 9e-15
gi|109089482|ref|XP_001110350.1| PREDICTED: similar to hexo... 85 9e-15
gi|4504391|ref|NP_000179.1| hexokinase 1 isoform HKI [Homo ... 85 1e-14
gi|114630831|ref|XP_001169044.1| PREDICTED: hexokinase 1 is... 85 1e-14
gi|3891376|pdb|1HKC|A Chain A, Recombinant Human Hexokinase... 85 1e-14
gi|51511835|gb|AAU05129.1| hexokinase [Aedes aegypti] 85 1e-14
gi|114630829|ref|XP_001169069.1| PREDICTED: hexokinase 1 is... 85 1e-14
gi|116242516|sp|P19367|HXK1_HUMAN Hexokinase-1 (Hexokinase ... 85 1e-14
gi|33303851|gb|AAQ02439.1| hexokinase 1 [synthetic construct] 85 1e-14
gi|121715264|ref|XP_001275241.1| hexokinase Kxk, putative [... 85 1e-14
gi|109089474|ref|XP_001110269.1| PREDICTED: similar to hexo... 85 1e-14
gi|7245424|pdb|1CZA|N Chain N, Mutant Monomer Of Recombinan... 85 1e-14
gi|7245352|pdb|1DGK|N Chain N, Mutant Monomer Of Recombinan... 85 1e-14
gi|47212304|emb|CAF90567.1| unnamed protein product [Tetrao... 84 1e-14
gi|46107234|ref|XP_380676.1| conserved hypothetical protein... 84 2e-14
gi|79408026|ref|NP_188639.2| ATP binding / hexokinase [Arab... 84 2e-14
gi|125806651|ref|XP_001360104.1| GA20820-PA [Drosophila pse... 84 2e-14
gi|3793|emb|CAA27203.1| unnamed protein product [Saccharomy... 84 2e-14
gi|15233457|ref|NP_194642.1| ATHXK1 (GLUCOSE INSENSITIVE 2)... 84 2e-14
gi|109089484|ref|XP_001110189.1| PREDICTED: similar to hexo... 84 2e-14
gi|6321184|ref|NP_011261.1| Hexokinase isoenzyme 2 that cat... 84 2e-14
gi|62320799|dbj|BAD93730.1| hexokinase [Arabidopsis thaliana] 84 2e-14
gi|19113860|ref|NP_592948.1| hypothetical protein SPAC24H6.... 84 2e-14
gi|7110599|ref|NP_036697.1| glucokinase [Rattus norvegicus]... 84 2e-14
gi|125982385|ref|XP_001355083.1| GA15574-PA [Drosophila pse... 84 2e-14
gi|71009859|ref|XP_758320.1| hypothetical protein UM02173.1... 84 2e-14
gi|125833087|ref|XP_001333260.1| PREDICTED: similar to Hexo... 84 2e-14
gi|30316354|sp|P17710|HXK1_MOUSE Hexokinase-1 (Hexokinase t... 84 3e-14
gi|619928|gb|AAA60333.1| hexokinase [Arabidopsis thaliana] ... 84 3e-14
gi|145234396|ref|XP_001400569.1| hexokinase hxk-Aspergillus... 84 3e-14
gi|50424765|ref|XP_460972.1| hypothetical protein DEHA0F151... 83 3e-14
gi|49114981|gb|AAH72832.1| Hk1-A protein [Xenopus laevis] 83 3e-14
gi|1008870|gb|AAC42074.1| glucokinase >gi|15029832|gb|AAH11... 83 3e-14
gi|148700161|gb|EDL32108.1| hexokinase 1, isoform CRA_f [Mu... 83 3e-14
gi|148700157|gb|EDL32104.1| hexokinase 1, isoform CRA_b [Mu... 83 3e-14
gi|123902|sp|P17712|HXK4_RAT Glucokinase (Hexokinase-4) (He... 83 4e-14
gi|148700160|gb|EDL32107.1| hexokinase 1, isoform CRA_e [Mu... 83 4e-14
gi|68477041|ref|XP_717498.1| putative hexokinase II [Candid... 83 4e-14
gi|156840029|ref|XP_001643699.1| hypothetical protein Kpol_... 83 4e-14
gi|125833184|ref|XP_708314.2| PREDICTED: hypothetical prote... 82 5e-14
gi|119480367|ref|XP_001260212.1| hexokinase Kxk, putative [... 82 5e-14
gi|155008466|gb|ABS89272.1| hexokinase 1a [Gadus morhua] 82 5e-14
gi|31982798|ref|NP_034422.2| glucokinase [Mus musculus] >gi... 82 5e-14
gi|67003902|gb|AAY60842.1| plastidic hexokinase [Solanum ly... 82 6e-14
gi|74150648|dbj|BAE25472.1| unnamed protein product [Mus mu... 82 6e-14
gi|309289|gb|AAA37804.1| hexokinase (EC 2.7.1.1) 82 6e-14
gi|49117745|gb|AAH72628.1| Hk1 protein [Mus musculus] >gi|1... 82 6e-14
gi|50285099|ref|XP_444978.1| hypothetical protein CAGL0A048... 82 6e-14
gi|50422061|ref|XP_459592.1| hypothetical protein DEHA0E070... 82 6e-14
gi|74207854|dbj|BAE29060.1| unnamed protein product [Mus mu... 82 6e-14
gi|68487478|ref|XP_712360.1| putative hexokinase [Candida a... 82 7e-14
gi|126303415|ref|XP_001379711.1| PREDICTED: similar to gluc... 82 7e-14
gi|156717322|ref|NP_001096201.1| hexokinase 1 [Xenopus trop... 82 7e-14
gi|33468329|gb|AAQ19647.1| hexokinase [Pichia angusta] 82 7e-14
gi|74195468|dbj|BAE39552.1| unnamed protein product [Mus mu... 82 7e-14
gi|45387413|gb|AAS60197.1| hexokinase 5 [Nicotiana tabacum] 82 7e-14
gi|51511833|gb|AAU05128.1| hexokinase [Aedes albopictus] 82 8e-14
gi|70989741|ref|XP_749720.1| hexokinase Kxk, putative [Aspe... 82 8e-14
gi|115400741|ref|XP_001215959.1| hexokinase [Aspergillus te... 82 8e-14
gi|116500997|gb|EAU83892.1| hypothetical protein CC1G_11986... 82 8e-14
gi|45383904|ref|NP_989432.1| hexokinase 1 [Gallus gallus] >... 82 8e-14
gi|67937782|gb|AAY83348.1| hexokinase [Hypocrea jecorina] 82 9e-14
gi|18026821|gb|AAL55635.1|AF118134_1 hexokinase-related pro... 82 9e-14
gi|148743500|gb|AAM83106.4|AF525739_1 liver glucokinase [Ga... 82 9e-14
gi|114613113|ref|XP_001143590.1| PREDICTED: glucokinase iso... 82 9e-14
gi|114613117|ref|XP_001143302.1| PREDICTED: glucokinase iso... 82 1e-13
gi|110189777|gb|ABG56071.1| hexokinase 2 [Monocercomonoides... 81 1e-13
gi|146423316|ref|XP_001487588.1| hypothetical protein PGUG_... 81 1e-13
gi|156121249|ref|NP_001095772.1| hypothetical protein LOC61... 81 1e-13
gi|149704614|ref|XP_001495888.1| PREDICTED: similar to gluc... 81 1e-13
gi|47221354|emb|CAF97272.1| unnamed protein product [Tetrao... 81 1e-13
gi|66525954|ref|XP_623403.1| PREDICTED: similar to Hexokina... 81 1e-13
gi|46114344|ref|XP_383190.1| hypothetical protein FG03014.1... 81 1e-13
gi|83772607|dbj|BAE62735.1| unnamed protein product [Asperg... 81 1e-13
gi|17507937|ref|NP_492905.1| H25P06.1 [Caenorhabditis elega... 81 2e-13
gi|114613115|ref|XP_001143661.1| PREDICTED: glucokinase iso... 81 2e-13
gi|145301541|ref|NP_001077423.1| glucokinase [Felis catus] ... 81 2e-13
gi|15967159|ref|NP_277042.1| glucokinase isoform 2 [Homo sa... 80 2e-13
gi|126139099|ref|XP_001386072.1| Glucokinase [Pichia stipit... 80 2e-13
gi|15967161|ref|NP_277043.1| glucokinase isoform 3 [Homo sa... 80 2e-13
gi|109066689|ref|XP_001092919.1| PREDICTED: similar to gluc... 80 2e-13
gi|113967763|gb|ABI49144.1| hexokinase [Trimastix pyriformis] 80 2e-13
gi|67903404|ref|XP_681958.1| glucokinase [Aspergillus nidul... 80 2e-13
gi|75291596|sp|Q6Q8A5|HXK2_TOBAC Hexokinase-2, chloroplast ... 80 2e-13
gi|47169424|pdb|1V4S|A Chain A, Crystal Structure Of Human ... 80 2e-13
gi|18079297|ref|NP_524848.1| Hexokinase A CG3001-PA, isofor... 80 2e-13
gi|56428895|gb|AAV91306.1| hexokinase A [Drosophila santome... 80 2e-13
gi|24640843|ref|NP_727350.1| Hexokinase A CG3001-PB, isofor... 80 2e-13
gi|6981022|ref|NP_036866.1| hexokinase 1 [Rattus norvegicus... 80 2e-13
gi|5542103|pdb|1BG3|A Chain A, Rat Brain Hexokinase Type I ... 80 2e-13
gi|74149550|dbj|BAE36411.1| unnamed protein product [Mus mu... 80 2e-13
gi|6754206|ref|NP_034568.1| hexokinase 1 [Mus musculus] >gi... 80 2e-13
gi|146417809|ref|XP_001484872.1| hypothetical protein PGUG_... 80 3e-13
gi|39582982|emb|CAE73047.1| Hypothetical protein CBG20417 [... 80 3e-13
gi|148700158|gb|EDL32105.1| hexokinase 1, isoform CRA_c [Mu... 80 3e-13
gi|47169425|pdb|1V4T|A Chain A, Crystal Structure Of Human ... 80 3e-13
gi|148700156|gb|EDL32103.1| hexokinase 1, isoform CRA_a [Mu... 80 3e-13
gi|30585129|gb|AAP36837.1| Homo sapiens glucokinase (hexoki... 80 3e-13
gi|109066687|ref|XP_001093035.1| PREDICTED: similar to gluc... 80 3e-13
gi|4503951|ref|NP_000153.1| glucokinase isoform 1 [Homo sap... 80 3e-13
gi|152211827|gb|ABS31137.1| glucokinase [Homo sapiens] 80 3e-13
gi|67003900|gb|AAY60841.1| hexokinase [Solanum lycopersicum] 80 3e-13
gi|109066691|ref|XP_001092803.1| PREDICTED: similar to gluc... 80 3e-13
gi|39958811|ref|XP_364444.1| hexokinase [Magnaporthe grisea... 80 4e-13
gi|156717562|ref|NP_001096321.1| hypothetical protein LOC10... 79 4e-13
gi|1708366|sp|P50506|HXK_DEBOC Hexokinase >gi|1041966|gb|AA... 79 4e-13
gi|27808608|gb|AAO24584.1| At2g19860 [Arabidopsis thaliana]... 79 4e-13
gi|30694182|ref|NP_175220.2| hexokinase, putative [Arabidop... 79 5e-13
gi|15224857|ref|NP_179576.1| ATHXK2 (HEXOKINASE 2); ATP bin... 79 5e-13
gi|60592784|ref|NP_001012686.1| hexokinase 1 [Bos taurus] >... 79 5e-13
gi|7662683|gb|AAC33586.2| glucokinase [Oncorhynchus mykiss] 79 5e-13
gi|74219346|dbj|BAE26802.1| unnamed protein product [Mus mu... 79 6e-13
gi|21703836|ref|NP_663394.1| hexokinase domain containing 1... 79 6e-13
gi|68437695|ref|XP_702631.1| PREDICTED: hypothetical protei... 79 6e-13
gi|126343367|ref|XP_001364147.1| PREDICTED: similar to Hexo... 79 6e-13
gi|71983705|ref|NP_001021106.1| F14B4.2a [Caenorhabditis el... 79 7e-13
gi|85114646|ref|XP_964736.1| hypothetical protein [Neurospo... 79 8e-13
gi|50307177|ref|XP_453567.1| HXK_KLULA [Kluyveromyces lacti... 78 9e-13
gi|71983713|ref|NP_001021107.1| F14B4.2b [Caenorhabditis el... 78 1e-12
gi|118092591|ref|XP_421579.2| PREDICTED: similar to Hexokin... 78 1e-12
gi|149038694|gb|EDL92983.1| hexokinase 1, isoform CRA_d [Ra... 78 1e-12
gi|54606886|ref|NP_998417.1| hexokinase 1 [Danio rerio] >gi... 78 1e-12
gi|183227|gb|AAB59563.1| glucokinase 78 1e-12
gi|72134844|ref|XP_798648.1| PREDICTED: similar to hexokina... 78 1e-12
gi|150007890|ref|YP_001302633.1| hexokinase type III [Parab... 78 1e-12
gi|121533847|ref|ZP_01665673.1| Hexokinase [Thermosinus car... 78 1e-12
gi|115386740|ref|XP_001209911.1| glucokinase [Aspergillus t... 78 1e-12
gi|149038698|gb|EDL92987.1| hexokinase 1, isoform CRA_h [Ra... 78 1e-12
gi|149038691|gb|EDL92980.1| hexokinase 1, isoform CRA_a [Ra... 78 1e-12
gi|149038700|gb|EDL92989.1| hexokinase 1, isoform CRA_j [Ra... 78 1e-12
gi|149038692|gb|EDL92981.1| hexokinase 1, isoform CRA_b [Ra... 78 1e-12
gi|156538374|ref|XP_001605294.1| PREDICTED: similar to ENSA... 78 1e-12
gi|149038695|gb|EDL92984.1| hexokinase 1, isoform CRA_e [Ra... 78 1e-12
gi|147781819|emb|CAN74362.1| hypothetical protein [Vitis vi... 78 1e-12
gi|45387411|gb|AAS60196.1| hexokinase 4b [Nicotiana tabacum] 78 2e-12
gi|121704084|ref|XP_001270306.1| glucokinase GlkA, putative... 77 2e-12
gi|313225|emb|CAA43855.1| hexakinase [Kluyveromyces lactis] 77 2e-12
gi|116192959|ref|XP_001222292.1| hypothetical protein CHGG_... 77 2e-12
gi|62702157|gb|AAX93084.1| unknown [Homo sapiens] 77 2e-12
gi|149038693|gb|EDL92982.1| hexokinase 1, isoform CRA_c [Ra... 77 2e-12
gi|149038696|gb|EDL92985.1| hexokinase 1, isoform CRA_f [Ra... 77 2e-12
gi|115464965|ref|NP_001056082.1| Os05g0522500 [Oryza sativa... 77 2e-12
gi|149690291|ref|XP_001502742.1| PREDICTED: similar to hexo... 77 2e-12
gi|149038701|gb|EDL92990.1| hexokinase 1, isoform CRA_k [Ra... 77 2e-12
gi|73953342|ref|XP_536376.2| PREDICTED: similar to Hexokina... 77 2e-12
gi|145247326|ref|XP_001395912.1| glucokinase glkA-Aspergill... 77 2e-12
gi|45387409|gb|AAS60195.1| hexokinase 4a [Nicotiana tabacum] 77 2e-12
gi|2495217|sp|Q92407|HXKG_ASPNG Glucokinase (Glucose kinase... 77 2e-12
gi|50512098|gb|AAT77511.1| hexokinase [Nicotiana sylvestris] 77 2e-12
gi|11066213|gb|AAG28503.1|AF196966_1 hexokinase [Citrus sin... 77 2e-12
gi|149038699|gb|EDL92988.1| hexokinase 1, isoform CRA_i [Ra... 77 2e-12
gi|149038697|gb|EDL92986.1| hexokinase 1, isoform CRA_g [Ra... 77 3e-12
gi|147820969|emb|CAN74594.1| hypothetical protein [Vitis vi... 77 3e-12
gi|39581300|emb|CAE72321.1| Hypothetical protein CBG19465 [... 76 3e-12
gi|154297364|ref|XP_001549109.1| hexokinase [Botryotinia fu... 76 4e-12
gi|47227723|emb|CAG09720.1| unnamed protein product [Tetrao... 76 4e-12
gi|204380|gb|AAA41239.1| glucokinase (EC 2.7.1.1) >gi|14904... 76 5e-12
gi|125527545|gb|EAY75659.1| hypothetical protein OsI_003506... 76 5e-12
gi|155008468|gb|ABS89273.1| hexokinase 1b [Gadus morhua] 75 6e-12
gi|156062314|ref|XP_001597079.1| hypothetical protein SS1G_... 75 6e-12
gi|148236406|ref|NP_001079298.1| glucokinase [Xenopus laevi... 75 7e-12
gi|149239002|ref|XP_001525377.1| glucokinase GLK1 [Lodderom... 75 7e-12
gi|157071924|gb|EAA36437.2| hexokinase [Neurospora crassa O... 75 8e-12
gi|204615|gb|AAA41334.1| hexokinase type II 75 8e-12
gi|118727370|ref|ZP_01575973.1| Hexokinase [Clostridium cel... 75 8e-12
gi|34670|emb|CAA47379.1| hexokinase type 1 [Homo sapiens] 75 8e-12
gi|50289391|ref|XP_447127.1| unnamed protein product [Candi... 75 9e-12
gi|18141293|gb|AAL60584.1|AF454962_1 hexokinase [Brassica o... 75 9e-12
gi|18141291|gb|AAL60583.1|AF454961_1 hexokinase [Brassica o... 75 9e-12
gi|15214423|gb|AAH12337.1| HKDC1 protein [Homo sapiens] 75 1e-11
gi|18204272|gb|AAH21278.1| HKDC1 protein [Homo sapiens] 75 1e-11
gi|2072641|emb|CAA72000.1| hexokinase [Entamoeba dispar] 74 1e-11
gi|156151420|ref|NP_079406.3| hexokinase domain containing ... 74 2e-11
gi|71018019|ref|XP_759240.1| hypothetical protein UM03093.1... 74 2e-11
gi|109089486|ref|XP_001110556.1| PREDICTED: similar to hexo... 74 2e-11
gi|50512100|gb|AAT77512.1| hexokinase 2 [Nicotiana sylvestris] 74 2e-11
gi|56242|emb|CAA37658.1| unnamed protein product [Rattus no... 74 2e-11
gi|149726625|ref|XP_001498596.1| PREDICTED: similar to Hexo... 74 3e-11
gi|39971149|ref|XP_366965.1| hypothetical protein MGG_03041... 74 3e-11
gi|7662685|gb|AAC33587.2| glucokinase [Cyprinus carpio] 74 3e-11
gi|6840980|gb|AAF28854.1| hexokinase I [Cyprinus carpio] 73 4e-11
gi|55665501|emb|CAH71500.1| hexokinase domain containing 1 ... 73 4e-11
gi|73954004|ref|XP_546212.2| PREDICTED: similar to Hexokina... 73 4e-11
gi|50542817|gb|AAT78658.1| HexA [synthetic construct] 73 4e-11
gi|50304581|ref|XP_452246.1| unnamed protein product [Kluyv... 73 4e-11
gi|50512104|gb|AAT77514.1| hexokinase 4 [Nicotiana sylvestris] 73 4e-11
gi|119903216|ref|XP_870563.2| PREDICTED: similar to hexokin... 73 4e-11
gi|7211440|gb|AAF40309.1|AF169368_1 glucokinase [Sparus aur... 73 5e-11
gi|19114777|ref|NP_593865.1| hypothetical protein SPAC4F8.0... 72 5e-11
gi|125553030|gb|EAY98739.1| hypothetical protein OsI_019972... 72 6e-11
gi|17864242|ref|NP_524674.1| Hexokinase C CG8094-PA [Drosop... 72 6e-11
gi|10765475|gb|AAG23066.1|AF257542_1 hexokinase-C [Drosophi... 72 6e-11
gi|10765495|gb|AAG23076.1|AF257552_1 hexokinase-C [Drosophi... 72 6e-11
gi|7662681|gb|AAC33585.2| glucokinase [Sparus aurata] 72 6e-11
gi|60098993|emb|CAH65327.1| hypothetical protein [Gallus ga... 72 6e-11
gi|67475982|ref|XP_653620.1| hexokinase [Entamoeba histolyt... 72 6e-11
gi|67900944|ref|XP_680728.1| hypothetical protein AN7459.2 ... 72 6e-11
gi|145236437|ref|XP_001390866.1| hypothetical protein An06g... 72 8e-11
gi|21954124|gb|AAM80479.1| hexokinase [Zea mays] 72 8e-11
gi|17402527|dbj|BAB78697.1| hexokinase [Nicotiana tabacum] 72 8e-11
gi|134087248|ref|ZP_01758216.1| hypothetical protein CNBB30... 72 1e-10
gi|10765479|gb|AAG23068.1|AF257544_1 hexokinase-C [Drosophi... 72 1e-10
gi|145698421|dbj|BAF57005.1| hexokinase 1 [Entamoeba nuttalli] 72 1e-10
gi|10765242|gb|AAG22944.1|AF257637_2 hexokinase-t2 [Drosoph... 72 1e-10
gi|156390224|ref|XP_001635171.1| predicted protein [Nematos... 71 1e-10
gi|2072643|emb|CAA72001.1| hexokinase [Entamoeba dispar] 71 1e-10
gi|61369021|gb|AAX43272.1| hexokinase 3 [synthetic construct] 71 1e-10
gi|20380888|gb|AAH28129.1| Hexokinase 3 (white cell) [Homo ... 71 1e-10
gi|114603561|ref|XP_001137121.1| PREDICTED: hexokinase 3 is... 71 1e-10
gi|114603559|ref|XP_518124.2| PREDICTED: hexokinase 3 isofo... 71 1e-10
gi|10765257|gb|AAG22954.1|AF257642_2 hexokinase-t2 [Drosoph... 71 1e-10
gi|58262886|ref|XP_568853.1| hexokinase [Cryptococcus neofo... 71 1e-10
gi|147860824|emb|CAN83149.1| hypothetical protein [Vitis vi... 71 1e-10
gi|10765213|gb|AAG22929.1|AF257623_1 hexokinase-C [Drosophi... 71 1e-10
gi|10765559|gb|AAG23108.1|AF257584_1 hexokinase-C [Drosophi... 71 1e-10
gi|18277270|sp|Q26609|HXK_SCHMA Hexokinase >gi|5107491|pdb|... 71 1e-10
gi|10765260|gb|AAG22956.1|AF257643_2 hexokinase-t2 [Drosoph... 71 2e-10
gi|50417378|gb|AAH77114.1| Hkdc1 protein [Danio rerio] 70 2e-10
gi|4504395|ref|NP_002106.1| hexokinase 3 [Homo sapiens] >gi... 70 2e-10
gi|119193240|ref|XP_001247226.1| hexokinase [Coccidioides i... 70 2e-10
gi|45387415|gb|AAS60198.1| hexokinase 6 [Nicotiana tabacum] 70 2e-10
gi|56428857|gb|AAV91305.1| Hex-C [Drosophila yakuba] 70 3e-10
gi|10505242|gb|AAG18422.1|AF288471_1 hexokinase I [Xenopus ... 70 3e-10
gi|73953327|ref|XP_546137.2| PREDICTED: similar to hexokina... 70 3e-10
gi|110808554|sp|Q1WM16|HXK7_ORYSJ Hexokinase-7 (Hexokinase-... 70 3e-10
gi|67481231|ref|XP_655965.1| hexokinase [Entamoeba histolyt... 70 4e-10
gi|149557345|ref|XP_001520120.1| PREDICTED: similar to gluc... 70 4e-10
gi|56428855|gb|AAV91304.1| Hex-C [Drosophila santomea] 70 4e-10
gi|125529055|gb|EAY77169.1| hypothetical protein OsI_005016... 69 4e-10
gi|10716939|gb|AAG21971.1|AF257651_1 hexokinase-C [Drosophi... 69 4e-10
gi|16183087|gb|AAL13623.1| GH15883p [Drosophila melanogaster] 69 4e-10
gi|45551986|ref|NP_733151.2| Hex-t2 CG32849-PA [Drosophila ... 69 5e-10
gi|1749604|dbj|BAA13859.1| unnamed protein product [Schizos... 69 5e-10
gi|71746804|ref|XP_822457.1| hexokinase [Trypanosoma brucei... 69 5e-10
gi|110808556|sp|Q2KNB7|HXK9_ORYSJ Hexokinase-9 (Hexokinase-... 69 5e-10
gi|10765202|gb|AAG22922.1|AF257605_2 hexokinase-t2 [Drosoph... 69 6e-10
gi|4583627|emb|CAB40412.1| hexokinase [Haemonchus contortus] 69 7e-10
gi|10765196|gb|AAG22918.1|AF257603_2 hexokinase-t2 [Drosoph... 69 7e-10
gi|10765163|gb|AAG22896.1|AF257592_2 hexokinase-t2 [Drosoph... 69 8e-10
gi|10765157|gb|AAG22892.1|AF257590_2 hexokinase-t2 [Drosoph... 69 8e-10
gi|73918015|gb|AAZ93624.1| hexokinase 7 [Oryza sativa (japo... 69 8e-10
gi|110808553|sp|Q2KNB4|HXK3_ORYSJ Hexokinase-3 (Hexokinase-... 69 8e-10
gi|76262735|gb|ABA41457.1| glucokinase [Erythroculter ilish... 69 8e-10
gi|74140372|dbj|BAE42341.1| unnamed protein product [Mus mu... 69 8e-10
gi|84370288|ref|NP_001028417.1| hexokinase 3 [Mus musculus]... 69 8e-10
gi|74200437|dbj|BAE37000.1| unnamed protein product [Mus mu... 69 8e-10
gi|74204817|dbj|BAE35470.1| unnamed protein product [Mus mu... 69 8e-10
gi|74211734|dbj|BAE29220.1| unnamed protein product [Mus mu... 69 8e-10
gi|74218150|dbj|BAE42045.1| unnamed protein product [Mus mu... 69 8e-10
gi|115527510|gb|AAI17862.1| Hk3 protein [Mus musculus] 69 8e-10
gi|145698423|dbj|BAF57006.1| hexokinase 2 [Entamoeba nuttalli] 69 9e-10
gi|10765181|gb|AAG22908.1|AF257598_2 hexokinase-t2 [Drosoph... 69 9e-10
gi|145329184|ref|NP_001077921.1| ATHXK2 (HEXOKINASE 2) [Ara... 69 9e-10
gi|110189775|gb|ABG56070.1| hexokinase 1 [Monocercomonoides... 68 9e-10
gi|10765205|gb|AAG22924.1|AF257606_2 hexokinase-t2 [Drosoph... 68 1e-09
gi|62988822|gb|AAY24209.1| unknown [Homo sapiens] 68 1e-09
gi|58270344|ref|XP_572328.1| hexokinase [Cryptococcus neofo... 68 1e-09
gi|14318578|ref|NP_116711.1| Hexokinase isoenzyme 1, a cyto... 68 1e-09
gi|57900403|dbj|BAD87613.1| putative hexokinase [Oryza sati... 68 1e-09
gi|15626363|emb|CAC69958.1| hexokinase [Trypanosoma brucei] 68 2e-09
gi|125557582|gb|EAZ03118.1| hypothetical protein OsI_024350... 68 2e-09
gi|109734501|gb|AAI17861.1| Hk3 protein [Mus musculus] 68 2e-09
gi|115471051|ref|NP_001059124.1| Os07g0197100 [Oryza sativa... 67 2e-09
gi|151940817|gb|EDN59204.1| hexokinase I (PI) (also called ... 67 2e-09
gi|50553534|ref|XP_504178.1| hypothetical protein [Yarrowia... 67 2e-09
gi|171737|gb|AAA34698.1| hexokinase (HXK1) 67 2e-09
gi|109079860|ref|XP_001086179.1| PREDICTED: hexokinase 3 [M... 67 2e-09
gi|74150193|dbj|BAE24390.1| unnamed protein product [Mus mu... 67 2e-09
gi|119497683|ref|XP_001265599.1| hexokinase [Neosartorya fi... 67 2e-09
gi|3791|emb|CAA27202.1| unnamed protein product [Saccharomy... 67 3e-09
gi|149432289|ref|XP_001517802.1| PREDICTED: similar to HKDC... 66 4e-09
gi|10716942|gb|AAG21973.1|AF257652_2 hexokinase-t2 [Drosoph... 66 5e-09
gi|66475806|ref|XP_627719.1| hexokinase [Cryptosporidium pa... 66 5e-09
gi|11559937|ref|NP_071515.1| hexokinase 3 [Rattus norvegicu... 66 6e-09
gi|71680940|gb|AAI00649.1| Hexokinase 3 [Rattus norvegicus]... 66 6e-09
gi|149039900|gb|EDL94016.1| hexokinase 3, isoform CRA_b [Ra... 66 6e-09
gi|74204011|dbj|BAE29007.1| unnamed protein product [Mus mu... 65 7e-09
gi|10765211|gb|AAG22928.1|AF257608_2 hexokinase-t2 [Drosoph... 65 9e-09
gi|77168470|gb|ABA63172.1| hexokinase [Culex pipiens quinqu... 65 9e-09
gi|71746802|ref|XP_822456.1| hexokinase [Trypanosoma brucei... 65 1e-08
gi|67609481|ref|XP_667007.1| hexokinase i [Cryptosporidium ... 64 1e-08
gi|71655813|ref|XP_816463.1| hexokinase [Trypanosoma cruzi ... 64 2e-08
gi|125553095|gb|EAY98804.1| hypothetical protein OsI_020037... 64 2e-08
gi|400025|sp|Q02155|HXK_PLAFA Hexokinase >gi|160321|gb|AAA2... 64 2e-08
gi|110808552|sp|Q2KNB9|HXK2_ORYSJ Hexokinase-2 (Hexokinase-... 64 2e-08
gi|154280563|ref|XP_001541094.1| glucokinase [Ajellomyces c... 64 2e-08
gi|46126633|ref|XP_387870.1| hypothetical protein FG07694.1... 63 3e-08
gi|110808555|sp|Q1WM15|HXK8_ORYSJ Hexokinase-8 (Hexokinase-... 63 3e-08
gi|73918017|gb|AAZ93625.1| hexokinase 8 [Oryza sativa (japo... 63 3e-08
gi|126291573|ref|XP_001380968.1| PREDICTED: similar to Hexo... 63 4e-08
gi|15072475|gb|AAK60444.1| glucokinase [Pichia angusta] 63 4e-08
gi|67528036|ref|XP_661859.1| hypothetical protein AN4255.2 ... 63 4e-08
gi|19703093|gb|AAL93565.1|AF488830_1 hexokinase [Trypanosom... 63 4e-08
gi|111061106|gb|EAT82226.1| hypothetical protein SNOG_10832... 63 4e-08
gi|115435012|ref|NP_001042264.1| Os01g0190400 [Oryza sativa... 63 5e-08
gi|116180908|ref|XP_001220303.1| hypothetical protein CHGG_... 63 5e-08
gi|70988645|ref|XP_749181.1| hexokinase, putative [Aspergil... 62 5e-08
gi|37537876|sp|Q969A8|HXK_TOXGO Hexokinase >gi|14164312|dbj... 62 9e-08
gi|71413728|ref|XP_808992.1| hexokinase [Trypanosoma cruzi ... 61 1e-07
gi|134092056|ref|ZP_01762978.1| hypothetical protein CNBL13... 61 1e-07
gi|67524361|ref|XP_660242.1| hypothetical protein AN2638.2 ... 61 2e-07
gi|157019630|gb|EAL41568.3| AGAP011208-PA [Anopheles gambia... 61 2e-07
gi|119574702|gb|EAW54317.1| hexokinase domain containing 1,... 60 2e-07
gi|125551109|gb|EAY96818.1| hypothetical protein OsI_018051... 60 2e-07
gi|45199235|ref|NP_986264.1| AFR716Cp [Ashbya gossypii ATCC... 60 2e-07
gi|115743062|ref|XP_001201741.1| PREDICTED: similar to hexo... 60 3e-07
gi|156847874|ref|XP_001646820.1| hypothetical protein Kpol_... 60 3e-07
gi|148709220|gb|EDL41166.1| mCG3203 [Mus musculus] 60 3e-07
gi|11386876|sp|O64390|HXK1_SOLTU Hexokinase-1 (StHK1) >gi|3... 60 4e-07
gi|156848221|ref|XP_001646993.1| hypothetical protein Kpol_... 60 4e-07
gi|116502046|gb|EAU84941.1| hypothetical protein CC1G_00460... 59 4e-07
gi|125552102|gb|EAY97811.1| hypothetical protein OsI_019044... 59 5e-07
gi|151943789|gb|EDN62089.1| glucokinase [Saccharomyces cere... 59 5e-07
gi|6319809|ref|NP_009890.1| Glk1p [Saccharomyces cerevisiae... 59 5e-07
gi|121703788|ref|XP_001270158.1| hexokinase, putative [Aspe... 59 6e-07
gi|154272367|ref|XP_001537036.1| conserved hypothetical pro... 59 8e-07
gi|115463553|ref|NP_001055376.1| Os05g0375100 [Oryza sativa... 59 9e-07
gi|71002576|ref|XP_755969.1| glucokinase, putative [Aspergi... 58 1e-06
gi|110808551|sp|Q2KNB5|HXK10_ORYSJ Hexokinase-10 (Hexokinas... 58 1e-06
gi|50287141|ref|XP_446000.1| unnamed protein product [Candi... 58 1e-06
gi|77168480|gb|ABA63177.1| hexokinase [Anopheles arabiensis] 57 2e-06
gi|71031857|ref|XP_765570.1| hexokinase [Theileria parva st... 57 2e-06
gi|125594029|gb|EAZ34088.1| hypothetical protein OsJ_017571... 57 2e-06
gi|115462471|ref|NP_001054835.1| Os05g0187100 [Oryza sativa... 57 3e-06
gi|62529131|gb|AAX84838.1| hexokinase [Triticum aestivum] 57 3e-06
gi|10439274|dbj|BAB15478.1| unnamed protein product [Homo s... 57 3e-06
gi|119467594|ref|XP_001257603.1| hexokinase, putative [Neos... 57 3e-06
gi|115471879|ref|NP_001059538.1| Os07g0446800 [Oryza sativa... 56 4e-06
gi|39585930|emb|CAE68219.1| Hypothetical protein CBG13890 [... 56 4e-06
gi|67937780|gb|AAY83347.1| glucokinase [Hypocrea jecorina] 56 4e-06
gi|1147781|gb|AAC50422.1| ATP:D-hexose 6-phosphotransferase 56 4e-06
gi|111069641|gb|EAT90761.1| hypothetical protein SNOG_02549... 56 5e-06
gi|125558170|gb|EAZ03706.1| hypothetical protein OsI_024938... 55 8e-06
gi|83282686|ref|XP_729878.1| hexokinase [Plasmodium yoelii ... 55 1e-05
>gi|42527969|ref|NP_973067.1| hexokinase family protein [Treponema denticola ATCC 35405]
gi|41819014|gb|AAS12986.1| hexokinase family protein [Treponema denticola ATCC 35405]
Length = 437
Score = 853 bits (2204), Expect = 0.0, Method: Composition-based stats.
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD
Sbjct: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
Query: 61 KKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLK 120
KKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLK
Sbjct: 61 KKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLK 120
Query: 121 DESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKI 180
DESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKI
Sbjct: 121 DESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKI 180
Query: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQII 240
IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQII
Sbjct: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQII 240
Query: 241 VCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPR 300
VCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPR
Sbjct: 241 VCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPR 300
Query: 301 VNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRL 360
VNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRL
Sbjct: 301 VNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRL 360
Query: 361 SAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLK 420
SAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLK
Sbjct: 361 SAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLK 420
Query: 421 TNDEAVTLGTALAAFLN 437
TNDEAVTLGTALAAFLN
Sbjct: 421 TNDEAVTLGTALAAFLN 437
>gi|15639496|ref|NP_218946.1| hexokinase (hxk) [Treponema pallidum subsp. pallidum str. Nichols]
gi|3322792|gb|AAC65489.1| hexokinase (hxk) [Treponema pallidum subsp. pallidum str. Nichols]
Length = 444
Score = 303 bits (775), Expect = 2e-80, Method: Composition-based stats.
Identities = 169/438 (38%), Positives = 258/438 (58%), Gaps = 12/438 (2%)
Query: 4 IDDFFKRNNFDYK-IDIEYAASILLEDMKKGLESEAE----SVSSMDMIPLWKNLPTDIP 58
+ FF R +FD + + +L DM +GLE EA+ S++ MIP W P P
Sbjct: 11 VSAFFGRFHFDVQGPSVRTVVDVLRADMVRGLEEEAQLPPRMGSALAMIPTWVAPPRVSP 70
Query: 59 KDKKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEP 118
+++VI+IDAGGTNFR+ +V F G P I + K PMP RE + EFF IA+ L
Sbjct: 71 CNRRVIVIDAGGTNFRSCLVRFGDSGTPHIENLEKRPMPGTTREYSRTEFFGEIADNLAR 130
Query: 119 LKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKI 177
LK +D I FCFSY I+I PDG G+ I+ +KEIK IG C + GL +ALS + W ++
Sbjct: 131 LKGAADCIGFCFSYPIRIRPDGDGEVIQFAKEIKAAEVIGTC-VGAGLTEALSARNWPEL 189
Query: 178 KKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKP 237
+ + M+ND + L +G F+ + F S++GF+LGTG+NSAY+E I K+ + P
Sbjct: 190 RSLKMLNDATSALLAGFFAAPEGCSFSSYVGFILGTGMNSAYLEPDPIPKIPA---HHTP 246
Query: 238 QIIVCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIF 297
Q++VCESGKSNK+P+S FD++ ++ + + LE+M SG YLG L S+ +R + EG+F
Sbjct: 247 QVVVCESGKSNKVPRSVFDELFTQTTAEPDIAHLEKMSSGTYLGPLASVVVRLAAQEGLF 306
Query: 298 SPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERA 357
S V+ L++ F+ ++ FL + G + A D ++ + RA
Sbjct: 307 SHAVHAA-LSTVSFTLVDMDRFLFAPSVSTTTL-GALLAPGTDTDREILFLLLDAVVARA 364
Query: 358 GRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYF 417
R++A VIAA+ +K+G G P +P+C+ A+G+ F + + ++ R+ L LTE+RG+YF
Sbjct: 365 ARIAAGVIAASVLKSGAGYDPLRPVCVLAEGTTFQRTYRLRTRVTSHLQAFLTEERGVYF 424
Query: 418 VLKTNDEAVTLGTALAAF 435
+ + + AVTLG+AL
Sbjct: 425 DIISLENAVTLGSALGGL 442
>gi|156868657|gb|EDO62029.1| hypothetical protein CLOLEP_00889 [Clostridium leptum DSM 753]
Length = 437
Score = 251 bits (642), Expect = 5e-65, Method: Composition-based stats.
Identities = 150/425 (35%), Positives = 228/425 (53%), Gaps = 14/425 (3%)
Query: 17 IDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAG 76
+++ A + + +M++GL+ E SS+ MIP + ++ IP +++I++DAGGTNFR
Sbjct: 22 VNLRENADVFIGEMERGLKGEE---SSLFMIPTYISIDKQIPAGERIIVVDAGGTNFRVA 78
Query: 77 IVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKI 136
V FD+KG I F +PMP E+T EEFFD+ AEYLEP+ D+SD I FCFSY +I
Sbjct: 79 TVVFDEKGNASIDDFNNYPMPGTQGEITIEEFFDTAAEYLEPVIDKSDKIGFCFSYPTEI 138
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
+P+ G+ I+ KE+K+ I +GL +A+ +G ++ K I++VND L G +
Sbjct: 139 YPNRDGRLIRFVKEVKVKGSEGAFIGKGLLEAVKARGHQEKKSIVLVNDAVTTLIGGKAA 198
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYG-KIEKLKTTEFYDKPQIIVCESGKSNKIPQSKF 255
D Q FDS+IGF+ GTG N+ Y+E +I KL + D +I ESG K P+
Sbjct: 199 CPDRQ-FDSYIGFIWGTGTNTCYMEQTRRITKLGSAADIDGTMLINVESGGYAKAPRGDL 257
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSCDFSTEE 315
D + Y E+M SG Y G + L + EG+F+ K + S++E
Sbjct: 258 DAGFDATTVNPGGYMFEKMISGAYQGGMVRTVLVQAAKEGLFTAETGKRIAALESLSSKE 317
Query: 316 ISLFLKEQNHDKNIFSGIIEAH---SVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKT 372
I FL + + AH V ED +Y + ERA R A +AA +KT
Sbjct: 318 IDDFLFRPYGENAL------AHCCGGVEEDCQTLYYLIDGLMERAARFVAFNLAAVMLKT 371
Query: 373 GKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAVTLGTAL 432
GKG +P +P+C++ DGS + K L K+++ + L E+ G+Y + +G A+
Sbjct: 372 GKGANPCRPVCVTMDGSTYYKSKLCKDKLSAYTKSFLNEELGLYCEFIKAENPNLIGAAI 431
Query: 433 AAFLN 437
A LN
Sbjct: 432 AGLLN 436
>gi|15222973|ref|NP_175463.1| hexokinase, putative [Arabidopsis thaliana]
gi|75311440|sp|Q9LPS1|HXK3_ARATH Hexokinase-3
gi|9454562|gb|AAF87885.1|AC012561_18 Putative hexokinase [Arabidopsis thaliana]
gi|18377722|gb|AAL67011.1| putative hexokinase [Arabidopsis thaliana]
gi|20465305|gb|AAM20056.1| putative hexokinase [Arabidopsis thaliana]
Length = 498
Score = 108 bits (269), Expect = 9e-22, Method: Composition-based stats.
Identities = 114/439 (25%), Positives = 201/439 (45%), Gaps = 47/439 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA-GIVYFDKKGVPE 87
+M GL SE S M ++ +LPT K + GGT FR ++ D++ +
Sbjct: 65 EMHAGLASEGGSKLKM-LLTFVDDLPTGREKGT-YYALHLGGTYFRILRVLLGDQRSYLD 122
Query: 88 ILSFFKHPMPALDREMTNEEFFD----SIAEYLEPLKDESDM------ISFCFSYAIKIF 137
+ +HP+P+ T+E F+ S+ ++E ++ SD ++F FS+ +K
Sbjct: 123 VQDVERHPIPSHLMNSTSEVLFNFLAFSLERFIEKEENGSDSQGVRRELAFTFSFPVKHT 182
Query: 138 PDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G IK +K ++ + I E L AL+R+G + +VNDT L G + +
Sbjct: 183 SISSGVLIKWTKGFEISEMVGQDIAECLQGALNRRGLD-MHVAALVNDTVGALSLGYYHD 241
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYG----KIEKLKTTEFYDKPQIIVCESGK--SNKIP 251
D + + V GTG N+ Y+E K + L TT ++ E G S+ +P
Sbjct: 242 PD-----TVVAVVFGTGSNACYLERTDAIIKCQGLLTTS---GSMVVNMEWGNFWSSHLP 293
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIFSPRVNKMLLNSCD 310
++ +D L S+ N+ E+M SG YLG++ + LR IF P ++ +L
Sbjct: 294 RTSYDIDLDAESSNANDMGFEKMISGMYLGDIVRRVILRMSEDSDIFGP-ISPVLSEPYV 352
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVK----IYSICKCFFERAGRLSAAVIA 366
T +S ++ + + I++ VS+ +K + IC RAGRL+AA IA
Sbjct: 353 LRTNSVSAIHEDDTPELQEVARILKDIGVSDVPLKVRKLVVKICDVVTRRAGRLAAAGIA 412
Query: 367 AACIKTGK--------GKSPD-----KPICISADGSMFLKGFLIKERIFKSLHTCLTEKR 413
K G+ G+S K ++ +G +++ + +E + ++L L E+
Sbjct: 413 GILKKIGRDGSGGITSGRSRSEIQMQKRTVVAVEGGLYMNYTMFREYMEEALVEILGEEV 472
Query: 414 GIYFVLKTNDEAVTLGTAL 432
Y V+K ++ ++G+AL
Sbjct: 473 SQYVVVKAMEDGSSIGSAL 491
>gi|153809463|ref|ZP_01962131.1| hypothetical protein BACCAC_03778 [Bacteroides caccae ATCC 43185]
gi|149127923|gb|EDM19145.1| hypothetical protein BACCAC_03778 [Bacteroides caccae ATCC 43185]
Length = 402
Score = 104 bits (259), Expect = 1e-20, Method: Composition-based stats.
Identities = 117/450 (26%), Positives = 198/450 (44%), Gaps = 83/450 (18%)
Query: 15 YKIDIEYAASI---LLEDMKKGLESEAESVSSMDMIPLWKNLPTDI-PK----DKKVIII 66
+K+D E +I E ++KGL +E + +PT I PK + K +++
Sbjct: 6 FKLDNEQLKAIARSFKEKVEKGLNTENAEIQC---------IPTFITPKADNINGKSLVL 56
Query: 67 DAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREM--------TNEEFFDSIAEYLEP 118
D GGTN+R +V F K VP+I HP ++M T EE F +A+ +
Sbjct: 57 DLGGTNYRVALVDFSKS-VPDI-----HPNNGWKKDMSIMKSLGYTQEELFKELADMITG 110
Query: 119 LKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKI 177
+K E +M I +CFSY + P G + ++ +K + + + I L L+ K K
Sbjct: 111 IKREEEMPIGYCFSYPTESVPGGDAKLLRWTKGVDIKEMIGKYIGNPLLNYLNEKNKIKF 170
Query: 178 KKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTTEFYDK 236
I ++NDT A L +G+ D +D++IG ++GTG N A +I KI+KL +
Sbjct: 171 TDIKVLNDTVASLFAGL----TDNSYDAYIGLIVGTGTNMATFIPADKIKKLNPADNIQG 226
Query: 237 PQIIVCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI 296
+ ESG + + D + S + E+ SG YLG++ L+A
Sbjct: 227 MIPVNLESGNFHPPFLTGVDNTVDVISGNPRKQRFEKAVSGMYLGDI----LKA------ 276
Query: 297 FSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSED-YVKIYSICKCFFE 355
F EE E+ D + I+ + +D YV+ + + +
Sbjct: 277 -------------TFPLEEF-----EEKFDAQKLTAIMNYPDIYKDVYVQ---VAQWIYT 315
Query: 356 RAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEK--- 412
R+ +L AA I + + IC+ A+GS+F + R K+ H+ +TE+
Sbjct: 316 RSAQLVAASITGLVMLLKSYNKDIRRICLVAEGSLFWS----ENRKDKNYHSIVTEELKE 371
Query: 413 -------RGIYFVLKTNDEAVTLGTALAAF 435
+ + +K+ + A +GTA+AA
Sbjct: 372 LFDLFGLKDVTVDIKSMNNANLIGTAIAAL 401
>gi|45387407|gb|AAS60194.1| hexokinase 3 [Nicotiana tabacum]
Length = 497
Score = 99.8 bits (247), Expect = 4e-19, Method: Composition-based stats.
Identities = 117/443 (26%), Positives = 183/443 (41%), Gaps = 32/443 (7%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
++ A + +M GL SE S M +I NLPT ++ +D GGTNFR V
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DEEGVFYALDLGGTNFRVLRV 112
Query: 79 YFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM-----------I 126
K G F + +P T+E FD IA L E + +
Sbjct: 113 QLGGKDGGIVHQEFTEASIPPNLMVGTSEALFDYIAAELAKFVAEEEEKFHQPPGKQREL 172
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDT 186
F FS+ I G I+ +K + + L +A+ RKG ++ +VNDT
Sbjct: 173 GFTFSFPIMQTSINSGTLIRWTKGFSIDDTVGQDVVAELTKAMQRKG-VDMRVSALVNDT 231
Query: 187 AAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG 245
L G FS D I +LGTG N+AY+E + I K +I E G
Sbjct: 232 VGTLAGGRFSNKD-----VSIAVILGTGTNAAYVERAQAIPKWHGPLPKSGEMVINMEWG 286
Query: 246 --KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPRVN 302
+S+ +P +++D + +S E E++CSG YLGE L + LR IF V
Sbjct: 287 NFRSSHLPLTEYDHAMDTDSLNPGEQIFEKICSGMYLGEILRRVLLRMSEEAAIFGDEVP 346
Query: 303 KMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFFERA 357
L N T E+S + + D + I+E + S + + +C R
Sbjct: 347 PKLKNQFILRTPEMSAMHHDTSSDLRVVGDKLKDILEISNTSLKTRRLVVELCNIVATRG 406
Query: 358 GRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRG 414
RL+AA + K G+ +S + I ++ DG ++ ++ + +L L E+
Sbjct: 407 ARLAAAGVLGIVKKMGRDTPRESGQEKIVVAMDGGLYEHYTEYRKCLENTLVELLGEEMA 466
Query: 415 IYFVLKTNDEAVTLGTALAAFLN 437
V + ++ +G AL A N
Sbjct: 467 TSIVFEHANDGSGIGAALLAASN 489
>gi|47218712|emb|CAG05684.1| unnamed protein product [Tetraodon nigroviridis]
Length = 913
Score = 99.0 bits (245), Expect = 6e-19, Method: Composition-based stats.
Identities = 110/437 (25%), Positives = 196/437 (44%), Gaps = 56/437 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD-----KK 83
+M+KGL S++ + +S+ M+P D + + + +D GG+ F+ V ++
Sbjct: 26 EMRKGLSSDSNAAASVKMLPTHVRSTPDGSEKGQFLALDLGGSKFKVLQVKVREGMGIRR 85
Query: 84 GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM-------ISFCFSYAIKI 136
G E + +P+P E FD +AE L+ E ++ ++F FS+ +
Sbjct: 86 GGVE-MEEKTYPIPEELLTGRETELFDHVAESLKDFMTERNISPEKKHPLAFTFSFPCEH 144
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I SK ++ + D + + L +A+ R G ++ + MVNDT A + + F
Sbjct: 145 TALNKGSLINWSKNYQVRGLRDKDVVQTLRKAIDRSGGMDVEVLAMVNDTVATMMTCGF- 203
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
DDQ + +G +LGTG N+ Y +E+L+ + + + +C + G
Sbjct: 204 --DDQYCE--VGLILGTGTNACY-----MEELRHVDLVEGDEGRMCVNTEWGGFGDDGSL 254
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
N ++FD+ + SN + LE+M SG YLGEL + L + G +F V++ L
Sbjct: 255 NDY-LTEFDRDIDAASNNPGKQTLEKMVSGMYLGELVRLVLLKMAKLGLLFEGHVSEALR 313
Query: 307 NSCDFSTEEISLFLKEQNHDKN---IFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
+T ++ + +N KN I +G+ S ED V + + R+ L AA
Sbjct: 314 TKGAITTANVAAMEEYKNGLKNTEAILTGLSLTPS-PEDCVAVQHVSTIVSFRSSNLVAA 372
Query: 364 VIAAA--------CIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGI 415
+AA C++T + I + DG+++ +R+ K + L E +
Sbjct: 373 CLAAILSRIRQNRCLRTMR-------ITVGVDGTVYKTHPQYPKRLHKVVRRLLPECH-V 424
Query: 416 YFVLKTNDEAVTLGTAL 432
FVL +D + G AL
Sbjct: 425 RFVL--SDSGSSKGAAL 439
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 173/409 (42%), Gaps = 60/409 (14%)
Query: 30 MKKGLES--EAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
M+ GLE+ + E S++ M+P + D + K + +D GGTNFRA +V F K G+ +
Sbjct: 475 MRAGLEAGLKNEGSSAVKMLPSYVYRTPDGTEHGKYLALDLGGTNFRALLVNF-KTGLQQ 533
Query: 88 --ILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPD 139
L+ + +P + T EE FD IA+ + D M F FS+ +
Sbjct: 534 NTRLNHKIYTIPVEIMQGTGEELFDHIAQCVSDFLDYMGMKNAQLPAGFTFSFPCEQTAL 593
Query: 140 GGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G + +K K DC+ + E L +A+ R+ + + +VNDT + S +
Sbjct: 594 DTGTLVSWTKGFKAT---DCEGHDVVEMLREAIKRRNEFDLDIVAVVNDTVGTMMSCAYE 650
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESGKSNKIPQ-SK 254
+ IG + GTG N Y+E K IEK K K + E K +K S
Sbjct: 651 DP-----QCEIGLIAGTGTNVCYMEEVKNIEKTKNISKNQKRE----EEDKGDKNEAGSS 701
Query: 255 FDKI-----------LSENSNLKN-----------------EYFLERMCSGRYLGELCSI 286
D+I L ++ +L++ E++ SG YLGE+
Sbjct: 702 DDEITRMCVNTEWGGLGDDGSLEDIVTPYDGEVNQMSVNPGRQRFEKLTSGMYLGEIVRH 761
Query: 287 ALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGI--IEAHSVSEDY 343
L ++ G +F RV + L F T+ +S ++ + S + + +D
Sbjct: 762 VLLDLTSGGLLFRGRVTEALKTPGIFETKYLSQIESDRVALLQVRSILQQLGLEGTCDDS 821
Query: 344 VKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+ + +C RA +L A +AA K + + ++ I + DG+++
Sbjct: 822 IIVKEVCGAVSRRAAQLCGAGMAAVVDKIRENRRLERLTITVGVDGALY 870
>gi|11494010|gb|AAG35735.1|AF208543_1 hexokinase [Lycopersicon esculentum]
Length = 496
Score = 99.0 bits (245), Expect = 6e-19, Method: Composition-based stats.
Identities = 120/448 (26%), Positives = 186/448 (41%), Gaps = 42/448 (9%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---------- 125
V K G F + +P T+E FD IA L DE
Sbjct: 111 RVQLGGKDGGIMHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVDEEGEKFHPPPGKQR 170
Query: 126 -ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKK---IKKII 181
+ F FS+ I G I+ +K + D + + + L++ K+ ++
Sbjct: 171 ELGFTFSFPIMQTSINSGTLIRWTKGFSI----DDTVGKDVVAELTKAMQKREIDMRVSA 226
Query: 182 MVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQII 240
+VNDT L G F++ D I +LGTG N+AY+E + I K +I
Sbjct: 227 LVNDTVGTLAGGRFTDKD-----VSIAVILGTGTNAAYVERAQAIPKWHGPLPNSGEMVI 281
Query: 241 VCESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIF 297
E G +S+ +P +++D + +S E E++CSG YLGE L + LR GIF
Sbjct: 282 NMEWGNFRSSHLPLTQYDNAMDTDSLNPGEQIFEKICSGMYLGEILRRVLLRMAKEAGIF 341
Query: 298 SPRVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKC 352
V L NS T E+S + + D + I+E + S + + C
Sbjct: 342 GEEVPPKLKNSFILRTPEMSAMHHDTSSDLRVVGDKLKDILEISNTSLKTRRLVVEXCNI 401
Query: 353 FFERAGRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCL 409
R RL+AA I K GK +S + I ++ DG ++ + + +L L
Sbjct: 402 VATRGARLAAAGILGIIKKMGKDTPRESGPEKIVVAMDGGLYEHYTEYSKCLENTLVELL 461
Query: 410 TEKRGIYFVLKTNDEAVTLGTALAAFLN 437
++ V K ++ +G AL A N
Sbjct: 462 GKEMATSIVFKHANDGSGIGAALLAASN 489
>gi|11386887|sp|Q9SQ76|HXK2_SOLTU Hexokinase-2 (StHK2)
gi|6492118|gb|AAF14186.1| hexokinase 2 [Solanum tuberosum]
Length = 496
Score = 98.2 bits (243), Expect = 1e-18, Method: Composition-based stats.
Identities = 119/446 (26%), Positives = 183/446 (41%), Gaps = 38/446 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
++ A + +M GL SE S M +I NLPT + +D GGTNFR V
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DEGGVFYALDLGGTNFRVLRV 112
Query: 79 YFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIA-----------EYLEPLKDESDMI 126
K I F + +P T+E FD IA E P +
Sbjct: 113 QLGGKDGGIIHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVAEEGEEFHPPPGRQREL 172
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKK---IKKIIMV 183
F FS+ I G I+ +K + D + + + L++ K+ ++ +V
Sbjct: 173 GFTFSFPIMQTSINSGTLIRWTKGFSI----DDTVGKDVVAELTKAMQKREIDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G F+ D I +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGRFTNKD-----VSIAVILGTGTNAAYVERAQAIPKWHGPLPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D + NS E E++CSG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTEYDHAMDTNSLNPGEQIFEKICSGMYLGEILRRVLLRMAEEAGIFGE 343
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFF 354
V L NS T E+S + + D + I+E + S + + +C
Sbjct: 344 EVPPKLKNSFILRTPEMSAMHHDTSSDLRVVGDKLKDILEISNSSLKTRRLVVELCNIVA 403
Query: 355 ERAGRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
R RL+AA I K GK +S + I ++ DG ++ + + +L L +
Sbjct: 404 TRGARLAAAGILGIIKKMGKDTPRESGPEKIVVAMDGGLYEHYTEYSKCLENTLVELLGK 463
Query: 412 KRGIYFVLKTNDEAVTLGTALAAFLN 437
+ V K ++ +G AL A N
Sbjct: 464 EMATSIVFKHANDGSGIGAALLAASN 489
>gi|34451887|gb|AAQ72424.1| hexokinase PpHxk1 [Physcomitrella patens]
gi|34451924|gb|AAQ72423.1| hexokinase PpHxk1 [Physcomitrella patens]
Length = 513
Score = 97.8 bits (242), Expect = 1e-18, Method: Composition-based stats.
Identities = 116/448 (25%), Positives = 193/448 (43%), Gaps = 50/448 (11%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD 81
A L+++M GL SE S + M+P + +NLP+ K +D GGTNFR V
Sbjct: 73 ADALVQEMYAGLASEGGS-DQLKMLPTYVENLPSGSEKGL-FYAVDLGGTNFRVLRVELG 130
Query: 82 KKGVPEILS--FFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMI------------- 126
K +ILS F + +P T ++ FD IA L D D
Sbjct: 131 GK-TGQILSQEFKEVVIPPELMVGTGKDLFDFIAGTLASFVDTEDESIKAHFVQSGKTRE 189
Query: 127 -SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
F FS+ ++ G I +K K+ I + A+SR +I +VND
Sbjct: 190 SGFAFSFPVRQTSVKSGIVIHWTKGFKVDDAVGKDIVKQFQDAISRSN-HQIMISALVND 248
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKP------QI 239
T L G F+ ++ + IG ++GTG N+ Y+E + +D+P +
Sbjct: 249 TVGTLAGGRFNFDEE----TMIGCIIGTGTNACYVE-----RADAVHKWDEPLPKSGEMV 299
Query: 240 IVCESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGI 296
I E G +S +P++ D+ + ++S + + E+M SG YLGE+ + L R +
Sbjct: 300 INMEWGNFRSPYLPRTFADETVDKDSVNPGDQWFEKMISGMYLGEIVRLVLARMAKEAEL 359
Query: 297 FSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSIC 350
F V LL T +S + + D ++ + + IE ++ E + ++ +C
Sbjct: 360 FGGNVPVKLLERLTLGTPHVSKIHLDNSPDLDVVAKVLKDVFEIETTTLEERKI-VHEVC 418
Query: 351 KCFFERAGRLSAAVIAAACIKTGK-GKSPD---KPICISADGSMFLKGFLIKERIFKSLH 406
ER GRL+AA + K G+ GKS + K I+ DG +F + + ++L
Sbjct: 419 DIMGERGGRLAAAGLYGILKKIGRTGKSRNGSKKKTVIAMDGGLFEHHVRYRSYMEEALQ 478
Query: 407 TCLTEKRGIYFVLKTNDEAVTLGTALAA 434
+ L+ ++ +G AL A
Sbjct: 479 ELMGSDAAYEVALRLQNDGSGIGAALLA 506
>gi|50512102|gb|AAT77513.1| hexokinase 3 [Nicotiana sylvestris]
Length = 496
Score = 97.4 bits (241), Expect = 2e-18, Method: Composition-based stats.
Identities = 118/446 (26%), Positives = 183/446 (41%), Gaps = 38/446 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
++ A + +M GL SE S M +I NLPT + +D GGTNFR V
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DEGGVFYALDLGGTNFRVLRV 112
Query: 79 YFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIA-----------EYLEPLKDESDMI 126
K I F + +P T+E FD IA E P +
Sbjct: 113 QLGGKDGGIIHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVAEEGEEFHPPPGRQREL 172
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKK---IKKIIMV 183
F FS+ I G I+ +K + D + + + L++ K+ ++ +V
Sbjct: 173 GFTFSFPIMQTSINSGTLIRWTKGFSI----DDTVGKDVVAELTKAMQKREIDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G F+ D I +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGRFTNKD-----VSIAVILGTGTNAAYVERAQAIPKWHGPLPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D + +S E E++CSG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTEYDHAMDTDSLNPGEQIFEKICSGMYLGEILRRVLLRMAEEAGIFGE 343
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFF 354
V L NS T E+S + + D + I+E + S + + +C
Sbjct: 344 EVPPKLKNSFILRTPEMSAMHHDTSSDLRVVGDKLKDILEISNTSLKTRRLVVELCNIVA 403
Query: 355 ERAGRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
R RL+AA I K GK +S + I ++ DG ++ + + +L L +
Sbjct: 404 TRGARLAAAGILGIIKKMGKDTPRESDPEKIVVAMDGGLYEHYTEYSKCLENTLVELLGK 463
Query: 412 KRGIYFVLKTNDEAVTLGTALAAFLN 437
+ V K ++ +G AL A N
Sbjct: 464 EMATSIVFKHANDGSGIGAALLAASN 489
>gi|74272328|gb|ABA01010.1| hexokinase [Solanum chacoense]
Length = 496
Score = 97.1 bits (240), Expect = 2e-18, Method: Composition-based stats.
Identities = 118/446 (26%), Positives = 183/446 (41%), Gaps = 38/446 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
++ A + +M GL SE S M +I NLPT + +D GGTNFR V
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DEGGVFYALDLGGTNFRVLRV 112
Query: 79 YFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIA-----------EYLEPLKDESDMI 126
K I F + +P T+E FD IA E P +
Sbjct: 113 QLGGKDGGIIHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVAEEGEEFHPPPGRQREL 172
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKK---IKKIIMV 183
F FS+ I G I+ +K + D + + + L++ K+ ++ +V
Sbjct: 173 GFTFSFPIMQTSINSGTLIRWTKGFSI----DDTVGKDVVAELTKAMQKREIDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G F+ D I +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGRFTNKD-----VSIAVILGTGTNAAYVERAQAIPKWHGPLPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D + +S E E++CSG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTEYDHAMDTDSLNPGEQIFEKICSGMYLGEILRRVLLRMAEEAGIFGE 343
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFF 354
V L NS T E+S + + D + I+E + S + + +C
Sbjct: 344 EVPPKLKNSFILRTPEMSAMHHDTSSDLRVVGDKLKDILEISNTSLKTRRLVVELCNIVA 403
Query: 355 ERAGRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
R RL+AA I K GK +S + I ++ DG ++ + + +L L +
Sbjct: 404 TRGARLAAAGILGIIKKMGKDTPRESGPEKIVVAMDGGLYEHYTEYSKCLENTLVELLGK 463
Query: 412 KRGIYFVLKTNDEAVTLGTALAAFLN 437
+ V K ++ +G AL A N
Sbjct: 464 EMATSIVFKHANDGSGIGAALLAASN 489
>gi|115439869|ref|NP_001044214.1| Os01g0742500 [Oryza sativa (japonica cultivar-group)]
gi|75157445|sp|Q8LQ68|HXK6_ORYSJ Hexokinase-6 (Hexokinase-2)
gi|20521420|dbj|BAB91930.1| putative hexokinase [Oryza sativa (japonica cultivar-group)]
gi|62130756|gb|AAX68418.1| hexokinase 2 [Oryza sativa (japonica cultivar-group)]
gi|73918013|gb|AAZ93623.1| hexokinase 6 [Oryza sativa (japonica cultivar-group)]
gi|113533745|dbj|BAF06128.1| Os01g0742500 [Oryza sativa (japonica cultivar-group)]
gi|125527661|gb|EAY75775.1| hypothetical protein OsI_003622 [Oryza sativa (indica
cultivar-group)]
Length = 506
Score = 97.1 bits (240), Expect = 2e-18, Method: Composition-based stats.
Identities = 119/444 (26%), Positives = 194/444 (43%), Gaps = 46/444 (10%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF-- 80
A ++E+M++GL ++ + M +I NLPT + +D GGTNFR V
Sbjct: 67 ADAMVEEMERGLRADPHAPLKM-LISYVDNLPTG-DEHGLFYALDLGGTNFRVIRVQLGG 124
Query: 81 -DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEP-LKDESD----------MISF 128
+K+ V + + + +P T+ E FD IA LE +K E + + F
Sbjct: 125 REKRVVSQ--QYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEGRQRELGF 182
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMVNDTA 187
FS+ + G IK +K + +G+ + E L +A+ R+G +K +VNDT
Sbjct: 183 TFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAE-LSRAMERQGLD-MKVTALVNDTV 240
Query: 188 AVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG- 245
L G + + D +LGTG N+AY+E+ I K +I E G
Sbjct: 241 GTLAGGRYVDNDVAA-----AVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGN 295
Query: 246 -KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIFSPRVNK 303
KS ++P+S +D L S E E+M SG YLGE+ I L+ +F V
Sbjct: 296 FKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPT 355
Query: 304 MLLNSCDFSTEEISLFLKEQNHD--------KNIFSGIIEAHSVSEDYVKIYSICKCFFE 355
L T ++S + +HD K+I G+ + S+ Y+ ++ +C E
Sbjct: 356 KLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDIL-GVADT-SLEARYITLH-VCDLVAE 412
Query: 356 RAGRLSAAVIAAACIKTGKGKSPD-----KPICISADGSMFLKGFLIKERIFKSLHTCLT 410
R RL+AA I K G+ + P + I+ DG ++ + + +L L
Sbjct: 413 RGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLG 472
Query: 411 EKRGIYFVLKTNDEAVTLGTALAA 434
E+ V+K ++ +G AL A
Sbjct: 473 EEAASSVVVKLANDGSGIGAALLA 496
>gi|587202|emb|CAA86511.1| Human hexokinase II cDNA [Homo sapiens]
Length = 917
Score = 96.3 bits (238), Expect = 3e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 331 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 383
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 384 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 431
Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats.
Identities = 89/390 (22%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 494 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 613 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 668
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 669 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 721 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 779
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 780 GIFETK----FLSQIESDCLALLQVRATLQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 835
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA + + + D + + DG+++
Sbjct: 836 AGMAAVVDRIRENRGLDALKVTVGVDGTLY 865
>gi|7549765|ref|NP_036867.1| hexokinase 2 [Rattus norvegicus]
gi|123895|sp|P27881|HXK2_RAT Hexokinase-2 (Hexokinase type II) (HK II)
gi|204613|gb|AAA41333.1| hexokinase type II
gi|149036481|gb|EDL91099.1| hexokinase 2 [Rattus norvegicus]
Length = 917
Score = 96.3 bits (238), Expect = 3e-18, Method: Composition-based stats.
Identities = 94/399 (23%), Positives = 185/399 (46%), Gaps = 33/399 (8%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQR 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L D+ + + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + + +A+ R+G I + +VNDT + + + DD
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKIP 251
Q + IG ++GTG N+ Y +E+++ + + + +C + G N I
Sbjct: 222 Q--NCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDI- 273
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCD 310
+++FD+ + S + E+M SG Y+GEL + L + AE +F +++ LL +
Sbjct: 274 RTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGS 333
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIE--AHSVSEDYVKIYSICKCFFERAGRLSAAVIAAA 368
F T+++S ++++ + + ++ + + ED V + IC+ R+ L AA +AA
Sbjct: 334 FETKDVSDIEEDKDGIEKAYQILMRLGLNPLQEDCVATHRICQIVSTRSASLCAATLAAV 393
Query: 369 C--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
IK KG+ + I DGS++ K +R+ K++
Sbjct: 394 LWRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKAV 431
Score = 74.3 bits (181), Expect = 1e-11, Method: Composition-based stats.
Identities = 91/391 (23%), Positives = 167/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E +V+ + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T EE FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKIYSIPQEVM--HGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 612 DQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 668
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E D + +C ++G +
Sbjct: 669 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
+ ++ FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 720 DL-RTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 779 RGIFETK----FLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDNLKVTVGVDGTLY 865
>gi|15553127|ref|NP_000180.2| hexokinase 2 [Homo sapiens]
gi|56405344|sp|P52789|HXK2_HUMAN Hexokinase-2 (Hexokinase type II) (HK II) (Muscle form hexokinase)
gi|4809269|gb|AAD30174.1|AF148513_1 hexokinase II [Homo sapiens]
gi|18088968|gb|AAH21116.1| Hexokinase 2 [Homo sapiens]
gi|39963174|gb|AAH64369.1| Hexokinase 2 [Homo sapiens]
gi|47777673|gb|AAT38114.1| hexokinase 2 [Homo sapiens]
gi|119620007|gb|EAW99601.1| hexokinase 2, isoform CRA_a [Homo sapiens]
gi|119620008|gb|EAW99602.1| hexokinase 2, isoform CRA_a [Homo sapiens]
gi|123998189|gb|ABM86696.1| hexokinase 2 [synthetic construct]
Length = 917
Score = 96.3 bits (238), Expect = 3e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 331 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 383
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 384 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 431
Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats.
Identities = 89/390 (22%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 494 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 613 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 668
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 669 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 721 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 779
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 780 GIFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 835
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA + + + D + + DG+++
Sbjct: 836 AGMAAVVDRIRENRGLDALKVTVGVDGTLY 865
>gi|150866927|ref|XP_001386689.2| Hexokinase [Pichia stipitis CBS 6054]
gi|149388183|gb|ABN68660.2| Hexokinase [Pichia stipitis CBS 6054]
Length = 482
Score = 96.3 bits (238), Expect = 3e-18, Method: Composition-based stats.
Identities = 112/422 (26%), Positives = 178/422 (42%), Gaps = 83/422 (19%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIVY------ 79
+++KGL + ++ MIP W D P K+ + ID GGTN R +V
Sbjct: 51 ELEKGLSKKGGNIP---MIPGWV---LDFPTGKETGDYLAIDLGGTNLRVVLVKLGGNRD 104
Query: 80 FDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPD 139
FD K+P+PA R +EE +D IA L+ ++ +P+
Sbjct: 105 FDTTQS-------KYPLPATMRTAKSEELWDFIAGCLKKFVEDE-------------YPE 144
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSR-----------------KGWKK----IK 178
G + + L P INEG Q ++ + KK I+
Sbjct: 145 GVTEPLPLGFTFSYP-ASQSSINEGFLQRWTKGFDIDGVEGRDVVPMLQEAIKKENVPIE 203
Query: 179 KIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFY--- 234
+ ++NDT L + +++ + + +G + GTG N AY + G+I KL+ +F+
Sbjct: 204 VVALINDTTGTLVASAYTDPE-----TKMGLIFGTGCNGAYYDVCGEIPKLEG-QFHGDV 257
Query: 235 --DKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
+ I CE G + +P+SKFD + S + E+M SG YLGE+ +AL
Sbjct: 258 AGESLMAINCEYGAFDNELAVLPRSKFDHQIDAESPRPGQQAFEKMISGYYLGEVLRLAL 317
Query: 289 RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD-----KNIFSGIIEAHSVSEDY 343
SA+GIF + LN ++E ++ +++F + + +
Sbjct: 318 LDLSAKGIFFKDQDLSKLNQPFILDTSFPARIEEDPYENLSDVQDLFQQELGIQTTDAER 377
Query: 344 VKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFK 403
I + + ER+ RLS IAA C K G K +ADGS+F K KER K
Sbjct: 378 SVIRRLAEVIGERSARLSVCGIAAICKKRGY-----KTAHAAADGSVFNKYPGFKERAAK 432
Query: 404 SL 405
L
Sbjct: 433 GL 434
>gi|114578344|ref|XP_001162535.1| PREDICTED: hexokinase 2 isoform 2 [Pan troglodytes]
Length = 917
Score = 96.3 bits (238), Expect = 4e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 331 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 383
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 384 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 431
Score = 68.2 bits (165), Expect = 1e-09, Method: Composition-based stats.
Identities = 90/390 (23%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 494 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKI-YAVPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 613 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 668
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 669 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 721 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 779
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 780 GIFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 835
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 836 AGMAAVVDKIRENRGLDALKVTVGVDGTLY 865
>gi|114578346|ref|XP_001162408.1| PREDICTED: hexokinase 2 isoform 1 [Pan troglodytes]
Length = 889
Score = 96.3 bits (238), Expect = 4e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 17 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 76
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 77 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 136
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 137 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 189
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 190 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 243
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 244 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 302
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 303 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 355
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 356 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 403
Score = 68.2 bits (165), Expect = 1e-09, Method: Composition-based stats.
Identities = 90/390 (23%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 466 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 525
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 526 EMHNKI-YAVPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 584
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 585 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 640
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 641 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 692
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 693 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 751
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 752 GIFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 807
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 808 AGMAAVVDKIRENRGLDALKVTVGVDGTLY 837
>gi|119390703|pdb|2NZT|A Chain A, Crystal Structure Of Human Hexokinase Ii
gi|119390704|pdb|2NZT|B Chain B, Crystal Structure Of Human Hexokinase Ii
Length = 902
Score = 96.3 bits (238), Expect = 4e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 31 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 90
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 91 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 150
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 151 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 203
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 204 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 257
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 258 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 316
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 317 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 369
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 370 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 417
Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats.
Identities = 89/390 (22%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 480 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 539
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 540 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 598
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 599 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 654
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 655 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 706
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 707 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 765
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 766 GIFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 821
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA + + + D + + DG+++
Sbjct: 822 AGMAAVVDRIRENRGLDALKVTVGVDGTLY 851
>gi|91077784|ref|XP_966410.1| PREDICTED: similar to CG3001-PA, isoform A isoform 1 [Tribolium
castaneum]
Length = 469
Score = 96.3 bits (238), Expect = 4e-18, Method: Composition-based stats.
Identities = 103/415 (24%), Positives = 181/415 (43%), Gaps = 60/415 (14%)
Query: 51 KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV---PEILSFFKHPMPALDREMTNEE 107
++LP D + K + +D GGTNFR ++ K +I + +H M + E+
Sbjct: 77 QDLP-DGSETGKFLALDLGGTNFRVLLIELSKNHFEMRSKIFAIPQHIMLG-----SGEQ 130
Query: 108 FFDSIAEYLEPL-KDES---DMISFCFSYAIKIFPDGGGQAI--KLSKEIKLPYIGDCKI 161
FD IA+ L KDE +++ F+++ + G + I + +K + +
Sbjct: 131 LFDHIADCLAKFAKDEKIQHEVLPLGFTFSFPLMQKGLTKGILERWTKGFNCSNVVGNDV 190
Query: 162 NEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE 221
+ L A+ R+G +I+ ++NDT L S + IG ++GTG N+ Y+E
Sbjct: 191 VQMLKDAIDRRGDIQIEVCAILNDTTGTLMSCAWKNRY-----CKIGLIIGTGTNACYVE 245
Query: 222 YGKIEKLKTTEFYDKPQ------IIVCESGK-----SNKIPQSKFDKILSENSNLKNEYF 270
K E +D+P +I CE G + ++++D+ + E++ +
Sbjct: 246 -----DQKNAEMFDEPDRGSGKVLINCEWGAFGDDGALDFVRTQYDREVDEHTVNPGKQL 300
Query: 271 LERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ----NH 325
E+M SG Y+GEL +AL + EG +F + + L F T+ +S + +
Sbjct: 301 HEKMISGMYMGELVRLALERFTNEGLLFGGKGSDQLFTRDRFYTKYVSEIESDPPGTFTN 360
Query: 326 DKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICIS 385
K I + H+ +D + + +C+C RA L++A IA K K P + +
Sbjct: 361 CKEILEELGLKHATEQDCINVRYVCECISRRAAHLASAGIATL---LNKMKEPR--VTVG 415
Query: 386 ADGSMFLKGFLIKERIFKSLHTCLTEK------RGIYFVLKTNDEAVTLGTALAA 434
DGS++ R H + EK GI F L +++ G AL A
Sbjct: 416 IDGSLY--------RFHPHFHNLMMEKISELVEPGIVFDLMLSEDGSGRGAALVA 462
>gi|5804910|emb|CAA86476.2| hexokinase II [Homo sapiens]
Length = 916
Score = 95.9 bits (237), Expect = 4e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEP------LKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLHIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 331 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 383
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 384 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 431
Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats.
Identities = 89/390 (22%), Positives = 167/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 494 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 613 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 668
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 669 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 721 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 779
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 780 GIFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 835
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA + + + D + + DG+++
Sbjct: 836 AGMAAVVDRIRENRGLDALKVTVGVDGTLY 865
>gi|7305143|ref|NP_038848.1| hexokinase 2 [Mus musculus]
gi|2495218|sp|O08528|HXK2_MOUSE Hexokinase-2 (Hexokinase type II) (HK II)
gi|1907083|emb|CAA72366.1| hexokinase II [Mus musculus]
gi|6911969|emb|CAB72257.1| hexokinase II [Mus musculus]
gi|32449857|gb|AAH54472.1| Hexokinase 2 [Mus musculus]
gi|148666622|gb|EDK99038.1| hexokinase 2 [Mus musculus]
Length = 917
Score = 95.9 bits (237), Expect = 4e-18, Method: Composition-based stats.
Identities = 94/399 (23%), Positives = 183/399 (45%), Gaps = 33/399 (8%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQR 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L D+ + + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + + +A+ R+G I + +VNDT + + + DD
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKIP 251
Q + IG ++GTG N+ Y +E+++ + + + +C + G N I
Sbjct: 222 Q--NCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDI- 273
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCD 310
+++FD+ + S + E+M SG Y+GEL + L + AE +F +++ LL +
Sbjct: 274 RTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGS 333
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIE--AHSVSEDYVKIYSICKCFFERAGRLSAAVIAAA 368
F T+++S +++ + + ++ + ED V + IC+ R+ L AA +AA
Sbjct: 334 FETKDVSDIEDDKDGIQKAYQILVRLGLSPLQEDCVATHRICQIVSTRSASLCAATLAAV 393
Query: 369 C--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
IK KG+ + I DGS++ K +R+ K++
Sbjct: 394 LWRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKAV 431
Score = 72.4 bits (176), Expect = 6e-11, Method: Composition-based stats.
Identities = 90/391 (23%), Positives = 165/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E + + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T EE FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKIYSIPQEVM--HGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 612 DQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYE--- 668
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E D + +C ++G +
Sbjct: 669 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
+ ++ FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 720 DL-RTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 779 RGIFETK----FLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDNLKVTVGVDGTLY 865
>gi|119620009|gb|EAW99603.1| hexokinase 2, isoform CRA_b [Homo sapiens]
Length = 792
Score = 95.9 bits (237), Expect = 4e-18, Method: Composition-based stats.
Identities = 101/409 (24%), Positives = 183/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 331 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 383
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 384 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 431
Score = 59.7 bits (143), Expect = 4e-07, Method: Composition-based stats.
Identities = 75/309 (24%), Positives = 137/309 (44%), Gaps = 34/309 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 494 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 613 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 668
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 669 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 721 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 779
Query: 309 CDFSTEEIS 317
F T+ +S
Sbjct: 780 GIFETKFLS 788
>gi|91077786|ref|XP_975828.1| PREDICTED: similar to CG3001-PA, isoform A isoform 3 [Tribolium
castaneum]
Length = 448
Score = 95.5 bits (236), Expect = 6e-18, Method: Composition-based stats.
Identities = 103/415 (24%), Positives = 181/415 (43%), Gaps = 60/415 (14%)
Query: 51 KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV---PEILSFFKHPMPALDREMTNEE 107
++LP D + K + +D GGTNFR ++ K +I + +H M + E+
Sbjct: 56 QDLP-DGSETGKFLALDLGGTNFRVLLIELSKNHFEMRSKIFAIPQHIMLG-----SGEQ 109
Query: 108 FFDSIAEYLEPL-KDES---DMISFCFSYAIKIFPDGGGQAI--KLSKEIKLPYIGDCKI 161
FD IA+ L KDE +++ F+++ + G + I + +K + +
Sbjct: 110 LFDHIADCLAKFAKDEKIQHEVLPLGFTFSFPLMQKGLTKGILERWTKGFNCSNVVGNDV 169
Query: 162 NEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE 221
+ L A+ R+G +I+ ++NDT L S + IG ++GTG N+ Y+E
Sbjct: 170 VQMLKDAIDRRGDIQIEVCAILNDTTGTLMSCAWKNRY-----CKIGLIIGTGTNACYVE 224
Query: 222 YGKIEKLKTTEFYDKPQ------IIVCESGK-----SNKIPQSKFDKILSENSNLKNEYF 270
K E +D+P +I CE G + ++++D+ + E++ +
Sbjct: 225 -----DQKNAEMFDEPDRGSGKVLINCEWGAFGDDGALDFVRTQYDREVDEHTVNPGKQL 279
Query: 271 LERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ----NH 325
E+M SG Y+GEL +AL + EG +F + + L F T+ +S + +
Sbjct: 280 HEKMISGMYMGELVRLALERFTNEGLLFGGKGSDQLFTRDRFYTKYVSEIESDPPGTFTN 339
Query: 326 DKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICIS 385
K I + H+ +D + + +C+C RA L++A IA K K P + +
Sbjct: 340 CKEILEELGLKHATEQDCINVRYVCECISRRAAHLASAGIATL---LNKMKEPR--VTVG 394
Query: 386 ADGSMFLKGFLIKERIFKSLHTCLTEK------RGIYFVLKTNDEAVTLGTALAA 434
DGS++ R H + EK GI F L +++ G AL A
Sbjct: 395 IDGSLY--------RFHPHFHNLMMEKISELVEPGIVFDLMLSEDGSGRGAALVA 441
>gi|29347840|ref|NP_811343.1| hexokinase type III [Bacteroides thetaiotaomicron VPI-5482]
gi|29339742|gb|AAO77537.1| hexokinase type III [Bacteroides thetaiotaomicron VPI-5482]
Length = 402
Score = 95.1 bits (235), Expect = 8e-18, Method: Composition-based stats.
Identities = 110/440 (25%), Positives = 186/440 (42%), Gaps = 63/440 (14%)
Query: 15 YKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR 74
+K+D E +I+ K E + + IP + T K K +++D GGTN+R
Sbjct: 6 FKLDNEQLKAIVCSFRDKTEEGLKTENAEIQCIPTFIAPKTTHIKGKS-LVLDLGGTNYR 64
Query: 75 AGIVYFDKKGVPEILSFFKHPMPALDREM--------TNEEFFDSIAEYLEPLKDESDM- 125
IV FDK P + HP ++M T EE F +A+ + +K E +M
Sbjct: 65 VAIVDFDK-ATPTV-----HPNNGWKKDMSIMKSVGYTREELFKELADMIIGIKREEEMP 118
Query: 126 ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
I +CFSY + P G + ++ +K + + + I + L L+ + K I +VND
Sbjct: 119 IGYCFSYPAESVPGGDAKLLRWTKGVDIKEMVGEFIGKPLLDYLNERNKIKFTGIKVVND 178
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTTEFYDKPQIIVCES 244
T A L +G+ D +D++IG ++GTG N A +I KIEKL + + ES
Sbjct: 179 TIASLFAGL----TDNSYDAYIGLIVGTGTNMATFIPADKIEKLDQSCNAHGLIPVNLES 234
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKM 304
G + + D + S + E+ SG YLG++ A
Sbjct: 235 GNFHPPFLTAVDDTVDAISGNPGKQRFEKAVSGMYLGDILKTA----------------- 277
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSED-YVKIYSICKCFFERAGRLSAA 363
F EE E+ D + I+ + +D YV++ + + R+ +L AA
Sbjct: 278 ------FPLEEF-----EEKFDAQKLTSIMNYPDIYKDVYVQV---AQWIYGRSAQLVAA 323
Query: 364 VIAAACIKTGKGKSPDKPICISADGSMFLK--------GFLIKERIFKSLHTCLTEKRGI 415
+ + + +C+ A+GS+F L+ E++ + L E I
Sbjct: 324 SLTGLIMLLKSYNKDIRKVCLVAEGSLFWSENRKDKNYNILVMEKLRELLQLFGLED--I 381
Query: 416 YFVLKTNDEAVTLGTALAAF 435
+K+ + A +GT +AA
Sbjct: 382 EVDIKSMNNANLIGTGIAAL 401
>gi|134299664|ref|YP_001113160.1| Hexokinase [Desulfotomaculum reducens MI-1]
gi|134052364|gb|ABO50335.1| Hexokinase [Desulfotomaculum reducens MI-1]
Length = 440
Score = 94.7 bits (234), Expect = 1e-17, Method: Composition-based stats.
Identities = 115/421 (27%), Positives = 177/421 (42%), Gaps = 60/421 (14%)
Query: 42 SSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEILS----FFKHPMP 97
SS+ M+ + PT + + + +D GGTN R +V KG I P
Sbjct: 41 SSLKMLHTFITPPTG-QETGEFLAVDFGGTNVRIQLVELLGKGRYRIRKNHSVMLCDPAG 99
Query: 98 ALDREM---TNEEFFDSIAEYLEPLKDESD--MISFCFSYAIKIFPDGGGQAIKLSKEIK 152
+ D + + EE FD I E + L D + FS+ K I +KE K
Sbjct: 100 SYDYTLECTSGEELFDFIVEQIVKLIDNKTHYFLGHTFSFPTKQIDPARAILINWTKEFK 159
Query: 153 LPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFD-SHIGFVL 211
++ L AL RK + ++ + ++NDT A L + + G D ++IG +
Sbjct: 160 TAGTEGKEVTSLLENALKRKSIRNVQPLSIINDTTATLLTAAY------GNDCANIGSIC 213
Query: 212 GTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIPQSKFDKILSENSNLKNEYFL 271
GTG N+ Y+E P II ESG NK P + FD +L+E S N L
Sbjct: 214 GTGHNTCYLEAAA-----------GPVIINMESGNFNKFPLTTFDLVLNEASEQPNLQQL 262
Query: 272 ERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS 331
E+ SGRY+GE+ + + AE + R + E+SL ++ NH +
Sbjct: 263 EKAVSGRYVGEIVRLIILDFVAEKMLFSRGINGIDEPFSIQAPEVSLMIR-GNHKPDDLL 321
Query: 332 GIIEAHSV----------SEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPD-- 379
+ AH V +++ + + I + RA RL IAA + + P+
Sbjct: 322 DL--AHWVGVKWCVKSPSADELIALRCIAQTVICRASRL----IAATFLGVLQHIDPELK 375
Query: 380 KPICISADGSM------FLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAVTLGTALA 433
I DGSM FL+G L IF +++ E + VLK +A +G A+A
Sbjct: 376 SRQVIGIDGSMFQNMPFFLQGIL---EIFSNIY----EDKAANIVLKYIRDASGVGAAIA 428
Query: 434 A 434
A
Sbjct: 429 A 429
>gi|156109318|gb|EDO11063.1| hypothetical protein BACOVA_02960 [Bacteroides ovatus ATCC 8483]
Length = 402
Score = 94.0 bits (232), Expect = 2e-17, Method: Composition-based stats.
Identities = 100/395 (25%), Positives = 171/395 (43%), Gaps = 66/395 (16%)
Query: 62 KVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREM--------TNEEFFDSIA 113
K +++D GGTN+R IV F K +P + HP ++M T EE F +A
Sbjct: 52 KSLVLDLGGTNYRVAIVDFSK--MPPTI----HPNNGWKKDMSIMKTPGYTREELFKEMA 105
Query: 114 EYLEPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRK 172
+ + +K E +M I +CFSY + P G + ++ +K + + + + + L L+ +
Sbjct: 106 DMITGIKREKEMPIGYCFSYPTESVPGGDAKLLRWTKGVDIKEMIGEVVGKPLLDYLNER 165
Query: 173 GWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTT 231
K I ++NDT A L +G+ D +D++IG ++GTG N A +I KI+KL +
Sbjct: 166 NKIKFTNIKVLNDTVASLFAGL----TDSSYDAYIGLIVGTGTNMATFIPADKIKKLNPS 221
Query: 232 EFYDKPQIIVCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAG 291
D + ESG + + D + S + E+ SG YLG++ L+A
Sbjct: 222 HKVDGLIPVNLESGNFHPPFLTAVDNTMDGISGNPGKQRFEKAVSGMYLGDI----LKA- 276
Query: 292 SAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIY-SIC 350
F EE E+ D + I+ + Y ++Y +
Sbjct: 277 ------------------TFPLEEF-----EEKFDAQKLTSIMNYPDI---YKEVYVEVA 310
Query: 351 KCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLT 410
+ + R+ +L AA + + + IC+ A+GS+F K R K+ + +
Sbjct: 311 QWIYSRSAQLVAASLTGLIMLLKSYNKNIRKICLVAEGSLFWS----KNRKDKNYNMIVM 366
Query: 411 EKRGIYFVL----------KTNDEAVTLGTALAAF 435
EK F L K+ + A +GT +AA
Sbjct: 367 EKLRELFSLFGLEDVEVDIKSMNNANLIGTGIAAL 401
>gi|91077818|ref|XP_970645.1| PREDICTED: similar to CG3001-PA, isoform A [Tribolium castaneum]
Length = 452
Score = 94.0 bits (232), Expect = 2e-17, Method: Composition-based stats.
Identities = 109/463 (23%), Positives = 202/463 (43%), Gaps = 54/463 (11%)
Query: 2 KEIDDFFKRNNFDYKIDIEYAASI---LLEDMKKGLESEAESVSSMD-MIPLWKNLPTDI 57
+++D K D +D++ I L D+ KGL + + S + + ++LP
Sbjct: 4 EKVDPVLKERCKDLILDLDTLREISRRFLHDVDKGLRKDTHATSIVKCFVTYVQDLPNGT 63
Query: 58 PKDKKVIIIDAGGTNFRAGIVYFDKKGV---PEILSFFKHPMPALDREMTNEEFFDSIAE 114
++ K + +D GGTNFR ++ K +I + +H M + E+ FD IA+
Sbjct: 64 -ENGKFLALDLGGTNFRVLLIELSKDHFEMRSKIYAIPQHIMLG-----SGEQLFDHIAD 117
Query: 115 YLEPLKDESDMIS----FCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEG---LFQ 167
L + +I+ F+++ + G + I L + K +C N+ L
Sbjct: 118 CLASFMKQEQVIAETLPLGFTFSFPLTQKGLTKGI-LERWTKGFNCSNCVGNDVVQLLKD 176
Query: 168 ALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEK 227
A++R+G +IK ++NDT L S + + IG ++GTG N+ Y+E K
Sbjct: 177 AIARRGDIQIKVCAILNDTTGTLMSCAWKNPN-----CRIGLIVGTGSNACYVE-----K 226
Query: 228 LKTTEFYDKPQ------IIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCS 276
K E +D II E G + ++++D+ + NS E+M S
Sbjct: 227 QKNAELFDDEDKGSGNVIINLEWGAFGDDGALDFIRTEYDRDVDANSVNPGRQLHEKMIS 286
Query: 277 GRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ----NHDKNIFS 331
G Y+GEL +AL + EG +F + + L F T+ +S + ++I
Sbjct: 287 GMYMGELTRLALEKFTKEGLLFEGKASDALFTRGKFYTKYVSEIEGDPAGVITSCRDILE 346
Query: 332 GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
+ H+ +D + +C+C +RA L++ IA K + + + ++ DGS++
Sbjct: 347 ELGIYHATDQDCFNVRYVCECVSKRAADLASTGIATLLNKMNEAR-----VTVAIDGSVY 401
Query: 392 LKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAVTLGTALAA 434
+ + +++ T + GI F L +++ G AL A
Sbjct: 402 RYHPHFHDLMMQTISTLVNP--GIKFDLMLSEDGSGRGAALVA 442
>gi|109103519|ref|XP_001111706.1| PREDICTED: similar to hexokinase 2 isoform 2 [Macaca mulatta]
Length = 917
Score = 94.0 bits (232), Expect = 2e-17, Method: Composition-based stats.
Identities = 98/397 (24%), Positives = 177/397 (44%), Gaps = 53/397 (13%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVTLIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 331 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 383
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLK 393
L AA +AA IK KG+ + + DGS++ K
Sbjct: 384 SLCAATLAAVLQRIKENKGEERLRST-VGVDGSVYKK 419
Score = 69.3 bits (168), Expect = 5e-10, Method: Composition-based stats.
Identities = 90/389 (23%), Positives = 167/389 (42%), Gaps = 43/389 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E +++ + M+P + D + + +D GGTNFR +V K G
Sbjct: 494 EMERGLSKETHAIAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 613 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 668
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNKIPQ 252
D H +G ++GTG N+ Y +E+++ E + + +C + G + +
Sbjct: 669 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 253 --SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 721 FCTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780
Query: 310 DFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
F T+ FL + D + + S +D + + +C RA +L A
Sbjct: 781 IFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGA 836
Query: 364 VIAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + + D + + DG+++
Sbjct: 837 GMAAVVDKIRENRGLDALKVTVGVDGTLY 865
>gi|45383696|ref|NP_989543.1| hexokinase 2 [Gallus gallus]
gi|23821302|dbj|BAC20933.1| hexokinase2 [Gallus gallus]
Length = 916
Score = 94.0 bits (232), Expect = 2e-17, Method: Composition-based stats.
Identities = 104/413 (25%), Positives = 183/413 (44%), Gaps = 49/413 (11%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVP- 86
++M+KGL ++ +S+ M+P + D +D + +D GGTNFR V G+
Sbjct: 45 KEMEKGLGADTNPTASVKMLPSFVRSTPDGTEDGDFLALDLGGTNFRVLRVKVSDNGLQK 104
Query: 87 -EILSFFKHPMPALDREMTNEEFFDSIAE----YLEPL--KDESDMISFCFSYAIKIFPD 139
E+ S L R + + FD IAE ++E L KD+ + F FS+
Sbjct: 105 VEMESQIYEIHEDLMRG-SGMQLFDHIAECLGNFMEKLKIKDKKLPLGFTFSFPCHQTKL 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+ +K K + + L +A+ ++G I + +VNDT + S + D
Sbjct: 164 DESILVNWTKGFKCSSVEGKDVVSLLRRAIKKRGDFDIDIVAVVNDTVGTMMSCGY---D 220
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKI 250
DQ + +G ++GTG N+ Y +E+++ + + + +C + G N I
Sbjct: 221 DQ--NCEVGLIVGTGTNACY-----MEEMRHIDLVEGDEGRMCINMEWGAFGDDGALNDI 273
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
+++FD + S + E+M SG Y+GEL + L + EG +F +++ L +
Sbjct: 274 -RTEFDHEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEGLLFQGKLSSDLRTTG 332
Query: 310 DFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAGRL 360
F T +S KE+ G+ +AH + ED + + IC+ R+ L
Sbjct: 333 HFETRFVSAIEKEK-------EGLQKAHEILTKLGLEPSHEDCLATHRICQIVSTRSANL 385
Query: 361 SAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
A +AA IK KG P + + DGS++ K R+ K++ L +
Sbjct: 386 CGATLAARLRRIKEYKGVDPLRST-VGVDGSVYKKYPHFARRLHKTVRKLLPD 437
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/390 (23%), Positives = 172/390 (44%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD---KKGV 85
+M+KGL E + +++ M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMEKGLGKETHAEATVKMLPTYVCSTPDGTEKGDFLALDLGGTNFRVLLVRVRNGMRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P+ + + T EE FD I+++LE +K S + F FS+ K
Sbjct: 554 EMHNKIYSIPLEVM--QGTGEELFDHIVHCISDFLEYMGMKGVSLPLGFTFSFPCKQTNL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
G +K +K K + L +A+ R+ + + +VNDT + + + +
Sbjct: 612 DEGILLKWTKGFKATGCEGEDVVSLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDP- 670
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKI 250
+G ++GTG N+ Y +E+++ E + + +C ++G + I
Sbjct: 671 ----YCEVGLIVGTGSNACY-----MEEMRNVELVEGDEGRMCVNMEWGAFGDNGCLDDI 721
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
Q++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 722 -QTEFDLAVDELSLNPGKQRFEKMISGMYLGEIVRNILMDFTKRGLLFRGRISERLKTRG 780
Query: 310 DFSTEEISLFLKEQNHD-------KNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D ++I + S +D + + +C RA +L
Sbjct: 781 IFETK----FLSQIESDCLALLQVRSILQH-LGLESTCDDSIIVKEVCTVVARRAAQLCG 835
Query: 363 AVIAAACIKTGKGKSPD-KPICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 836 AGMAAVVDKIRENRGLDFLKVTVGVDGTLY 865
>gi|109103521|ref|XP_001111663.1| PREDICTED: similar to hexokinase 2 isoform 1 [Macaca mulatta]
Length = 889
Score = 94.0 bits (232), Expect = 2e-17, Method: Composition-based stats.
Identities = 98/397 (24%), Positives = 177/397 (44%), Gaps = 53/397 (13%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 17 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 76
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 77 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 136
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 137 ESFLVSWTKGFKSSGVEGRDVVTLIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 189
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 190 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 243
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 244 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 302
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 303 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 355
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLK 393
L AA +AA IK KG+ + + DGS++ K
Sbjct: 356 SLCAATLAAVLQRIKENKGEERLRST-VGVDGSVYKK 391
Score = 69.3 bits (168), Expect = 5e-10, Method: Composition-based stats.
Identities = 89/389 (22%), Positives = 165/389 (42%), Gaps = 43/389 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E +++ + M+P + D + + +D GGTNFR +V K G
Sbjct: 466 EMERGLSKETHAIAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 525
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S + F FS+ +
Sbjct: 526 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLD 584
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A+ R+ + + +VNDT + + F
Sbjct: 585 ESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFE---- 640
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIPQ------ 252
D H +G ++GTG N+ Y +E+++ E + + +C + +
Sbjct: 641 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 692
Query: 253 --SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 693 FCTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 752
Query: 310 DFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
F T+ FL + D + + S +D + + +C RA +L A
Sbjct: 753 IFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGA 808
Query: 364 VIAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + + D + + DG+++
Sbjct: 809 GMAAVVDKIRENRGLDALKVTVGVDGTLY 837
>gi|91077782|ref|XP_975717.1| PREDICTED: similar to CG3001-PA, isoform A isoform 2 [Tribolium
castaneum]
Length = 448
Score = 93.2 bits (230), Expect = 3e-17, Method: Composition-based stats.
Identities = 101/415 (24%), Positives = 180/415 (43%), Gaps = 60/415 (14%)
Query: 51 KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV---PEILSFFKHPMPALDREMTNEE 107
++LP D + K + +D GGTNFR ++ K +I + +H M + E+
Sbjct: 56 QDLP-DGSETGKFLALDLGGTNFRVLLIELSKNHFEMRSKIFAIPQHIMLG-----SGEQ 109
Query: 108 FFDSIAEYLEPL-KDES---DMISFCFSYAIKIFPDGGGQAI--KLSKEIKLPYIGDCKI 161
FD IA+ L KDE +++ F+++ + G + I + +K + +
Sbjct: 110 LFDHIADCLAKFAKDEKIQHEVLPLGFTFSFPLMQKGLTKGILERWTKGFNCSNVVGNDV 169
Query: 162 NEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE 221
+ L A+ R+G I + ++ND+ L S + +G ++GTG N+ Y+E
Sbjct: 170 VQMLKDAIDRRGDITISIMAILNDSTGTLMSCAWKNRY-----CRVGIIIGTGTNACYVE 224
Query: 222 YGKIEKLKTTEFYDKPQ------IIVCESGK-----SNKIPQSKFDKILSENSNLKNEYF 270
K E +D+P +I CE G + ++++D+ + E++ +
Sbjct: 225 -----DQKNAEMFDEPDRGSGKVLINCEWGAFGDDGALDFVRTQYDREVDEHTVNPGKQL 279
Query: 271 LERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ----NH 325
E+M SG Y+GEL +AL + EG +F + + L F T+ +S + +
Sbjct: 280 HEKMISGMYMGELVRLALERFTNEGLLFGGKGSDQLFTRDRFYTKYVSEIESDPPGTFTN 339
Query: 326 DKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICIS 385
K I + H+ +D + + +C+C RA L++A IA K K P + +
Sbjct: 340 CKEILEELGLKHATEQDCINVRYVCECISRRAAHLASAGIATL---LNKMKEPR--VTVG 394
Query: 386 ADGSMFLKGFLIKERIFKSLHTCLTEK------RGIYFVLKTNDEAVTLGTALAA 434
DGS++ R H + EK GI F L +++ G AL A
Sbjct: 395 IDGSLY--------RFHPHFHNLMMEKISELVEPGIVFDLMLSEDGSGRGAALVA 441
>gi|119903225|ref|XP_001255832.1| PREDICTED: similar to hexokinase II, partial [Bos taurus]
Length = 948
Score = 93.2 bits (230), Expect = 3e-17, Method: Composition-based stats.
Identities = 97/402 (24%), Positives = 181/402 (45%), Gaps = 39/402 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +S+ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 202 KEMEKGLGATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVRVTDNGLQK 261
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 262 VEMESQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCLQTKLD 321
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + + + DD
Sbjct: 322 ESFLVSWTKGFKSSGVEGKDVVTLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY---DD 378
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCE------SGKSNKIPQSK 254
Q + IG ++GTG N+ Y+E ++ + T E + I E G + I +++
Sbjct: 379 Q--NCEIGLIVGTGSNACYME--EMRHIDTVEGDEGRMCINMEWGAFGDDGALDDI-RTE 433
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCDFST 313
FD+ + S + E+M SG Y+GEL + L + E +F +++ LL + F T
Sbjct: 434 FDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLATGHFET 493
Query: 314 EEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAGRLSAAV 364
+++S E++ GI +A + ED V + +C+ R+ L AA
Sbjct: 494 KDVSDIEGEKD-------GIQKAREILVRLGLDPTHEDCVATHRVCQIVSTRSASLCAAT 546
Query: 365 IAAACIKTGKGKSPDK-PICISADGSMFLKGFLIKERIFKSL 405
+AA + + K D+ + DGS++ K +R+ K++
Sbjct: 547 LAAVLWRIKENKGVDRLRSTVGVDGSVYKKHPHFAKRLHKTV 588
Score = 63.9 bits (154), Expect = 2e-08, Method: Composition-based stats.
Identities = 73/310 (23%), Positives = 137/310 (44%), Gaps = 36/310 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E +++ + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 651 EMERGLSKETHAIAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 710
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T +E FD IA++LE +K S + F FS+ +
Sbjct: 711 EMHNKIYSIPQEVM--HGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 768
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 769 DESILLKWTKGFKASGCEGEDVVMLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 825
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 826 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLD 876
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
+ +++FD + E S E+M SG YLGE+ L + G +F R+++ L
Sbjct: 877 DL-RTEFDAAVDELSLNPGRQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 935
Query: 308 SCDFSTEEIS 317
F T+ +S
Sbjct: 936 RGIFETKFLS 945
>gi|11066979|gb|AAG28789.1|AF309088_1 hexokinase [Tuber borchii]
Length = 497
Score = 93.2 bits (230), Expect = 3e-17, Method: Composition-based stats.
Identities = 129/474 (27%), Positives = 205/474 (43%), Gaps = 64/474 (13%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWK-NLPTDIPK 59
MK I D K D + S+ E++ KGL ++ M P W PT +
Sbjct: 24 MKHIHDLEKMFTID-TTKLHEVVSVFQEELVKGLSVTGGTIP---MNPTWVIGYPTG-DE 78
Query: 60 DKKVIIIDAGGTNFRAGIVYF-DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL-- 116
+ +D GGTN R V +++G +I K+ +P + T E+ FD IAE +
Sbjct: 79 TGTYLALDMGGTNLRVCEVELPEEQGQYDIYQS-KYRLPEEIKSGTGEQLFDYIAECVKQ 137
Query: 117 --------EPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQ 167
+ +KD ++ + F FSY + G + +K + + + +
Sbjct: 138 FLIANHEGQDIKDLKELHLGFTFSYPCEQNAIDHGILQRWTKGFDIEGVEGHDVVPMFEE 197
Query: 168 ALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIE 226
AL RKG IK +VNDT L + +++ + IG + GTG N+AY+E G I
Sbjct: 198 ALERKG-VPIKITALVNDTTGTLIASAYTDNT-----TRIGCIFGTGCNAAYMETIGCIP 251
Query: 227 KLKTTEFYDKPQIIV-CESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLG 281
KL +I + CE G + +P++ +DK + ENS + E+M +G YLG
Sbjct: 252 KLAHMNLDPSLEIAINCEWGAFDNEHRVLPRTVYDKHIDENSPRPGQQTFEKMVAGLYLG 311
Query: 282 ELCSIALRAGSAEGIFSPRVNKMLLNSCDFST--EEISL---FLKEQNHDKNIFSGIIEA 336
E+ + L + +P V+ + D ST E SL FL E D + ++E
Sbjct: 312 EIFRLVL----VDLYSNPDVS--IFEKQDISTLQAEYSLDASFLAEIESDP--WENLMET 363
Query: 337 HSVSEDYVKIYS----------ICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-IS 385
H++ E +KI + + + RA RL A +AA C K + C +
Sbjct: 364 HALFEKKLKIVTTEPERKLIRRLAELIGTRAARLGACGVAAIC------KMKNIESCHVG 417
Query: 386 ADGSMFLKGFLIKERIFKSLHTCLTEKRGIY---FVLKTNDEAVTLGTALAAFL 436
ADGS+F K +ER K+L R I + +++ +G AL A L
Sbjct: 418 ADGSVFNKYPNFQERGAKALREIFGWGRTIRKDPIQIVPSEDGSGVGAALIAAL 471
>gi|51476140|emb|CAH18060.1| hypothetical protein [Homo sapiens]
Length = 889
Score = 92.8 bits (229), Expect = 4e-17, Method: Composition-based stats.
Identities = 100/409 (24%), Positives = 182/409 (44%), Gaps = 53/409 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTN R V G+ +
Sbjct: 17 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNSRVLWVKVTDNGLQK 76
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 77 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 136
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 137 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 189
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 190 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 243
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 244 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 302
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAG 358
+ F T++IS E++ GI +A V ED V + IC+ R+
Sbjct: 303 TGRFETKDISDIEGEKD-------GIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 355
Query: 359 RLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
L AA +AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 356 SLCAATLAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 403
Score = 64.3 bits (155), Expect = 1e-08, Method: Composition-based stats.
Identities = 89/390 (22%), Positives = 165/390 (42%), Gaps = 45/390 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E + + + M+P + D + + +D GGTNFR +V K G
Sbjct: 466 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGV 525
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
E+ + + +P T +E FD IA++LE +K S F FS+ +
Sbjct: 526 EMHNKI-YAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPQGFTFSFPCQQNSLD 584
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+K +K K + L +A R+ + + +VNDT + + F
Sbjct: 585 ESILLKWTKGFKASGCEGEDVVTLLKEATHRREEFDLDVVAVVNDTVGTMMTCGFE---- 640
Query: 201 QGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 641 ---DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 692
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 693 F-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTR 751
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSA 362
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 752 GIFETK----FLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCG 807
Query: 363 AVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA + + + D + + DG+++
Sbjct: 808 AGMAAVVDRIRENRGLDALKVTVGVDGTLY 837
>gi|2689658|gb|AAB91396.1| mutant type II hexokinase [Rattus norvegicus]
Length = 917
Score = 92.8 bits (229), Expect = 4e-17, Method: Composition-based stats.
Identities = 93/401 (23%), Positives = 187/401 (46%), Gaps = 37/401 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQR 104
Query: 88 ILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
+ ++ + A+ ++ + + FD IAE L D+ + + F FS+
Sbjct: 105 VE--MENQIYAILEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTK 162
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
+ +K K + + + + + + R+G I + +VNDT + + +
Sbjct: 163 LDESFLVSWTKGFKSSGVEGRDVVDLIRKVIQRRGDFDIDIVAVVNDTVGTMMTCGY--- 219
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
DDQ + IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 220 DDQ--NCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLND 272
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNS 308
I +++FD+ + S + E+M SG Y+GEL + L + AE +F +++ LL +
Sbjct: 273 I-RTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTT 331
Query: 309 CDFSTEEISLFLKEQNHDKNIFSGIIE--AHSVSEDYVKIYSICKCFFERAGRLSAAVIA 366
F T+++S ++++ + + ++ + + ED V + IC+ R+ L AA +A
Sbjct: 332 GSFETKDVSDIEEDKDGIEKAYQILMRLGLNPLQEDCVATHRICQIVSTRSASLCAATLA 391
Query: 367 AAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
A IK KG+ + I DGS++ K +R+ K++
Sbjct: 392 AVLWRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKAV 431
Score = 74.3 bits (181), Expect = 1e-11, Method: Composition-based stats.
Identities = 91/391 (23%), Positives = 167/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E +V+ + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T EE FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKIYSIPQEVM--HGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 612 DQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 668
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E D + +C ++G +
Sbjct: 669 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
+ ++ FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 720 DL-RTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
T+ FL + D + + S +D + + +C RA +L
Sbjct: 779 RGISETK----FLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDKP-ICISADGSMF 391
A +AA K + + D P + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDNPKVTVGVDGTLY 865
>gi|126304047|ref|XP_001381777.1| PREDICTED: similar to hexokinase II [Monodelphis domestica]
Length = 917
Score = 92.4 bits (228), Expect = 5e-17, Method: Composition-based stats.
Identities = 94/394 (23%), Positives = 175/394 (44%), Gaps = 23/394 (5%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL ++ +S+ M+P + D +D + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGADTHPTASVKMLPTFVRSTPDGTEDGDFLALDLGGTNFRVLRVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + +P + + FD IA+ L D+ + + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIADCLANFMDKLQIKNKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + + + DD
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVSLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIP-----QSKF 255
Q + IG ++GTG N+ Y+E ++ + E + I E G +++F
Sbjct: 222 Q--NCEIGLIVGTGTNACYME--EMRYIDAVEGDEGRMCINMEWGAFGDDGVLDDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG Y+GEL + L + E +F +++ LL + F T+
Sbjct: 278 DREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEEMLFGGKLSPDLLTTGRFETK 337
Query: 315 EISLFLKEQNHDKNIFSGI--IEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKT 372
++S E++ K + + ED V + IC+ R+ L AA +AA +
Sbjct: 338 DVSDIEGEKDGIKKALDILTRLGLQPSQEDCVATHRICQIVSTRSANLCAATLAAVLRRL 397
Query: 373 GKGKSPDK-PICISADGSMFLKGFLIKERIFKSL 405
+ K D+ I DGS++ K R+ K++
Sbjct: 398 KENKGDDRLRSTIGVDGSVYKKHPHFATRLHKAV 431
Score = 70.9 bits (172), Expect = 1e-10, Method: Composition-based stats.
Identities = 93/388 (23%), Positives = 164/388 (42%), Gaps = 41/388 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD---KKGV 85
+M++GL E + +S+ M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMERGLSKETHAAASVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGMRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKIYAIPQEVM--HGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L A+ R+ + + +VNDT + + +
Sbjct: 612 DESILLKWTKGFKATGCVGEDVVGLLKDAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 668
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIP-----Q 252
D H +G ++GTG N+ Y+E ++ ++ E D I E G +
Sbjct: 669 ----DPHCEVGLIVGTGSNACYME--EMRNVELVEGDDGRMCINMEWGAFGDEGCLDDIR 722
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDF 311
++FD + E S + E+M SG YLGE+ L + G +F R+++ L F
Sbjct: 723 TEFDLAVDELSLNPGKQRFEKMISGMYLGEIVRNILINFTKRGLLFRGRISERLKTRGIF 782
Query: 312 STEEISLFLKEQNHD-------KNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAV 364
T+ FL + D + I + S +D + + +C RA +L A
Sbjct: 783 ETK----FLSQIESDCLALLQVRTILRH-LGLESTCDDSIIVKEVCTVVARRAAQLCGAG 837
Query: 365 IAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + + D + I DG+++
Sbjct: 838 MAAVVDKIRENRQLDSLKVTIGVDGTLY 865
>gi|126352418|ref|NP_001075245.1| hexokinase II [Equus caballus]
gi|146324940|sp|A2PYL8|HXK2_EQUGR Hexokinase-2 (Hexokinase type II) (HK II)
gi|146324941|sp|A2PYL7|HXK2_EQUZE Hexokinase-2 (Hexokinase type II) (HK II)
gi|146324942|sp|A2PYL6|HXK2_HORSE Hexokinase-2 (Hexokinase type II) (HK II)
gi|124271125|dbj|BAF45850.1| hexokinase II [Equus caballus]
gi|124271127|dbj|BAF45851.1| hexokinase II [Equus zebra]
gi|124271129|dbj|BAF45852.1| hexokinase II [Equus grevyi]
Length = 917
Score = 91.7 bits (226), Expect = 8e-17, Method: Composition-based stats.
Identities = 102/403 (25%), Positives = 184/403 (45%), Gaps = 41/403 (10%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +S+ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLAATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSI----AEYLEPL--KDESDMISFCFSYAIKIFPDG 140
+ + + +P + + + FD I A +++ L KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMQGSGTQLFDHIAGCLANFMDKLQIKDKKLPLGFTFSFPCIQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + MVNDT A + + + DD
Sbjct: 165 ESFLVSWTKGFKSRGVEGRDVVTLIRKAIQRRGDFDIDIVAMVNDTVATMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCE------SGKSNKIPQSK 254
Q + IG ++G G N+ Y+E ++ + T E + I E G + I +++
Sbjct: 222 Q--NCEIGLIVGMGSNACYME--EMRYIDTVEGDEGRMCINMEWGAFGDDGTLDDI-RTE 276
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCDFST 313
FD+ + S + E+M SG Y+GEL + L + E +F +++ LL + F T
Sbjct: 277 FDQEIDMGSLNPGQQLFEKMISGMYMGELVRLILVKMAKEELLFRGKLSPELLTTGRFET 336
Query: 314 EEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAGRLSAAV 364
+++S E++ GI +A V ED V + IC+ R+ L AA
Sbjct: 337 KDVSEIEGEKD-------GIQKAREVLVRLGMDPTQEDCVATHRICQIVSTRSASLCAAT 389
Query: 365 IAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 390 LAAVLQRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLQKTV 431
Score = 70.1 bits (170), Expect = 3e-10, Method: Composition-based stats.
Identities = 91/398 (22%), Positives = 168/398 (42%), Gaps = 61/398 (15%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E + + + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T +E FD IA++LE +K S + F FS+
Sbjct: 554 EMHNKIYSIPQDIM--HGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPC----- 606
Query: 140 GGGQAIKLSKEIKLPYIGDCKIN--EG------LFQALSRKGWKKIKKIIMVNDTAAVLQ 191
Q +L + I L + K + EG L +A+ R+ + + +VNDT +
Sbjct: 607 ---QQNRLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMM 663
Query: 192 SGIFSETDDQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNK 249
+ + D H +G ++GTG N+ Y +E+++ E + + +C + +
Sbjct: 664 TCGYE-------DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNTEWGA 711
Query: 250 IPQ--------SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPR 300
++FD + E S + E+M SG YLGE+ L + G +F R
Sbjct: 712 FGDNGCLDDFCTEFDVAVDELSLNPGKQRFEKMMSGMYLGEIVRNILIDFTKRGLLFRGR 771
Query: 301 VNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFF 354
+++ L F T+ FL + D + + S +D + + +C
Sbjct: 772 ISERLKTRGIFETK----FLSQIESDCLALQQVRAILQHLGLESTCDDSIIVKEVCTVVA 827
Query: 355 ERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+RA +L A +AA K + + D + + DG+++
Sbjct: 828 QRAAQLCGAGMAAVVDKIRENRGLDTLKVTVGVDGTLY 865
>gi|122134685|sp|Q1W674|HXK2_PIG Hexokinase-2 (Hexokinase type II) (HK II)
gi|90820093|gb|ABD98801.1| hexokinase II [Sus scrofa]
Length = 917
Score = 91.7 bits (226), Expect = 9e-17, Method: Composition-based stats.
Identities = 99/406 (24%), Positives = 183/406 (45%), Gaps = 47/406 (11%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +S+ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVRVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCIQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + + + DD
Sbjct: 165 ESFLVSWTKGFKSSGVEGKDVVTLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKIP 251
Q + IG ++GTG N+ Y +E+++ + + + +C + G + I
Sbjct: 222 Q--NCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGALDDI- 273
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCD 310
+++FD+ + S + E+M SG Y+GEL + L + E +F +++ LL +
Sbjct: 274 RTEFDQEIDMGSLNPGKQLFEKMISGLYMGELVRLILVKMAKEELLFGGKLSPELLATGH 333
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAGRLS 361
F T+++S E++ GI +A V ED V + +C+ R+ L
Sbjct: 334 FETKDVSDIEGEKD-------GIRKAREVLVRLGLDPTQEDCVATHRVCQIVSTRSASLC 386
Query: 362 AAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
AA +AA IK KG+ + I DGS++ K +R+ K+L
Sbjct: 387 AATLAAVLRRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTL 431
Score = 70.1 bits (170), Expect = 2e-10, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 166/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E +++ + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 494 EMERGLSKETHAIAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T +E FD IA++LE +K S + F FS+ +
Sbjct: 554 EMHNKIYSIPQEVM--HGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 612 DESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 668
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 669 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
+++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 720 DF-RTEFDAAVDELSLNAGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D + + S D + + +C RA +L
Sbjct: 779 RGIFETK----FLSQIESDCLALLQVRAILHHLGLESTCGDSIIVKEVCTVVARRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDTLKVTVGVDGTLY 865
>gi|68492091|ref|XP_710176.1| hexokinase-like protein [Candida albicans SC5314]
gi|68492104|ref|XP_710170.1| hexokinase-like protein [Candida albicans SC5314]
gi|46431316|gb|EAK90901.1| hexokinase-like protein [Candida albicans SC5314]
gi|46431324|gb|EAK90908.1| hexokinase-like protein [Candida albicans SC5314]
Length = 472
Score = 91.3 bits (225), Expect = 1e-16, Method: Composition-based stats.
Identities = 120/453 (26%), Positives = 189/453 (41%), Gaps = 51/453 (11%)
Query: 22 AASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIV 78
A +E M GLES S M MIP + T IP K+V + D GGTNFR +
Sbjct: 28 ATEYFIESMNVGLESPKPSKDVMPMIPTYV---TSIPTGKEVGLYLAADLGGTNFR--VC 82
Query: 79 YFDKKGVPEI---LSFFKHPMPALDREMTNEEF-----------FDSIAEYLEPLKDESD 124
D KG S ++ P+ + E +N+ F F++ +E E
Sbjct: 83 SIDLKGDHTFSMKQSKYRIPVDLMKAEKSNDLFGFLAKKVQSFLFENHSEACTAKNTEPL 142
Query: 125 MISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ + G I+ +K +P D + E L QA +K + + N
Sbjct: 143 KLGFTFSFPVNQTALNRGTLIRWTKGFDIPDTVDRDVVE-LLQANLTILEVNVKVVAIAN 201
Query: 185 DTAAVLQSGIFS-ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCE 243
DT L + +S ++ ++ IG + GTG N AY E KI KL ++ + +I E
Sbjct: 202 DTVGTLLTAAYSNDSAKTNRNTIIGCIFGTGTNGAYFE-SKIPKLSSSTSKSQGMVINTE 260
Query: 244 SGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSP 299
G + +P ++FD+I+ + + E+ SG +LGE+ +AL +G+
Sbjct: 261 WGSFDNGLKILPSTEFDEIVDSETANPGYHLFEKRISGMFLGEILRVALIHLFKKGLIFQ 320
Query: 300 RVNKMLLNSCDFSTEEISLFLKE-----QNHDKN-------IFSGIIEAHSVSEDYVKIY 347
+ K S EE L E Q D I ++ + E+ I
Sbjct: 321 ELYKARGGSLPHRIEEPWLLDAEVLSYLQIDDSTDLKTSGLILQNVLRLETNKEEREVIQ 380
Query: 348 SICKCFFERAGRLSAAVIAAACIKT-GKGKSPDKPICISADGSM--FLKGFLIKERIFKS 404
+ + +RA LSA IAA K + K D+ + DGS+ F GF ++ + +S
Sbjct: 381 RLTRAISQRAAHLSAIPIAAIAKKVKDQYKDDDRDFEVGCDGSVIEFYPGF--RQAVLES 438
Query: 405 LHTCLTEK---RGIYFVLKTNDEAVTLGTALAA 434
+ K + IY LK + +G AL A
Sbjct: 439 IEKINPLKGTNKKIY--LKIAKDGSGVGAALCA 469
>gi|30961939|gb|AAP40021.1| hexokinase [Nicotiana benthamiana]
Length = 497
Score = 90.9 bits (224), Expect = 1e-16, Method: Composition-based stats.
Identities = 115/447 (25%), Positives = 187/447 (41%), Gaps = 40/447 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LITYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---------- 125
V K I F + +P T+EE FD IA L E +
Sbjct: 111 RVQLGGKDGGIIHQEFAEASIPPNLMVGTSEELFDYIAAELAKFVAEEEEKFQQPPGKQR 170
Query: 126 -ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMV 183
+ F FS+ + G ++ +K + +G + E L +A+ RKG ++ +V
Sbjct: 171 ELGFTFSFPVMQTSINSGTIMRWTKGFSIDDAVGQDVVGE-LTKAMKRKG-VDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G ++ D + +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGKYTHND-----VAVAVILGTGTNAAYVERVQAIPKWHGPMPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D L NS + E+M SG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTQYDHALDTNSLNPGDQIFEKMTSGMYLGEILRRVLLRMAEEAGIFGD 343
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFF 354
V L + T ++S + + D + I+E + S + + +C
Sbjct: 344 EVPPKLKSPFVLRTPDMSAMHHDTSSDLRVVGDKLKDILEISNTSLKTRRLVVELCNIVA 403
Query: 355 ERAGRLSAAVIAAACIKTGKGK----SPDKPICISADGSMFLKGFLIKERIFKSLHTCLT 410
R RL+AA + K G+ P K + ++ DG ++ + + +L L
Sbjct: 404 TRGARLAAAGVLGILKKMGRDTPRQGGPQK-MVVAMDGGLYEHYAEYRTCLENTLKELLG 462
Query: 411 EKRGIYFVLKTNDEAVTLGTALAAFLN 437
++ V + +++ +G AL A N
Sbjct: 463 DELATSIVFEHSNDGSGIGAALLAASN 489
>gi|47085787|ref|NP_998231.1| hexokinase 2 [Danio rerio]
gi|28278945|gb|AAH45496.1| Hexokinase 2 [Danio rerio]
Length = 919
Score = 90.9 bits (224), Expect = 1e-16, Method: Composition-based stats.
Identities = 94/396 (23%), Positives = 172/396 (43%), Gaps = 53/396 (13%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M KGL + +++ M+P + D + + +D GGTNFR +V G+ +
Sbjct: 45 KEMDKGLGRDTNPTAAVKMLPTFVRSTPDGTETGDFLALDLGGTNFRVLLVKVSSNGMQK 104
Query: 88 ILSFFKHPMPALDREMT---NEEFFDSIAE----YLEPL--KDESDMISFCFSYAIKIFP 138
+ ++ + A+ + E FD IAE +LE L K++ + F FS+ +
Sbjct: 105 VE--MENQIYAISENIMRGCGSELFDHIAECLANFLEKLGIKEKKLPLGFTFSFPCQQTK 162
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
+ +K K + + L +A+ ++G I + ++NDT + +
Sbjct: 163 LDESFLVSWTKGFKASGVEGKDVVSLLRKAIRKRGDFDIDIVAVINDTVGTMMTC----- 217
Query: 199 DDQGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGK 246
G+D H IG ++GTG N+ Y +E+++ E D + +C + G
Sbjct: 218 ---GYDDHHCEIGLIVGTGTNACY-----MEEMRHLELVDGDEGRMCVNMEWGAFGDDGA 269
Query: 247 SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKML 305
+ + +++FD+ + S + E+M SG Y+GEL + L + +G +F L
Sbjct: 270 LDDL-RTEFDREIDAGSLNPGKQLFEKMISGMYMGELVRLILVKMAKDGLLFQGHTTPDL 328
Query: 306 LNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFER 356
L + F T +S ++ + GI+ A V ED V +C+ R
Sbjct: 329 LTTGHFQTSFVSAIENRKDDE-----GIVSAEQVLRGLGLDPTPEDCVATQRVCQIVSTR 383
Query: 357 AGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A L AA +AA + K+ D+ I DGS++
Sbjct: 384 AAHLCAASLAAVLRQIRDNKASDRLRTSIGVDGSVY 419
Score = 80.9 bits (198), Expect = 2e-13, Method: Composition-based stats.
Identities = 89/387 (22%), Positives = 171/387 (44%), Gaps = 36/387 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKG 84
E+MK+GL + + +++ M+P + D + + +D GGTNFR +V ++
Sbjct: 495 EEMKRGLAKKTHNNATVKMLPTFVRSTPDGTERGDFLALDLGGTNFRVLLVRVRGGKRRN 554
Query: 85 VPEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFP 138
V ++ + +P + T EE FD IA++LE +K S + F FS+
Sbjct: 555 VE--MNNKIYTIPQDITQGTGEELFDHIVHCIADFLEYMGMKGASLPLGFTFSFPCHQDK 612
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G IK +K K + L A+ R + + +VNDT + + + +
Sbjct: 613 LDQGILIKWTKGFKASGCEGEDVASLLKDAIHRCEEFDLDVVAVVNDTVGTMMTCGYEDP 672
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
+G ++GTG N+ Y +E++ E D + +C + G+ +
Sbjct: 673 -----QCEVGLIVGTGTNACY-----MEEMSNVELVDGDEGRMCVNMEWGAFGDQGELDD 722
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
I ++FD+ + + S E+M SG YLGE+ L +A+G +F ++++ L
Sbjct: 723 I-WTEFDRAVDDQSTYPGRQRYEKMISGMYLGEIVRNVLLHFTAKGLLFRGKLSERLKTR 781
Query: 309 CDFSTEEISLFLKEQ---NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVI 365
F T+ +S ++ ++I + S +D + + +C +RA +L A +
Sbjct: 782 GIFETKFLSQIESDRLALRQVRSILQHLGLTSSTCDDSILVKEVCSVVSKRAAQLCGAGL 841
Query: 366 AAACIKTGKGKSPDK-PICISADGSMF 391
AA K + ++ I + DG+++
Sbjct: 842 AAVVDKIRLNRGLNQLSITVGVDGTLY 868
>gi|68477224|ref|XP_717405.1| putative hexokinase II [Candida albicans SC5314]
gi|46439114|gb|EAK98436.1| likely hexokinase II [Candida albicans SC5314]
Length = 484
Score = 90.9 bits (224), Expect = 2e-16, Method: Composition-based stats.
Identities = 117/441 (26%), Positives = 181/441 (41%), Gaps = 114/441 (25%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIVYFDK 82
+ ++ +GL +++ ++ MIP W D P K+ + ID GGTN R +V
Sbjct: 48 FISELDRGL---SKAGGNIPMIPGWV---MDFPTGKETGSYLAIDLGGTNLRVVLVKLGG 101
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGG 142
+ K +PA R T++E +D IA+ L+ DE I+PDG
Sbjct: 102 NRDFDTTQS-KFALPAHMRTATSDELWDFIAKCLKEFVDE-------------IYPDGCS 147
Query: 143 QAIKLSKEIKLPYIGDCKINEGLFQALSRKGW---------------KKIKKI------- 180
+ + L P +INEG+ Q + KGW K IKK+
Sbjct: 148 EPLPLGFTFSYP-ASQNRINEGILQRWT-KGWSIDGIEGKDVVPMLQKAIKKVGVPIDVV 205
Query: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYD---- 235
++NDT L + ++++ + + +G + GTG+N AY + K I KL+ D
Sbjct: 206 ALINDTTGTLVASMYTDPE-----AKMGLIFGTGVNGAYFDVVKDIPKLEGKCPSDIPPE 260
Query: 236 KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAG 291
P I CE G + +P++K+D + E S + E+M SG YLGE+ + L
Sbjct: 261 SPMAINCEYGSFDNEKYILPRTKYDVQIDEESPRPGQQTFEKMISGYYLGEVLRLIL--- 317
Query: 292 SAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEA---HSVSEDYVKIYS 348
+F+ EE L K QN DK +++A + ED + S
Sbjct: 318 -----------------LEFA-EEKKLIFKGQNLDKLKVPYVMDASYPSKIEEDPFENLS 359
Query: 349 --------------------ICKCFF----ERAGRLSAAVIAAACIKTGKGKSPDKPICI 384
I +C ER+ R S IAA C K G K
Sbjct: 360 DVADLFREKLGIETTEPERKIIRCLAELIGERSARFSVCGIAAICQKRGY-----KTAHC 414
Query: 385 SADGSMFLKGFLIKERIFKSL 405
+ADGS++ K KER ++L
Sbjct: 415 AADGSVYNKYPGFKERTAQAL 435
>gi|45387403|gb|AAS60192.1| hexokinase 1a [Nicotiana tabacum]
Length = 497
Score = 89.7 bits (221), Expect = 3e-16, Method: Composition-based stats.
Identities = 115/447 (25%), Positives = 187/447 (41%), Gaps = 40/447 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LITYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---------- 125
V K G F + +P T+E FD IA L E +
Sbjct: 111 RVQLGGKDGGIVHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVAEEEEKFQQPPGKQR 170
Query: 126 -ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMV 183
+ F FS+ + G ++ +K + +G + E L +A+ RKG ++ +V
Sbjct: 171 ELGFTFSFPVMQTSINSGTIMRWTKGFSIDDAVGQDVVGE-LTKAMKRKG-VDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G ++ D + +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGKYTHND-----VAVAVILGTGTNAAYVERVQAIPKWHGPVPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D L NS + E+M SG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTQYDHALDTNSLNPGDQIFEKMTSGMYLGEILRRVLLRVAEDAGIFGD 343
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFF 354
V L + T ++S + + D + I+E + S + + +C
Sbjct: 344 EVPPKLKSPFVLRTPDMSAMHHDISSDLRVVGDKLKDILEISNTSLKTRRLVVELCNIVA 403
Query: 355 ERAGRLSAAVIAAACIKTGKGK----SPDKPICISADGSMFLKGFLIKERIFKSLHTCLT 410
R RL+AA I K G+ P+K + ++ DG ++ + + +L L
Sbjct: 404 TRGARLAAAGILGILKKMGRDTPRQGGPEKTV-VAMDGGLYEHYTEYRTCLENTLKELLG 462
Query: 411 EKRGIYFVLKTNDEAVTLGTALAAFLN 437
++ V + +++ +G AL A N
Sbjct: 463 DELATSIVFEHSNDGSGIGAALLAASN 489
>gi|73980943|ref|XP_532991.2| PREDICTED: similar to hexokinase 2 [Canis familiaris]
Length = 909
Score = 89.4 bits (220), Expect = 4e-16, Method: Composition-based stats.
Identities = 99/402 (24%), Positives = 179/402 (44%), Gaps = 39/402 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +S+ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 37 KEMEKGLGATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQK 96
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 97 VEMENQIYAIPEDLMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCVQTKLD 156
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + + + DD
Sbjct: 157 ESFLVSWTKGFKSSGVEGKDVVTLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY---DD 213
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIP-----QSKF 255
Q + IG ++GTG N+ Y+E ++ + E + I E G +++F
Sbjct: 214 Q--NCEIGLIVGTGSNACYME--EMRHIDMVEGDEGRMCINMEWGAFGDDGILDDFRTEF 269
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG Y+GEL + L + E +F +++ LL + F T+
Sbjct: 270 DQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPGLLATGQFETK 329
Query: 315 EISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAGRLSAAVI 365
++S E++ GI +A V ED V + +C+ R+ L AA +
Sbjct: 330 DVSDIEGEKD-------GIRKAREVLVRLGIDPTQEDCVATHRVCQIVSTRSASLCAATL 382
Query: 366 AAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
AA IK KG+ + I DGS++ K +R+ K++
Sbjct: 383 AAVLRRIKENKGEERLRST-IGVDGSVYKKHPHFAKRLHKTV 423
Score = 71.6 bits (174), Expect = 1e-10, Method: Composition-based stats.
Identities = 89/391 (22%), Positives = 167/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M +GL E +++ + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 486 EMGRGLSKETHAIAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVKNGKRRGV 545
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T +E FD IA++LE +K S + F FS+ +
Sbjct: 546 EMHNKIYSIPQEVM--HGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 603
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 604 DESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 660
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E + + +C ++G +
Sbjct: 661 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLD 711
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I +++FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 712 DI-RTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 770
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 771 RGIFETK----FLSQIESDCLALLQVRAILHHLGLESTCDDSIIVKEVCTVVARRAAQLC 826
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 827 GAGMAAVVDKIRENRGLDTLKVTVGVDGTLY 857
>gi|149238644|ref|XP_001525198.1| hexokinase [Lodderomyces elongisporus NRRL YB-4239]
gi|146450691|gb|EDK44947.1| hexokinase [Lodderomyces elongisporus NRRL YB-4239]
Length = 485
Score = 89.0 bits (219), Expect = 5e-16, Method: Composition-based stats.
Identities = 107/426 (25%), Positives = 180/426 (42%), Gaps = 84/426 (19%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIVY--- 79
+ ++ KGL +++ ++ MIP W D P K+ + ID GGTN R +V
Sbjct: 48 FITELDKGL---SKAGGNIPMIPGWV---MDFPTGKETGDYLAIDLGGTNLRVVLVKLGG 101
Query: 80 ---FDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKI 136
FD K P+P+ R T+EE + IA L+ +E
Sbjct: 102 NRDFDTTQS-------KFPLPSNMRTATSEELWSFIANCLKTFFEEE------------- 141
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWK--------------------- 175
FP+G + + L P I +G+ Q + KGW
Sbjct: 142 FPNGVEEPLPLGFTFSYP-ASQNTITQGVLQRWT-KGWAIEGVEGHDVVPMLQSAIEKVQ 199
Query: 176 -KIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY----GKIE-KLK 229
+K + ++NDT L + +++ + + +G + GTG+N AY + K+E KL+
Sbjct: 200 VPVKIVAVINDTVGTLVASNYTDPE-----AKLGLIFGTGVNGAYYDVVGDIPKLEGKLE 254
Query: 230 TTEFYDKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCS 285
+ D P I CE G + +P++K+D ++ E S + E+M SG YLGE+
Sbjct: 255 SDIGVDSPMAINCEYGSFDNEKFILPRNKYDVMIDEESPRPGQQTFEKMNSGYYLGEILR 314
Query: 286 IAL--RAGSAEGIFS----PRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV 339
+ L A + + IF ++N++ + F + + + + IF ++ +
Sbjct: 315 LVLVDLAENKKVIFKNQDLTKLNEVYILDTSFPAKIEEDPFENLSDVQEIFQSVLGLETT 374
Query: 340 SEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKE 399
+ I I + R+ RLS IAA C K G K +ADGS++ K K+
Sbjct: 375 VPERKVIRRIAELIGNRSARLSVCGIAAICKKRGY-----KTAHCAADGSVYSKYPDFKQ 429
Query: 400 RIFKSL 405
R +SL
Sbjct: 430 RAAQSL 435
>gi|38195100|gb|AAR13363.1| hexokinase [Brugia malayi]
Length = 566
Score = 88.6 bits (218), Expect = 7e-16, Method: Composition-based stats.
Identities = 95/385 (24%), Positives = 177/385 (45%), Gaps = 35/385 (9%)
Query: 29 DMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
+M KGLE E+ S++ M+P + LP ++ + I +D GGTN R ++ D K E
Sbjct: 79 NMDKGLEGGPEN-STISMLPSFVPELPNGT-EEGRFIAMDLGGTNLR--VMLMDIKPGEE 134
Query: 88 ILS-FFKHPMPALDREMTNEEFFDSI----AEYLEPLKDESD--MISFCFSYAIKIFPDG 140
+ + F +P T E+ FD I AE+L E+D + F FSY
Sbjct: 135 LKTEQFNTRIPNWAMRGTGEQLFDYITKCLAEFLIEKSIENDGLPVGFTFSYPCDQKSLR 194
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
++ +K + + + E L Q+++R+G K++ + ++NDT + + +
Sbjct: 195 SATLLRWTKGFETTGVVGEDVVELLEQSIARRGDIKVEVVALINDTVGTM----VAAAHE 250
Query: 201 QGFDSHIGFVLGTGLNSAYIE-YGKIEK--LKTTEFYDKPQIIV-CESGKSNKIPQ---- 252
G + HIG ++ TG N++Y+E KI+ K Y+ P++I+ E G +
Sbjct: 251 SGGECHIGVIIATGTNASYMEDTSKIKYGLSKAIAAYNYPEMIIDTEWGGFGDRSEADYI 310
Query: 253 -SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNSCD 310
+++DKI+ S +++ G+ +GE+ + L + A +F+ + + L
Sbjct: 311 LTQYDKIVDSRSEHPGVNTFDKLVGGKCMGEVVRVVLEKLTRARVLFNGKGSDALFQQDS 370
Query: 311 FSTEEISLFLKEQN----HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIA 366
F T+ IS L++++ H ++I + H D + + +C R+ L AA IA
Sbjct: 371 FPTKYISEILRDESGSYVHTRDILGELGIDHYSFSDMLLLREVCVVVSRRSANLGAAAIA 430
Query: 367 AACIKTGKGKSPDKPICISADGSMF 391
+ K + + + DGS +
Sbjct: 431 CVLNRVRK-----QNMVVGIDGSTY 450
>gi|47218711|emb|CAG05683.1| unnamed protein product [Tetraodon nigroviridis]
Length = 988
Score = 88.6 bits (218), Expect = 8e-16, Method: Composition-based stats.
Identities = 95/415 (22%), Positives = 180/415 (43%), Gaps = 45/415 (10%)
Query: 8 FKRNNFD-YKIDIEYAASILLE-------DMKKGLESEAESVSSMDMIPLWKNLPTDIPK 59
++R D Y + ++ LL+ +M KGL + +++ M+P + D +
Sbjct: 128 YERTKIDKYLYSMRFSDETLLDITQQFRREMVKGLGRDTNPTAALKMLPTFVRSIPDGSE 187
Query: 60 DKKVIIIDAGGTNFR---AGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL 116
I +D GG+NFR + + K+ V + P + T + FD +AE L
Sbjct: 188 KGDFIALDLGGSNFRILRVKVSHEKKQTVQMESQIYDTPEDII--HGTGTKLFDHVAECL 245
Query: 117 ------EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+KD+ + F FS+ G + +K K + + + L +A+
Sbjct: 246 GDFMEKHNIKDKKLPVGFTFSFPCLQTKLDEGVLVTWTKRFKASGVEGMDVVKLLSKAIK 305
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKT 230
++G + + +VNDT + + F DDQ +G ++GTG N+ Y+E +L+
Sbjct: 306 KRGDYNAEIMAVVNDTVGTMMTCGF---DDQ--RCEVGIIIGTGTNACYME-----ELRN 355
Query: 231 TEFYDKPQIIVC---------ESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLG 281
+ + + +C + G+ I +++FD+ + S + E+M SG YLG
Sbjct: 356 IDLVEGDEGRMCVNTEWGAFGDDGRLEDI-RTEFDREIDRGSLNPGQQLFEKMVSGMYLG 414
Query: 282 ELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ---NHDKNIFSGIIEAH 337
EL + L + EG +F R+ LL F T+ +S K + + K I + +
Sbjct: 415 ELVRLILVKMAREGLLFEGRITPELLTRGKFGTKHMSAIEKSKEGLSKAKEILTR-LGVE 473
Query: 338 SVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+ED + + +C R+ L AAV++ ++ + K + + DGS++
Sbjct: 474 PSTEDCIAVQHVCTIVSFRSANLIAAVLSGILLRLKENKGTTRVRTTVGIDGSLY 528
Score = 71.6 bits (174), Expect = 1e-10, Method: Composition-based stats.
Identities = 88/383 (22%), Positives = 157/383 (40%), Gaps = 68/383 (17%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+++ GL + ++++ M+P + D ++ + +D GGTNFR +V ++ V
Sbjct: 605 EIQNGLSKNTQDIATVKMLPTFVQSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKRRSV 664
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPD 139
+ P+ + + T EE FD I + D M + F FS+ K
Sbjct: 665 EMHNKIYAIPLEVM--QGTGEELFDHIVHCISDFLDYMGMKNTRLPLGFTFSFPCKQTSL 722
Query: 140 GGGQAIKLSKEIKLPYIGDCKINE--GLF-QALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G + +K K DC+ + GL +A+ R+ + + +VNDT + + +
Sbjct: 723 DAGILLTWTKGFKAT---DCEGEDVVGLLREAIKRREEFDLDVVAIVNDTVGTMMTCAYE 779
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIPQSKFD 256
E Q +G + GTG N+ Y +E++K E D G+ +I
Sbjct: 780 EPTCQ-----VGLIAGTGSNACY-----MEEMKNVEMID---------GEKGQI------ 814
Query: 257 KILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEE 315
E+MCSG YLGE+ L + G +F ++++ L F T+
Sbjct: 815 --------------YEKMCSGMYLGEIVRNILIDMTKRGFLFRGQISETLKTRGIFETK- 859
Query: 316 ISLFLKEQNHDKNIFSGI--IEAH----SVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
FL + D+ + I H S +D + + +C RA +L A +AA
Sbjct: 860 ---FLSQIESDRLALLQVRSILQHLGLDSTCDDSIIVKEVCGTVSCRAAQLCGAGMAAVV 916
Query: 370 IKTGKGKSPD-KPICISADGSMF 391
K + + D I + DG+++
Sbjct: 917 DKIRENRGLDFLNITVGVDGTLY 939
>gi|11386886|sp|Q9SEK3|HXK1_SPIOL Hexokinase-1 (SoHxK1)
gi|6594672|gb|AAF18584.1|AF118132_1 chloroplast outer envelope hexokinase 1 [Spinacia oleracea]
Length = 498
Score = 88.2 bits (217), Expect = 1e-15, Method: Composition-based stats.
Identities = 116/439 (26%), Positives = 186/439 (42%), Gaps = 38/439 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF-- 80
A + +M GL SE S M +I NLPT + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASEGASKLKM-LISYVDNLPTG-DEHGLFYALDLGGTNFRVLRVKLGG 116
Query: 81 -DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL-----------EPLKDESDMISF 128
+K+ V + F + +P T+E+ FD IAE L P ++ + F
Sbjct: 117 KEKRVVEQ--EFDEVSIPPELMVGTSEQLFDYIAEALAKFVATESEGLHPEPNKQRELGF 174
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMVNDTA 187
FS+ +K G I+ +K + +G+ + E L +A+ RKG ++ +VNDT
Sbjct: 175 TFSFPVKQTSIASGTLIRWTKGFNIEDTVGEDVVAE-LTKAMLRKG-VDMRVTALVNDTV 232
Query: 188 AVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG- 245
L G + + D +LGTG N+AY+E I K +I E G
Sbjct: 233 GTLAGGRYYKEDVIA-----AVILGTGTNAAYVERASAIHKWHGPLPKSGEMVINMEWGN 287
Query: 246 -KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNK 303
+S+ +P +++D L E S E E+M SG YLGE+ L R +F V
Sbjct: 288 FRSSYLPLTEYDIALDEESLNPGEQIFEKMISGMYLGEIVRRVLYRMADEASLFGDTVPS 347
Query: 304 MLLNSCDFSTEEISLFLKEQNHD-KNIFSGIIEAHSVSEDYVK----IYSICKCFFERAG 358
L T ++S + + D K + S + + + +K I +C R
Sbjct: 348 KLKTPFILRTPDMSAMHHDTSPDLKVVASKLKDVLGIPNSSLKVRKIIVDVCDVIASRGA 407
Query: 359 RLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGI 415
+SAA I K G+ + ++ I+ DG +F +E + SL L ++
Sbjct: 408 CISAAGILGIIKKLGRDTLKQGENQKSVIALDGGLFEHYAKFRECMEDSLKELLGDEVAE 467
Query: 416 YFVLKTNDEAVTLGTALAA 434
V++ +++ +G AL A
Sbjct: 468 TIVIEHSNDGSGIGAALLA 486
>gi|68485995|ref|XP_713116.1| putative hexokinase [Candida albicans SC5314]
gi|68486042|ref|XP_713093.1| putative hexokinase [Candida albicans SC5314]
gi|46434569|gb|EAK93975.1| likely hexokinase [Candida albicans SC5314]
gi|46434594|gb|EAK93999.1| likely hexokinase [Candida albicans SC5314]
Length = 472
Score = 88.2 bits (217), Expect = 1e-15, Method: Composition-based stats.
Identities = 109/411 (26%), Positives = 170/411 (41%), Gaps = 44/411 (10%)
Query: 22 AASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIV 78
A +E M GLES S M MIP + T IP K+V + D GGTNFR +
Sbjct: 28 ATEYFIESMNVGLESPKPSKDVMPMIPTYV---TSIPTGKEVGLYLAADLGGTNFR--VC 82
Query: 79 YFDKKGVPEI---LSFFKHPMPALDREMTNEEF-----------FDSIAEYLEPLKDESD 124
D KG S ++ P+ + E +N+ F ++ +E E
Sbjct: 83 SIDLKGDHTFSMKQSKYRIPVDLMKAEKSNDLFGFLAKKVQSFLLENHSEACTAKNTEPL 142
Query: 125 MISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ + G I+ +K +P D + E L QA +K + + N
Sbjct: 143 KLGFTFSFPVNQTALNRGTLIRWTKGFDIPDTVDRDVVE-LLQANLTILEVNVKVVAIAN 201
Query: 185 DTAAVLQSGIFS-ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCE 243
DT L + +S ++ ++ IG + GTG N AY E KI KL ++ + +I E
Sbjct: 202 DTVGTLLTAAYSNDSAKTNRNTIIGCIFGTGTNGAYFE-SKIPKLSSSTGKSQGMVINTE 260
Query: 244 SGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSP 299
G + +P ++FD+I+ + + E+ SG +LGE+ +AL +G+
Sbjct: 261 WGSFDNGLKILPSTEFDEIVDSETANPGYHLFEKRISGMFLGEILRVALIHLFKKGLIFQ 320
Query: 300 RVNKMLLNSCDFSTEEISLFLKE-----QNHDKN-------IFSGIIEAHSVSEDYVKIY 347
+ K S EE L E Q D I ++ + E+ I
Sbjct: 321 ELYKARGGSLPHRIEEPWLLDAEVLSYLQIDDSTDLKTSGLILQNVLRLETNKEEREVIQ 380
Query: 348 SICKCFFERAGRLSAAVIAAACIKT-GKGKSPDKPICISADGSM--FLKGF 395
+ + +RA LSA IAA K + K D+ + DGS+ F GF
Sbjct: 381 RLTRAISQRAAHLSAIPIAAIAKKVKDQYKDDDRDFEVGCDGSVIEFYPGF 431
>gi|126343371|ref|XP_001380610.1| PREDICTED: similar to hexokinase 1, [Monodelphis domestica]
Length = 919
Score = 87.8 bits (216), Expect = 1e-15, Method: Composition-based stats.
Identities = 94/387 (24%), Positives = 173/387 (44%), Gaps = 41/387 (10%)
Query: 30 MKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA--GIVYFDKKGVPE 87
M GL +S+ M+P + D + I +D GG++FR V DK E
Sbjct: 47 MSNGLSRNYNVTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVSHDKNQHVE 106
Query: 88 ILS-FFKHPMPALDREM--TNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFP 138
+ S ++ P DR M + E FD +AE L + +KD++ I F FS+ +
Sbjct: 107 MDSEVYETP----DRIMRGSGPELFDHVAECLGNFMEKKKIKDKNLPIGFTFSFPCRQTK 162
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
I +K K+ + + + L +A+ ++G + + +VNDT + + F +
Sbjct: 163 INEAVLITWTKRFKVSGVEGSDVVQLLNKAIKKRGEYEANIMAVVNDTVGTMMTCAFDDP 222
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNK 249
+ +G ++GTG N+ Y +E+L+ + + + +C + G N+
Sbjct: 223 -----ECEVGLIVGTGTNACY-----MEELRHIDMVEGDEGRMCINTEWGSFGDDGCINE 272
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
I +++FDK + S + E+M SG Y+GEL + + + G +F R+ LL
Sbjct: 273 I-RTEFDKEIDRGSLNPGKQLFEKMVSGMYMGELVRLIIVKMAKGGLLFDGRLTPELLTK 331
Query: 309 CDFSTEEISLFLKEQ---NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVI 365
F T+ +S K + + K+I + + S ED V + +C R+ L AA++
Sbjct: 332 GKFETKNVSAIEKTKEGLDRAKDILTNLGLEPS-PEDCVSVQHVCAIVSHRSANLVAAML 390
Query: 366 AAACIKTGKGKS-PDKPICISADGSMF 391
A + + K+ P + DG+++
Sbjct: 391 AGILFRLKENKNLPRLRTTVGVDGTLY 417
Score = 70.9 bits (172), Expect = 2e-10, Method: Composition-based stats.
Identities = 84/385 (21%), Positives = 160/385 (41%), Gaps = 35/385 (9%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M GL+ + + + M P + D + + +D GGTNFR +V KK V
Sbjct: 494 EMDLGLKKSSHDSAKVKMWPSYVTGTLDGSESGDFLALDLGGTNFRVLLVKIRSGKKKSV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPD 139
+ P + + T EE FD I + D M + F FS+
Sbjct: 554 EMHNKIYAIPESVM--QGTGEELFDHIVSCISDFLDYMGMKTARLPLGFTFSFPCHQTSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
GG + +K + L A+ R+G + + +VNDT + + + E
Sbjct: 612 DGGTLVTWTKGFNASNCVGQDVPTLLRDAIKRRGEFDLDVVALVNDTVGTMMTCAYEER- 670
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSN-----KIPQSK 254
+G ++GTG N+ Y+E +++ ++ E + I E G + +++
Sbjct: 671 ----TCEVGLIVGTGSNACYME--EMKNIELVEGNEGRMCINMEWGAFGDNGCLEDLRTE 724
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFST 313
+D+I+ + S + E+M SG YLGE+ L + G +F +++ L F T
Sbjct: 725 YDRIVDDFSLNAGKQRYEKMISGMYLGEIVRNILIDFTKNGFLFRGHISEALKTRGIFKT 784
Query: 314 EEISLFLKEQNHDK------NIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAA 367
+ FL + D+ + + +S +D + + +C +RA +L A +AA
Sbjct: 785 K----FLSQIESDRLALLQVRVILQELGLNSTCDDSILVKMVCGVVSKRAAQLCGAGVAA 840
Query: 368 ACIKTGKGKSPDK-PICISADGSMF 391
K + ++ + + + DG+++
Sbjct: 841 VVDKIRENRNLETLKVTVGVDGTLY 865
>gi|125571979|gb|EAZ13494.1| hypothetical protein OsJ_003319 [Oryza sativa (japonica
cultivar-group)]
Length = 462
Score = 87.8 bits (216), Expect = 1e-15, Method: Composition-based stats.
Identities = 108/401 (26%), Positives = 173/401 (43%), Gaps = 44/401 (10%)
Query: 66 IDAGGTNFRAGIVYF---DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEP-LKD 121
+D GGTNFR V +K+ V + + + +P T+ E FD IA LE +K
Sbjct: 64 LDLGGTNFRVIRVQLGGREKRVVSQ--QYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 121
Query: 122 ESD----------MISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALS 170
E + + F FS+ + G IK +K + +G+ + E L +A+
Sbjct: 122 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAE-LSRAME 180
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLK 229
R+G +K +VNDT L G + + D +LGTG N+AY+E+ I K
Sbjct: 181 RQGLD-MKVTALVNDTVGTLAGGRYVDNDVAA-----AVILGTGTNAAYVEHANAIPKWT 234
Query: 230 TTEFYDKPQIIVCESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SI 286
+I E G KS ++P+S +D L S E E+M SG YLGE+ I
Sbjct: 235 GLLPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 294
Query: 287 ALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD--------KNIFSGIIEAHS 338
L+ +F V L T ++S + +HD K+I G+ + S
Sbjct: 295 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDIL-GVADT-S 352
Query: 339 VSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPD-----KPICISADGSMFLK 393
+ Y+ ++ +C ER RL+AA I K G+ + P + I+ DG ++
Sbjct: 353 LEARYITLH-VCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEH 411
Query: 394 GFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAVTLGTALAA 434
+ + +L L E+ V+K ++ +G AL A
Sbjct: 412 YKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLA 452
>gi|66507476|ref|XP_392350.2| PREDICTED: similar to Hexokinase A CG3001-PA, isoform A [Apis
mellifera]
Length = 470
Score = 87.4 bits (215), Expect = 2e-15, Method: Composition-based stats.
Identities = 100/411 (24%), Positives = 185/411 (45%), Gaps = 34/411 (8%)
Query: 4 IDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEA-----ESVSSMDMIPLWKNLPTDIP 58
+ D KR+ + K+ ++ ++++++ ESE + SS+ M + D
Sbjct: 20 LSDNVKRHKIEQKLARLQFSTTVVKNIQDVFESEMNKGIHQQPSSLQMENTYVPELLDGT 79
Query: 59 KDKKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL-- 116
+ + +D GGTNFR ++ D G+P+ K+ + + R + FD +AE +
Sbjct: 80 EKGLYLALDLGGTNFRVLLLELDH-GIPKREEVKKYHISSDLRVGSGIRLFDYLAECVSD 138
Query: 117 ----EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRK 172
+ L+D + F FS+ + G + +K P + + + L +AL R+
Sbjct: 139 FVIAQGLQDVELPLGFTFSFPMIQHSLDIGILVTWTKTFNCPDVVNEDAVKLLREALDRR 198
Query: 173 GWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYG-KIEKLKTT 231
G K+K + ++NDT L G S D D+ IG +LGTG N+ YIE ++E +T
Sbjct: 199 GDTKVKVVAILNDTTGTLVQG--STLDP---DTAIGLILGTGSNACYIERADRVEHWETE 253
Query: 232 EFYDKPQIIVCESGKSNK-----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSI 286
++ II E G ++ FD+ NS + N + E+ SG+YLGE+ +
Sbjct: 254 RHGERQVIIDIEWGAFGDNGVLDFIKTDFDRENDANSLIVNSFTFEKYISGKYLGEIVRV 313
Query: 287 ALRAGSAEGIF--SPRVNKMLLNSCDFSTEEISLFLKEQ-NHDKNIFSGIIEAHSV--SE 341
L +G+ LL + +++ +S ++ + D N ++ + E
Sbjct: 314 VLAKLYKDGLLFIGDHTPGSLLVPGNLTSDLVSDIEQDSVDGDYNSTKEVLMKFGIIPDE 373
Query: 342 DYVKIYS-ICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
D VKI +C+ R AA++ + C+ + K + I+ DGS++
Sbjct: 374 DDVKIVQYVCEVVSNR-----AALLVSICLAVLLKRIDRKHVTIAVDGSLY 419
>gi|113207858|emb|CAJ28915.1| hexokinase [Crassostrea gigas]
Length = 477
Score = 87.0 bits (214), Expect = 2e-15, Method: Composition-based stats.
Identities = 107/447 (23%), Positives = 189/447 (42%), Gaps = 57/447 (12%)
Query: 14 DYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNF 73
DYK+ ++ I+L + KGL E + + M P + D ++ + +D GGTNF
Sbjct: 37 DYKLLMD----IMLGEFNKGLGKETNPTAKVKMYPTYVRDVPDGSENGNFLALDLGGTNF 92
Query: 74 RAGIVYFDKKGV---PEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMIS--- 127
R ++ + + V +I +H M T E+ FD IA+ + D++
Sbjct: 93 RVLLINLNGQEVTMESKIYLIPQHIMTG-----TGEQLFDHIAKCIHKFMSNHDLLKEKI 147
Query: 128 ---FCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
F FS+ K + +K K + + L +A+ R+G ++ + ++N
Sbjct: 148 PLGFTFSFPCKQIGLNHAILTQWTKGFKCEGVEGEDVVRLLHEAIKRRGDIDVECLAVIN 207
Query: 185 DTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF-YDKPQ--IIV 241
DT L S S+ D IG +LGTG N+ YIE K+E + + Y++P +I
Sbjct: 208 DTVGALMSCAHSDR-----DCAIGLILGTGTNACYIE--KLENVGLWDGDYNEPNQVMIN 260
Query: 242 CESGKSN-----KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG- 295
E G ++++D+ + ++S E+M SG Y+GE+ +AL G
Sbjct: 261 TEWGALGDDGCLDFVKTEYDRQVDKHSINPGRQIYEKMISGMYMGEIVRLALEKLRKHGL 320
Query: 296 IFSPRVNKMLLNSCDFSTEEISLFLKE-QNHDKN---IFSGIIEAHSVSEDYVKIYSICK 351
+F + ++ L F T+ +S + +H KN +F + ED +C
Sbjct: 321 LFGGKGSEELSTRGRFYTKYVSEIESDVDDHFKNTKQVFEELALEKYSDEDCRIAQYVCS 380
Query: 352 CFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
RA L++ +AA K + + + ++ DGS++ R H + E
Sbjct: 381 LVSTRAAFLASVGVAALLNKMDR-----QDVTVAVDGSLY--------RFHPHFHDLMEE 427
Query: 412 ------KRGIYFVLKTNDEAVTLGTAL 432
K GI F L + + G A+
Sbjct: 428 KIQQLVKPGIKFKLMLSHDGSGKGAAI 454
>gi|157123146|ref|XP_001660030.1| hexokinase [Aedes aegypti]
gi|108874523|gb|EAT38748.1| hexokinase [Aedes aegypti]
Length = 461
Score = 87.0 bits (214), Expect = 2e-15, Method: Composition-based stats.
Identities = 94/397 (23%), Positives = 175/397 (44%), Gaps = 41/397 (10%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
IE LL+++ +GL + + + I ++LP K K + +D GGTNFR +
Sbjct: 33 IEEIMRRLLKEINRGLGKATQPEADIKCFITYVQDLPNGKEKGK-FLALDLGGTNFRVLL 91
Query: 78 VYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFS 131
++ + E+LS + +P + + FD IAE L E + + F FS
Sbjct: 92 IHLKDENDFEMLSKI-YAIPQSIMLGSGTQLFDHIAECLANFMKEHSVYEEKLPLGFTFS 150
Query: 132 YAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQ 191
+ + G + +K + + + L A++R+G +I+ ++NDT L
Sbjct: 151 FPLTQLGLTKGILARWTKGFNCSGVVGEDVVQLLKDAIARRGDVQIEICAILNDTTGTLM 210
Query: 192 SGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQ-------IIVCES 244
S + + + IG ++GTG N+ Y+E K++ E +D P+ +I E
Sbjct: 211 SCAW-----KNHNCRIGLIVGTGSNACYVE-----KVENCEMFDGPKDPKKEHVLINTEW 260
Query: 245 GK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FS 298
G + ++++D+ + S E+M SG Y+GEL +A+ + G+ F
Sbjct: 261 GAFGDNGALDFVRTEYDREIDHFSINPGRQIQEKMISGMYMGELARLAIVKFTRAGLLFG 320
Query: 299 PRVNKMLLNSCDFSTEEISLFLKEQN----HDKNIFSGIIEAHSVSEDYVKIYSICKCFF 354
+ +L F T+ +S ++ + +++ + H+ ED + IC+C
Sbjct: 321 GVGSDILFKRGQFFTKYVSEIESDKPGTYMYCRDVLDELGLEHATDEDCANVRYICECVS 380
Query: 355 ERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
RA L +A IAA K +K + + DGS++
Sbjct: 381 SRAAHLVSAGIAALI-----NKMDEKSVTVGVDGSVY 412
>gi|23477117|emb|CAC81350.1| hexokinase [Solanum lycopersicum]
Length = 498
Score = 87.0 bits (214), Expect = 2e-15, Method: Composition-based stats.
Identities = 114/444 (25%), Positives = 185/444 (41%), Gaps = 40/444 (9%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LITYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYL------------EPLKDES 123
V K I F + +P T++E FD IA L +P +
Sbjct: 111 RVQLGGKDGGIIHQEFAEASIPPSLMVGTSDELFDYIAAELAKFVAAEEEKFHQPPGKQR 170
Query: 124 DMISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIM 182
++ F FS+ + G ++ +K + +G + E L +A+ RKG ++ +
Sbjct: 171 EL-GFTFSFPVMQTSINSGNIMRWTKGFSIDDAVGQDVVGE-LTKAMKRKG-VDMRVSAL 227
Query: 183 VNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIV 241
VNDT L G +++ D + +LGTG N+AY+E + I K +I
Sbjct: 228 VNDTVGTLAGGKYTQKD-----VAVAVILGTGTNAAYVERVQAIPKWHGPVPKSGEMVIN 282
Query: 242 CESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFS 298
E G +S+ +P +++D L S E E+M SG YLGE L + LR G+F
Sbjct: 283 MEWGNFRSSHLPLTEYDHALDNESLNPGEQIFEKMTSGMYLGEILRRVLLRVAEEAGVFG 342
Query: 299 PRVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCF 353
V L T ++S + + D + I+E + S K + +C
Sbjct: 343 DEVPPKLKEPFVLRTPDMSAMHHDTSSDLKVVGEKLKDILEISNTSLKTRKLVVELCNIV 402
Query: 354 FERAGRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLT 410
R RL+AA + K G+ + + I+ DG ++ + + SL L
Sbjct: 403 ATRGARLAAAGVLGILKKMGRDTPKQGGSERTVIAMDGGLYEHYTEYRMCLENSLKDLLG 462
Query: 411 EKRGIYFVLKTNDEAVTLGTALAA 434
E+ V +++ +G AL A
Sbjct: 463 EELATSIVFVHSNDGSGIGAALLA 486
>gi|72082796|ref|XP_786955.1| PREDICTED: similar to hexokinase II [Strongylocentrotus purpuratus]
gi|115954215|ref|XP_001196431.1| PREDICTED: similar to hexokinase II [Strongylocentrotus purpuratus]
Length = 485
Score = 86.7 bits (213), Expect = 3e-15, Method: Composition-based stats.
Identities = 89/396 (22%), Positives = 176/396 (44%), Gaps = 28/396 (7%)
Query: 13 FDYKIDIEYAASILLED-MKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGT 71
F+ +++Y LED M KGL++ + + + M+P + D ++ + +D GG+
Sbjct: 20 FELTRELQYDIMGRLEDEMNKGLKAALNAEAKIKMLPTYVTSLPDGTENGDFLALDLGGS 79
Query: 72 NFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFC-- 129
NFR V + + P + ++ FD IAE+L + C
Sbjct: 80 NFRVMWVKIKDGKSKACMDVYTIPGEVM--RGPGDQLFDYIAEHLAKFTSYHKLCEMCIP 137
Query: 130 --FSYAIKIFPDGGGQAIKLSKEIKLPYIG-DCKINEGLFQALSRKGWKKIKKIIMVNDT 186
F+++ F G A ++ G + K L +A ++ ++ + ++NDT
Sbjct: 138 LGFTFSFPCFHKGLASATLVTWTKGYDAAGVEGKDVVPLLEAACKRKNVRVDIVAVINDT 197
Query: 187 AAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIVCESG 245
A +G F + D +G +LGTG N++Y+E K+E + + DK I+ CE G
Sbjct: 198 VATQMAGAF-----KNHDCVVGLILGTGCNASYLECTEKVEMYEGPKGPDKFVILDCECG 252
Query: 246 KSN-----KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSP 299
+ ++ FD+ + + + F E+M +G YLGE+ +++ + + IF
Sbjct: 253 AFGDNGCLEDIRTDFDRDIDGRTFNHGKQFYEKMIAGMYLGEILRLSMIHLINQKVIFGG 312
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVK---IYSICKCFFER 356
+ + L F T+ ++ K++ D + I+++ + + I ++ + + R
Sbjct: 313 VLPEALEKEWGFDTKYLTYIEKDKTEDLSGTRKILQSFDLQPTAAELQIIRALSRSIWTR 372
Query: 357 AGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFL 392
A RL A+ I+ + K I ++ DGS++L
Sbjct: 373 ASRLIASGISQIARRINK-----PSITVAVDGSLYL 403
>gi|53713814|ref|YP_099806.1| hexokinase type III [Bacteroides fragilis YCH46]
gi|52216679|dbj|BAD49272.1| hexokinase type III [Bacteroides fragilis YCH46]
Length = 402
Score = 86.7 bits (213), Expect = 3e-15, Method: Composition-based stats.
Identities = 94/388 (24%), Positives = 162/388 (41%), Gaps = 53/388 (13%)
Query: 15 YKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR 74
+K+D E I +K E ++ + + IP + LP K +++D GGTN+R
Sbjct: 6 FKLDNEQLKGIAHAFREKVEEGLNKNNAEIQCIPTFI-LPKATDVKGKALVLDLGGTNYR 64
Query: 75 AGIVYFDKK--------GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM- 125
IV F + G + +S K P T EE F +A+ + +K E +M
Sbjct: 65 VAIVDFSTEKPIIYPNNGWKKDMSIMKSP------GYTREELFKELADLIVEIKREEEMP 118
Query: 126 ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
I +CFSY + P G + ++ +K + + + + + L L+ K + + ++ND
Sbjct: 119 IGYCFSYPTESIPGGDARLLRWTKGVDIREMVGQFVGKPLLDYLNEKNKIRFTGVKVLND 178
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTTEFYDKPQIIVCES 244
T A L +G+ D+ +D++IG ++GTG N A +I KI KL + ES
Sbjct: 179 TIASLFAGL----TDKSYDAYIGLIVGTGTNMATFIPSDKITKLDPECHVQGLIPVNLES 234
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKM 304
G + D + S+ + E+ SG YLG++ A
Sbjct: 235 GNFYPPFLTAVDDTVDATSDSLGKQRFEKAVSGMYLGDILKAA----------------- 277
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSED-YVKIYSICKCFFERAGRLSAA 363
F EE E+ D + I+ + +D YV+ + + R+ +L AA
Sbjct: 278 ------FPLEEF-----EEKFDARKLTAIMNYPDIHKDIYVQ---VAHWIYNRSAQLVAA 323
Query: 364 VIAAACIKTGKGKSPDKPICISADGSMF 391
+A +C+ A+GS+F
Sbjct: 324 SLAGLIALLKSYNRDIHRVCLIAEGSLF 351
>gi|11386885|sp|Q9SEK2|HXK1_TOBAC Hexokinase-1 (NtHxK1)
gi|6594674|gb|AAF18585.1|AF118133_1 chloroplast outer envelope hexokinase 1 [Nicotiana tabacum]
Length = 497
Score = 86.7 bits (213), Expect = 3e-15, Method: Composition-based stats.
Identities = 114/450 (25%), Positives = 185/450 (41%), Gaps = 46/450 (10%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LITYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---------- 125
V K G F + +P T+E FD IA L +E
Sbjct: 111 RVQLGGKDGGIVHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVNEEGEKFQQPPGKQR 170
Query: 126 -ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMV 183
+ F FS+ + G ++ +K + +G + E L +A+ RKG ++ +V
Sbjct: 171 ELGFTFSFPVMQTSINSGTIMRWTKGFSIDDAVGQDVVGE-LAKAMKRKG-VDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G ++ D + +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGKYTHND-----VAVAVILGTGTNAAYVERVQAIPKWHGPVPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D L NS + E+M SG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTQYDHALDTNSLNPGDQIFEKMTSGMYLGEILRRVLLRVAEEAGIFGD 343
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFF 354
V L + T ++S + + D + I+E + S + + +C
Sbjct: 344 EVPPKLKSPFVLRTPDMSAMHHDASSDLRVVGDKLKDILEISNTSLKTRRLVIELCNIVA 403
Query: 355 ERAGRLSAAVIAAACIKTGKGKSPDKP-------ICISADGSMFLKGFLIKERIFKSLHT 407
R RL+AA + K G+ D P ++ DG ++ + + +L
Sbjct: 404 TRGARLAAAGVLGILKKMGR----DTPRQGGLEKTVVAMDGGLYEHYTEYRMCLENTLKE 459
Query: 408 CLTEKRGIYFVLKTNDEAVTLGTALAAFLN 437
L ++ V + +++ +G AL A N
Sbjct: 460 LLGDELATSIVFEHSNDGSGIGAALLAASN 489
>gi|50346083|gb|AAT74901.1| general specificity hexokinase [Bacteroides fragilis]
Length = 402
Score = 86.7 bits (213), Expect = 3e-15, Method: Composition-based stats.
Identities = 94/388 (24%), Positives = 162/388 (41%), Gaps = 53/388 (13%)
Query: 15 YKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR 74
+K+D E I +K E ++ + + IP + LP K +++D GGTN+R
Sbjct: 6 FKLDNEQLKGIAHAFREKVEEGLNKNNAEIQCIPTFI-LPKATDIKGKALVLDLGGTNYR 64
Query: 75 AGIVYFDKK--------GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM- 125
IV F + G + +S K P T EE F +A+ + +K E +M
Sbjct: 65 VAIVDFSTEKPIIYPNNGWKKDMSIMKSP------GYTREELFKELADLIVEIKREEEMP 118
Query: 126 ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
I +CFSY + P G + ++ +K + + + + + L L+ K + + ++ND
Sbjct: 119 IGYCFSYPTESIPGGDARLLRWTKGVDIREMVGQFVGKPLLDYLNEKNKIRFTGVKVLND 178
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTTEFYDKPQIIVCES 244
T A L +G+ D+ +D++IG ++GTG N A +I KI KL + ES
Sbjct: 179 TIASLFAGL----TDKSYDAYIGLIVGTGTNMATFIPSDKITKLDPECHVQGLIPVNLES 234
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKM 304
G + D + S+ + E+ SG YLG++ A
Sbjct: 235 GNFYPPFLTAVDDTVDATSDSLGKQRFEKAVSGMYLGDILKAA----------------- 277
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSED-YVKIYSICKCFFERAGRLSAA 363
F EE E+ D + I+ + +D YV+ + + R+ +L AA
Sbjct: 278 ------FPLEEF-----EEKFDARKLTAIMNYPDIHKDIYVQ---VAHWIYNRSAQLVAA 323
Query: 364 VIAAACIKTGKGKSPDKPICISADGSMF 391
+A +C+ A+GS+F
Sbjct: 324 SLAGLIALLKSYNRDIHRVCLIAEGSLF 351
>gi|157123148|ref|XP_001660031.1| hexokinase [Aedes aegypti]
gi|108874524|gb|EAT38749.1| hexokinase [Aedes aegypti]
Length = 453
Score = 86.7 bits (213), Expect = 3e-15, Method: Composition-based stats.
Identities = 94/397 (23%), Positives = 175/397 (44%), Gaps = 41/397 (10%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
IE LL+++ +GL + + + I ++LP K K + +D GGTNFR +
Sbjct: 25 IEEIMRRLLKEINRGLGKATQPEADIKCFITYVQDLPNGKEKGK-FLALDLGGTNFRVLL 83
Query: 78 VYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFS 131
++ + E+LS + +P + + FD IAE L E + + F FS
Sbjct: 84 IHLKDENDFEMLSKI-YAIPQSIMLGSGTQLFDHIAECLANFMKEHSVYEEKLPLGFTFS 142
Query: 132 YAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQ 191
+ + G + +K + + + L A++R+G +I+ ++NDT L
Sbjct: 143 FPLTQLGLTKGILARWTKGFNCSGVVGEDVVQLLKDAIARRGDVQIEICAILNDTTGTLM 202
Query: 192 SGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQ-------IIVCES 244
S + + + IG ++GTG N+ Y+E K++ E +D P+ +I E
Sbjct: 203 SCAW-----KNHNCRIGLIVGTGSNACYVE-----KVENCEMFDGPKDPKKEHVLINTEW 252
Query: 245 GK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FS 298
G + ++++D+ + S E+M SG Y+GEL +A+ + G+ F
Sbjct: 253 GAFGDNGALDFVRTEYDREIDHFSINPGRQIQEKMISGMYMGELARLAIVKFTRAGLLFG 312
Query: 299 PRVNKMLLNSCDFSTEEISLFLKEQN----HDKNIFSGIIEAHSVSEDYVKIYSICKCFF 354
+ +L F T+ +S ++ + +++ + H+ ED + IC+C
Sbjct: 313 GVGSDILFKRGQFFTKYVSEIESDKPGTYMYCRDVLDELGLEHATDEDCANVRYICECVS 372
Query: 355 ERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
RA L +A IAA K +K + + DGS++
Sbjct: 373 SRAAHLVSAGIAALI-----NKMDEKSVTVGVDGSVY 404
>gi|70984695|ref|XP_747854.1| glucokinase GlkA, putative [Aspergillus fumigatus Af293]
gi|66845481|gb|EAL85816.1| glucokinase GlkA, putative [Aspergillus fumigatus Af293]
Length = 493
Score = 86.7 bits (213), Expect = 3e-15, Method: Composition-based stats.
Identities = 115/439 (26%), Positives = 182/439 (41%), Gaps = 81/439 (18%)
Query: 13 FDYKID-IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDA 68
FD+ + I+ + +M +GL E ++S IP + T +P + + +D
Sbjct: 16 FDFSAEQIQSGVKEYIREMCEGLTKEHTTLSQ---IPTYV---TSVPNGTEKGLYLAVDL 69
Query: 69 GGTNFRA------GIVYFD----KKGVP----------EILSFFKHPMPALDREMTNEEF 108
GGTNFR G F+ K +P ++ F + A R NE F
Sbjct: 70 GGTNFRVCSIDLHGDTTFNLTQSKIMIPRELMASGTSKDLFLFLARQIEAFLRIHHNEHF 129
Query: 109 FDSIAEYLEPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGD--CKINEG 164
+ EP +E + F FS+ ++ G I+ +K +P +G C + +
Sbjct: 130 EAHLRRRREPNSEEELFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGHDVCALLQN 189
Query: 165 LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YG 223
L ++ +VNDT L + ++ D + IG + GTG N AY+E
Sbjct: 190 AIDELDLP----VRVAALVNDTVGTLMARSYTSPGDT--STFIGAIFGTGTNGAYVEKLD 243
Query: 224 KIEKLKTTEFYDKPQ-----IIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERM 274
+I KL+T E D + II E G + +P +K+DK L E+SN E+
Sbjct: 244 RITKLQTIEHADYEKSTGEMIINAEWGSFDNHLSVLPNTKWDKELDEDSNNPGIQMFEKR 303
Query: 275 CSGRYLGELCSIAL---RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS 331
SG +LGE+ AL A G+F P S T E S ++ D + S
Sbjct: 304 VSGMFLGEILRRALLDMHKDEAFGLFKPN------QSSKVVTPENSPLYRQWGIDTSFLS 357
Query: 332 GIIEAHSVS---------EDYVKIYS-----------ICKCFFERAGRLSAAVIAAACIK 371
++EA +D++KI + + +RA RLSA +AA I
Sbjct: 358 -LVEADKTDRMEEVKAALKDHLKIENPSDAECQAVKVLVHAIGKRAARLSAVPLAAILIS 416
Query: 372 TGKGKSPDKPICISADGSM 390
TGK ++ D + I DGS+
Sbjct: 417 TGKLETDDM-VDIGVDGSL 434
>gi|50512106|gb|AAT77515.1| hexokinase 7 [Nicotiana tabacum]
Length = 497
Score = 86.3 bits (212), Expect = 3e-15, Method: Composition-based stats.
Identities = 114/444 (25%), Positives = 186/444 (41%), Gaps = 40/444 (9%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LITYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYL------------EPLKDES 123
V K I F + +P T++ FD IA L +P +
Sbjct: 111 RVQLGGKDGGIIHQEFAEASIPPSLMVGTSDALFDYIAAELAKFVAAEEEKFHQPPGKQR 170
Query: 124 DMISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIM 182
++ F FS+ + G ++ +K + +G + E L +A+ RKG ++ +
Sbjct: 171 EL-GFTFSFPVMQTSINSGTIMRWTKGFSIDDAVGQDVVGE-LTKAMKRKG-VDMRVSAL 227
Query: 183 VNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIV 241
VNDT L G +++ D + +LGTG N+AY+E + I K +I
Sbjct: 228 VNDTVGTLAGGKYTQKD-----VAVAVILGTGTNAAYVERVQAIPKWHGPVPKSGEMVIN 282
Query: 242 CESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFS 298
E G +S+ +P +++D L S E E+M SG YLGE L + LR G+F
Sbjct: 283 MEWGNFRSSHLPLTEYDHALDNESLNPGEQIFEKMTSGMYLGEILRRVLLRVSEEAGVFG 342
Query: 299 PRVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCF 353
V L +S T ++S + + D + I+E + S K + +C
Sbjct: 343 DEVPPKLKDSFVLRTPDMSAMHHDTSPDLKVVGEKLKDILEISNTSLKTRKLVVELCNIV 402
Query: 354 FERAGRLSAAVIAAACIKTGKG---KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLT 410
R RL+AA + K G+ + + I+ DG ++ + + SL L
Sbjct: 403 ATRGARLAAAGVLGILKKMGRDTPKQGGSERTVIAMDGGLYEHYTEYRMCLENSLKDLLG 462
Query: 411 EKRGIYFVLKTNDEAVTLGTALAA 434
E+ V +++ +G AL A
Sbjct: 463 EELATSIVFVHSNDGSGIGAALLA 486
>gi|60682032|ref|YP_212176.1| putative hexokinase [Bacteroides fragilis NCTC 9343]
gi|60493466|emb|CAH08252.1| putative hexokinase [Bacteroides fragilis NCTC 9343]
Length = 402
Score = 86.3 bits (212), Expect = 4e-15, Method: Composition-based stats.
Identities = 80/306 (26%), Positives = 135/306 (44%), Gaps = 21/306 (6%)
Query: 15 YKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR 74
+K+D E I +K E ++ + + IP + LP K +++D GGTN+R
Sbjct: 6 FKLDNEQLKGIAHAFREKVEEGLNKNNAEIQCIPTFI-LPKATDVKGKALVLDLGGTNYR 64
Query: 75 AGIVYFDKK--------GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM- 125
IV F + G + +S K P T EE F +A+ + +K E +M
Sbjct: 65 VAIVDFSTEKPIIYPNNGWKKDMSIMKSP------GYTREELFKELADLIVEIKREEEMP 118
Query: 126 ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
I +CFSY + P G + ++ +K + + + + + L L+ K + + ++ND
Sbjct: 119 IGYCFSYPTESIPGGDARLLRWTKGVDIREMVGQFVGKPLLDYLNEKNKIRFTGVKVLND 178
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTTEFYDKPQIIVCES 244
T A L +G+ D+ +D++IG ++GTG N A +I KI KL + ES
Sbjct: 179 TIASLFAGL----TDKSYDAYIGLIVGTGTNMATFIPSDKITKLDPECHVQGLIPVNLES 234
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKM 304
G + D + S+ + E+ SG YLG++ A E F R
Sbjct: 235 GNFYPPFLTAVDDTVDATSDSLGKQRFEKAVSGMYLGDILKAAFPLEEFEEKFDARKLTA 294
Query: 305 LLNSCD 310
++N D
Sbjct: 295 MMNYPD 300
>gi|75061917|sp|Q5RC71|HXK1_PONPY Hexokinase-1 (Hexokinase type I) (HK I)
gi|55727771|emb|CAH90636.1| hypothetical protein [Pongo pygmaeus]
Length = 917
Score = 86.3 bits (212), Expect = 4e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKSPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 90/391 (23%), Positives = 172/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + +++ M+P + D ++ + +D GGTNFR +V KK
Sbjct: 494 EMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ K
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEG---LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC N+ L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGNDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 720 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|171735|gb|AAA34697.1| hexokinase P-II peptide
gi|224664|prf||1110197A hexokinase PII
Length = 486
Score = 86.3 bits (212), Expect = 4e-15, Method: Composition-based stats.
Identities = 116/447 (25%), Positives = 190/447 (42%), Gaps = 77/447 (17%)
Query: 1 MKEIDDFFKRNNFDYKID-IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPK 59
M++I++F K NF + ++ + +++KGL + ++ MIP W D P
Sbjct: 24 MQQIENFEK--NFTVPTETLQAVTKHFISELEKGLSKKGGNIP---MIPGWV---MDFPT 75
Query: 60 DKK---VIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTN-EEFFDSIAEY 115
K+ + ID GGTN R +V + K+ +P R N +E ++ IA+
Sbjct: 76 GKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQS-KYRLPDAMRTTQNPDELWEFIADS 134
Query: 116 LEPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW- 174
L+ DE FP G + I L P KINEG+ Q + KG+
Sbjct: 135 LKAFIDEQ-------------FPQGISEPIPLGFTFSFP-ASQNKINEGILQRWT-KGFD 179
Query: 175 --------------KKIKK-------IIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGT 213
K+I K + ++NDT L + +++ + + +G + GT
Sbjct: 180 IPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPE-----TKMGVIFGT 234
Query: 214 GLNSAYIEY-GKIEKLKTTEFYD----KPQIIVCESGKSNK----IPQSKFDKILSENSN 264
G+N AY + IEKL+ D P I CE G + +P++K+D + E S
Sbjct: 235 GVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESP 294
Query: 265 LKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFS----PRVNKMLLNSCDFSTE-EISL 318
+ E+M SG YLGE+ +AL +G IF + +K + + E
Sbjct: 295 RPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDP 354
Query: 319 FLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSP 378
F ++ D ++F ++ ++ I + + RA RLS IAA C K G
Sbjct: 355 FENLEDTD-DLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGY---- 409
Query: 379 DKPICISADGSMFLKGFLIKERIFKSL 405
K I+ADGS+ + KE+ +L
Sbjct: 410 -KTGHIAADGSVSTRYPGFKEKAANAL 435
>gi|171739|gb|AAA34699.1| hexokinase (HXK2)
Length = 486
Score = 86.3 bits (212), Expect = 4e-15, Method: Composition-based stats.
Identities = 116/447 (25%), Positives = 190/447 (42%), Gaps = 77/447 (17%)
Query: 1 MKEIDDFFKRNNFDYKID-IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPK 59
M++I++F K NF + ++ + +++KGL + ++ MIP W D P
Sbjct: 24 MQQIENFEK--NFTVPTETLQAVTKHFISELEKGLSKKGGNIP---MIPGWV---MDFPT 75
Query: 60 DKK---VIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTN-EEFFDSIAEY 115
K+ + ID GGTN R +V + K+ +P R N +E ++ IA+
Sbjct: 76 GKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQS-KYRLPDAMRTTQNPDELWEFIADS 134
Query: 116 LEPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW- 174
L+ DE FP G + I L P KINEG+ Q + KG+
Sbjct: 135 LKAFIDEQ-------------FPQGISEPIPLGFTFSFP-ASQNKINEGILQRWT-KGFD 179
Query: 175 --------------KKIKK-------IIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGT 213
K+I K + ++NDT L + +++ + + +G + GT
Sbjct: 180 IPNIENHDVVPMLQKQITKRNIHIEVVALINDTTGTLVASYYTDPE-----TKMGVIFGT 234
Query: 214 GLNSAYIEY-GKIEKLKTTEFYD----KPQIIVCESGKSNK----IPQSKFDKILSENSN 264
G+N AY + IEKL+ D P I CE G + +P++K+D + E S
Sbjct: 235 GVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESP 294
Query: 265 LKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFS----PRVNKMLLNSCDFSTE-EISL 318
+ E+M SG YLGE+ +AL +G IF + +K + + E
Sbjct: 295 RPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDP 354
Query: 319 FLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSP 378
F ++ D ++F ++ ++ I + + RA RLS IAA C K G
Sbjct: 355 FENLEDTD-DLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGY---- 409
Query: 379 DKPICISADGSMFLKGFLIKERIFKSL 405
K I+ADGS+ + KE+ +L
Sbjct: 410 -KTGHIAADGSVSTRYPGFKEKAANAL 435
>gi|27805797|ref|NP_776744.1| FK506 binding protein 12-rapamycin associated protein 1 [Bos
taurus]
gi|123891|sp|P27595|HXK1_BOVIN Hexokinase-1 (Hexokinase type I) (HK I) (Brain form hexokinase)
gi|163152|gb|AAA51661.1| hexokinase 1
Length = 918
Score = 85.9 bits (211), Expect = 4e-15, Method: Composition-based stats.
Identities = 98/396 (24%), Positives = 179/396 (45%), Gaps = 51/396 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKK 83
L +M+ GL E S ++++M+P + D +D + +D GGTNFR +V KK
Sbjct: 491 LRTEMEMGLRKETNSNATVNMLPSFLRSIPDGTEDGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 84 GVPEILS-FFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
E+ + ++ P+ + + T EE FD I + D + + F FS+ +
Sbjct: 551 STVEMHNKIYRIPIEIM--QGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 609 TSLDAGILITWTKGFKAT---DCVGHDVVTLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 665
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E +G ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 666 AYEEP-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGNQRQMCINMEWGAFGDN 715
Query: 245 GKSNKIPQSKFDKILSENS-NLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVN 302
G S+ I ++ FDK++ E S N N+ F E M SG YLGE+ L + +G +F +++
Sbjct: 716 GCSDDI-RTDFDKVVDEYSLNSGNQRF-ENMISGIYLGEIVRNILIDFTKKGFLFRGQIS 773
Query: 303 KMLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFER 356
+ L F T+ FL + D+ + + +S +D + + ++C +R
Sbjct: 774 EPLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKR 829
Query: 357 AGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +L A +AA K + + D+ + + DG+++
Sbjct: 830 AAQLCGAGMAAVVEKIRENRGLDRLNVTVGVDGTLY 865
Score = 70.5 bits (171), Expect = 2e-10, Method: Composition-based stats.
Identities = 89/397 (22%), Positives = 163/397 (41%), Gaps = 29/397 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD-KKGVP 86
++MK GL + +++ M+P + D + I +D GG++FR V + ++ P
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNRP 104
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + P + + FD + E L ++ + + F FS+ +
Sbjct: 105 VHMESEVYDTPENIMHGSGSQLFDHVLECLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + L +A+ ++G + +VNDT + I DD
Sbjct: 165 QAILITWTKRFKARGAEGNYVVKLLDKAIKKRGDYDANIVAVVNDTVGTM---IDCGYDD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFY---DKPQIIVCESGK-----SNKIPQ 252
Q +G ++GTG N+ Y +E+L+ +F D I E G S + +
Sbjct: 222 Q--HCEVGLIIGTGTNACY-----MEELRQIDFGWGDDGRMCINTEWGDLGDDGSLEDIR 274
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDF 311
+FD+ S + E+M SGRY+ ++ + L + EG +F R+ LL F
Sbjct: 275 KEFDREFRRGSLNPGKQRFEKMVSGRYMEDVVRLVLVKMAKEGLLFEGRITPELLTRGKF 334
Query: 312 STEEISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+T ++S K++ H+ + +D V + +C R+ L AA + A
Sbjct: 335 NTSDVSAIEKDKEGLHNAKEILTRLGVERSDDDCVSVQHVCTIVSFRSANLVAATLGAIL 394
Query: 370 IKTGKGKS-PDKPICISADGSMFLKGFLIKERIFKSL 405
+ KS P + DGS++ R K+L
Sbjct: 395 NRLRDNKSTPRLRTTVRVDGSLYKTHPQYSRRFHKTL 431
>gi|119467212|ref|XP_001257412.1| glucokinase GlkA, putative [Neosartorya fischeri NRRL 181]
gi|119405564|gb|EAW15515.1| glucokinase GlkA, putative [Neosartorya fischeri NRRL 181]
Length = 493
Score = 85.9 bits (211), Expect = 4e-15, Method: Composition-based stats.
Identities = 114/439 (25%), Positives = 181/439 (41%), Gaps = 81/439 (18%)
Query: 13 FDYKID-IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDA 68
FD+ + I+ + +M +GL E ++S IP + T +P + + +D
Sbjct: 16 FDFSAEQIQSGVKEYIREMCEGLTKEHTTLSQ---IPTYV---TSVPNGTEKGLYLAVDL 69
Query: 69 GGTNFRA------GIVYFD----KKGVP----------EILSFFKHPMPALDREMTNEEF 108
GGTNFR G F+ K +P ++ F + A R NE F
Sbjct: 70 GGTNFRVCSIDLHGDTTFNLTQSKIMIPRELMASGTSKDLFLFLARQIEAFLRIHHNEHF 129
Query: 109 FDSIAEYLEPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGD--CKINEG 164
+ EP +E + F FS+ ++ G I+ +K +P +G C + +
Sbjct: 130 EAHLRRRREPNHEEELFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGHDVCALLQN 189
Query: 165 LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YG 223
L ++ +VNDT L + ++ D + IG + GTG N AY+E
Sbjct: 190 AIDELDLP----VRVAALVNDTVGTLMARSYTSPGDT--STFIGAIFGTGTNGAYVEKLD 243
Query: 224 KIEKLKTTEFYD-----KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERM 274
+I KL+T E D I+ E G + +P +K+DK L E+SN E+
Sbjct: 244 RITKLRTIEHSDYETSTGEMIVNAEWGSFDNHLSVLPNTKWDKELDEDSNNPGIQMFEKR 303
Query: 275 CSGRYLGELCSIAL---RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS 331
SG +LGE+ AL A G+F P S T E S ++ D + S
Sbjct: 304 VSGMFLGEILRRALLDMHKDEAFGLFKPN------QSSKVVTPENSPLYRQWGIDTSFLS 357
Query: 332 GIIEAHSVS---------EDYVKIYS-----------ICKCFFERAGRLSAAVIAAACIK 371
++EA +D++KI + + +RA RLSA +AA I
Sbjct: 358 -LVEADKTDRMEEVKAALKDHLKIENPSDADCQAVKVLVHAIGKRAARLSAVPLAAILIS 416
Query: 372 TGKGKSPDKPICISADGSM 390
TGK ++ D + I DGS+
Sbjct: 417 TGKLETDDM-VDIGVDGSL 434
>gi|119113166|ref|XP_564289.2| ENSANGP00000028361 [Anopheles gambiae str. PEST]
Length = 453
Score = 85.9 bits (211), Expect = 5e-15, Method: Composition-based stats.
Identities = 103/449 (22%), Positives = 192/449 (42%), Gaps = 59/449 (13%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
IE +++++ +GL E + + + I ++LP K K + +D GGTNFR +
Sbjct: 23 IEEIMRRVIKEINRGLSKETHAEADVKCFITYVQDLPNGKEKGK-FLALDLGGTNFRVLL 81
Query: 78 VYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFS 131
++ + E+LS + +P + + FD IAE L E + + F FS
Sbjct: 82 IHLKDENDFEMLSKI-YAIPQSIMLGSGTQLFDHIAECLANFMKEHSVYEERLPLGFTFS 140
Query: 132 YAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQ 191
+ + G + +K + + + L A++R+G +I ++NDT L
Sbjct: 141 FPLTQLGLTKGILARWTKGFNCSGVVGEDVVQLLKDAIARRGDVQIDICAILNDTTGTLM 200
Query: 192 SGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQ---------IIVC 242
S + + + IG ++GTG N+ Y+E +++ + +D P+ +I
Sbjct: 201 SCAW-----KNHNCRIGLIVGTGSNACYVE-----RVENCDLFDGPKSGPNIKQHVMINT 250
Query: 243 ESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGI 296
E G + ++++D+ + ++S E+M SG Y+GEL +A+ R A +
Sbjct: 251 EWGAFGDDGALDFVRTEYDREIDQHSINPGRQLQEKMISGMYMGELARLAIVRFTKAGLL 310
Query: 297 FSPRVNKMLLNSCDFSTEEISLFLKEQN----HDKNIFSGIIEAHSVSEDYVKIYSICKC 352
F + +L F T+ +S ++ + + + + H+ ED + IC+C
Sbjct: 311 FGGVGSDILFKRGQFFTKYVSEIESDKPGTYYNCREVLEELGLEHATDEDCANVRYICEC 370
Query: 353 FFERAGRLSAAVIAAACIKTGKGKSPDKP-ICISADGSMFLKGFLIKERIFKSLHTCLTE 411
RA L +A IAA K D+P + + DGS++ R H + +
Sbjct: 371 VSSRAAHLVSAGIAALINKM------DEPSVTVGVDGSVY--------RFHPKFHDLMVQ 416
Query: 412 ------KRGIYFVLKTNDEAVTLGTALAA 434
K I F L +++ G AL A
Sbjct: 417 KIRQFVKPHISFDLMLSEDGSGRGAALVA 445
>gi|45198797|ref|NP_985826.1| AFR279Cp [Ashbya gossypii ATCC 10895]
gi|44984826|gb|AAS53650.1| AFR279Cp [Ashbya gossypii ATCC 10895]
Length = 488
Score = 85.9 bits (211), Expect = 5e-15, Method: Composition-based stats.
Identities = 109/414 (26%), Positives = 176/414 (42%), Gaps = 84/414 (20%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIV---- 78
+ ++ KGL + ++ MIP W D P + + ID GGTN R +V
Sbjct: 48 FVTELDKGLSKKGGNIP---MIPGWV---MDYPTGNETGDYLAIDLGGTNLRVVLVKLLG 101
Query: 79 --YFDKKGVPEILSFFKHPMPALDREMTN-EEFFDSIAEYLEPLKDESDMISFCFSYAIK 135
FD K+ +P R N E +D IAE L+ +E
Sbjct: 102 NHQFDTTQS-------KYRLPNRMRTTQNASELWDFIAESLKDFLEEQ------------ 142
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS---------------------RKGW 174
FP+G Q + L P D KIN G+ Q + RK
Sbjct: 143 -FPEGVHQTLPLGFTFSYPASQD-KINMGILQRWTKGFDIPGVEGHDVVPMLQESLRKVN 200
Query: 175 KKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEF 233
I+ + ++NDT L + ++++ + + +G + GTG+N AY + K IEKL+
Sbjct: 201 VPIEVVALINDTTGTLVASLYTDAE-----TKMGVIFGTGVNGAYYDVVKDIEKLEGRLP 255
Query: 234 YDKP----QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCS 285
D P I CE G + +P++K+D ++ E S + E+M SG YLGE+
Sbjct: 256 EDIPPESAMAINCEYGSFDNEHLVLPRTKYDILIDEQSPRPGQQAFEKMTSGYYLGEVLR 315
Query: 286 IALRAGSAEG-IFSPR-VNKM----LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV 339
+AL +G IF + ++K+ ++++ + E F + D ++F ++ +
Sbjct: 316 LALLDLHGQGLIFQGQDISKLETPYVMDTSFPARIEDDPFENLEETD-DLFKDNLDIDTT 374
Query: 340 SEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLK 393
+ I + + RA RLS IAA C K G + I+ADGS+F K
Sbjct: 375 RPERKLIRKLSEMIGNRAARLSVCGIAAICQKRGYETAH-----IAADGSVFNK 423
>gi|15991833|ref|NP_277035.1| hexokinase 1 isoform HKI-td [Homo sapiens]
gi|8996018|gb|AAF82320.1|AAF82320 hexokinase 1 isoform td [Homo sapiens]
gi|119574704|gb|EAW54319.1| hexokinase 1, isoform CRA_a [Homo sapiens]
Length = 905
Score = 85.5 bits (210), Expect = 6e-15, Method: Composition-based stats.
Identities = 95/424 (22%), Positives = 179/424 (42%), Gaps = 28/424 (6%)
Query: 2 KEIDDFFKRNNFDYKIDIEYAASILL---EDMKKGLESEAESVSSMDMIPLWKNLPTDIP 58
+ + DF + + ++ E I+ ++MK GL + +++ M+P + D
Sbjct: 4 RALRDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGS 63
Query: 59 KDKKVIIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYL- 116
+ I +D GG++FR V + + + + + P + + FD +AE L
Sbjct: 64 EKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLG 123
Query: 117 -----EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSR 171
+KD+ + F FS+ + I +K K + + + L +A+ +
Sbjct: 124 DFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 183
Query: 172 KGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTT 231
+G + +VNDT + + + DDQ +G ++GTG N+ Y+E ++ +
Sbjct: 184 RGDYDANIVAVVNDTVGTMMTCGY---DDQ--HCEVGLIIGTGTNACYME--ELRHIDLV 236
Query: 232 EFYDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSI 286
E + I E G S + +++FD+ + S + E+M SG YLGEL +
Sbjct: 237 EGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRL 296
Query: 287 ALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQN--HDKNIFSGIIEAHSVSEDY 343
L + EG +F R+ LL F+T ++S K + H+ + +D
Sbjct: 297 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDC 356
Query: 344 VKIYSICKCFFERAGRLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERI 401
V + +C R+ L AA + A ++ KG +P + DGS++ R
Sbjct: 357 VSVQHVCTIVSFRSANLVAATLGAILNRLRDNKG-TPRLRTTVGVDGSLYKTHPQYSRRF 415
Query: 402 FKSL 405
K+L
Sbjct: 416 HKTL 419
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 482 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 541
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 542 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 600
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 601 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 657
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 658 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 707
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 708 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 766
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 767 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 822
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 823 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 853
>gi|109089480|ref|XP_001110227.1| PREDICTED: similar to hexokinase 1 isoform HKI-ta/tb isoform 2
[Macaca mulatta]
Length = 952
Score = 85.5 bits (210), Expect = 7e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 80 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 139
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 140 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 199
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 200 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 256
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 257 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 312
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 313 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 372
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 373 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 432
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 433 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 466
Score = 79.3 bits (194), Expect = 5e-13, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 173/391 (44%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 529 EMELGLRKQTHNNAVVKMLPSFVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 588
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 589 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 647
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 648 AGILITWTKGFKAT---DCVGHDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 704
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q ++C ++G+ +
Sbjct: 705 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGLMCINMEWGAFGDNGRLD 754
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++++D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 755 DI-RTQYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKT 813
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 814 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 869
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 870 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 900
>gi|114630843|ref|XP_001169123.1| PREDICTED: hexokinase 1 isoform 4 [Pan troglodytes]
gi|114630845|ref|XP_001169173.1| PREDICTED: hexokinase 1 isoform 6 [Pan troglodytes]
Length = 905
Score = 85.5 bits (210), Expect = 7e-15, Method: Composition-based stats.
Identities = 95/424 (22%), Positives = 179/424 (42%), Gaps = 28/424 (6%)
Query: 2 KEIDDFFKRNNFDYKIDIEYAASILL---EDMKKGLESEAESVSSMDMIPLWKNLPTDIP 58
+ + DF + + ++ E I+ ++MK GL + +++ M+P + D
Sbjct: 4 RALRDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGS 63
Query: 59 KDKKVIIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYL- 116
+ I +D GG++FR V + + + + + P + + FD +AE L
Sbjct: 64 EKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLG 123
Query: 117 -----EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSR 171
+KD+ + F FS+ + I +K K + + + L +A+ +
Sbjct: 124 DFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 183
Query: 172 KGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTT 231
+G + +VNDT + + + DDQ +G ++GTG N+ Y+E ++ +
Sbjct: 184 RGDYDANIVAVVNDTVGTMMTCGY---DDQ--HCEVGLIIGTGTNACYME--ELRHIDLV 236
Query: 232 EFYDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSI 286
E + I E G S + +++FD+ + S + E+M SG YLGEL +
Sbjct: 237 EGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRL 296
Query: 287 ALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQN--HDKNIFSGIIEAHSVSEDY 343
L + EG +F R+ LL F+T ++S K + H+ + +D
Sbjct: 297 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDC 356
Query: 344 VKIYSICKCFFERAGRLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERI 401
V + +C R+ L AA + A ++ KG +P + DGS++ R
Sbjct: 357 VSVQHVCTIVSFRSANLVAATLGAILNRLRDNKG-TPRLRTTVGVDGSLYKTHPQYSRRF 415
Query: 402 FKSL 405
K+L
Sbjct: 416 HKTL 419
Score = 75.1 bits (183), Expect = 9e-12, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + +++ M+P + D ++ + +D GGTNFR +V KK
Sbjct: 482 EMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 541
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 542 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 600
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 601 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 657
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 658 P-----SCEVGLIVGTGSNACY-----MEEMKNVETVEGDQGQMCINMEWGAFGDNGCLD 707
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 708 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 766
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 767 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 822
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 823 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 853
>gi|114630841|ref|XP_001169215.1| PREDICTED: hexokinase 1 isoform 8 [Pan troglodytes]
Length = 952
Score = 85.5 bits (210), Expect = 7e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 80 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 139
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 140 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 199
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 200 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 256
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 257 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 312
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 313 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 372
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 373 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 432
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 433 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 466
Score = 75.5 bits (184), Expect = 6e-12, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + +++ M+P + D ++ + +D GGTNFR +V KK
Sbjct: 529 EMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 588
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 589 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 647
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 648 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 704
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 705 P-----SCEVGLIVGTGSNACY-----MEEMKNVETVEGDQGQMCINMEWGAFGDNGCLD 754
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 755 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 813
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 814 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 869
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 870 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 900
>gi|109089478|ref|XP_001110396.1| PREDICTED: similar to hexokinase 1 isoform HKI-R isoform 6 [Macaca
mulatta]
Length = 916
Score = 85.1 bits (209), Expect = 8e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 44 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 103
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 104 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 163
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 164 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 220
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 221 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 276
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 277 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 336
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 337 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 396
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 397 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 430
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 173/391 (44%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 493 EMELGLRKQTHNNAVVKMLPSFVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 552
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 553 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 611
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 612 AGILITWTKGFKAT---DCVGHDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 668
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q ++C ++G+ +
Sbjct: 669 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGLMCINMEWGAFGDNGRLD 718
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++++D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DI-RTQYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKT 777
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 778 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 833
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 834 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 864
>gi|15991827|ref|NP_277031.1| hexokinase 1 isoform HKI-R [Homo sapiens]
gi|2873350|gb|AAC15863.1|AAC15863 hexokinase IR [Homo sapiens]
gi|119574705|gb|EAW54320.1| hexokinase 1, isoform CRA_b [Homo sapiens]
Length = 916
Score = 85.1 bits (209), Expect = 8e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 44 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 103
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 104 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 163
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 164 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 220
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 221 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 276
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 277 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 336
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 337 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 396
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 397 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 430
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 493 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 552
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 553 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 611
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 612 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 668
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 669 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 718
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 777
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 778 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 833
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 834 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 864
>gi|9955857|dbj|BAB12228.1| hexokinase [Aspergillus oryzae]
gi|83767060|dbj|BAE57200.1| unnamed protein product [Aspergillus oryzae]
Length = 490
Score = 85.1 bits (209), Expect = 8e-15, Method: Composition-based stats.
Identities = 119/464 (25%), Positives = 204/464 (43%), Gaps = 51/464 (10%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+K+ +D F + K A +++++KGL E ++ M W D +
Sbjct: 27 IKQFEDIFTVDGAKLK----QIADHFVKELEKGLSVEGGNIP---MNVTWVMGFPDGDEQ 79
Query: 61 KKVIIIDAGGTNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
+ +D GGTN R I ++KG +I K+ MP + T EE ++ IA+ L+
Sbjct: 80 GTFLALDMGGTNLRVCEITLTEEKGAFDITQS-KYRMPEELKTGTAEELWEYIADCLQQF 138
Query: 120 KD---ESDMIS-----FCFSY-AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+ E++ +S F FSY A + + D G + +K + + + L L
Sbjct: 139 IESHHENEKLSKLPLGFTFSYPATQEYIDHGVLQ-RWTKGFDIDGVEGQDVVPPLEAILK 197
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLK 229
++G IK ++NDT L + ++++D + IG + GTG+N+AY+E+ G + KL
Sbjct: 198 KRGLP-IKVAALINDTTGTLIASSYTDSDMK-----IGCIFGTGVNAAYMEHCGSVPKLA 251
Query: 230 TTEFY-DKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC 284
D P I CE G + +P +K+D I+ +S + E+M +G YLGE+
Sbjct: 252 HKNLPPDMPVAINCEYGAFDNEHVVLPLTKYDIIIDRDSPRPGQQAFEKMTAGLYLGEIF 311
Query: 285 SIAL------RAGSA-EGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAH 337
+AL R G +G + ++ K L F + + + +
Sbjct: 312 RLALLDLLETRPGLIFQGQDTSQLRKPYLLDASFLAAIEDDPYENLQETQELMERKLNIK 371
Query: 338 SVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLKGFL 396
+ ++ I + + RA RLSA +AA C K + C + ADGS+F K
Sbjct: 372 ATQQELEMIRRLAELIGTRAARLSACGVAAIC------KKKNIESCHVGADGSVFTKYPH 425
Query: 397 IKERIFKSLHTCL----TEKRGIYFVLKTNDEAVTLGTALAAFL 436
K R ++L L EK + V+ ++ +G AL A L
Sbjct: 426 FKARGAQALREILDWAPNEKDKV--VIMAAEDGSGVGAALIAAL 467
>gi|119574708|gb|EAW54323.1| hexokinase 1, isoform CRA_d [Homo sapiens]
Length = 969
Score = 85.1 bits (209), Expect = 8e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 97 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 156
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 157 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 216
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 217 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 273
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 274 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 329
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 330 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 389
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 390 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 449
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 450 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 483
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 546 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 605
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 606 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 664
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 665 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 721
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 722 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 771
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 772 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 830
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 831 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 886
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 887 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 917
>gi|68492364|ref|XP_710054.1| putative hexokinase [Candida albicans SC5314]
gi|46431152|gb|EAK90778.1| likely hexokinase [Candida albicans SC5314]
Length = 472
Score = 85.1 bits (209), Expect = 9e-15, Method: Composition-based stats.
Identities = 108/411 (26%), Positives = 167/411 (40%), Gaps = 44/411 (10%)
Query: 22 AASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIV 78
A +E M GLES S M MIP + T IP K+V + D GGTNFR +
Sbjct: 28 ATEYFVESMNVGLESPKPSKDVMPMIPTYV---TSIPTGKEVGLYLAADLGGTNFR--VC 82
Query: 79 YFDKKGVPEI---LSFFKHPMPALDREMTNEEF-----------FDSIAEYLEPLKDESD 124
D KG S ++ P+ + E +N+ F ++ +E E
Sbjct: 83 SIDLKGDHTFSMKQSKYRIPVDLMKAEKSNDLFGFLAKKVQSFLLENHSEACTAKNTEPL 142
Query: 125 MISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ + G I+ +K +P D + E L QA +K + + N
Sbjct: 143 KLGFTFSFPVNQTALNRGTLIRWTKGFDIPDTVDRDVVE-LLQANLTILEVNVKVVAIAN 201
Query: 185 DTAAVLQSGIFS-ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCE 243
DT L + +S ++ ++ IG + GTG N Y E KI KL + + +I E
Sbjct: 202 DTVGTLLTAAYSNDSAKTNRNTIIGCIFGTGTNGVYFE-SKIPKLSSLTGKSQGMVINTE 260
Query: 244 SGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSP 299
G + +P ++FD+I+ + + E+ SG +LGE+ +AL G+
Sbjct: 261 WGSFDNGLKILPSTEFDEIVDSETANPGYHLFEKRISGMFLGEILRVALIHLFKNGLIFQ 320
Query: 300 RVNKMLLNSCDFSTEEISLFLKE-----QNHDKN-------IFSGIIEAHSVSEDYVKIY 347
+ K S EE L E Q D I ++ + E+ I
Sbjct: 321 ELYKARGGSLPHRIEEPWLLDAEVLSYLQIDDSTDLKTSGLILQNVLRLETNKEEREVIQ 380
Query: 348 SICKCFFERAGRLSAAVIAAACIKT-GKGKSPDKPICISADGSM--FLKGF 395
+ + +RA LSA IAA K + K D+ + DGS+ F GF
Sbjct: 381 RLTRAISQRAAHLSAIPIAAIAKKVKDQYKDDDRDFEVGCDGSVIEFYPGF 431
>gi|114630847|ref|XP_507830.2| PREDICTED: hexokinase 1 isoform 10 [Pan troglodytes]
Length = 916
Score = 85.1 bits (209), Expect = 9e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 44 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 103
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 104 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 163
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 164 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 220
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 221 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 276
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 277 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 336
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 337 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 396
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 397 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 430
Score = 75.5 bits (184), Expect = 7e-12, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + +++ M+P + D ++ + +D GGTNFR +V KK
Sbjct: 493 EMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 552
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 553 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 611
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 612 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 668
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 669 P-----SCEVGLIVGTGSNACY-----MEEMKNVETVEGDQGQMCINMEWGAFGDNGCLD 718
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 777
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 778 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 833
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 834 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 864
>gi|148230649|ref|NP_001090603.1| hypothetical protein LOC100036846 [Xenopus laevis]
gi|120537871|gb|AAI29527.1| LOC100036846 protein [Xenopus laevis]
Length = 913
Score = 85.1 bits (209), Expect = 9e-15, Method: Composition-based stats.
Identities = 93/405 (22%), Positives = 186/405 (45%), Gaps = 41/405 (10%)
Query: 25 ILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG 84
++L DM++GL + S++ M+P + D + +++D GG FR I++ + K
Sbjct: 40 LMLGDMERGLMKTPQKPSTLKMLPTYVRSTPDGTERGDFLVLDLGGAQFR--ILHVELKD 97
Query: 85 VPEI-LSFFKHPMPALDREMTNEEFFDSIAE----YLEPLKDESDMISFCFSYAIKIFPD 139
++ + + +P T ++ FD +AE +L K ++ F+++ FP
Sbjct: 98 SAKVEMESQVYAIPDEVMHGTGQQLFDHVAECLGQFLRQQKLHQKVLPLGFTFS---FPC 154
Query: 140 GGGQAIKLSKEIKLPYIG--DCKINEG-----LF-QALSRKGWKKIKKIIMVNDTAAVLQ 191
Q L K + + + C EG LF +A+ R+G + I +VNDT +
Sbjct: 155 VQSQ---LDKSVLISWTKGFHCSEVEGKDVVHLFREAIRRQGGYDVDVIAIVNDTVGAMM 211
Query: 192 SGIFSETDDQGFDSHIGFVLGTGLNSAYI-EYGKIEKLKTTE---FYDKPQIIVCESGKS 247
S + Q +GF++GTG N Y+ E G +E ++ E + + + G+
Sbjct: 212 SCGY-----QDHSCEVGFIVGTGTNLCYMEEMGNVESVEGDEGKMCINTEWGALGDDGEL 266
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ + Q++ D+ + +NS + + +++ SG Y+GE+ + L + +G +F ++ LL
Sbjct: 267 SSV-QTEVDEQVDQNSLVPGKQCFDKLVSGMYMGEIVRLILVKLANQGLLFDGTTSQSLL 325
Query: 307 NSCDFSTEEISLFLKEQNH-----DKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLS 361
T+ +S E +H + + S ++ + +D V + +C R+ L
Sbjct: 326 TKGCIETKHVSAI--EDDHFGLAAARKMLS-VLGLNPSEQDCVNVQHVCSAVSTRSANLC 382
Query: 362 AAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLH 406
AA +AA + + + + I I DGS++ + ER+ +L
Sbjct: 383 AAGLAAVATRL-QLNNHNLKITIGVDGSVYKQHPKFSERLHSALQ 426
Score = 81.6 bits (200), Expect = 9e-14, Method: Composition-based stats.
Identities = 97/410 (23%), Positives = 173/410 (42%), Gaps = 34/410 (8%)
Query: 3 EIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK 62
+IDD + +E S + ++ GL E + +++ M+P + D +
Sbjct: 463 QIDDILAPFQLS-QAKLEEVKSQMRAEIDIGLCKETHAGATVKMLPTYVRSTPDGTERGD 521
Query: 63 VIIIDAGGTNFRAGIVYFDKK---GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
I +D GGTNFR V+ ++ GV + + P + + T + FD I + +
Sbjct: 522 FIALDLGGTNFRVLYVHIGRREDAGVQIVSKTYTLPQEII--QGTGGQLFDHIIDCISEF 579
Query: 120 KDESDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKG 173
+ E+++ + F FS+ K G I +K + L +A RK
Sbjct: 580 QSENNLRGRRLPLGFTFSFPCKQTNLDQGILITWTKGFSASGCVGKDVVTLLREAALRKK 639
Query: 174 WKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF 233
I + +VNDT + S +++ IG ++GTG N+ Y +E+LK E
Sbjct: 640 NNDIIVVALVNDTVGTMMSCGYNDP-----ACEIGLIVGTGTNACY-----MEELKNVEL 689
Query: 234 YDKPQIIVCES------GKSNKIPQ--SKFDKILSENSNLKNEYFLERMCSGRYLGELCS 285
D + +C + G +N + + FD + S + E+M SG YLGE+
Sbjct: 690 LDGDEGQMCVNMEWGAFGDNNCLEDITTSFDHDVDTFSINPGKQRYEKMISGMYLGEIVR 749
Query: 286 IALRAGSAEGI-FSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIE--AHSVSED 342
L + GI F ++++ LL F T +SL + + S + E S +D
Sbjct: 750 QILIVLTRRGILFGGKISERLLTRDLFPTRFLSLIESDTLGLVQVRSILTELGLRSTCDD 809
Query: 343 YVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+ + +C RA +L AA +AA K + D+ + + DG+++
Sbjct: 810 TMLVKEVCTTVSRRAAQLCAAGVAAVVEKMRANRGLDQLKVTVGVDGTLY 859
>gi|15991829|ref|NP_277032.1| hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
gi|15991831|ref|NP_277033.1| hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
gi|8996017|gb|AAF82319.1|AAF82319 hexokinase 1 isoform ta/tb [Homo sapiens]
gi|119574706|gb|EAW54321.1| hexokinase 1, isoform CRA_c [Homo sapiens]
gi|119574707|gb|EAW54322.1| hexokinase 1, isoform CRA_c [Homo sapiens]
Length = 921
Score = 85.1 bits (209), Expect = 9e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 49 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 108
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 109 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 168
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 169 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 225
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 226 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 281
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 282 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 341
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 342 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 401
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 402 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 435
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 498 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 557
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 558 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 616
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 617 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 673
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 674 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 723
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 724 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 782
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 783 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 838
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 839 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 869
>gi|62088632|dbj|BAD92763.1| hexokinase 1 isoform HKI variant [Homo sapiens]
Length = 949
Score = 85.1 bits (209), Expect = 9e-15, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 77 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 136
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 137 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 196
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 197 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 253
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 254 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 309
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 310 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 369
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 370 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 429
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 430 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 463
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 526 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 585
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 586 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 644
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 645 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 701
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 702 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 751
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 752 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 810
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 811 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 866
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 867 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 897
>gi|109089482|ref|XP_001110350.1| PREDICTED: similar to hexokinase 1 isoform HKI-td isoform 5 [Macaca
mulatta]
Length = 905
Score = 85.1 bits (209), Expect = 9e-15, Method: Composition-based stats.
Identities = 95/420 (22%), Positives = 177/420 (42%), Gaps = 28/420 (6%)
Query: 6 DFFKRNNFDYKIDIEYAASILL---EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK 62
DF + + ++ E I+ ++MK GL + +++ M+P + D +
Sbjct: 8 DFIDKYLYAMRLSDETLIDIMTRFKKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 67
Query: 63 VIIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYL----- 116
I +D GG++FR V + + + + + P + + FD +AE L
Sbjct: 68 FIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 127
Query: 117 -EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWK 175
+KD+ + F FS+ + I +K K + + + L +A+ ++G
Sbjct: 128 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 187
Query: 176 KIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYD 235
+ +VNDT + + + DDQ +G ++GTG N+ Y+E ++ + E +
Sbjct: 188 DANIVAVVNDTVGTMMTCGY---DDQ--QCEVGLIIGTGTNACYME--ELRHIDLVEGDE 240
Query: 236 KPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRA 290
I E G S + +++FD+ + S + E+M SG YLGEL + L
Sbjct: 241 GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVK 300
Query: 291 GSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIY 347
+ EG +F R+ LL F+T ++S K + H+ + +D V +
Sbjct: 301 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQ 360
Query: 348 SICKCFFERAGRLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+C R+ L AA + A ++ KG +P + DGS++ R K+L
Sbjct: 361 HVCTIVSFRSANLVAATLGAILNRLRDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 419
Score = 78.6 bits (192), Expect = 7e-13, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 173/391 (44%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 482 EMELGLRKQTHNNAVVKMLPSFVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 541
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 542 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 600
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 601 AGILITWTKGFKAT---DCVGHDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 657
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q ++C ++G+ +
Sbjct: 658 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGLMCINMEWGAFGDNGRLD 707
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++++D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 708 DI-RTQYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKT 766
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 767 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 822
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 823 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 853
>gi|4504391|ref|NP_000179.1| hexokinase 1 isoform HKI [Homo sapiens]
gi|184021|gb|AAA52646.1| hexokinase 1 [Homo sapiens]
Length = 917
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 73.9 bits (180), Expect = 2e-11, Method: Composition-based stats.
Identities = 87/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 494 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D++++E S + E+M SG YLGE+ L + +G +F ++++ +
Sbjct: 720 DI-RTHYDRLVNEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETMKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|114630831|ref|XP_001169044.1| PREDICTED: hexokinase 1 isoform 1 [Pan troglodytes]
gi|114630833|ref|XP_001169098.1| PREDICTED: hexokinase 1 isoform 3 [Pan troglodytes]
gi|114630835|ref|XP_001169148.1| PREDICTED: hexokinase 1 isoform 5 [Pan troglodytes]
gi|114630837|ref|XP_001169190.1| PREDICTED: hexokinase 1 isoform 7 [Pan troglodytes]
gi|114630839|ref|XP_001169264.1| PREDICTED: hexokinase 1 isoform 9 [Pan troglodytes]
Length = 921
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 49 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 108
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 109 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 168
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 169 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 225
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 226 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 281
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 282 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 341
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 342 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 401
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 402 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 435
Score = 75.1 bits (183), Expect = 9e-12, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + +++ M+P + D ++ + +D GGTNFR +V KK
Sbjct: 498 EMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 557
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 558 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 616
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 617 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 673
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 674 P-----SCEVGLIVGTGSNACY-----MEEMKNVETVEGDQGQMCINMEWGAFGDNGCLD 723
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 724 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 782
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 783 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 838
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 839 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 869
>gi|3891376|pdb|1HKC|A Chain A, Recombinant Human Hexokinase Type I Complexed With Glucose
And Phosphate
gi|6573639|pdb|1QHA|A Chain A, Human Hexokinase Type I Complexed With Atp Analogue
Amp-Pnp
gi|6573640|pdb|1QHA|B Chain B, Human Hexokinase Type I Complexed With Atp Analogue
Amp-Pnp
Length = 917
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 494 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D++++E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 720 DI-RTHYDRLVNEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|51511835|gb|AAU05129.1| hexokinase [Aedes aegypti]
Length = 461
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 90/396 (22%), Positives = 172/396 (43%), Gaps = 39/396 (9%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
IE LL+++ +GL + + + + + + K + +D GGTNFR ++
Sbjct: 33 IEEIMRRLLKEINRGLGKATQPEADIKWFITYVQDLANGKEKGKFLALDLGGTNFRVLLI 92
Query: 79 YFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSY 132
+ + E+LS + +P + + FD IAE L E + + F FS+
Sbjct: 93 HLKDENDFEMLSKI-YAIPQSIMLGSGTQLFDHIAECLANFMKEHSVYEEKLPLGFTFSF 151
Query: 133 AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQS 192
+ G + +K + + + L A++R+G +I+ ++NDT L S
Sbjct: 152 PLTQLGLTKGILARWTKGFNCSGVVGEDVVQLLKDAIARRGDVQIEICAILNDTTGTLMS 211
Query: 193 GIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQ-------IIVCESG 245
+ + + IG ++GTG N+ Y+E K++ E +D P+ +I E G
Sbjct: 212 CAW-----KNHNCRIGLIVGTGSNACYVE-----KVENCEMFDGPKDPKKEHVLINTEWG 261
Query: 246 K-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FSP 299
+ ++++D+ + S E+M SG Y+GEL +A+ + G+ F
Sbjct: 262 AFGDNGALDFVRTEYDREIDHFSINPGRQIQEKMISGMYMGELARLAIVKFTRAGLLFGG 321
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQN----HDKNIFSGIIEAHSVSEDYVKIYSICKCFFE 355
+ +L F T+ +S ++ + +++ + H+ ED + IC+C
Sbjct: 322 VGSDILFKRGQFFTKYVSEIESDKPGTYMYCRDVLDELGLEHATDEDCANVRYICECVSS 381
Query: 356 RAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
RA L +A IAA K +K + + DGS++
Sbjct: 382 RAAHLVSAGIAALI-----NKMDEKSVTVGVDGSVY 412
>gi|114630829|ref|XP_001169069.1| PREDICTED: hexokinase 1 isoform 2 [Pan troglodytes]
Length = 971
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 99 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 158
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 159 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 218
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 219 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 275
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 276 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 331
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 332 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 391
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 392 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 451
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 452 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 485
Score = 75.1 bits (183), Expect = 9e-12, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + +++ M+P + D ++ + +D GGTNFR +V KK
Sbjct: 548 EMELGLRKQTHNNAAVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 607
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 608 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 666
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 667 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 723
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 724 P-----SCEVGLIVGTGSNACY-----MEEMKNVETVEGDQGQMCINMEWGAFGDNGCLD 773
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 774 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 832
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 833 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 888
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 889 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 919
>gi|116242516|sp|P19367|HXK1_HUMAN Hexokinase-1 (Hexokinase type I) (HK I) (Brain form hexokinase)
gi|3319075|pdb|1HKB|A Chain A, Crystal Structure Of Recombinant Human Brain Hexokinase
Type I Complexed With Glucose And Glucose-6-Phosphate
gi|3319076|pdb|1HKB|B Chain B, Crystal Structure Of Recombinant Human Brain Hexokinase
Type I Complexed With Glucose And Glucose-6-Phosphate
gi|2873349|gb|AAC15862.1|AAC15862 hexokinase I [Homo sapiens]
gi|14250554|gb|AAH08730.1| Hexokinase 1 [Homo sapiens]
gi|55665506|emb|CAH71506.1| hexokinase 1 [Homo sapiens]
gi|123993211|gb|ABM84207.1| hexokinase 1 [synthetic construct]
gi|124000505|gb|ABM87761.1| hexokinase 1 [synthetic construct]
Length = 917
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 74.3 bits (181), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 494 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 720 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|33303851|gb|AAQ02439.1| hexokinase 1 [synthetic construct]
Length = 918
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 74.3 bits (181), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 494 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 720 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|121715264|ref|XP_001275241.1| hexokinase Kxk, putative [Aspergillus clavatus NRRL 1]
gi|119403398|gb|EAW13815.1| hexokinase Kxk, putative [Aspergillus clavatus NRRL 1]
Length = 490
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 116/435 (26%), Positives = 196/435 (45%), Gaps = 49/435 (11%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+KE +D F + K +++ ++++++GL E ++ M W D +
Sbjct: 27 IKEFEDMFTVDRTKLKQVVDH----FVKELEQGLTVEGGNIP---MNVTWVMGFPDGDEQ 79
Query: 61 KKVIIIDAGGTNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
+ +D GGTN R I ++KG +I K+ MP + T EE ++ IA+ L+
Sbjct: 80 GTFLALDMGGTNLRVCEITLTEEKGAFDICQS-KYRMPEELKTGTAEELWEYIADCLQQF 138
Query: 120 KD---ESDMIS-----FCFSY-AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
D E + +S F FSY A + + D G + +K + + + L L
Sbjct: 139 IDFHHEDEELSQLPLGFTFSYPATQDYIDHGVLQ-RWTKGFDIDGVEGQDVVPPLEAILQ 197
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLK 229
+KG IK ++NDT L + +++ + + IG + GTG+N+AY++ G + KL
Sbjct: 198 KKGLP-IKVAALINDTTGTLIASAYTDPEMK-----IGCIFGTGVNAAYMDNVGSVPKLA 251
Query: 230 TTEFY-DKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC 284
D P I CE G + +P +K+D I+ +S + E+M +G YLGE+
Sbjct: 252 HMNLPPDMPVAINCEYGAFDNEHIVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIF 311
Query: 285 SIAL------RAGSA-EGIFSPRVNKMLLNSCDF--STEEISLFLKEQNHDKNIFSGIIE 335
+AL R G EG + ++ K L F + EE E+ + +F +
Sbjct: 312 RLALIDLLDSRPGLIFEGQDTSKLRKPYLLDASFLAAIEEDPYENLEETQE--LFQRELN 369
Query: 336 AHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLKG 394
+ I + + RA RLSA +AA C K K+ ++ C + ADGS+F K
Sbjct: 370 IKPTQAELEMIRRLAELIGTRAARLSACGVAAIC----KKKNIER--CHVGADGSVFTKY 423
Query: 395 FLIKERIFKSLHTCL 409
K R ++L L
Sbjct: 424 PNFKARGAQALREIL 438
>gi|109089474|ref|XP_001110269.1| PREDICTED: similar to hexokinase 1 isoform HKI-ta/tb isoform 3
[Macaca mulatta]
gi|109089476|ref|XP_001110310.1| PREDICTED: similar to hexokinase 1 isoform HKI-ta/tb isoform 4
[Macaca mulatta]
Length = 921
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 49 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 108
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 109 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 168
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 169 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 225
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 226 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 281
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 282 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 341
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 342 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 401
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 402 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 435
Score = 78.6 bits (192), Expect = 8e-13, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 173/391 (44%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 498 EMELGLRKQTHNNAVVKMLPSFVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 557
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 558 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 616
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 617 AGILITWTKGFKAT---DCVGHDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 673
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q ++C ++G+ +
Sbjct: 674 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGLMCINMEWGAFGDNGRLD 723
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++++D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 724 DI-RTQYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKT 782
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 783 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 838
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 839 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 869
>gi|7245424|pdb|1CZA|N Chain N, Mutant Monomer Of Recombinant Human Hexokinase Type I
Complexed With Glucose, Glucose-6-Phosphate, And Adp
Length = 917
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DRAIDAYSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 74.3 bits (181), Expect = 1e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 494 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 720 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|7245352|pdb|1DGK|N Chain N, Mutant Monomer Of Recombinant Human Hexokinase Type I With
Glucose And Adp In The Active Site
Length = 917
Score = 84.7 bits (208), Expect = 1e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--HCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 278 DRAIDAYSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 338 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 398 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 72.4 bits (176), Expect = 5e-11, Method: Composition-based stats.
Identities = 87/391 (22%), Positives = 169/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GG NFR +V KK
Sbjct: 494 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGANFRVLLVKIRSGKKRTV 553
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 554 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 613 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 670 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 720 DI-RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|47212304|emb|CAF90567.1| unnamed protein product [Tetraodon nigroviridis]
Length = 959
Score = 84.3 bits (207), Expect = 1e-14, Method: Composition-based stats.
Identities = 102/420 (24%), Positives = 182/420 (43%), Gaps = 49/420 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
++++GL + +++ M+P + D ++ + +D GGTNFR +V + G
Sbjct: 545 EIERGLRKKTHQEATVKMLPTFVRSTPDGSENGDFLALDLGGTNFRVLLVKI-RSGKRRT 603
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDMIS------FCFSYAIKIFPDG 140
+ + +P + T EE FD I + D M S F FS+
Sbjct: 604 VEMHNKIYAIPIEVMQGTGEELFDHIVHCISDFLDYMGMKSARLPLGFTFSFPCHQTSLD 663
Query: 141 GGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K DC+ + E L +A+ RK ++ + +VNDT + + + E
Sbjct: 664 AGTLVTWTKGFKAT---DCEGEDVVELLREAIKRKEEFELDVVAIVNDTVGTMMTCAYEE 720
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTE------FYDKPQIIVCESGKSNKI 250
+G + GTG N+ Y+E K IE ++ TE F D +G + I
Sbjct: 721 PT-----CEVGLIAGTGSNACYMEEMKNIEIVEGTEGAHWGAFGD--------NGCLDDI 767
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++++DK + ENS + + E+MCSG YLGE+ L + G +F ++++ L
Sbjct: 768 -RTRYDKAVDENSLNEGKQRYEKMCSGMYLGEIVRQILIDLTKRGFLFRGQISETLKTRG 826
Query: 310 DFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
F T+ FL + D+ + + S +D + + +C RA ++ A
Sbjct: 827 IFETK----FLSQIESDRLALLQVRAILQQLGLDSTCDDSIIVKEVCGTVSRRAAQICGA 882
Query: 364 VIAAACIKTGKGKSPDK-PICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTN 422
+AA K + + D I + DG+++ K RIF+ L K + F+L +
Sbjct: 883 GMAAVVDKIRENRRLDHLDITVGVDGTLY-KLHPHFSRIFQQTVKDLAPKCDVNFLLSED 941
>gi|46107234|ref|XP_380676.1| conserved hypothetical protein [Gibberella zeae PH-1]
Length = 572
Score = 84.3 bits (207), Expect = 2e-14, Method: Composition-based stats.
Identities = 112/409 (27%), Positives = 176/409 (43%), Gaps = 42/409 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA-GIVYFDKKG 84
+ ++ KGL E S+ M P W D + + +D GGTN R I D+K
Sbjct: 128 FVSELAKGLSVEGGSIP---MNPTWVMSYPDGYETGTYLALDMGGTNLRVCQITLTDEKS 184
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAE----YLEP-----LKDESDMISFCFSY-AI 134
+I+ K+ MP + T+EE ++ IAE +LE K E + F FSY A
Sbjct: 185 EFDIIQS-KYRMPEELKSGTSEELWEYIAECLYQFLETHHGDCTKLEKIPLGFTFSYPAT 243
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
+ + D G + +K + + I +AL +G IK ++NDT L +
Sbjct: 244 QNYIDEGILQ-RWTKGFDIDGVEGQNIVPMFEEALKTRG-VPIKLAAIINDTTGTLIASA 301
Query: 195 FSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEF-YDKPQIIVCESGKSNK--- 249
+++T + IG + GTG N+AY+E G I K+ D P I CE G +
Sbjct: 302 YTDTAMK-----IGCIFGTGCNAAYMEDCGSIPKIADLNLPADLPMAINCEWGAFDNEHK 356
Query: 250 -IPQSKFDKILSENSNLKNEYFLERMCSGRYLGE---LCSIALRAGSAEGIFSPRVNKML 305
+P++ +D I+ + S + E+M +G YLGE L + L + IF + +L
Sbjct: 357 VLPRTPYDVIIDKESPRPGQQAFEKMIAGLYLGEIFRLILVDLHDNKSIHIFENQDIALL 416
Query: 306 LNSCDFSTEEISLFLKEQ----NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLS 361
+S ++ + ++FS + + I + RA RLS
Sbjct: 417 RKPYSLDASFLSAIEEDPWENLSETSDLFSKKLNLKCTQPELELIRRTAELIGTRAARLS 476
Query: 362 AAVIAAACIKTGKGKSPDKPIC-ISADGSMFLKGFLIKERIFKSLHTCL 409
A +AA C K + C + ADGS+F K KER K+L L
Sbjct: 477 ACGVAAIC------KKKNYQSCHVGADGSVFNKYPHFKERGAKALRDIL 519
>gi|79408026|ref|NP_188639.2| ATP binding / hexokinase [Arabidopsis thaliana]
gi|117949418|sp|Q56XE8|HXK4_ARATH Hexokinase-4
gi|9293958|dbj|BAB01861.1| chloroplast outer envelope hexokinase [Arabidopsis thaliana]
Length = 502
Score = 84.3 bits (207), Expect = 2e-14, Method: Composition-based stats.
Identities = 104/436 (23%), Positives = 182/436 (41%), Gaps = 44/436 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD-KKGVPE 87
+M+ GL SE S M ++ +LP + + GG+ FR V+ ++ E
Sbjct: 65 EMQAGLVSEGGSKLKM-LLTFVDDLPNG-SETGTYYALHLGGSYFRIIKVHLGGQRSSLE 122
Query: 88 ILSFFKHPMPALDREMTNEEFFDSIAEYLE--------------PLKDESDMISFCFSYA 133
+ +H +P T+E FD +A L+ PLK E ++F FS+
Sbjct: 123 VQDVERHSIPTSLMNSTSEVLFDFLASSLQRFIEKEGNDFSLSQPLKRE---LAFTFSFP 179
Query: 134 IKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
+K G IK +K + + I E L AL+++G I+ +VNDT L G
Sbjct: 180 VKQTSISSGVLIKWTKGFAISEMAGEDIAECLQGALNKRGLD-IRVAALVNDTVGALSFG 238
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIVCESGK--SNKI 250
F + D + V GTG N+ Y+E I K + ++ E G S+++
Sbjct: 239 HFHDPD-----TIAAVVFGTGSNACYLERTDAIIKCQNPRTTSGSMVVNMEWGNFWSSRL 293
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIFSPRVNKMLLNSC 309
P++ +D L S N+ E+M G YLG++ + LR IF P ++ +L
Sbjct: 294 PRTSYDLELDAESMNSNDMGFEKMIGGMYLGDIVRRVILRMSQESDIFGP-ISSILSTPF 352
Query: 310 DFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVK----IYSICKCFFER--------- 356
T +S ++ + + I++ VSE +K + IC R
Sbjct: 353 VLRTNSVSAMHEDDTSELQEVARILKDLGVSEVPMKVRKLVVKICDVVTRRAARLAAAGI 412
Query: 357 AGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
AG L + K + ++ +G ++L + +E + ++L L E +
Sbjct: 413 AGILKKVGRDGSGGGRRSDKQIMRRTVVAVEGGLYLNYRMFREYMDEALRDILGEDVAQH 472
Query: 417 FVLKTNDEAVTLGTAL 432
V+K ++ ++G+AL
Sbjct: 473 VVVKAMEDGSSIGSAL 488
>gi|125806651|ref|XP_001360104.1| GA20820-PA [Drosophila pseudoobscura]
gi|54635275|gb|EAL24678.1| GA20820-PA [Drosophila pseudoobscura]
Length = 454
Score = 84.3 bits (207), Expect = 2e-14, Method: Composition-based stats.
Identities = 102/412 (24%), Positives = 188/412 (45%), Gaps = 56/412 (13%)
Query: 14 DYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTN 72
DY++ Y S ++ KGL+ ++++ P + ++LPT + K + +D GGTN
Sbjct: 17 DYQVQEVY--SRFCAEISKGLKRSTHALANTKCFPTYVQDLPTG-DEMGKYLALDLGGTN 73
Query: 73 FRAGIV----YFDKKGVPEILSFFKHPM--PALDREMTNEEFFDSIAEYLEPLKDESDM- 125
FR +V + D +I + K M P + E FD IA+ L ++ +M
Sbjct: 74 FRVLLVSLKGHHDAMVESQIYAVPKDLMVGPGV-------ELFDHIADCLARFVEKHEMR 126
Query: 126 ---ISFCFSYAIKIFPDGGGQAI--KLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKI 180
+ F+++ G +AI + +K P + + L +A+ R+G +I +
Sbjct: 127 NSHLPLGFTFSFPCEQKGLKEAILTRWTKGFGCPGVEGEDVGRLLHEAIQRRGDAEIAVV 186
Query: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQI 239
++NDT L S + D IG ++GTG N+ Y+E ++ L ++ +
Sbjct: 187 AILNDTTGTLMS-----CAHRNADCRIGVIVGTGCNACYVEDVANVDLLHADFKRNQKDV 241
Query: 240 IV-------CESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCS-IALRAG 291
+V ESG+ + + ++++D+ + + S K+E E+M SG YLG L I +RA
Sbjct: 242 LVNAEWGAFGESGQLDFV-RTEYDREVDDTSINKSEQLFEKMTSGMYLGRLVRLILMRAM 300
Query: 292 SAEGIFSPRVNKMLLNSCDFSTEEI--SLFLKEQNHD--------KNIFSGI--IEAHSV 339
++ IF + + E++ + F+ E D + I + + +E SV
Sbjct: 301 QSKVIFKLSNRREHFATALQKNEDVFETRFISEIESDSFPEFSKTRTIITELFGLEKASV 360
Query: 340 SEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
ED KI IC+C +RA L A ++ + D+ + + DGS++
Sbjct: 361 -EDCQKIKYICECVSKRAATLVAIGVSGLI-----NRISDRRVVVGMDGSVY 406
>gi|3793|emb|CAA27203.1| unnamed protein product [Saccharomyces cerevisiae]
Length = 486
Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats.
Identities = 110/421 (26%), Positives = 178/421 (42%), Gaps = 74/421 (17%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVYFDK 82
+ +++KGL + ++ MIP W D P K+ + ID GGTN R +V
Sbjct: 48 FISELEKGLSKKGVNIP---MIPGWV---MDFPTGKESGDFLAIDLGGTNLRVVLVKLGG 101
Query: 83 KGVPEILSFFKHPMPALDREMTN-EEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGG 141
+ K+ +P R N +E ++ IA+ L+ DE FP G
Sbjct: 102 DRTFDTTQS-KYRLPDAMRTTQNPDELWEFIADSLKAFIDEQ-------------FPQGI 147
Query: 142 GQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW---------------KKIKK------- 179
+ I L P KINEG+ Q + KG+ K+I K
Sbjct: 148 SEPIPLGFTFSFP-ASQNKINEGILQRWT-KGFDIPNIENHDVVPMLQKQISKRNIPIEV 205
Query: 180 IIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFYD--- 235
+ ++NDT L + +++ + + +G + GTG+N AY + IEKL+ D
Sbjct: 206 VALINDTTGTLVASYYTDPE-----TKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPP 260
Query: 236 -KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRA 290
P I CE G + +P++K+D + E S + E+M SG YLGE+ +AL
Sbjct: 261 SAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMD 320
Query: 291 GSAEG-IFS----PRVNKMLLNSCDFSTE-EISLFLKEQNHDKNIFSGIIEAHSVSEDYV 344
+G IF + +K + + E F ++ D ++F ++ ++
Sbjct: 321 MYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTD-DLFQNEFGINTTVQERK 379
Query: 345 KIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKS 404
I + + RA RLS IAA C K G K I+ADGS++ + KE+ +
Sbjct: 380 LIRRLSELIGARAARLSVCGIAAICQKRGY-----KTGHIAADGSVYNRYPGFKEKAANA 434
Query: 405 L 405
L
Sbjct: 435 L 435
>gi|15233457|ref|NP_194642.1| ATHXK1 (GLUCOSE INSENSITIVE 2); ATP binding / hexokinase
[Arabidopsis thaliana]
gi|12644433|sp|Q42525|HXK1_ARATH Hexokinase-1 (Protein GLUCOSE INSENSITIVE 2)
gi|881521|gb|AAB49908.1| hexokinase 1
gi|4972059|emb|CAB43927.1| hexokinase [Arabidopsis thaliana]
gi|7269811|emb|CAB79671.1| hexokinase [Arabidopsis thaliana]
gi|18700107|gb|AAL77665.1| AT4g29130/F19B15_160 [Arabidopsis thaliana]
gi|21700789|gb|AAM70518.1| AT4g29130/F19B15_160 [Arabidopsis thaliana]
gi|110740344|dbj|BAF02067.1| hexokinase [Arabidopsis thaliana]
Length = 496
Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats.
Identities = 120/439 (27%), Positives = 176/439 (40%), Gaps = 38/439 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAGIVYF 80
A + +M GL S+ S M +I NLP+ D+K + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASDGGSKLKM-LISYVDNLPSG---DEKGLFYALDLGGTNFRVMRVLL 114
Query: 81 DKKGVPEILSFFKH-PMPALDREMTNEEFFDSIAEYLEPL-----------KDESDMISF 128
K + F+ +P ++E F+ IAE L + + F
Sbjct: 115 GGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGF 174
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ +K G IK +K + + L +AL R G ++ +VNDT
Sbjct: 175 TFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLD-MRIAALVNDTVG 233
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG-- 245
L G + D +LGTG N+AY+E I K +I E G
Sbjct: 234 TLAGGRYYNPDVVA-----AVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF 288
Query: 246 KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPRVNKM 304
+S+ +P ++FD L S E LE++ SG YLGE L + L+ F V
Sbjct: 289 RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSK 348
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNIFSG----IIEAHSVSEDYVKIY-SICKCFFERAGR 359
L T +S + + D I I+E + S K+ S+C R R
Sbjct: 349 LRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGAR 408
Query: 360 LSAAVIAAACIKTGKGKSPDKPI---CISADGSMFLKGFLIKERIFKSLHTCL-TEKRGI 415
LSAA I K G+ + D+ + I+ DG +F E + SL L E G
Sbjct: 409 LSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGS 468
Query: 416 YFVLKTNDEAVTLGTALAA 434
V +ND + +G AL A
Sbjct: 469 VEVTHSNDGS-GIGAALLA 486
>gi|109089484|ref|XP_001110189.1| PREDICTED: similar to hexokinase 1 isoform HKI-td isoform 1 [Macaca
mulatta]
Length = 827
Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats.
Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 33 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 92
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 93 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKID 152
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 153 EAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 209
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 210 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 265
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + EG +F R+ LL F+T
Sbjct: 266 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 325
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D V + +C R+ L AA + A +
Sbjct: 326 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRL 385
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 386 RDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 419
Score = 65.9 bits (159), Expect = 5e-09, Method: Composition-based stats.
Identities = 71/307 (23%), Positives = 137/307 (44%), Gaps = 30/307 (9%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 482 EMELGLRKQTHNNAVVKMLPSFVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 541
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 542 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 600
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
G I +K K + L A+ R+ + + +VNDT + + + E
Sbjct: 601 AGILITWTKGFKATDCVGHDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEP-- 658
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKIP 251
+G ++GTG N+ Y +E++K E + Q ++C ++G+ + I
Sbjct: 659 ---TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGLMCINMEWGAFGDNGRLDDI- 709
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCD 310
++++D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 710 RTQYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGI 769
Query: 311 FSTEEIS 317
F T+ +S
Sbjct: 770 FETKFLS 776
>gi|6321184|ref|NP_011261.1| Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in
the cytosol; predominant hexokinase during growth on
glucose; functions in the nucleus to repress expression
of HXK1 and GLK1 and to induce expression of its own
gene [Saccharomyces cerevisiae]
gi|417162|sp|P04807|HXKB_YEAST Hexokinase-2 (Hexokinase-B) (Hexokinase PII)
gi|14278239|pdb|1IG8|A Chain A, Crystal Structure Of Yeast Hexokinase Pii With The Correct
Amino Acid Sequence
gi|1150586|emb|CAA64134.1| HXK2 alternate name HEX1;SCI2;HKB [Saccharomyces cerevisiae]
gi|1322931|emb|CAA96973.1| HXK2 [Saccharomyces cerevisiae]
gi|151943566|gb|EDN61876.1| hexokinase II (PII) (also called hexokinase B) [Saccharomyces
cerevisiae YJM789]
Length = 486
Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats.
Identities = 110/421 (26%), Positives = 178/421 (42%), Gaps = 74/421 (17%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVYFDK 82
+ +++KGL + ++ MIP W D P K+ + ID GGTN R +V
Sbjct: 48 FISELEKGLSKKGGNIP---MIPGWV---MDFPTGKESGDFLAIDLGGTNLRVVLVKLGG 101
Query: 83 KGVPEILSFFKHPMPALDREMTN-EEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGG 141
+ K+ +P R N +E ++ IA+ L+ DE FP G
Sbjct: 102 DRTFDTTQS-KYRLPDAMRTTQNPDELWEFIADSLKAFIDEQ-------------FPQGI 147
Query: 142 GQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW---------------KKIKK------- 179
+ I L P KINEG+ Q + KG+ K+I K
Sbjct: 148 SEPIPLGFTFSFP-ASQNKINEGILQRWT-KGFDIPNIENHDVVPMLQKQITKRNIPIEV 205
Query: 180 IIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFYD--- 235
+ ++NDT L + +++ + + +G + GTG+N AY + IEKL+ D
Sbjct: 206 VALINDTTGTLVASYYTDPE-----TKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPP 260
Query: 236 -KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRA 290
P I CE G + +P++K+D + E S + E+M SG YLGE+ +AL
Sbjct: 261 SAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMD 320
Query: 291 GSAEG-IFS----PRVNKMLLNSCDFSTE-EISLFLKEQNHDKNIFSGIIEAHSVSEDYV 344
+G IF + +K + + E F ++ D ++F ++ ++
Sbjct: 321 MYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTD-DLFQNEFGINTTVQERK 379
Query: 345 KIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKS 404
I + + RA RLS IAA C K G K I+ADGS++ + KE+ +
Sbjct: 380 LIRRLSELIGARAARLSVCGIAAICQKRGY-----KTGHIAADGSVYNRYPGFKEKAANA 434
Query: 405 L 405
L
Sbjct: 435 L 435
>gi|62320799|dbj|BAD93730.1| hexokinase [Arabidopsis thaliana]
Length = 480
Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats.
Identities = 104/436 (23%), Positives = 182/436 (41%), Gaps = 44/436 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD-KKGVPE 87
+M+ GL SE S M ++ +LP + + GG+ FR V+ ++ E
Sbjct: 43 EMQAGLVSEGGSKLKM-LLTFVDDLPNG-SETGTYYALHLGGSYFRIIKVHLGGQRSSLE 100
Query: 88 ILSFFKHPMPALDREMTNEEFFDSIAEYLE--------------PLKDESDMISFCFSYA 133
+ +H +P T+E FD +A L+ PLK E ++F FS+
Sbjct: 101 VQDVERHSIPTSLMNSTSEVLFDFLASSLQRFIEKEGNDFSLSQPLKRE---LAFTFSFP 157
Query: 134 IKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
+K G IK +K + + I E L AL+++G I+ +VNDT L G
Sbjct: 158 VKQTSISSGVLIKWTKGFAISEMAGEDIAECLQGALNKRGLD-IRVAALVNDTVGALSFG 216
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIVCESGK--SNKI 250
F + D + V GTG N+ Y+E I K + ++ E G S+++
Sbjct: 217 HFHDPD-----TIAAVVFGTGSNACYLERTDAIIKCQNPRTTSGSMVVNMEWGNFWSSRL 271
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIFSPRVNKMLLNSC 309
P++ +D L S N+ E+M G YLG++ + LR IF P ++ +L
Sbjct: 272 PRTSYDLELDAESMNSNDMGFEKMIGGMYLGDIVRRVILRMSQESDIFGP-ISSILSTPF 330
Query: 310 DFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVK----IYSICKCFFER--------- 356
T +S ++ + + I++ VSE +K + IC R
Sbjct: 331 VLRTNSVSAMHEDDTSELQEVARILKDLGVSEVPMKVRKLVVKICDVVTRRAARLAAAGI 390
Query: 357 AGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
AG L + K + ++ +G ++L + +E + ++L L E +
Sbjct: 391 AGILKKVGRDGSGGGRRSDKQIMRRTVVAVEGGLYLNYRMFREYMDEALRDILGEDVAQH 450
Query: 417 FVLKTNDEAVTLGTAL 432
V+K ++ ++G+AL
Sbjct: 451 VVVKAMEDGSSIGSAL 466
>gi|19113860|ref|NP_592948.1| hypothetical protein SPAC24H6.04 [Schizosaccharomyces pombe 972h-]
gi|1170446|sp|Q09756|HXK1_SCHPO Hexokinase-1
gi|984701|emb|CAA90848.1| SPAC24H6.04 [Schizosaccharomyces pombe]
gi|1160508|emb|CAA63487.1| hexokinase 1 [Schizosaccharomyces pombe]
Length = 484
Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats.
Identities = 105/430 (24%), Positives = 178/430 (41%), Gaps = 34/430 (7%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV 85
+ ++ KGL + V M+P W D + + +D GGTN R V G
Sbjct: 52 FVSELYKGLTTNPGDVP---MVPTWIIGTPDGNEHGSYLALDLGGTNLRVCAVEVQGNGK 108
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIA-------EYLEPLKDESDMISFCFSYAIKIFP 138
+I K+ +P + T E FD IA E + P K ++ I F FSY
Sbjct: 109 FDITQS-KYRLPQELKVGTREALFDYIADCIKKFVEEVHPGKSQNLEIGFTFSYPCVQRS 167
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
+ +K + + + L AL R G ++ +++DT L + ++
Sbjct: 168 INDASLVAWTKGFDIDGVEGESVGPLLSAALKRVGCNNVRLNAILSDTTGTLVASNYASP 227
Query: 199 DDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEF-YDKPQIIVCE----SGKSNKIPQ 252
+ IG + GTG N+ YIE + +I KL +F D II CE + +P+
Sbjct: 228 G-----TEIGVIFGTGCNACYIEKFSEIPKLHKYDFPEDMNMIINCEWCDFDNQHVVLPR 282
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPR-VNK----MLL 306
+K+D + E S E+M +G YLG+ L I L +F+ + V K + +
Sbjct: 283 TKYDVAIDEESPRPGLQTYEKMIAGCYLGDILRRILLDLYEQGALFNGQDVTKIRDPLAM 342
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIA 366
++ S E+ F + + + +F + E+ I C+ R+ RLSA +
Sbjct: 343 DTSVLSAIEVDPF-ENLDETQTLFEETYGLKTTEEERQFIRRACELIGTRSARLSACGVC 401
Query: 367 AACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAV 426
A K K + + DGS++ K+R+ ++ L E+ G V ++
Sbjct: 402 ALVRKMNK-----PSMIVGTDGSVYNLYPRFKDRLAQAFKDILGEEIGSKVVTIPAEDGS 456
Query: 427 TLGTALAAFL 436
+G AL + L
Sbjct: 457 GVGAALVSAL 466
>gi|7110599|ref|NP_036697.1| glucokinase [Rattus norvegicus]
gi|56240|emb|CAA37657.1| unnamed protein product [Rattus norvegicus]
gi|204332|gb|AAA41229.1| glucokinase (EC 2.7.1.1)
gi|204344|gb|AAA41230.1| glucokinase gene
gi|149047654|gb|EDM00324.1| glucokinase, isoform CRA_b [Rattus norvegicus]
Length = 465
Score = 83.6 bits (205), Expect = 2e-14, Method: Composition-based stats.
Identities = 104/440 (23%), Positives = 192/440 (43%), Gaps = 38/440 (8%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ S + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYEDR-----QCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDK---NIFSGIIEAHSVSE-DYVKIYSICKCFFE 355
++ L F T +S + K NI S + SV++ D V+ C+
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVR--RACESVST 376
Query: 356 RAGRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRG 414
RA + +A +A + + +S D I + DGS++ KER S+ LT
Sbjct: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPNCE 435
Query: 415 IYFVLKTNDEAVTLGTALAA 434
I F+ ++E G AL +
Sbjct: 436 ITFI--ESEEGSGRGAALVS 453
>gi|125982385|ref|XP_001355083.1| GA15574-PA [Drosophila pseudoobscura]
gi|54643395|gb|EAL32139.1| GA15574-PA [Drosophila pseudoobscura]
Length = 549
Score = 83.6 bits (205), Expect = 2e-14, Method: Composition-based stats.
Identities = 98/440 (22%), Positives = 194/440 (44%), Gaps = 58/440 (13%)
Query: 26 LLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG 84
+L ++++GL + +++ + ++LP + K + +D GGTNFR +++ +
Sbjct: 124 ILHEIRRGLAKDTHPKANVKCFVTYVQDLPNGDERGK-FLALDLGGTNFRVLLIHLQENN 182
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
++ S + +P + + FD IAE L E ++ + F FS+ ++
Sbjct: 183 DFQMESRI-YAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYAERLPLGFTFSFPLRQLG 241
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G +K + + + + L A++R+G +I ++NDT L S +
Sbjct: 242 LTCGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAW--- 298
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYD-----KPQIIV-------CESGK 246
+ IG ++GTG N+ Y+E +++ E +D KP +++ ++G
Sbjct: 299 --KNHHCRIGLIVGTGSNACYVE-----RVEEAELFDAQGNRKPHVLINTEWGAFGDNGA 351
Query: 247 SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLL 306
+ + +++FD+ + +S + E+M SG Y+GEL + L + GI + +L
Sbjct: 352 LDFV-RTEFDQDIDSHSINPGKQTFEKMISGMYMGELVRLVLVKMTHAGILFKGQDSEVL 410
Query: 307 NSCD-FSTEEISLFLKEQ----NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLS 361
N+ F T+ +S ++ + + +F + ++ D + IC+C +RA L
Sbjct: 411 NTRGLFFTKYVSEIEADEPGTFTNCRLVFEELGLTNATDGDCANVRYICECVSKRAAHLV 470
Query: 362 AAVIAAACIKTGKGKSPDKP-ICISADGSMFLKGFLIKERIFKSLHTCLTE------KRG 414
+A IA K D+P + + DGS++ R H + E K G
Sbjct: 471 SAGIATLINKM------DEPHVTVGVDGSVY--------RFHPKFHNLMVEKITKLIKPG 516
Query: 415 IYFVLKTNDEAVTLGTALAA 434
I F L +++ G AL A
Sbjct: 517 ITFDLMLSEDGSGRGAALVA 536
>gi|71009859|ref|XP_758320.1| hypothetical protein UM02173.1 [Ustilago maydis 521]
gi|46098062|gb|EAK83295.1| hypothetical protein UM02173.1 [Ustilago maydis 521]
Length = 473
Score = 83.6 bits (205), Expect = 2e-14, Method: Composition-based stats.
Identities = 101/399 (25%), Positives = 165/399 (41%), Gaps = 36/399 (9%)
Query: 42 SSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALD 100
+ M MIP + +PT K + +D GGTN R V D KG I K+ +
Sbjct: 47 AEMQMIPSFVTGVPTGSEKGT-YLALDLGGTNLRVCEVALDGKGTFAIKQE-KYKVSDQL 104
Query: 101 REMTNEEFFD----SIAEYLEPLKDESD----MISFCFSYAIKIFPDGGGQAIKLSKEIK 152
++ + FD S+ +L S + F FS+ ++ G I +K
Sbjct: 105 KQGPVRDLFDYMATSVDNFLTDFGTSSTEDVLHLGFTFSFPVEQTAIDSGHLIHWTKGFN 164
Query: 153 LPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLG 212
P + + L +AL RK K +K +VNDT L + ++ + I + G
Sbjct: 165 CPDAPGKDVVQLLQEALDRKHIK-VKCSALVNDTVGALLAHAYASNG-----ALISAIFG 218
Query: 213 TGLNSAYIEY-GKIEKLKTTEFYDKPQIIVCESG----KSNKIPQSKFDKILSENSNLKN 267
TG N AY+E+ KI+KLKT +I E G +P + +D + S
Sbjct: 219 TGTNGAYLEHISKIKKLKTAHGSVSHMVINTEWGGFDDDRKALPVTIYDNQVDRESIRPR 278
Query: 268 EYFLERMCSGRYLGELCS-IALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD 326
+ E+M SG YLGE+ + L +F +K+ F T +S +
Sbjct: 279 NHIFEKMISGMYLGEVARCVLLHLVDQLVLFQGFSSKLFNTQYAFDTAYMSAIEADTQDA 338
Query: 327 KNIFSG----IIEAHSVSEDYVK------IYSICKCFFERAGRLSAAVIAAACIKTGKGK 376
+ S +++ + ++YV + +IC RA RLSA IAA ++TG +
Sbjct: 339 ASPTSATRKVLVQTMQIKDEYVSAEDVETVRTICNIVGTRAARLSAVAIAATMVQTGNVQ 398
Query: 377 SP---DKPICISADGSMFLKGFLIKERIFKSLHTCLTEK 412
D + + DGS+ +ER+ +L + E+
Sbjct: 399 GTGLNDDGVKVGMDGSVIEYYPYFEERMRGALRELIGEQ 437
>gi|125833087|ref|XP_001333260.1| PREDICTED: similar to Hexokinase domain containing 1 [Danio rerio]
Length = 919
Score = 83.6 bits (205), Expect = 2e-14, Method: Composition-based stats.
Identities = 94/414 (22%), Positives = 176/414 (42%), Gaps = 40/414 (9%)
Query: 2 KEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDK 61
KEIDD +E + +E +++GL+ E +S+ M+P + D +
Sbjct: 468 KEIDDTLAAFALTSTQLLEVKQKMHVE-LERGLKKETHPTASVKMLPTYVYRTPDGTERG 526
Query: 62 KVIIIDAGGTNFRAGIVYFDKKGVPEILSFFK--HPMPALDREMTNEEFFDSIAEYLEPL 119
K + +D GGTNFR +V + G+ + + + +P + T EE FD I + +
Sbjct: 527 KYLALDLGGTNFRVLVVKI-RTGMRNSVRMYNKIYAIPLEIMQGTGEELFDHIVQCISDF 585
Query: 120 KDESDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKG 173
D M + F FS+ G + +K K + + L +A+ R+
Sbjct: 586 LDYMGMKNTRLPLGFTFSFPCNQTGIDKGDLVCWTKGFKATDCEGYDVVDMLREAIKRRN 645
Query: 174 WKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF 233
+ + +VNDT + + + + Q IG + GTG N Y +E++K E
Sbjct: 646 EFDLDIVAIVNDTVGTMMTCAYEDPKCQ-----IGLIAGTGSNVCY-----MEEMKNIEI 695
Query: 234 YDKPQIIVCES------GKSNKIP--QSKFDKILSENSNLKNEYFLERMCSGRYLGELCS 285
+ + +C + G+++ I ++++D+ + S + E+M SG YLGE+
Sbjct: 696 VEGDEGQMCVNTEWGGFGENDNIEDIRTRYDREVDSGSLNAGKQRFEKMTSGMYLGEIVR 755
Query: 286 IALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHS 338
L + G +F R+ + L F T+ FL + D+ + + S
Sbjct: 756 QILIDLTKRGFLFRGRITERLKTKGIFETK----FLSQIESDRLALLQVRCILQSLGLDS 811
Query: 339 VSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+D + + +C RA +L A +AA K + + D+ I + DG+++
Sbjct: 812 TCDDSIIVKEVCGAVSRRAAQLCGAGMAAIVDKIRENRGLDRLDITVGVDGTLY 865
Score = 70.1 bits (170), Expect = 3e-10, Method: Composition-based stats.
Identities = 83/334 (24%), Positives = 147/334 (44%), Gaps = 27/334 (8%)
Query: 1 MKEIDDFF--KRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIP 58
+K++D F R + D DI +A LE M+KGL SE+ + +++ M+P D
Sbjct: 19 IKKVDRFLYAMRLSEDQLKDI--SARFRLE-MEKGLSSESNAAAAVKMLPTHVYSTPDGS 75
Query: 59 KDKKVIIIDAGGTNFRAGIVYF--DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL 116
+ + + +D GG+ F+ V D KG E+ S P+P E F+ +AE L
Sbjct: 76 EKGEFLALDLGGSKFKVLQVKVSEDGKGKVEMES-ETFPIPEEIVNGRGTELFEHVAESL 134
Query: 117 EPLKDESDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+ + + + F FS+ G + SK K+ + + + L +A+
Sbjct: 135 KSFLQKHHINHTRKPLGFTFSFPCAQSKIDEGVLLSWSKNFKVRGVQGTNVVQSLRKAIR 194
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKT 230
+ G + + MVNDT + + + DDQ + +G ++GTG N+ Y+E ++ +
Sbjct: 195 KVGDLDVDVLAMVNDTVGAMMTCGY---DDQ--NCEVGVIVGTGTNACYME--EMRHIDL 247
Query: 231 TEFYDKPQIIVCESGKSNKIPQ-----SKFDKILSENSNLKNEYFLERMCSGRYLGELCS 285
E + I E G + FD+ + S + E+M SG Y+GEL
Sbjct: 248 VEGDEGRMCINTEWGAFGDDGVLDDFITSFDREIDAASINPGKQLFEKMVSGMYMGELVR 307
Query: 286 IALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISL 318
+ L + +G +F +++ L F T + L
Sbjct: 308 LILLRMAKKGLLFRGQISDALRTKGTFHTNHMCL 341
>gi|30316354|sp|P17710|HXK1_MOUSE Hexokinase-1 (Hexokinase type I) (HK I) (Hexokinase, tumor isozyme)
Length = 974
Score = 83.6 bits (205), Expect = 3e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 101 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 160
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 161 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 220
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 221 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 277
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 278 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 333
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 334 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 393
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 394 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 450
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 451 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 487
Score = 80.1 bits (196), Expect = 2e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 547 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 606
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 607 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 664
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 665 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 721
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 722 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 771
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 772 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 830
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 831 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 886
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 887 AQLCGAGMAAVVQKIRENRGLDHLNVTVGVDGTLY 921
>gi|619928|gb|AAA60333.1| hexokinase [Arabidopsis thaliana]
gi|1582383|prf||2118367A hexokinase
Length = 435
Score = 83.6 bits (205), Expect = 3e-14, Method: Composition-based stats.
Identities = 119/433 (27%), Positives = 174/433 (40%), Gaps = 38/433 (8%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAGIVYFDKKGVP 86
+M GL S+ S M +I NLP+ D+K + +D GGTNFR V K
Sbjct: 4 EMHAGLASDGGSKLKM-LISYVDNLPSG---DEKGLFYALDLGGTNFRVMRVLLGGKQER 59
Query: 87 EILSFFKH-PMPALDREMTNEEFFDSIAEYLEPL-----------KDESDMISFCFSYAI 134
+ F+ +P ++E F+ IAE L + + F FS+ +
Sbjct: 60 VVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPV 119
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
K G IK +K + + L +AL R G ++ +VNDT L G
Sbjct: 120 KQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLD-MRIAALVNDTVGTLAGGR 178
Query: 195 FSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG--KSNKIP 251
+ D +LGTG N+AY+E I K +I E G +S+ +P
Sbjct: 179 YYNPDVVA-----AVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLP 233
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPRVNKMLLNSCD 310
++FD L S E LE++ SG YLGE L + L+ F V L
Sbjct: 234 LTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFI 293
Query: 311 FSTEEISLFLKEQNHDKNIFSG----IIEAHSVSEDYVKIY-SICKCFFERAGRLSAAVI 365
T +S + + D I I+E + S K+ S+C R RLSAA I
Sbjct: 294 IRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGI 353
Query: 366 AAACIKTGKGKSPDKPI---CISADGSMFLKGFLIKERIFKSLHTCL-TEKRGIYFVLKT 421
K G+ + D+ + I+ DG +F E + SL L E G V +
Sbjct: 354 YGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHS 413
Query: 422 NDEAVTLGTALAA 434
ND + +G AL A
Sbjct: 414 NDGS-GIGAALLA 425
>gi|145234396|ref|XP_001400569.1| hexokinase hxk-Aspergillus niger
gi|4140255|emb|CAA08922.1| hexokinase [Aspergillus niger]
gi|134057515|emb|CAK48869.1| hexokinase hxk-Aspergillus niger
Length = 490
Score = 83.6 bits (205), Expect = 3e-14, Method: Composition-based stats.
Identities = 118/435 (27%), Positives = 196/435 (45%), Gaps = 46/435 (10%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+++I DF + D + ++ + +++++KGL E ++ M W D +
Sbjct: 24 LQQIKDFEDQFTVD-RSKLKQIVNHFVKELEKGLSVEGGNIP---MNVTWVLGFPDGDEQ 79
Query: 61 KKVIIIDAGGTNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
+ +D GGTN R I +KG +I K+ MP + T EE ++ IA+ L+
Sbjct: 80 GTFLALDMGGTNLRVCEITLTQEKGAFDITQS-KYRMPEELKTGTAEELWEYIADCLQQF 138
Query: 120 KD---ESDMIS-----FCFSY-AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+ E++ IS F FSY A + + D G + +K + + + L L
Sbjct: 139 IESHHENEKISKLPLGFTFSYPATQDYIDHGVLQ-RWTKGFDIDGVEGHDVVPPLEAILQ 197
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLK 229
++G IK ++NDT L + ++++D + IG + GTG+N+AY+E G I KL
Sbjct: 198 KRGLP-IKVAALINDTTGTLIASSYTDSDMK-----IGCIFGTGVNAAYMENAGSIPKLA 251
Query: 230 TTEF-YDKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC 284
D P I CE G + +P +K+D I+ +S + E+M +G YLGE+
Sbjct: 252 HMNLPADMPVAINCEYGAFDNEHIVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIF 311
Query: 285 SIAL------RAGSA-EGIFSPRVNKMLLNSCDF--STEEISLFLKEQNHDKNIFSGIIE 335
+AL R G G + ++ K + F + EE E+ + I+
Sbjct: 312 RLALMDLVENRPGLIFNGQDTTKLRKPYILDASFLAAIEEDPYENLEETEELMERELNIK 371
Query: 336 AHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLKG 394
A + ++ + + RA RLSA +AA C K K D C + ADGS+F K
Sbjct: 372 ATPAELEMIR--RLAELIGTRAARLSACGVAAICTK----KKIDS--CHVGADGSVFTKY 423
Query: 395 FLIKERIFKSLHTCL 409
K R K+L L
Sbjct: 424 PHFKARGAKALREIL 438
>gi|50424765|ref|XP_460972.1| hypothetical protein DEHA0F15169g [Debaryomyces hansenii CBS767]
gi|49656641|emb|CAG89330.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 482
Score = 83.2 bits (204), Expect = 3e-14, Method: Composition-based stats.
Identities = 110/430 (25%), Positives = 173/430 (40%), Gaps = 98/430 (22%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVY------ 79
+++KGL + ++ MIP W D P K+ + ID GGTN R +V
Sbjct: 51 ELEKGLSKQGGNIP---MIPGWV---LDFPTGKEKGDYLAIDLGGTNLRVVLVKLGGNRD 104
Query: 80 FDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPD 139
FD K +P R T++E + IAE L+ E FP
Sbjct: 105 FDTTQS-------KFALPETMRTATSDELWTFIAECLKKFVQEE-------------FPQ 144
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW---------------KKIKKI---- 180
G + + L P IN G+ Q + KGW K I+K+
Sbjct: 145 GCTKPLPLGFTFSYP-ASQKSINTGVLQRWT-KGWDIDGVEGHDVVPMLQKAIEKVGVPI 202
Query: 181 ---IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFYD- 235
++NDT L + ++++ + + +G + GTG N AY + I KL+ D
Sbjct: 203 NVVALINDTTGTLVASMYTDAE-----TRMGLIYGTGCNGAYYDVVSDIPKLEGKMPSDV 257
Query: 236 ---KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
P I CE G + +P++K+D ++ + S + E+M SG YLGE+ + L
Sbjct: 258 DQSAPMAINCEYGAFDNELVVLPRTKYDILIDKQSPRPGQQSYEKMISGYYLGEVLRLIL 317
Query: 289 RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLK-------EQNHDKN------IFSGIIE 335
+ E K++ D S E L E++ +N +F +
Sbjct: 318 LDLAKE-------KKLIFKGQDLSKLETEFILDTSFPSRIEEDPFENLSDTAELFQKELG 370
Query: 336 AHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGF 395
+ S + I + + ER+ RL IAA C K G K +ADGS++ K
Sbjct: 371 IQTTSPERKIIRRLAELIGERSARLFVCGIAAICKKRGY-----KTAHCAADGSVYNKYP 425
Query: 396 LIKERIFKSL 405
+KER K+L
Sbjct: 426 GVKERTAKAL 435
>gi|49114981|gb|AAH72832.1| Hk1-A protein [Xenopus laevis]
Length = 916
Score = 83.2 bits (204), Expect = 3e-14, Method: Composition-based stats.
Identities = 92/384 (23%), Positives = 164/384 (42%), Gaps = 33/384 (8%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR---AGIVYFDKKGV 85
+M GL + + + M+P + D + I +D GG+NFR + + K+ V
Sbjct: 46 EMANGLSRDTNPTAIIKMLPTFVRSIPDGTEKGDFIALDLGGSNFRILRVKVSHEKKQTV 105
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPD 139
+ P + T FD +AE L + +KD+ + F FS+
Sbjct: 106 QMESEIYDTPEDIIHGSGT--RLFDHVAECLGDFMQKKQIKDKKLPVGFTFSFPCIQTKI 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
G + +K K + + + L +A+ ++G + + +VNDT + + F D
Sbjct: 164 DEGVLVTWTKRFKASGVEGMDVVKLLNRAIKKRGDYEADIMAVVNDTVGTMMTCGF---D 220
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSN-----KIPQSK 254
DQ +G ++GTG N+ Y+E ++ + E + I E G + +++
Sbjct: 221 DQ--RCEVGIIIGTGTNACYME--ELRHIDMVEGDEGRMCINTEWGAFGDEGCLEDIRTE 276
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFST 313
FD+ + S + E+M SG Y+GEL + L + EG +F R+ LL F T
Sbjct: 277 FDREIDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFET 336
Query: 314 EEISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAA 368
+ IS K + + K+I + G+ +H ED + + +C R+ L AA +
Sbjct: 337 KHISAIEKSKEGLSKAKDILTRLGVEPSH---EDCIAVQHVCTIVSFRSANLVAATLGGI 393
Query: 369 CIKTGKGKS-PDKPICISADGSMF 391
I+ K P + DGS++
Sbjct: 394 LIRLRDNKGVPRLRTTVGIDGSLY 417
Score = 70.5 bits (171), Expect = 2e-10, Method: Composition-based stats.
Identities = 86/391 (21%), Positives = 164/391 (41%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+M+ GL + + + M+ + D ++ + +D GGTNFR +V + G
Sbjct: 494 EMENGLRKKTHESAKVKMLATFVRSTPDGTENGDFLALDLGGTNFRVLLVKI-RSGKRRT 552
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + +P + T EE FD I + D + + F FS+ K
Sbjct: 553 VEMHNKIYAIPTDVMQGTGEELFDHIVHCISDFLDYMGIKGARLPLGFTFSFPCKQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K DC+ + L + + R+ + + +VNDT + + + +
Sbjct: 613 AGILVTWTKGFKST---DCEGEDVVNLLREGIKRREEFDLDVVAIVNDTVGTMMTCAYED 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+ IG ++GTG N+ Y +E+ K E D Q +C ++G +
Sbjct: 670 P-----NCEIGLIVGTGSNACY-----MEETKNIEMVDGEQGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +DK + E S + E+M SG YLGE+ L + G +F ++++ L
Sbjct: 720 DI-RTVYDKAVDELSLNSGKQRYEKMISGMYLGEIVRNILIDFTKRGFLFRGQISEALKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
+ F T+ FL + D+ + + +S +D + + +C RA +L
Sbjct: 779 TSIFETK----FLSQIESDRLALLQVRSILQQLGLNSTCDDSIIVKEVCGAVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDHLDVTVGVDGTLY 865
>gi|1008870|gb|AAC42074.1| glucokinase
gi|15029832|gb|AAH11139.1| Gck protein [Mus musculus]
gi|56207105|emb|CAI25265.1| glucokinase [Mus musculus]
gi|148708620|gb|EDL40567.1| glucokinase, isoform CRA_a [Mus musculus]
Length = 465
Score = 83.2 bits (204), Expect = 3e-14, Method: Composition-based stats.
Identities = 103/440 (23%), Positives = 193/440 (43%), Gaps = 38/440 (8%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ S + ++M +GL+ E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYEDR-----QCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDK---NIFSGIIEAHSVSE-DYVKIYSICKCFFE 355
++ L F T +S + + NI S + SV++ D V+ C+
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVR--RACESVST 376
Query: 356 RAGRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRG 414
RA + +A +A + + +S D I + DGS++ KER S+ LT
Sbjct: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPNCE 435
Query: 415 IYFVLKTNDEAVTLGTALAA 434
I F+ ++E G AL +
Sbjct: 436 ITFI--ESEEGSGRGAALVS 453
>gi|148700161|gb|EDL32108.1| hexokinase 1, isoform CRA_f [Mus musculus]
Length = 917
Score = 83.2 bits (204), Expect = 3e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 44 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 103
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 104 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 163
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 164 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 220
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 221 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 276
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 277 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 336
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 337 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 393
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 394 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 430
Score = 79.7 bits (195), Expect = 3e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 490 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 549
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 550 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 607
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 608 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 664
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 665 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 714
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 715 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 773
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 774 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 829
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 830 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 864
>gi|148700157|gb|EDL32104.1| hexokinase 1, isoform CRA_b [Mus musculus]
Length = 902
Score = 83.2 bits (204), Expect = 3e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 29 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 88
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 89 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 148
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 149 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 205
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 206 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 261
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 262 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 321
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 322 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 378
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 379 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 415
Score = 79.7 bits (195), Expect = 3e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 475 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 534
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 535 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 592
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 593 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 649
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 650 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 699
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 700 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 758
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 759 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 814
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 815 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 849
>gi|123902|sp|P17712|HXK4_RAT Glucokinase (Hexokinase-4) (Hexokinase type IV) (HK IV) (HK4)
(Hexokinase-D)
gi|149047655|gb|EDM00325.1| glucokinase, isoform CRA_c [Rattus norvegicus]
Length = 465
Score = 82.8 bits (203), Expect = 4e-14, Method: Composition-based stats.
Identities = 104/440 (23%), Positives = 192/440 (43%), Gaps = 38/440 (8%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ S + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYEDR-----QCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDK---NIFSGIIEAHSVSE-DYVKIYSICKCFFE 355
++ L F T +S + K NI S + SV++ D V+ C+
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVR--RACESVST 376
Query: 356 RAGRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRG 414
RA + +A +A + + +S D I + DGS++ KER S+ LT
Sbjct: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPNCE 435
Query: 415 IYFVLKTNDEAVTLGTALAA 434
I F+ ++E G AL +
Sbjct: 436 ITFI--ESEEGSGRGAALVS 453
>gi|148700160|gb|EDL32107.1| hexokinase 1, isoform CRA_e [Mus musculus]
Length = 904
Score = 82.8 bits (203), Expect = 4e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 31 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 90
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 91 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 150
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 151 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 207
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 208 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 263
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 264 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 323
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 324 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 380
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 381 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 417
Score = 79.7 bits (195), Expect = 4e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 477 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 536
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 537 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 594
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 595 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 651
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 652 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 701
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 702 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 760
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 761 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 816
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 817 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 851
>gi|68477041|ref|XP_717498.1| putative hexokinase II [Candida albicans SC5314]
gi|46439211|gb|EAK98532.1| likely hexokinase II [Candida albicans SC5314]
Length = 414
Score = 82.8 bits (203), Expect = 4e-14, Method: Composition-based stats.
Identities = 109/406 (26%), Positives = 163/406 (40%), Gaps = 117/406 (28%)
Query: 64 IIIDAGGTNFR------AGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLE 117
+ ID GGTN R AG FD K +PA R T++E +D IA+ L+
Sbjct: 13 LAIDLGGTNLRVVLVKLAGNRDFDTTQS-------KFALPAHMRTATSDELWDFIAKCLK 65
Query: 118 PLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW--- 174
DE I+PDG + + L P +INEG+ Q + KGW
Sbjct: 66 EFVDE-------------IYPDGCSEPLPLGFTFSYP-ASQNRINEGILQRWT-KGWSID 110
Query: 175 ------------KKIKKI-------IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGL 215
K IKK+ ++NDT L + ++++ + + +G + GTG+
Sbjct: 111 GIEGKDVVPMLQKAIKKVGVPIDVVALINDTTGTLVASMYTDPE-----AKMGLIFGTGV 165
Query: 216 NSAYIEYGK-IEKLKTTEFYD----KPQIIVCESGKSNK----IPQSKFDKILSENSNLK 266
N AY + K I KL+ D P I CE G + +P++K+D + E S
Sbjct: 166 NGAYFDVVKDIPKLEGKCPSDIPPESPMAINCEYGSFDNEKYILPRTKYDVQIDEESPRP 225
Query: 267 NEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD 326
+ E+M SG YLGE+ + L +F+ EE L K QN D
Sbjct: 226 GQQTFEKMISGYYLGEVLRLIL--------------------LEFA-EEKKLIFKGQNLD 264
Query: 327 KNIFSGIIEA---HSVSEDYVK------------------------IYSICKCFFERAGR 359
K +++A + ED + I + + ER+ R
Sbjct: 265 KLKVPYVMDASYPSKIEEDPFENLSDVADLFREKLGIETTEPERKIIRRLAELIGERSAR 324
Query: 360 LSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
S IAA C K G + C +ADGS++ K KER ++L
Sbjct: 325 FSVCGIAAICQKRGY----ETAHC-AADGSVYNKYPGFKERTAQAL 365
>gi|156840029|ref|XP_001643699.1| hypothetical protein Kpol_507p3 [Vanderwaltozyma polyspora DSM
70294]
gi|156114321|gb|EDO15841.1| hypothetical protein Kpol_507p3 [Vanderwaltozyma polyspora DSM
70294]
Length = 486
Score = 82.8 bits (203), Expect = 4e-14, Method: Composition-based stats.
Identities = 106/419 (25%), Positives = 178/419 (42%), Gaps = 76/419 (18%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVYFD-KKG 84
++ KGL + ++ MIP W D P K+ + ID GGTN R +V +
Sbjct: 51 ELDKGLSKKGGNIP---MIPGWV---MDYPTGKESGDYLAIDLGGTNLRVVLVKLGGDRT 104
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGGQA 144
S ++ P A+ EE ++ IA+ LE +E FP+G +
Sbjct: 105 FDTTQSKYRLP-DAMRTTQDPEELWEFIADSLEAFVNEQ-------------FPEGCTKP 150
Query: 145 IKLSKEIKLPYIGDCKINEGLFQALSR-----------------KGWKK----IKKIIMV 183
+ L P D KINEG+ Q ++ K +K I+ + ++
Sbjct: 151 LPLGFTFSFPASQD-KINEGILQRWTKGFDIPETEGKDVVKMLQKQLEKRNIPIRVVALI 209
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLK----TTEFYDKPQ 238
NDT L + ++++ + + +G + GTG+N AY + +EKL+ D P
Sbjct: 210 NDTTGTLVASLYTDGE-----TKMGVIFGTGVNGAYYDVISGVEKLQGRLPADITADTPM 264
Query: 239 IIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-----R 289
I CE G + +P+++ D I+ E S + E+M SG YLGEL +A+
Sbjct: 265 AINCEYGSFDNEHVVLPRNRHDIIIDEESPRPGQQAFEKMSSGYYLGELLRLAILEMVDN 324
Query: 290 AGSAEGIFSPRVNKMLLNSCDFSTE-EISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYS 348
+G ++ K + F + E F +N D+ + S + + ++ I
Sbjct: 325 GHILKGQDCSKLRKPYIMDTSFPSRIEDDPFENLENTDE-LLSKTLGLSTTVQERKLIRR 383
Query: 349 ICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF--LKGFLIKERIFKSL 405
+ + R+ R++A IA C K G + I+ADGS++ GF KER +L
Sbjct: 384 VSELIGTRSARIAACGIAGICQKRGYDTAH-----IAADGSVYNLYPGF--KERAAAAL 435
>gi|125833184|ref|XP_708314.2| PREDICTED: hypothetical protein LOC321224 isoform 3 [Danio rerio]
Length = 919
Score = 82.4 bits (202), Expect = 5e-14, Method: Composition-based stats.
Identities = 87/387 (22%), Positives = 167/387 (43%), Gaps = 39/387 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
++++GL+ E +S+ M+P + D + K + +D GGTNFR +V + G+
Sbjct: 494 ELERGLKKETHPTASVKMLPTYVYRTPDGTERGKYLALDLGGTNFRVLVVKI-RTGMRNS 552
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + +P + T EE FD I + + D M + F FS+
Sbjct: 553 VRMYNKIYAIPLEIMQGTGEELFDHIVQCISDFLDYMGMKNTRLPLGFTFSFPCNQTGID 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
G + +K K + + L +A+ R+ + + +VNDT + + + +
Sbjct: 613 KGDLVCWTKGFKATDCEGYDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCAYEDPKC 672
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNKIP--Q 252
Q IG + GTG N Y +E++K E + + +C + G+++ I +
Sbjct: 673 Q-----IGLIAGTGSNVCY-----MEEMKNIEIVEGDEGQMCVNTEWGGFGENDNIEDIR 722
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDF 311
+++D+ + S + E+M SG YLGE+ L + G +F R+ + L F
Sbjct: 723 TRYDREVDSGSLNAGKQRFEKMTSGMYLGEIVRQILIDLTKRGFLFRGRITERLKTKGIF 782
Query: 312 STEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSAAVI 365
T+ FL + D+ + + S +D + + +C RA +L A +
Sbjct: 783 ETK----FLSQIESDRLALLQVRCILQSLGLDSTCDDSIIVKEVCGAVSRRAAQLCGAGM 838
Query: 366 AAACIKTGKGKSPDK-PICISADGSMF 391
AA K + + D+ I + DG+++
Sbjct: 839 AAIVDKIRENRGLDRLDITVGVDGTLY 865
Score = 70.1 bits (170), Expect = 3e-10, Method: Composition-based stats.
Identities = 83/334 (24%), Positives = 147/334 (44%), Gaps = 27/334 (8%)
Query: 1 MKEIDDFF--KRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIP 58
+K++D F R + D DI +A LE M+KGL SE+ + +++ M+P D
Sbjct: 19 IKKVDRFLYAMRLSEDQLKDI--SARFRLE-MEKGLSSESNAAAAVKMLPTHVYSTPDGS 75
Query: 59 KDKKVIIIDAGGTNFRAGIVYF--DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL 116
+ + + +D GG+ F+ V D KG E+ S P+P E F+ +AE L
Sbjct: 76 EKGEFLALDLGGSKFKVLQVKVSEDGKGKVEMES-ETFPIPEEIVNGRGTELFEHVAESL 134
Query: 117 EPLKDESDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+ + + + F FS+ G + SK K+ + + + L +A+
Sbjct: 135 KSFLQKHHINHTRKPLGFTFSFPCAQSKIDEGVLLSWSKNFKVRGVQGTNVVQSLRKAIR 194
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKT 230
+ G + + MVNDT + + + DDQ + +G ++GTG N+ Y+E ++ +
Sbjct: 195 KVGDLDVDVLAMVNDTVGAMMTCGY---DDQ--NCEVGVIVGTGTNACYME--EMRHIDL 247
Query: 231 TEFYDKPQIIVCESGKSNKIPQ-----SKFDKILSENSNLKNEYFLERMCSGRYLGELCS 285
E + I E G + FD+ + S + E+M SG Y+GEL
Sbjct: 248 VEGDEGRMCINTELGAFGDDGVLDDFITSFDREIDAASINPGKQLFEKMVSGMYMGELVR 307
Query: 286 IALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISL 318
+ L + +G +F +++ L F T + L
Sbjct: 308 LILLRMAKKGLLFRGQISDALRTKGTFHTNHMCL 341
>gi|119480367|ref|XP_001260212.1| hexokinase Kxk, putative [Neosartorya fischeri NRRL 181]
gi|119408366|gb|EAW18315.1| hexokinase Kxk, putative [Neosartorya fischeri NRRL 181]
Length = 490
Score = 82.4 bits (202), Expect = 5e-14, Method: Composition-based stats.
Identities = 112/436 (25%), Positives = 188/436 (43%), Gaps = 48/436 (11%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIP-- 58
+++I DF + D + ++ +++++KGL E + IP+ D P
Sbjct: 24 LQQIKDFEEMFTVD-RAKLKQVVDHFVKELEKGLSVEGGN------IPMNVTWVMDFPDG 76
Query: 59 -KDKKVIIIDAGGTNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFF----DSI 112
+ + +D GGTN R I ++KG +I K+ MP + T EE + D I
Sbjct: 77 DEQGTFLALDMGGTNLRVCEITLTEEKGGFDICQS-KYRMPEELKSGTAEELWEYIADCI 135
Query: 113 AEYLEPLKDESDMIS----FCFSY-AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQ 167
+++E E + S F FSY A + + D G + +K + + + L +
Sbjct: 136 QQFIEFHHGEEGLTSLPLGFTFSYPATQEYIDHGVLQ-RWTKGFDIDGVEGQDVVPPLEE 194
Query: 168 ALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIE 226
L RKG IK ++NDT L + +++ + + IG + GTG+N+AY+E G +
Sbjct: 195 TLKRKGLP-IKVAALINDTTGTLIASAYTDPEMK-----IGCIFGTGVNAAYMEDVGSVP 248
Query: 227 KLKTTEFY-DKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLG 281
KL D P I CE G + +P +K+D I+ +S + E+M +G YLG
Sbjct: 249 KLAHMNLPPDMPVAINCEYGAFDNEHVVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLG 308
Query: 282 ELCSIAL--RAGSAEGIF-----SPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGII 334
E+ +AL S G+ + ++ K L F + + +F +
Sbjct: 309 EIFRLALIDLLDSRPGLIFQNQDTSKLRKPYLLDASFLAAIEEDPYENLQETQELFEREL 368
Query: 335 EAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLK 393
+ I + + RA RLSA +AA C K + C + ADGS+F K
Sbjct: 369 NIKPTLAELEMIRRLAELIGTRAARLSACGVAAIC------KKKNIESCHVGADGSVFTK 422
Query: 394 GFLIKERIFKSLHTCL 409
K R ++L L
Sbjct: 423 YPHFKARGAQALREIL 438
>gi|155008466|gb|ABS89272.1| hexokinase 1a [Gadus morhua]
Length = 919
Score = 82.4 bits (202), Expect = 5e-14, Method: Composition-based stats.
Identities = 90/392 (22%), Positives = 173/392 (44%), Gaps = 49/392 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
++++GL+ E+ +++ M+P + D ++ + +D GGTNFR +V + G
Sbjct: 494 EIERGLKKESNEEATVKMLPTFVRSTPDGTENGDFLALDLGGTNFRVLLVKI-RSGKRRT 552
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + +P + T EE FD I + D M + F FS+
Sbjct: 553 VEMHNKIYAIPIEVMQGTGEELFDHIVFCISDFLDYMGMKSARLPLGFTFSFPCHQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G+ + +K K DC+ + E L + + RK ++ + +VNDT + + + E
Sbjct: 613 AGRLVNWTKGFKAT---DCEGEDVVELLREGIKRKEEFELDVVAIVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G + GTG N+ Y +E++K E + + +C ++G +
Sbjct: 670 P-----TCEVGLIAGTGSNACY-----MEEMKNIESVEGNEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++++D+ + ENS + + E+MCSG YLGE+ L + G +F ++++ L
Sbjct: 720 DI-RTQYDRAVDENSLNEGKQRYEKMCSGMYLGEIVRNILIDLTRRGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHD-------KNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D + I G + S +D + + +C RA ++
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRAILQG-LGLDSTCDDSIIVKEVCGSVSRRAAQI 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D I + DG+++
Sbjct: 834 CGAGMAAVVDKIRENRGLDHLDITVGVDGTLY 865
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 87/413 (21%), Positives = 176/413 (42%), Gaps = 24/413 (5%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDK-KGVPE 87
+M+ GL + + +++ M+P + D + + +D GG+NFR V + K P
Sbjct: 46 EMQNGLGRDTNATATVKMLPTFVRSIPDGSEKGDFLALDLGGSNFRILRVKVTRDKKQPV 105
Query: 88 ILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDGG 141
+ + P ++ FD +A+ L + +KD++ + F FS+
Sbjct: 106 QMESQVYETPDDIIHGSSTRLFDHVADCLGDFMEKQNIKDKNLPVGFTFSFPCAQTKLNE 165
Query: 142 GQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQ 201
+ +K+ K+ + + + L +A+ ++G + + +VNDT + + F DDQ
Sbjct: 166 AVLVTWTKKFKVSGVEGMDVVKLLNKAIKKRGDYEADIMAVVNDTTGTMMTCGF---DDQ 222
Query: 202 GFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKFD 256
+G ++GTG N+ Y+E ++ + E + I E G S + +++FD
Sbjct: 223 --RCEVGIIIGTGTNACYME--ELRHMDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFD 278
Query: 257 KILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEE 315
+ + S + E+M SG Y+GEL + L + E +F R+ LL T+
Sbjct: 279 REIDRGSLNPGKQLFEKMASGMYMGELVRLILVKMAKESLLFEGRITPELLTKGTIETKH 338
Query: 316 ISLFLKEQNHDKNIFSGI--IEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTG 373
+S K + K + + ED + + +C R+ L AA + ++
Sbjct: 339 VSAIEKSKEGLKKCMEILTRLGVEPSDEDCLAVQHVCTIVSFRSANLVAATLGGILLRLK 398
Query: 374 KGKSPDK-PICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEA 425
+ + + + DGS++ R+ K++ + E + F+L + A
Sbjct: 399 ENRGGMRLRTTVGIDGSLYKMHPQYARRLHKTVRRLVPET-DVRFLLSESGSA 450
>gi|31982798|ref|NP_034422.2| glucokinase [Mus musculus]
gi|1708365|sp|P52792|HXK4_MOUSE Glucokinase (Hexokinase-4) (Hexokinase type IV) (HK IV) (HK4)
(Hexokinase-D)
gi|886344|gb|AAB00360.1| glucokinase
gi|56207106|emb|CAI25266.1| glucokinase [Mus musculus]
gi|148708621|gb|EDL40568.1| glucokinase, isoform CRA_b [Mus musculus]
Length = 465
Score = 82.4 bits (202), Expect = 5e-14, Method: Composition-based stats.
Identities = 103/440 (23%), Positives = 193/440 (43%), Gaps = 38/440 (8%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ S + ++M +GL+ E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYEDR-----QCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDK---NIFSGIIEAHSVSE-DYVKIYSICKCFFE 355
++ L F T +S + + NI S + SV++ D V+ C+
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVR--RACESVST 376
Query: 356 RAGRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRG 414
RA + +A +A + + +S D I + DGS++ KER S+ LT
Sbjct: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPNCE 435
Query: 415 IYFVLKTNDEAVTLGTALAA 434
I F+ ++E G AL +
Sbjct: 436 ITFI--ESEEGSGRGAALVS 453
>gi|67003902|gb|AAY60842.1| plastidic hexokinase [Solanum lycopersicum]
Length = 499
Score = 82.4 bits (202), Expect = 6e-14, Method: Composition-based stats.
Identities = 104/396 (26%), Positives = 166/396 (41%), Gaps = 31/396 (7%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
+ + A + +DM+ GL + S M ++ LPT K +D GGTNFR V
Sbjct: 59 LRHVADAMADDMRAGLAVDGGSDLKM-ILSYVDTLPTGNEKGL-FYALDLGGTNFRVLRV 116
Query: 79 YFDKKGVPEILSFFKH-PMPALDREMTNEEFFDSIAEYL-----------EPLKDESDMI 126
K + + F+ +P T+EE FD IA L E + + I
Sbjct: 117 QLGGKEERVVATEFEQVSIPQELMFATSEELFDFIASALGKFAQKEGGNFELQQGRTREI 176
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDT 186
F FS+ +K G IK +K + + L +A+ R+G ++ +VNDT
Sbjct: 177 GFTFSFPVKQTSIRTGILIKWTKGFAVSGTAGKDVVACLNEAMERRG-MDMQVSALVNDT 235
Query: 187 AAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIVCESG 245
L + DD D+ + +LGTG N+ Y+E I KL I+ E G
Sbjct: 236 VGTLAGARY--WDD---DAMVAVILGTGTNACYVERVDAIPKLAKRMSKSPITIVNTEWG 290
Query: 246 K-SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIF-SPRVN 302
SN +P ++FD+ + S E E+ SG YLGE+ + ++ G+F S V
Sbjct: 291 AFSNGLPLTEFDREMDAESINPGEQIFEKTISGMYLGEIVRRVLVKMAKVGGLFGSSYVP 350
Query: 303 KMLLNSCDFSTEEISLFLKEQNHD-KNIFSGIIEAHSVSEDYV---KIYSICKCFFERAG 358
+ L+ T +I ++ + D + + S + + V D + IC +R G
Sbjct: 351 EKLVTPFVLRTPDICAMQQDTSIDLEAVESVLYDVAGVKSDLSARKTVVDICDTIAKRGG 410
Query: 359 RLSAAVIAAACIKT---GKGKSPDKPICISADGSMF 391
RL+ A I K KG K ++ DG ++
Sbjct: 411 RLAGAGIVGILQKMEEDSKGLIFGKRTVVAMDGGLY 446
>gi|74150648|dbj|BAE25472.1| unnamed protein product [Mus musculus]
Length = 918
Score = 82.4 bits (202), Expect = 6e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 337
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 338 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 394
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 395 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 431
Score = 78.2 bits (191), Expect = 9e-13, Method: Composition-based stats.
Identities = 92/392 (23%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 491 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 551 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I +K K + L A+ R+ + + +VNDT + + +
Sbjct: 609 TSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E IG ++GTG N+ Y +E++K E + Q +C ++G
Sbjct: 669 EP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNI---FSGIIEA---HSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ I++ +S +D + + ++C +RA +L
Sbjct: 778 TRGIFETK----FLSQIESDRLAPLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 834 CGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 865
>gi|309289|gb|AAA37804.1| hexokinase (EC 2.7.1.1)
Length = 918
Score = 82.4 bits (202), Expect = 6e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 337
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 338 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 394
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 395 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 431
Score = 78.2 bits (191), Expect = 9e-13, Method: Composition-based stats.
Identities = 91/392 (23%), Positives = 167/392 (42%), Gaps = 43/392 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 491 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 551 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I +K K + L A+ R+ + + +VNDT + + +
Sbjct: 609 TSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E IG ++GTG N+ Y +E++K E + Q +C ++G
Sbjct: 669 EP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ + + +S D + + ++C +RA +L
Sbjct: 778 TRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCSDSILVKTVCGVVSKRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 834 CGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 865
>gi|49117745|gb|AAH72628.1| Hk1 protein [Mus musculus]
gi|148700159|gb|EDL32106.1| hexokinase 1, isoform CRA_d [Mus musculus]
Length = 918
Score = 82.4 bits (202), Expect = 6e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 337
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 338 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 394
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 395 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 431
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 91/392 (23%), Positives = 168/392 (42%), Gaps = 43/392 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 491 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 551 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I +K K + L A+ R+ + + +VNDT + + +
Sbjct: 609 TSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E IG ++GTG N+ Y +E++K E + Q +C ++G
Sbjct: 669 EP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ + + +S +D + + ++C +RA +L
Sbjct: 778 TRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 834 CGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 865
>gi|50285099|ref|XP_444978.1| hypothetical protein CAGL0A04829g [Candida glabrata CBS138]
gi|49524280|emb|CAG57871.1| unnamed protein product [Candida glabrata CBS 138]
Length = 486
Score = 82.0 bits (201), Expect = 6e-14, Method: Composition-based stats.
Identities = 107/421 (25%), Positives = 181/421 (42%), Gaps = 77/421 (18%)
Query: 15 YKIDIEYAASI---LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDA 68
Y +D E + + ++ KGL + ++ MIP W + P K+ + ID
Sbjct: 34 YTVDGETLRKVTKHFITELDKGLSKKGGNIP---MIPGWV---MEYPSGKEKGDYLAIDL 87
Query: 69 GGTNFRAGIVYFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMIS 127
GGTN R +V + S +K P A+ +EE + IA+ L+ ++
Sbjct: 88 GGTNLRVVLVKLGGDRTFDTTQSKYKLP-EAMRTTKNHEELWSFIADSLQAFLEDQ---- 142
Query: 128 FCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW------------- 174
FP+G + L P D +IN+G+ Q + KG+
Sbjct: 143 ---------FPEGVKGKLPLGFTFSYPASQD-RINQGVLQRWT-KGFDIPNVEGHDVVPM 191
Query: 175 --KKIKK-------IIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY--- 222
K+I+K + ++NDT L + ++++ + + +G + GTG+N AY +
Sbjct: 192 LQKQIEKRNLPIDIVALINDTTGTLVASLYTDGE-----TKMGVIFGTGVNGAYYDVVSD 246
Query: 223 -GKIE-KLKTTEFYDKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCS 276
K+E KL D P I CE G + +P++K+D I+ E S + E+M S
Sbjct: 247 IPKLEGKLADDIPNDSPMAINCEYGSFDNEHVVLPRNKYDLIIDEESPRPGQQAFEKMSS 306
Query: 277 GRYLGELCSIALRAGSAEGI------FSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIF 330
G YLGE+ +AL +G+ S ++++ S E F ++ D+ +
Sbjct: 307 GYYLGEMLRLALLDLYDQGLILKGQDISKLKKPYVMDTSYPSKIEDDPFENLEDTDELLQ 366
Query: 331 SGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSM 390
+ +V E + I +C+ R+ RLS IAA C K G + I+ADGS+
Sbjct: 367 KNLGIQTTVQERKL-IRRLCELIGTRSARLSVCGIAAICQKRGYETAH-----IAADGSV 420
Query: 391 F 391
F
Sbjct: 421 F 421
>gi|50422061|ref|XP_459592.1| hypothetical protein DEHA0E07007g [Debaryomyces hansenii CBS767]
gi|49655260|emb|CAG87822.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 473
Score = 82.0 bits (201), Expect = 6e-14, Method: Composition-based stats.
Identities = 117/450 (26%), Positives = 193/450 (42%), Gaps = 56/450 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVYFDKKG 84
+ M GL++ A M MIP + T IP K+ + D GGTNFR V
Sbjct: 33 KSMDTGLQNTASKREYMPMIPTYV---TGIPTGKEKGLFLAADLGGTNFRVCSVNLHGDH 89
Query: 85 VPEILSFFKHPMPA-LDREMTNEEFFDSIAEYLEP-LKDESD--------MISFCFSYAI 134
E L K+ +P L + T + F +A+ +E LKD D + F FS+ I
Sbjct: 90 THE-LKQSKYSIPLDLMKNSTADSLFSFLAKKVETFLKDNHDDLEADEQLKLGFTFSFPI 148
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
G I+ +K LP D + E L + G K + + + NDT L S
Sbjct: 149 NQTALNRGTLIRWTKGFDLPDCVDKDVVELLQSNIDLLGCK-VNVVALANDTVGTLLSRA 207
Query: 195 FSETDDQ-GFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYD--KPQIIVCESGKSNK- 249
+S ++ ++ +G + GTG N AY E I KLK+T + K +I E G +
Sbjct: 208 YSNNPEKTNANTIVGAIFGTGTNGAYFETLDNIPKLKSTNIPEGAKGMVINTEWGSFDNT 267
Query: 250 ---IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL------------RAGSAE 294
+P++K+D+I+ + K + E+ SG ++GE+ + L S
Sbjct: 268 LKILPKTKYDEIVDSETANKGFHLFEKRISGMFMGEILRVCLIDLFQRDLIFVDLYKSRG 327
Query: 295 GIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAH----SVSEDYVKIYSIC 350
G R+++ L S+E +S + + D + I+E + E+ + I +
Sbjct: 328 GSLPHRLSEEWL----LSSEVLSYLQIDDSTDLKMSELILENELRLPTTKEERIVIQKLT 383
Query: 351 KCFFERAGRLSAAVIAAACIKT-GKGKSPDKPICISADGSM--FLKGFLIKERIFKSL-- 405
+ RA LSA +AA + G+ + ++ DGS+ F GF + I ++L
Sbjct: 384 QAIAHRAAYLSAIPVAAILNRVKGQFSNDNRDFEFGCDGSVVEFYPGF--QASILEALEI 441
Query: 406 -HTCLTEKRGIYFVLKTNDEAVTLGTALAA 434
+ EK+ ++ LK + +G AL A
Sbjct: 442 INPLEGEKKKVH--LKIAKDGSGVGAALCA 469
>gi|74207854|dbj|BAE29060.1| unnamed protein product [Mus musculus]
Length = 864
Score = 82.0 bits (201), Expect = 6e-14, Method: Composition-based stats.
Identities = 92/398 (23%), Positives = 172/398 (43%), Gaps = 31/398 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 337
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 338 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 394
Query: 370 --IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 395 NRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 431
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 91/391 (23%), Positives = 167/391 (42%), Gaps = 43/391 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 491 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 551 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I +K K + L A+ R+ + + +VNDT + + +
Sbjct: 609 TSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E IG ++GTG N+ Y +E++K E + Q +C ++G
Sbjct: 669 EP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DDI-RTDFDKVVGEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ + + +S +D + + ++C +RA +L
Sbjct: 778 TRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSM 390
A +AA K + + D + + DG++
Sbjct: 834 CGAGMAAVVEKIRENRGLDHLNVTVGVDGTL 864
>gi|68487478|ref|XP_712360.1| putative hexokinase [Candida albicans SC5314]
gi|68487551|ref|XP_712324.1| putative hexokinase [Candida albicans SC5314]
gi|46433703|gb|EAK93134.1| likely hexokinase [Candida albicans SC5314]
gi|46433742|gb|EAK93172.1| likely hexokinase [Candida albicans SC5314]
Length = 376
Score = 82.0 bits (201), Expect = 7e-14, Method: Composition-based stats.
Identities = 81/289 (28%), Positives = 128/289 (44%), Gaps = 29/289 (10%)
Query: 22 AASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIV 78
A +E M GLES S M MIP + T IP K+V + D GGTNFR +
Sbjct: 28 ATEYFIESMNVGLESPKPSKDVMPMIPTYV---TSIPTGKEVGLYLAADLGGTNFR--VC 82
Query: 79 YFDKKGVPEI---LSFFKHPMPALDREMTNEEF-----------FDSIAEYLEPLKDESD 124
D KG S ++ P+ + E +N+ F ++ +E E
Sbjct: 83 SIDLKGDHTFSMKQSKYRIPVDLMKAEKSNDLFGFLAKKVQSFLLENHSEACTAKNTEPL 142
Query: 125 MISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ + G I+ +K +P D + E L QA +K + + N
Sbjct: 143 KLGFTFSFPVNQTALNRGTLIRWTKGFDIPDTVDRDVVE-LLQANLTILEVNVKVVAIAN 201
Query: 185 DTAAVLQSGIFS-ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCE 243
DT L + +S ++ ++ IG + GTG N AY E KI KL ++ +K +I E
Sbjct: 202 DTVGTLLTAAYSNDSAKTNRNTIIGCIFGTGTNGAYFE-SKIPKLSSSTGDNKGMVINTE 260
Query: 244 SGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
G + +P ++FD+I+ + + E+ SG +LGE+ +AL
Sbjct: 261 WGSFDNGLKILPSTEFDEIVDSETANPGYHLFEKRISGMFLGEILRVAL 309
>gi|126303415|ref|XP_001379711.1| PREDICTED: similar to glucokinase [Monodelphis domestica]
Length = 460
Score = 82.0 bits (201), Expect = 7e-14, Method: Composition-based stats.
Identities = 87/395 (22%), Positives = 175/395 (44%), Gaps = 31/395 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 24 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 83
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V ++ + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 84 VKVGEEEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHHMKHKKLPLGF 143
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 144 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 203
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSN 248
+ S + + +G ++GTG N+ Y+E ++E ++ E + + E G
Sbjct: 204 TMISCYYEDR-----QCEVGMIVGTGCNACYME--EMENVELVEGDEGRMCVNTEWGAFG 256
Query: 249 KIPQ-----SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVN 302
+ ++D+++ E S + E++ G+Y+GE+ + L E +F+ +
Sbjct: 257 NAGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLMKLVDENLLFNGEAS 316
Query: 303 KMLLNSCDFSTEEISLFLKEQNHDKNIFS-----GIIEAHSVSEDYVKIYSICKCFFERA 357
+ L F T +S + K I++ G+I + + D V++ +C+ RA
Sbjct: 317 EQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLIPS-TTDCDIVRM--VCESVSTRA 373
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMF 391
++ +A +A + + +S + I + DGS++
Sbjct: 374 AQMCSAGLAGVINRMRESRSEEVMRITVGVDGSVY 408
>gi|156717322|ref|NP_001096201.1| hexokinase 1 [Xenopus tropicalis]
gi|134025567|gb|AAI35850.1| Hk1 protein [Xenopus tropicalis]
Length = 917
Score = 82.0 bits (201), Expect = 7e-14, Method: Composition-based stats.
Identities = 94/404 (23%), Positives = 171/404 (42%), Gaps = 33/404 (8%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR---AGIVYFDKKGV 85
+M GL + + + M+P + D + I +D GG++FR + + K+ V
Sbjct: 46 EMANGLSRDTNPTAIIKMLPTFVRSIPDGTEKGDFIALDLGGSHFRILRVKVSHEKKQTV 105
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPD 139
+ P + T FD +AE L + +KD+ + F FS+
Sbjct: 106 QMESEIYDTPEDIIHGSGT--RLFDHVAECLGDFMQKKQIKDKKLPVGFTFSFPCIQTKI 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
G + +K K + + + L +A+ ++G + + +VNDT + + F D
Sbjct: 164 DEGVLVTWTKRFKASGVEGMDVVKLLNKAIKKRGDYEADIMAVVNDTVGTMMTCGF---D 220
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSN-----KIPQSK 254
DQ +G ++GTG N+ Y+E ++ + E + I E G + +S+
Sbjct: 221 DQ--RCEVGIIIGTGTNACYME--ELRHIDMVEGDEGRMCINTEWGAFGDDGCLEDIRSE 276
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFST 313
FD+ + S + E+M SG Y+GEL + L + EG +F R+ LL F T
Sbjct: 277 FDREIDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFET 336
Query: 314 EEISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAA 368
+ +S K + + K+I + G+ +H ED + + +C R+ L AA +
Sbjct: 337 KHVSAIEKSKEGLSKAKDILTRLGVEPSH---EDCIAVQHVCTIVSFRSANLVAATLGGI 393
Query: 369 CIKTGKGKS-PDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
I+ K P + DGS++ R+ K++ + E
Sbjct: 394 LIRLRDNKGVPRLRTTVGIDGSLYKMHPQYARRLHKTVRRLVPE 437
Score = 68.9 bits (167), Expect = 6e-10, Method: Composition-based stats.
Identities = 84/392 (21%), Positives = 166/392 (42%), Gaps = 49/392 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+++ GL + + + M+P + D ++ + +D GGTNFR +V ++ V
Sbjct: 494 EIENGLRKKTHESAKVKMLPTYVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKRRTV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPD 139
+ P+ + + T EE FD IA + D + + F FS+
Sbjct: 554 EMHNKIYAIPIDVM--QGTGEELFDHIAHCISDFLDYMGIKGARLPLGFTFSFPCMQTSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G + +K K DC+ + L + + R+ + + +VNDT + + +
Sbjct: 612 DAGILVTWTKGFKAT---DCEGEDVVNLLREGIKRREEFDLDVVAIVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
+ + IG ++GTG N+ Y +E+ K E D Q +C ++G
Sbjct: 669 DP-----NCEIGLIVGTGSNACY-----MEETKNIEMVDGDQGRMCVNMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ +DK + + S + E+M SG YLGE+ L + G +F ++++ L
Sbjct: 719 DDI-RTVYDKAVDDLSLNSGKQRYEKMISGMYLGEIVRNILIDFTKRGFLFRGQISEALK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
+ F T+ FL + D+ + + +S +D + + +C RA ++
Sbjct: 778 TTSIFETK----FLSQIESDRLALLQVRSILQQLGLNSTCDDSIIVKEVCGAVSRRAAQV 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 834 CGAGMAAVVDKIRENRGLDHLDVTVGVDGTLY 865
>gi|33468329|gb|AAQ19647.1| hexokinase [Pichia angusta]
Length = 483
Score = 82.0 bits (201), Expect = 7e-14, Method: Composition-based stats.
Identities = 110/420 (26%), Positives = 180/420 (42%), Gaps = 63/420 (15%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKK 83
+E++++G ++ + + M P W + + + ID GGTN R + + D K
Sbjct: 37 FIEELERG-NADGTDPTGIPMNPAWVLEYPNGSETGDYLAIDLGGTNLRVVLAHLLGDHK 95
Query: 84 GVPEILSFFKHPMPALDREMTN-EEFFDSIAEYLE-------PLKDESDMI---SFCFSY 132
E K+ +P+ R N +E F+ IA+ LE P SD + F FSY
Sbjct: 96 FSTEQT---KYHIPSHMRTTKNRDELFEFIAQCLEDFLKSKHPDGIPSDAVFPLGFTFSY 152
Query: 133 AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQS 192
G + +K +P + + L + + +KG IK ++NDT+ L +
Sbjct: 153 PATQNSIFEGVLQRWTKGFDIPNVEGHDVVPLLMEQVEKKGLP-IKIGALINDTSGTLVA 211
Query: 193 GIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYD----KPQIIVCESGKS 247
+ TD+ + +G + GTG+N AY + K I KLK + D P +I CE G
Sbjct: 212 SRY--TDEL---TEMGCIFGTGVNGAYYDRIKNIPKLKGKLYDDIDPESPMLINCEYGSF 266
Query: 248 NK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNK 303
+ +P++KFD + + S + E+M SG YLGEL + + +G
Sbjct: 267 DNAHKVLPRTKFDIRIDDESPRPGQQSFEKMTSGYYLGELLRMIMLDTYKKG-------- 318
Query: 304 MLLNSCDFSTEEI----------SLFLKEQNHD--------KNIFSGIIEAHSVSEDYVK 345
++ S S+E+I + FL D N FS + + E+ +
Sbjct: 319 LIFKSYTESSEQIKNLETPYFLDTSFLSIAEADDTPSLSVVSNEFSNKLFIDTTFEERLY 378
Query: 346 IYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ + + RA RLS I+A C K K ++ADGS+FLK ER + L
Sbjct: 379 VRKLSQFIGTRAARLSICGISAVCKKMNYKKCH-----VAADGSVFLKYPYFPERAAQGL 433
>gi|74195468|dbj|BAE39552.1| unnamed protein product [Mus musculus]
Length = 918
Score = 82.0 bits (201), Expect = 7e-14, Method: Composition-based stats.
Identities = 89/384 (23%), Positives = 168/384 (43%), Gaps = 31/384 (8%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 105 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 337
Query: 315 EISLFLKEQ---NHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC 369
+++ ++ + K I + G+ +H +D V + +C R+ L AA + A
Sbjct: 338 DVAAIETDKEGVQNAKEILTRLGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAIL 394
Query: 370 --IKTGKGKSPDKPICISADGSMF 391
++ KG +P + DGS++
Sbjct: 395 NRLRDNKG-TPRLRTTVGVDGSLY 417
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 91/392 (23%), Positives = 168/392 (42%), Gaps = 43/392 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 491 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 551 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I +K K + L A+ R+ + + +VNDT + + +
Sbjct: 609 TSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E IG ++GTG N+ Y +E++K E + Q +C ++G
Sbjct: 669 EP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ + + +S +D + + ++C +RA +L
Sbjct: 778 TRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 834 CGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 865
>gi|45387413|gb|AAS60197.1| hexokinase 5 [Nicotiana tabacum]
Length = 499
Score = 82.0 bits (201), Expect = 7e-14, Method: Composition-based stats.
Identities = 109/419 (26%), Positives = 171/419 (40%), Gaps = 43/419 (10%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
++ A + +M GL SE S M +I NLPT ++ +D GGTNFR V
Sbjct: 56 LKQVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DEEGLFYALDLGGTNFRVMRV 113
Query: 79 YFD-------KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ 125
K V E+ S ++ M E+ + ++AE++ D+ +
Sbjct: 114 QLGGNEKRIVKHEVKEV-SIPQNVMAGSSSEVLFDFIATALAEFVATEGDDFHLPPGRQR 172
Query: 126 -ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ +K G IK +K + + + L +A+ R G ++ +VN
Sbjct: 173 ELGFTFSFPVKQLSIASGTLIKWTKGFSIEDVVGQDVVGELAKAMERAGLD-VRVTALVN 231
Query: 185 DTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCE 243
DT L G +++ D +LGTG N+AY+E I K +I E
Sbjct: 232 DTVGTLAGGRYNDPDVIA-----AVILGTGTNAAYVERAHAIPKWHGLLPKSGEMVINME 286
Query: 244 SGK--SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPR 300
G S+ +P +++D+ L S E E+M SG YLGE+ L R +F
Sbjct: 287 WGNFLSSHLPVTEYDQNLDVESLNPGEQIYEKMISGMYLGEILRRVLCRMAKEASLFGDY 346
Query: 301 VNKMLLNSCDFSTEEISLFLKEQNHD----KNIFSGIIEAHSVSEDYVKI-YSICKCFFE 355
V L T +++ +++ D N I+E + + KI +C
Sbjct: 347 VPSKLKIPFILRTPDMAAMHHDESADLKVVGNKLKDILEVPNSTLKMRKIVVELCDIITS 406
Query: 356 RAGRLSAAVIAAACIKTGKGKSPD---KPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
R RLSAA I K GK D + I+ DG++F ER + CL E
Sbjct: 407 RGARLSAAGIVGILKKLGKDTLKDGENQRSVIAVDGALF-------ER-YTKFRNCLEE 457
>gi|51511833|gb|AAU05128.1| hexokinase [Aedes albopictus]
Length = 445
Score = 82.0 bits (201), Expect = 8e-14, Method: Composition-based stats.
Identities = 92/397 (23%), Positives = 171/397 (43%), Gaps = 41/397 (10%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
IE LL+++ KGL + + I ++LP K K + +D GGTNFR +
Sbjct: 26 IEEIMRRLLKEINKGLNKATHPEADIKCFITYVQDLPNGKEKGK-FLALDLGGTNFRVLL 84
Query: 78 VYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFS 131
++ + E++S + +P + + FD IAE L E + + F FS
Sbjct: 85 IHLKDENDFEMVSKI-YAIPQSIMLGSGTQLFDHIAECLANFMKEHSVYEEKLPLGFTFS 143
Query: 132 YAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQ 191
+ + G + +K + + + A++R+G +I+ ++NDT L
Sbjct: 144 FPLTQLGLTKGILARWTKGFNCSGVVGEDVVQLQKDAIARRGDVQIEICAILNDTTGTLM 203
Query: 192 SGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQ-------IIVCES 244
S + + + IG ++GTG N+ Y+E ++ E +D P+ +I E
Sbjct: 204 SCAW-----KNHNCRIGLIVGTGSNACYVE-----RVDNCEMFDGPKDPNKKHVLINTEW 253
Query: 245 GKSNK-----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FS 298
G ++++D+ + S E+M SG Y+GEL +A+ + G+ F
Sbjct: 254 GAFGDNGMLDFVRTEYDREIDHFSINPGRQIQEKMISGMYMGELARLAIVKFTWAGLLFG 313
Query: 299 PRVNKMLLNSCDFSTEEISLFLKEQN----HDKNIFSGIIEAHSVSEDYVKIYSICKCFF 354
+ +L F T+ +S ++ + +++ + H+ ED + IC+C
Sbjct: 314 GVGSDILFKRGQFFTKYVSEIESDKPGTYMYCRDVLDELGLEHATDEDCANVRYICECVS 373
Query: 355 ERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
RA L +A IAA K +K + + DGS++
Sbjct: 374 SRAAHLVSAGIAALI-----NKMDEKSVTVGVDGSVY 405
>gi|70989741|ref|XP_749720.1| hexokinase Kxk, putative [Aspergillus fumigatus Af293]
gi|66847351|gb|EAL87682.1| hexokinase Kxk, putative [Aspergillus fumigatus Af293]
Length = 490
Score = 81.6 bits (200), Expect = 8e-14, Method: Composition-based stats.
Identities = 112/433 (25%), Positives = 186/433 (42%), Gaps = 42/433 (9%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+++I DF + D K ++ ++++ KGL E ++ M W D +
Sbjct: 24 LQQIKDFEEMFTVD-KAKLKQVVDHFVKELDKGLSVEGGNIP---MNVTWVMGFPDGDEQ 79
Query: 61 KKVIIIDAGGTNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFF----DSIAEY 115
+ +D GGTN R I ++KG +I K+ MP + T EE + D I ++
Sbjct: 80 GTFLALDMGGTNLRVCEITLTEEKGGFDICQS-KYRMPEELKTGTAEELWEYIADCIQQF 138
Query: 116 LEPLKDESDMIS----FCFSY-AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+E E + S F FSY A + + D G + +K + + + L + L
Sbjct: 139 IEFHHGEEGLTSLPLGFTFSYPATQEYIDHGILQ-RWTKGFDIDGVEGQDVVPPLEETLK 197
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLK 229
RKG IK ++NDT L + +++ + + IG + GTG+N+AY+E G + KL
Sbjct: 198 RKGLP-IKVAALINDTTGTLIASAYTDPEMK-----IGCIFGTGVNAAYMENVGSVPKLA 251
Query: 230 TTEFY-DKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC 284
D P I CE G + +P +K+D I+ +S + E+M +G YLGE+
Sbjct: 252 HMNLPPDMPVAINCEYGAFDNEHVVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIF 311
Query: 285 SIAL--RAGSAEGIF-----SPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAH 337
+AL S G+ + ++ K L F + + +F +
Sbjct: 312 RLALIDLLDSRPGLIFQNQDTSKLRKPYLLDASFLAAIEEDPYENLQETQELFERELNIK 371
Query: 338 SVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLKGFL 396
+ I + + RA RLSA +AA C K + C + ADGS+F K
Sbjct: 372 PTLAELEMIRRLAELIGTRAARLSACGVAAIC------KKKNIESCHVGADGSVFTKYPH 425
Query: 397 IKERIFKSLHTCL 409
K R ++L L
Sbjct: 426 FKARGAQALREIL 438
>gi|115400741|ref|XP_001215959.1| hexokinase [Aspergillus terreus NIH2624]
gi|114191625|gb|EAU33325.1| hexokinase [Aspergillus terreus NIH2624]
Length = 490
Score = 81.6 bits (200), Expect = 8e-14, Method: Composition-based stats.
Identities = 110/435 (25%), Positives = 189/435 (43%), Gaps = 49/435 (11%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+KE +D F + K + + +++++KGL E ++ M W D +
Sbjct: 27 IKEFEDIFTVDTAKLKQVVAH----FVKELEKGLTVEGGNIP---MNVTWVMGFPDGNEQ 79
Query: 61 KKVIIIDAGGTNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
+ +D GGTN R I ++KG +I K+ MP + T EE ++ IA+ LE
Sbjct: 80 GTFLALDMGGTNLRVCEITLTEEKGAFDITQS-KYRMPEELKTGTAEELWEYIADCLEQF 138
Query: 120 KD--------ESDMISFCFSY-AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALS 170
+ + + F FSY A + + D G + +K + + + L + L
Sbjct: 139 INAHHENENLDKLPLGFTFSYPATQEYIDHGILQ-RWTKGFDIDGVEGQDVVPPLEEILK 197
Query: 171 RKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLK 229
++G IK ++NDT L + +++ + IG + GTG+N+AY+E G + KL
Sbjct: 198 KRGLP-IKVAALINDTTGTLIASAYTDPAIK-----IGCIFGTGVNAAYMEDVGSVPKLA 251
Query: 230 TTEFY-DKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC 284
D P I CE G + +P +K+D I+ +S + E+M +G YLGE+
Sbjct: 252 YMNLPPDMPVAINCEYGAFDNEHVVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIF 311
Query: 285 SIAL------RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIE--- 335
+AL R G IF+ + +L + ++ ++ + S ++E
Sbjct: 312 RLALLDLLESRPGL---IFNGQDTSLLRKPYLLDSSFLAAIEEDPYENLQETSELLERKL 368
Query: 336 -AHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKG 394
+ + I + + RA RLSA +AA C K K + ADGS+F K
Sbjct: 369 NIKATEAELEMIRRLAELIGTRAARLSACGVAAICTKKNI-----KSCHVGADGSVFTKY 423
Query: 395 FLIKERIFKSLHTCL 409
K R ++L L
Sbjct: 424 PHFKARGAQALREIL 438
>gi|116500997|gb|EAU83892.1| hypothetical protein CC1G_11986 [Coprinopsis cinerea okayama7#130]
Length = 443
Score = 81.6 bits (200), Expect = 8e-14, Method: Composition-based stats.
Identities = 109/439 (24%), Positives = 182/439 (41%), Gaps = 42/439 (9%)
Query: 25 ILLEDMKKGLESEAESV-SSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKK 83
I++E K LE+ E + MIP + + + + ID GGTN R ++
Sbjct: 3 IIVEAFKDALETGLEKHDQELPMIPTYVFGWPSGNERGEFVAIDLGGTNLRVCLLNLQGD 62
Query: 84 GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESD--------------MISFC 129
G EI K+ + ++ ++ FD AE L+ + + + F
Sbjct: 63 GKFEITQS-KYRLSEEQKQDDGQKLFDFCAESLQTFIEGNSGEDGILQLAPGQKLPLGFT 121
Query: 130 FSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAV 189
FSY K G ++ +K P + E ++L + ++ ++NDT
Sbjct: 122 FSYPCKQEKIDHGVLMRWTKGFVAPNTEGHDVAEMFRKSLEKYNLP-VELKALINDTTGT 180
Query: 190 LQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE----YGKIEKLKTTEFYDKPQIIVCESG 245
L + + + I + GTG N+AY+E GKI+ L + D +I CE G
Sbjct: 181 LIASRYVNPS-----TKIACIFGTGCNAAYMERVKDIGKIKYLGIDD--DVEMVINCEWG 233
Query: 246 KSNK-----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPR 300
+ +P++K+D + E+S+ + E++ SGRYLGE+ + + EG+
Sbjct: 234 AFDSHNHEHLPRTKYDISIDESSSKPGQQTFEKLISGRYLGEIVRLIICELIDEGVLFLG 293
Query: 301 VNKMLLN-SCDFSTEEISLFLKEQNHDK----NIFSGIIEAHSVSEDYVKIYSICKCFFE 355
N L F T +SL + + IFS + + + +I +
Sbjct: 294 QNTYKLEVPWAFDTALLSLMESDPTDELLMIIGIFSHFFALETTLAERQFLRAIARLVGR 353
Query: 356 RAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGI 415
RA RLSA IAA K G D+ + ADGS++ K ERI + L E RG
Sbjct: 354 RAARLSACGIAAIVSKMG---YLDEGCSVGADGSLYNKYPGFAERIHEGLVDIFGE-RGR 409
Query: 416 YFVLKTNDEAVTLGTALAA 434
V ++ +G+A+ A
Sbjct: 410 NIVTHHAEDGSGVGSAIIA 428
>gi|45383904|ref|NP_989432.1| hexokinase 1 [Gallus gallus]
gi|23821300|dbj|BAC20932.1| hexokinase1 [Gallus gallus]
Length = 917
Score = 81.6 bits (200), Expect = 8e-14, Method: Composition-based stats.
Identities = 97/412 (23%), Positives = 175/412 (42%), Gaps = 34/412 (8%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+K+ID + + I+ A E MK GL + +++ M+P + D +
Sbjct: 19 VKKIDKYLYAMRLSDETLIDIMARFRRE-MKNGLSRDFNPTATVKMLPTFVRSIPDGSEK 77
Query: 61 KKVIIIDAGGTNFR---AGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL- 116
I +D GG+ FR + + K+ V + P + T FD +AE L
Sbjct: 78 GDFIALDLGGSYFRILRVKVSHEKKQTVQMESEIYNTPEDIIHGSGT--RLFDHVAECLG 135
Query: 117 -----EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSR 171
+ +KD+ + F FS+ + G I +K K + + + L +A+ +
Sbjct: 136 DFMEKQQIKDKKLPVGFTFSFPCRQSKLDEGILITWTKRFKASGVEGADVVKLLNKAIKK 195
Query: 172 KGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTT 231
+G + +VNDT + + F DDQ +G ++GTG N+ Y+E ++ +
Sbjct: 196 RGDYDADIMAVVNDTVGTMMTCGF---DDQ--RCEVGLIIGTGTNACYME--EMRHIDLV 248
Query: 232 EFYDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSI 286
E + I E G S + +++FD+ + S + E+M SG Y+GEL +
Sbjct: 249 EGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYMGELVRL 308
Query: 287 ALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ---NHDKNIFS--GIIEAHSVS 340
L + EG +F R+ L F T+ +S K + N K I + G+ +H
Sbjct: 309 ILVKMAKEGLLFEGRITPELPTKGKFETKHVSAIEKSKEGLNKAKEILTRLGVEPSH--- 365
Query: 341 EDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
ED + + +C R+ L+A+ + A + K + + DGS++
Sbjct: 366 EDCIAVQHVCTIVSFRSANLAASTLGAILNQLRDNKGVGRLRTTVGVDGSLY 417
Score = 72.4 bits (176), Expect = 6e-11, Method: Composition-based stats.
Identities = 87/393 (22%), Positives = 173/393 (44%), Gaps = 51/393 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+M+ GL+ ++ + + M+P + D ++ + +D GGTNFR +V + G
Sbjct: 494 EMEAGLKKKSHETAKVKMLPTFVRSTPDGTENGDFLALDLGGTNFRVLLVKI-RSGKRRT 552
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + +P + T EE FD I + D + + F FS+ K
Sbjct: 553 VEMHNKIYAIPIEVMQGTGEELFDHIVTCISDFLDYMGIRGARLPLGFTFSFPCKQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKK-----IIMVNDTAAVLQSGIF 195
G + +K K DC+ + ++ L R+G K+ ++ + +VNDT + + +
Sbjct: 613 AGILLNWTKGFKAT---DCEGEDVVY--LLREGIKRREEFDLDVVAVVNDTVGTMMTCAY 667
Query: 196 SETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGK 246
+ + IG ++GTG N+ Y +E+++ E D Q +C ++G
Sbjct: 668 EDP-----NCEIGLIVGTGSNACY-----MEEMRNIEMVDGEQGRMCVNMEWGAFGDNGC 717
Query: 247 SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKML 305
+ I ++ +DK + + S + E+M SG YLGE+ L + G +F ++++ L
Sbjct: 718 LDDI-RTIYDKAVDDYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKRGFLFRGQISETL 776
Query: 306 LNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGR 359
F T+ FL + D+ + + +S +D + + ++C +RA +
Sbjct: 777 KTRHIFETK----FLSQIESDRLALLQVRTILQQLGLNSTCDDSIIVKTVCGGVSKRAAQ 832
Query: 360 LSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
L A +AA K + + + I + DG+++
Sbjct: 833 LCGAGMAAVVDKIRENRGLEHLEITVGVDGTLY 865
>gi|67937782|gb|AAY83348.1| hexokinase [Hypocrea jecorina]
Length = 492
Score = 81.6 bits (200), Expect = 9e-14, Method: Composition-based stats.
Identities = 112/422 (26%), Positives = 178/422 (42%), Gaps = 68/422 (16%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA-GIVYFDKKG 84
+ ++ KGL E S+ M P W D + + +D GGTN R I D+K
Sbjct: 48 FVNELAKGLSVEGGSIP---MNPTWVMSYPDGHETGSFLALDMGGTNLRVCEITLTDRKS 104
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL---------KDESDMISFCFSYAIK 135
+I+ K+ MP + ++EE ++ IA+ L K E+ + F FSY
Sbjct: 105 EFDIIQS-KYRMPEELKTGSSEELWEYIADCLHQFIETHHGDCSKLEALPLGFTFSYPAT 163
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIF 195
G + +K + + + A++++G IK ++NDT L + +
Sbjct: 164 QHYIDEGILQRWTKGFDIAGVEGKNVVPMFEAAIAKRG-VPIKLSALINDTTGTLIASAY 222
Query: 196 SETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFY-DKPQIIVCESGKSNK---- 249
++ + IG + GTG N+AY+E G I KL D P I CE G +
Sbjct: 223 TDPKVK-----IGCIFGTGCNAAYMEDCGSIPKLAHMNLPPDCPMAINCEWGAFDNEHKV 277
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSC 309
+P++K+D + E+S + E+M +G YLGE+ + L L ++
Sbjct: 278 LPRTKYDIAIDEDSPRPGQQAFEKMIAGLYLGEIFRLVLVD--------------LHDNK 323
Query: 310 D---FSTEEISLFLKEQNHDKNIFSGIIEA--HSVSEDYVKIYS---------------- 348
D F ++ISL + D + SGI E ++ E + S
Sbjct: 324 DIHIFENQDISLLRRPYTLDSSFLSGIEEDPFENLQETFDTFQSKLNITPTGPELELVRR 383
Query: 349 ICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLKGFLIKERIFKSLHT 407
+ + RA RLSA +AA C K KS + C + ADGS+F K K R K+L
Sbjct: 384 LSELIGTRAARLSACGVAAIC----KKKSFES--CHVGADGSVFNKYPHFKARGAKALRE 437
Query: 408 CL 409
L
Sbjct: 438 IL 439
>gi|18026821|gb|AAL55635.1|AF118134_1 hexokinase-related protein 1 [Solanum tuberosum]
Length = 499
Score = 81.6 bits (200), Expect = 9e-14, Method: Composition-based stats.
Identities = 106/397 (26%), Positives = 167/397 (42%), Gaps = 33/397 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
+ + A + +DM+ GL + S M ++ LPT K +D GGTNFR V
Sbjct: 59 LRHVADAMADDMRAGLAVDGGSDLKM-ILSYVDTLPTGNEKGL-FYALDLGGTNFRVLRV 116
Query: 79 YFDKKGVPEILSFFKH-PMPALDREMTNEEFFDSIAEYL-----------EPLKDESDMI 126
K + + F+ +P T+EE FD IA L E + + I
Sbjct: 117 QLGGKEERVVATEFEQVSIPPELMFATSEELFDFIASALGKFAQKEGGNFELQQGRTREI 176
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDT 186
F FS+ +K G IK +K + + L +A+ R+G ++ +VNDT
Sbjct: 177 GFTFSFPVKQTSIRTGILIKWTKGFAVSGTAGKDVVACLNEAMERRG-MDMQVSALVNDT 235
Query: 187 AAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIV-CES 244
L + DD D+ + +LGTG N+ Y+E I KL T P IV E
Sbjct: 236 VGTLAGARY--WDD---DAMVAVILGTGTNACYVERVDAIPKL-TKRMSKSPITIVNTEW 289
Query: 245 GK-SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIF-SPRV 301
G SN +P ++FD+ + S E E+ SG YLGE+ + ++ G+F V
Sbjct: 290 GAFSNGLPLTEFDREMDAESINPGEQIFEKTISGMYLGEIVRRVLVKMSKVGGLFGGSYV 349
Query: 302 NKMLLNSCDFSTEEISLFLKEQNHD-KNIFSGIIEAHSVSEDYV---KIYSICKCFFERA 357
+ L+ T +I ++ + D + + S + + V D + IC +R
Sbjct: 350 PEKLVTPFVLRTPDICAMQQDTSRDLEAVESVLYDVAGVKSDLSARKTVVDICDTIAKRG 409
Query: 358 GRLSAAVIAAACIKT---GKGKSPDKPICISADGSMF 391
GRL+ A I K KG K ++ DG ++
Sbjct: 410 GRLAGAGIVGILQKMEEDSKGLIFGKRAVVAMDGGLY 446
>gi|148743500|gb|AAM83106.4|AF525739_1 liver glucokinase [Gallus gallus]
Length = 442
Score = 81.6 bits (200), Expect = 9e-14, Method: Composition-based stats.
Identities = 87/396 (21%), Positives = 175/396 (44%), Gaps = 33/396 (8%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D+ + ++M +GL+ E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLRKVMHRMQKEMDRGLKLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEEGQWKVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G +K +K K + L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLKRTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + + +G ++GTG N+ Y +E++ E + + +C +
Sbjct: 209 TMISCYYEDHRRE-----VGMIVGTGCNACY-----MEEMHNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIA-LRAGSAEGIFSP 299
G S ++ + ++D+++ E S + E++ G+Y+GE+ + LR +FS
Sbjct: 259 AFGASGELDEFLLEYDRVVDETSLNPGQQLYEKIIGGKYMGEIVRLVLLRLVDENLLFSG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSV---SEDYVKIYSICKCFFER 356
+ + L F T +S + K I++ I+ A + D + +C+ R
Sbjct: 319 QACEKLKTRGAFETRFVSQVESDSGDRKQIYN-ILTAFGLLPSGSDCDIVRMVCESVSTR 377
Query: 357 AGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A ++ +A +A + + +S + I + DGS++
Sbjct: 378 AAQMCSAGLAGVINRMRESRSQETLKITVGVDGSVY 413
>gi|114613113|ref|XP_001143590.1| PREDICTED: glucokinase isoform 2 [Pan troglodytes]
Length = 466
Score = 81.6 bits (200), Expect = 9e-14, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 188/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 30 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 89
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 90 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 149
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 150 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 209
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 210 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 259
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 260 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 319
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
+ ++ L F T +S + K I++ + + D + C+ RA
Sbjct: 320 KASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 379
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 380 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 438
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 439 FI--ESEEGSGRGAALVS 454
>gi|114613117|ref|XP_001143302.1| PREDICTED: glucokinase isoform 1 [Pan troglodytes]
Length = 464
Score = 81.6 bits (200), Expect = 1e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 188/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 28 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 87
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 88 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 147
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 148 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 207
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 208 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 257
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 258 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 317
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
+ ++ L F T +S + K I++ + + D + C+ RA
Sbjct: 318 KASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 377
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 378 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 436
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 437 FI--ESEEGSGRGAALVS 452
>gi|110189777|gb|ABG56071.1| hexokinase 2 [Monocercomonoides sp. PA203]
Length = 517
Score = 81.3 bits (199), Expect = 1e-13, Method: Composition-based stats.
Identities = 112/470 (23%), Positives = 188/470 (40%), Gaps = 88/470 (18%)
Query: 15 YKIDIEYAASIL---LEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGT 71
+ ID+ IL LE M GL+ + S M MIP + ++P+ P + + +D GGT
Sbjct: 11 FNIDVRAVQPILFTMLEHMHTGLQGPSHS---MLMIPTFTDVPSK-PVNGLYLALDFGGT 66
Query: 72 NFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLE--------PLKDES 123
NFR ++ EIL + + T++E + +++ L
Sbjct: 67 NFRCLLLNIKHN---EILDSWSDSRKIDPQIPTSKELMSVLGGFIQDFLHLHEKELTPRP 123
Query: 124 DMI--SFCFSYAIKIFPDGGGQAIKLSKE-IKLPYIGDCKINEGLFQALSRKGWKKIKKI 180
D++ + FS+ + G + +KE I +G+ + + L + L+++ +K I
Sbjct: 124 DILYTGYTFSFPTEQTSLNSGTLVHWTKEFITKGCVGEDPVKQ-LQEELNKRNLDWVKII 182
Query: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQI 239
M NDT L + ++ + IG +LGTG N++Y E I+KL Y +
Sbjct: 183 AMCNDTVGTLCTRRLTDPSVE-----IGVILGTGSNASYREKISNIKKLDPKAIYSSDHM 237
Query: 240 IV-CESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFS 298
++ E G + +PQ++FDKI+ E + + E+ SGRYL + ALR G
Sbjct: 238 LINMEWGSFSGMPQNEFDKIIFEKTKEHSSQPFEKQISGRYLPMMAREALRKAILTGCV- 296
Query: 299 PRVNKMLLNSCDFSTEEISLFL---KEQNHDKNIFSG----------------------- 332
N + + S EE S F +E +K+ G
Sbjct: 297 --FNGLWGDGSTLSDEEKSPFSDIHREMWDEKHRLRGEEMEEIIWDESEKKEKVEEILRQ 354
Query: 333 ----------IIEAHSVS-EDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKG------ 375
+ E ++ D + + K R+ RLSA ++A I KG
Sbjct: 355 LWCKSNPRLKLREGVTLQLSDLSLVQQLFKAILTRSARLSAIAVSAVVIHIVKGFIEEAK 414
Query: 376 -----------KSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRG 414
K P I + DGS+F KE + +S+ CL +G
Sbjct: 415 EKGRSETDYLAKHPK--ITAAIDGSLFTHNRGYKEEMARSVELCLDSVKG 462
>gi|146423316|ref|XP_001487588.1| hypothetical protein PGUG_00965 [Pichia guilliermondii ATCC 6260]
gi|146388709|gb|EDK36867.1| hypothetical protein PGUG_00965 [Pichia guilliermondii ATCC 6260]
Length = 481
Score = 81.3 bits (199), Expect = 1e-13, Method: Composition-based stats.
Identities = 106/414 (25%), Positives = 180/414 (43%), Gaps = 60/414 (14%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD-KK 83
+ ++ KGL + ++ MIP W + PT K + ID GGTN R +V D +
Sbjct: 46 FITELDKGLSKKGGNIP---MIPGWVMDFPTGKEKGD-YLAIDLGGTNLRVVLVKLDGNR 101
Query: 84 GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKD--------ESDMISFCFSYAIK 135
I S K+ +P R T +E F IA+ L+ + E + F FSY
Sbjct: 102 SFQTIQS--KYALPLDMRTSTADELFGFIAKCLKEFVEQEFNDGCTEPLPLGFTFSYPAT 159
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIF 195
+ G + +K + + + L A+ G I + ++NDT L + ++
Sbjct: 160 QYSINTGVLQRWTKGFDIDGVEGHDVVPMLQDAIKNIG-VPIDVVALINDTTGTLVASMY 218
Query: 196 SETDDQGFDSHIGFVLGTGLNSAYIEY----GKIE-KLKTTEFYDKPQIIVCESGKSNK- 249
++ + + +G + GTG N AY + K+E K+++ D P I CE G +
Sbjct: 219 TDPE-----TIMGLIFGTGCNGAYYDVVKDIPKLEGKVESDVAQDGPMAINCEYGAFDNE 273
Query: 250 ---IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLL 306
+P++K+D ++ + S + E+M SG YLGE+ + L + E K++
Sbjct: 274 LVVLPRTKYDVLIDKQSPRPGQQSFEKMISGYYLGEVLRLILLDLAEE-------KKLIF 326
Query: 307 NSCDFS--TEEISL------FLKEQNHD-----KNIFSGIIEAHSVSEDYVKIYSICKCF 353
D S EE + ++E ++ + +F ++ + + I I +
Sbjct: 327 QGQDLSKLKEEFIMDTSFPARIEEDPYESLTEVEALFKEVLNLDTTFNERAVISRIAQKV 386
Query: 354 FERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMF--LKGFLIKERIFKSL 405
ER+ RLS IAA C K G K +ADGS++ GF KER ++L
Sbjct: 387 GERSARLSVCGIAAICKKRGY-----KTGHCAADGSVYNMYPGF--KERTARAL 433
>gi|156121249|ref|NP_001095772.1| hypothetical protein LOC616576 [Bos taurus]
gi|151554675|gb|AAI50098.1| MGC166120 protein [Bos taurus]
Length = 465
Score = 81.3 bits (199), Expect = 1e-13, Method: Composition-based stats.
Identities = 99/436 (22%), Positives = 186/436 (42%), Gaps = 34/436 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMRRMQKEMDRGLRLETHKEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + H M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEAGQWSVKTTHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYEDR-----RCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ ENS + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGDSGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRA 378
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ AA +A + + +S D I + DGS++ KER F ++ LT I
Sbjct: 379 AHMCAAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKER-FHAIVRRLTPSCEIT 437
Query: 417 FVLKTNDEAVTLGTAL 432
F+ ++E G AL
Sbjct: 438 FI--ESEEGSGRGAAL 451
>gi|149704614|ref|XP_001495888.1| PREDICTED: similar to glucokinase [Equus caballus]
Length = 466
Score = 81.3 bits (199), Expect = 1e-13, Method: Composition-based stats.
Identities = 97/436 (22%), Positives = 185/436 (42%), Gaps = 34/436 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + E+M +GL E +++ M+P + + + + +D GGTNFR +
Sbjct: 30 DLKKVMRRMQEEMDRGLRLETHEEATVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 89
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 90 VKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 149
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K I L A+ R+G ++ + MVNDT A
Sbjct: 150 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVA 209
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 210 TMISCYYEDR-----RCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 259
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G + ++ + ++D+++ ENS + E++ G+Y+GEL + L E +F
Sbjct: 260 AFGDAGELDEFLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFHG 319
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + D + C+ RA
Sbjct: 320 EASEQLRTRGAFETRLVSQVESDSGDRKQIYNILSTLGLRPSGTDCDIVRRACESVSTRA 379
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +AA + + + D I + DGS++ K+R S+ LT I
Sbjct: 380 AHMCSAGLAAVINRMRESRREDVMRITVGVDGSVYKLHPSFKQRFHASVRR-LTPNCEIT 438
Query: 417 FVLKTNDEAVTLGTAL 432
F+ ++E G AL
Sbjct: 439 FI--ESEEGSGRGAAL 452
>gi|47221354|emb|CAF97272.1| unnamed protein product [Tetraodon nigroviridis]
Length = 1314
Score = 81.3 bits (199), Expect = 1e-13, Method: Composition-based stats.
Identities = 85/320 (26%), Positives = 144/320 (45%), Gaps = 28/320 (8%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV 85
L +DM +GL+ + + + M+P + D + + +D GGTNFR + V
Sbjct: 25 LRKDMIRGLKKHSHQNAPVKMLPTFVRATPDGTEKGDFLALDLGGTNFRV----LHVRVV 80
Query: 86 PEILSFFK--HPMPALDREMT---NEEFFDSIAEYLEP------LKDESDMISFCFSYAI 134
E K + + +EM E+ FD IA L LK ++ + F FS+
Sbjct: 81 EEEQKVLKMDSQICTIPKEMMLGPGEKLFDHIAACLSEFISSRNLKGQTLPLGFTFSFPC 140
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
+ I+ +K K + + L +A+ R+G +I + MVNDT + S
Sbjct: 141 EQKEIDKSILIRWTKGFKCSGVEGEDVVRLLKEAIRRRGDYEIGTVAMVNDTVGTMMSCG 200
Query: 195 FSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESG-----KSNK 249
+ DQ + IG ++GTG N+ Y+E +++ +K E D I E G + K
Sbjct: 201 YR---DQSCE--IGLIIGTGTNACYME--EMKNVKRVEGEDGRMCINTEWGGFGDDGALK 253
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLNS 308
Q+ FD + E S + E+M SG YLGE+ + L + + +F + ++ LL
Sbjct: 254 DIQTTFDVTVDETSVNPGVHIFEKMISGMYLGEIVRLLLVKLTEDQLLFGGQASEALLTP 313
Query: 309 CDFSTEEISLFLKEQNHDKN 328
F T+ IS +E++ +N
Sbjct: 314 ETFETKFISQIEEEEHSLEN 333
>gi|66525954|ref|XP_623403.1| PREDICTED: similar to Hexokinase A CG3001-PA, isoform A [Apis
mellifera]
Length = 445
Score = 80.9 bits (198), Expect = 1e-13, Method: Composition-based stats.
Identities = 98/409 (23%), Positives = 172/409 (42%), Gaps = 45/409 (11%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG 84
L + + KGL E + ++ P + ++LP K + +D GGTNFR ++ D++
Sbjct: 27 LNDQLHKGLGKETHATATTKCFPTYVQDLPQGTEKGN-FLALDLGGTNFRVLLITLDEQN 85
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFP 138
+ P + T + FD IA L L++E + F FS+ +
Sbjct: 86 FDMKSKIYVIPQSLM--VGTGVQLFDHIAHCLALFVKDLNLQNEVLPLGFTFSFPLDQHG 143
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G I+ +K K I I + L QA+ ++G KI+ ++NDT L S +
Sbjct: 144 LTKGYLIRWTKGFKCDDIIGEDIVDLLEQAIKKRGDVKIQICAILNDTTGTLMSCAWKNK 203
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTE----FYDKPQIIV------CESGKSN 248
+ IG ++GTG N+ Y+E K+E ++T KP++++ G
Sbjct: 204 -----NCRIGLIVGTGTNACYVE--KLENIQTVYPENVLPGKPKMLINIEWGAFGEGTLL 256
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
+ D+ + ENS + E+M SG Y+GEL + + +A +A +F + L
Sbjct: 257 DFIATDIDRDVDENSINPAKQVFEKMISGMYMGELVRLLIEKAINAGLLFIGKSTNELKK 316
Query: 308 SCDFSTEEISLFLKEQNHD----KNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
F + +S + N + + + + + +D + IC RA L++A
Sbjct: 317 RGRFYAKYVSEIENDPNGKYTNCREVLAELGLRNVTDQDCENVKYICSVVSRRAAHLASA 376
Query: 364 VIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEK 412
IA T K + + + DGS++ R H +TEK
Sbjct: 377 GIA-----TLLNKMDEDNVVVGIDGSVY--------RYHPHFHNLMTEK 412
>gi|46114344|ref|XP_383190.1| hypothetical protein FG03014.1 [Gibberella zeae PH-1]
Length = 453
Score = 80.9 bits (198), Expect = 1e-13, Method: Composition-based stats.
Identities = 109/408 (26%), Positives = 173/408 (42%), Gaps = 47/408 (11%)
Query: 14 DYKID---IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGG 70
D+ ID +++ + +++++KGL + S+ M P W D + K +++D GG
Sbjct: 14 DFVIDTAKLKHVTNHFVQELEKGLSIKGGSIP---MNPTWVTNYPDGNEKGKSLVLDMGG 70
Query: 71 TNFRA-GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---- 125
TN R I +KG E+ H +P + T +E +D IA L+ +D
Sbjct: 71 TNLRVYSIQLTSEKGGFEVKQE-SHKLPEELKTATADELWDFIAGCLDSFLQSADFDLST 129
Query: 126 ---ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIM 182
+SF FS+ G + +K + E L QA+ +K +K ++
Sbjct: 130 EIDLSFIFSFPTTQRTIDEGILQRWTKGFNISNTEGKDAAESLRQAIKKKNLP-LKVRVV 188
Query: 183 VNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKP-QII 240
NDT A + + + +D + IG V GTG N AY E G I KL + I
Sbjct: 189 TNDTTATMMASAYLNSD-----TEIGCVFGTGCNGAYFEKVGAIPKLANDNLNGESFMAI 243
Query: 241 VCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGEL-----CSIALRAG 291
CE G + +P + +D + E+S K + E+M +G YLGEL I R
Sbjct: 244 NCEWGAFDNEHAVLPLTSYDIAIDEDSPRKGQQAFEKMVAGLYLGELFRRIILEIHQRDP 303
Query: 292 SA--EGIFSPRVNKMLLNSCDFST---EEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKI 346
EG R+N F + E+ S L+E ++ + S I ++K
Sbjct: 304 HTFLEGQSMERLNDTYCLDSSFLSAIEEDASDGLREA-YETCVSSLGISPTLAELQFMK- 361
Query: 347 YSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPIC-ISADGSMFLK 393
++ RA RLSA +AA C K D C + +GS+F K
Sbjct: 362 -AVATLITTRAARLSATGVAAICQKR------DLQQCHVGVEGSLFEK 402
>gi|83772607|dbj|BAE62735.1| unnamed protein product [Aspergillus oryzae]
Length = 493
Score = 80.9 bits (198), Expect = 1e-13, Method: Composition-based stats.
Identities = 110/439 (25%), Positives = 180/439 (41%), Gaps = 81/439 (18%)
Query: 13 FDYKID-IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDA 68
FD+ + ++ + ++ +GL E ++S IP T +P + + +D
Sbjct: 16 FDFPAEGVQRGVKEYIREIDEGLSKEGTTLSQ---IP---TFVTSVPNGTEKGLYLAVDL 69
Query: 69 GGTNFRAGIVYF----------DKKGVP----------EILSFFKHPMPALDREMTNEEF 108
GGTNFR V K +P ++ +F + A R NE F
Sbjct: 70 GGTNFRVCSVDLHGDNTFSLTQSKIMIPRELMASGTSKDLFTFLARQIEAFLRIHHNEHF 129
Query: 109 FDSIAEYLEPLKDESDM--ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGD--CKINE 163
+ E E D+ + F FS+ ++ G I+ +K +P +G C + +
Sbjct: 130 EAHLKRRREG-NSEEDLFDLGFTFSFPVRQVGINKGTLIRWTKGFNIPDAVGHDVCALLQ 188
Query: 164 GLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-Y 222
AL ++ +VNDT L + ++ + G + +G + GTG N AY+E
Sbjct: 189 NALDALELP----VRVAALVNDTVGTLMARSYTSPGETG--TFLGAIFGTGTNGAYVEKL 242
Query: 223 GKIEKLKTTEF--YDKP---QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLER 273
KI K+ T E YDK II E G + +P + +D+ L E SN E+
Sbjct: 243 DKITKMATIEHSDYDKTTGEMIINAEWGSFDNHLSVLPNTVYDQQLDEESNNPGIQMFEK 302
Query: 274 MCSGRYLGELCS---IALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIF 330
SG +LGE+ + L + G+F P S D E S ++ D ++
Sbjct: 303 RVSGMFLGEILRRVLVDLHRNESLGLFKPSA------SSDVIVPENSTLFRQWGLDTSLL 356
Query: 331 SGIIEAHSVS--------EDYVKI-----------YSICKCFFERAGRLSAAVIAAACIK 371
S + +S S +D++KI +I +RA RLSA IAA I
Sbjct: 357 SLVEADNSESMEPTKTALKDHLKIERASTTDCKAVKTIVHAIGKRAARLSAVPIAAILIA 416
Query: 372 TGKGKSPDKPICISADGSM 390
T K ++ D + + DGS+
Sbjct: 417 TKKLET-DDLVDVGVDGSL 434
>gi|17507937|ref|NP_492905.1| H25P06.1 [Caenorhabditis elegans]
gi|3878040|emb|CAB07234.1| Hypothetical protein H25P06.1 [Caenorhabditis elegans]
Length = 552
Score = 80.9 bits (198), Expect = 2e-13, Method: Composition-based stats.
Identities = 83/319 (26%), Positives = 149/319 (46%), Gaps = 30/319 (9%)
Query: 24 SILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDK---KVIIIDAGGTNFRAGIVYF 80
S L ++M +GLES E S++ M+P + ++P K K + +D GGTN R ++
Sbjct: 66 SHLSDNMDRGLESGLER-STIAMLP---SFVPELPNGKERGKFVAMDLGGTNLRVMLMEL 121
Query: 81 DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAI 134
+ G P F MP T ++ FD IA+ L L DE + F FSY
Sbjct: 122 EP-GEPMRTKQFNTRMPNAAMHGTGQKLFDYIAKALCDFLVERELADEHLPVGFTFSYPC 180
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
++ +K + + + L A++R G K+ + ++NDT + +
Sbjct: 181 DQTGLRSATLLRWTKGVTATGCVGEDVVQLLEDAIARDGRVKVNIVALINDTVGTMVAAA 240
Query: 195 FSETDDQGFDSHIGFVLGTGLNSAYIEYGK--IEKL-KTTEFYDKPQIIV-------CES 244
+ + G IG ++GTG N++Y+E + + L TE Y+ +I+ ++
Sbjct: 241 Y----EAGGHCDIGVIIGTGTNASYMEDSRKIVHGLANATEDYNHKSMIIDTEWGGFGDN 296
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNK 303
G+++ I +++DKI+ S+ L+++ +G +GEL + L R + +F+ +K
Sbjct: 297 GEADYI-FTRYDKIVDSKSDHPGVNSLDKLIAGMCMGELVRLVLERLCENKVLFNGIGSK 355
Query: 304 MLLNSCDFSTEEISLFLKE 322
ML F T+ IS L +
Sbjct: 356 MLRTRNTFPTKYISEILHD 374
>gi|114613115|ref|XP_001143661.1| PREDICTED: glucokinase isoform 3 [Pan troglodytes]
Length = 465
Score = 80.9 bits (198), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 188/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
+ ++ L F T +S + K I++ + + D + C+ RA
Sbjct: 319 KASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 378
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 379 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 437
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 438 FI--ESEEGSGRGAALVS 453
>gi|145301541|ref|NP_001077423.1| glucokinase [Felis catus]
gi|125434898|gb|ABN42207.1| glucokinase [Felis catus]
Length = 465
Score = 80.9 bits (198), Expect = 2e-13, Method: Composition-based stats.
Identities = 99/428 (23%), Positives = 183/428 (42%), Gaps = 34/428 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M +GL E +S+ M+P + + + + +D GGTNFR +V + +
Sbjct: 39 KEMARGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQ 98
Query: 88 ILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
KH M ++ + T E FD I+E + D+ M + F FS+ ++
Sbjct: 99 WSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHED 158
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G + +K K I L A+ R+G ++ + MVNDT A + S + +
Sbjct: 159 IDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDR 218
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNKIPQ 252
+G ++GTG N+ Y +E++ E + + +C + G S ++ +
Sbjct: 219 -----RCEVGMIVGTGCNACY-----MEEMHNVELVEGDEGRMCVNTEWGAFGDSGELDE 268
Query: 253 S--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++D+++ ENS + E++ G+Y+GEL + L E +F ++ L
Sbjct: 269 FLLEYDRVVDENSLNPGQQLYEKLIGGKYMGELVRLVLLKLVDENLLFRGEASEQLRTRG 328
Query: 310 DFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAA 367
F T +S + K I++ + + D + C+ RA + AA +A
Sbjct: 329 AFETRFVSQVESDSGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAYMCAAGLAG 388
Query: 368 ACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAV 426
+ + +S D I + DGS++ KER F ++ LT I F+ ++E
Sbjct: 389 VINRMRESRSEDVMRITVGVDGSVYKLHPSFKER-FHAIVRRLTPSCEITFI--ESEEGS 445
Query: 427 TLGTALAA 434
G AL +
Sbjct: 446 GRGAALVS 453
>gi|15967159|ref|NP_277042.1| glucokinase isoform 2 [Homo sapiens]
gi|2773377|gb|AAB97681.1| glucokinase [Homo sapiens]
gi|51094509|gb|EAL23765.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
[Homo sapiens]
gi|119581520|gb|EAW61116.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2),
isoform CRA_c [Homo sapiens]
Length = 466
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 30 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 89
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 90 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 149
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 150 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 209
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 210 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 259
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 260 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 319
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 320 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 379
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 380 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 438
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 439 FI--ESEEGSGRGAALVS 454
>gi|126139099|ref|XP_001386072.1| Glucokinase [Pichia stipitis CBS 6054]
gi|126093354|gb|ABN68043.1| Glucokinase [Pichia stipitis CBS 6054]
Length = 471
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 103/403 (25%), Positives = 170/403 (42%), Gaps = 39/403 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVYFDKKG 84
E M GL + + M MIP + T IP K+ + D GGTNFR ++
Sbjct: 32 ESMSAGLATSTPTRDYMPMIPTYV---TGIPTGKEKGLYLAADLGGTNFRVCSIHLGGDH 88
Query: 85 VPEI-LSFFKHPMPALDRE-MTNEEFFDSIAEYLEPLKD-------ESDMISFCFSYAIK 135
E+ S +K P+ + E T + F+ +AE ++ D E + F FS+ +
Sbjct: 89 TFEMKQSKYKIPVDLMQGEDATADGLFNYLAEKVKTFLDQHHNEHAEQLKLGFTFSFPVN 148
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIF 195
G I+ +K LP D + E L + + G K+ + NDT L S +
Sbjct: 149 QTALNRGTLIRWTKGFDLPDCVDKDVVELLQKHMELLG-VKVHVAALANDTVGTLLSRAY 207
Query: 196 S-ETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYD--KPQIIVCESGKSNK-- 249
S + ++ +G + GTG N AY E K I KLK + + K +I E G +
Sbjct: 208 SNDISKTNSNTVVGAIFGTGTNGAYFETLKNIPKLKKEDIPEGAKGMVINTEWGSFDNTL 267
Query: 250 --IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKM--- 304
+P +K+DK++ + + + E+ SG +LGEL +AL G+ + K
Sbjct: 268 KILPCTKYDKLVDDETANVGYHLFEKRISGMFLGELLRVALMDLFDRGLIFQELYKARGG 327
Query: 305 -----LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAH----SVSEDYVKIYSICKCFFE 355
+ S E +S + + D + ++E H + E+ + I + +
Sbjct: 328 TLPHRIFEPWLISAEVLSYLQIDDSTDLKMSELVLENHLRLPTNKEERLVIQKLTQSISH 387
Query: 356 RAGRLSAAVIAAACIKT-GKGKSPDKPICISADGSM--FLKGF 395
RA LSA +A+ + + K D+ DGS+ F GF
Sbjct: 388 RAAYLSAIPLASIVARVQDQYKDDDRDFEFGCDGSVVEFYPGF 430
>gi|15967161|ref|NP_277043.1| glucokinase isoform 3 [Homo sapiens]
gi|2773378|gb|AAB97682.1| glucokinase [Homo sapiens]
gi|51094510|gb|EAL23766.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
[Homo sapiens]
gi|119581518|gb|EAW61114.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2),
isoform CRA_a [Homo sapiens]
Length = 464
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 28 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 87
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 88 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 147
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 148 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 207
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 208 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 257
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 258 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 317
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 318 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 377
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 378 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 436
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 437 FI--ESEEGSGRGAALVS 452
>gi|109066689|ref|XP_001092919.1| PREDICTED: similar to glucokinase isoform 2 isoform 2 [Macaca
mulatta]
Length = 466
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 30 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 89
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 90 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 149
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 150 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 209
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 210 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 259
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 260 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 319
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 320 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRA 379
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 380 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 438
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 439 FI--ESEEGSGRGAALVS 454
>gi|113967763|gb|ABI49144.1| hexokinase [Trimastix pyriformis]
Length = 456
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 100/417 (23%), Positives = 188/417 (45%), Gaps = 53/417 (12%)
Query: 26 LLEDMKKGLESE-AESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF-DKK 83
++ED+ + +E A SS+ MIP + + T ++ K + +D GGTNFR +V+ D K
Sbjct: 20 IIEDIHRQMEDGLAGRPSSLKMIPSYADAATG-REEGKFLALDFGGTNFRIVMVHLHDGK 78
Query: 84 GVPEILSFF-----KHPMPA-LDREMTNE--EFFDSIAEYLEPLKDESDM-ISFCFSYAI 134
V +I+S K P+ A L R++ +F D +L+P E + + F FS+ +
Sbjct: 79 IVDKIISSNNRLNEKTPLGADLFRQVAAHIVKFLDD--HHLKPAAGEPALPLGFTFSFPV 136
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGW-KKIKKIIMVNDTAAVLQSG 193
G I +KE + + L AL G + I + +VNDT + +
Sbjct: 137 NQTSISSGTLIYWTKEFIASGVEGNDVVALLRTALHEVGLDQSINVVALVNDTVGTMAAH 196
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIVCESGKSNKIPQ 252
F + + +G ++GTG N+ Y E +I KL II E G + +P
Sbjct: 197 SFEHPE-----TAMGVIMGTGTNACYRESISQIPKLHNPPAGKSHTIINMEWGNYDHMPA 251
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRV----------- 301
++ D++L ++ E+M SGRY+G L + A+G+ P +
Sbjct: 252 TEMDELLFTHTGQPALMRFEKMTSGRYMGLLMREVITKCIADGVLFPALPQGAGWVFDPE 311
Query: 302 --------NKMLLNSCDFS-TEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKC 352
+++L + + T L + D N+F ++A+ + + + +
Sbjct: 312 SRFDAMWMDRILTDRAPYPVTRGYLLQCAGRPADDNVF---LDANHLE----FLLYLSRA 364
Query: 353 FFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLK--GF--LIKERIFKSL 405
R+ R + ++AA + + ++P + + ++ DGS+F K G+ L++E + ++L
Sbjct: 365 ILSRSARFAGLMVAAVVARLYR-QAPTRAMVVAVDGSVFHKSPGYDTLMQETVTQAL 420
>gi|67903404|ref|XP_681958.1| glucokinase [Aspergillus nidulans FGSC A4]
gi|40741048|gb|EAA60238.1| HXKG_ASPNG GLUCOKINASE (GLUCOSE KINASE) (GLK) [Aspergillus nidulans
FGSC A4]
Length = 489
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 101/419 (24%), Positives = 176/419 (42%), Gaps = 72/419 (17%)
Query: 27 LEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRAGIVYFDKK 83
+ ++++GL E ++S IP T +P + + +D GGTNFR + D
Sbjct: 30 IREVEEGLSEEGTTLSQ---IP---TFVTSVPNGTEKGLYLAVDLGGTNFR--VCSIDLH 81
Query: 84 G------------VP----------EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKD 121
G +P E+ F + + R NE F + +
Sbjct: 82 GNHTFSLTQSKIMIPREMMTSGSAKELFLFLARQIESFLRIHHNEHFEAHLKRKIAGTAR 141
Query: 122 ESDM--ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGD--CKINEGLFQALSRKGWKK 176
E D+ + F FS+ ++ G I+ +K +P +G C + + + L+
Sbjct: 142 EEDLFDLGFTFSFPVRQLGINKGTLIRWTKGFDIPDAVGQDVCALLQNAIEELNLP---- 197
Query: 177 IKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEF-- 233
++ +VNDT L + ++ + G + +G + GTG N AY+E KI K+ E
Sbjct: 198 VRVAALVNDTVGTLMARSYTSPGETG--TFLGAIFGTGTNGAYVEKLNKITKMAKIEHSD 255
Query: 234 YDKP---QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSI 286
YDK II E G + +P +++D+ L +SN E+ SG +LGE+ +
Sbjct: 256 YDKSTGEMIINAEWGSFDNHLSVLPTTEYDRQLDADSNNPGIQMFEKRVSGMFLGEILRL 315
Query: 287 AL----------RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD----KNIFSG 332
L + S +F P + L T +S+ +++ D K+
Sbjct: 316 VLLDLHKSQGLFKPASGSDVFIPE-SSSLYRQWGIDTSLLSIVEADKSKDFEQVKSALKD 374
Query: 333 IIEAHSVSEDYVK-IYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSM 390
++ SE+ K + ++ +RA RL+A IAA I TGK K ++ + I DGS+
Sbjct: 375 HLKVERASENDCKAVQTVVHAIGKRAARLAAVPIAATLISTGKLK--EELVDIGVDGSL 431
>gi|75291596|sp|Q6Q8A5|HXK2_TOBAC Hexokinase-2, chloroplast precursor (NtHxK2)
gi|45387405|gb|AAS60193.1| hexokinase 2 [Nicotiana tabacum]
Length = 499
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 105/397 (26%), Positives = 165/397 (41%), Gaps = 33/397 (8%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIV 78
+ + A + DM+ GL + S M ++ LPT K +D GGTNFR V
Sbjct: 59 LRHVADAMAVDMRAGLAVDGGSDLKM-ILSYIDTLPTGNEKGL-FYALDLGGTNFRVLRV 116
Query: 79 YFDKKGVPEILSFFKH-PMPALDREMTNEEFFDSIAEYL-----------EPLKDESDMI 126
K I + F+ +P T+EE FD IA L E + + I
Sbjct: 117 QLGGKEERVIATEFEQVSIPQELMFATSEELFDFIASELGKFSQSEGGKFEMQQGRTREI 176
Query: 127 SFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDT 186
F FS+ +K G IK +K + + L +A+ R+G ++ +VNDT
Sbjct: 177 GFTFSFPVKQTSVKSGILIKWTKGFAVSGTAGKDVVACLNEAMERQGLG-MQVSALVNDT 235
Query: 187 AAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKPQIIV-CES 244
A L + + D + +LGTG N+ Y+E I KL + P+ IV E
Sbjct: 236 VATLAGARYWDND-----VMVAVILGTGTNACYVERVDAIPKLPQ-RMSNSPETIVNTEW 289
Query: 245 GK-SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIF-SPRV 301
G SN +P ++FD+ + S E E+ SG YLGE+ + ++ G+F V
Sbjct: 290 GAFSNGLPLTEFDREMDAESINPGEQIFEKTISGMYLGEIVRRVLVKMAKVGGLFGGGYV 349
Query: 302 NKMLLNSCDFSTEEISLFLKEQNHD-KNIFSGIIEAHSVSEDYV---KIYSICKCFFERA 357
+ L+ T +I ++ + D + + S + + V D + IC R
Sbjct: 350 PEKLVTPFVLRTPDICAMQQDTSRDLEAVESVLYDIAGVKSDLSARKTVVDICDTIANRG 409
Query: 358 GRLSAAVIAAACIKT---GKGKSPDKPICISADGSMF 391
GRL+ A I K KG K ++ DG ++
Sbjct: 410 GRLAGAGIVGILQKMEEDSKGVIFGKRTVVAMDGGLY 446
>gi|47169424|pdb|1V4S|A Chain A, Crystal Structure Of Human Glucokinase
Length = 455
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 19 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 78
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 79 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 138
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 139 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 198
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 199 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 248
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 249 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 308
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 309 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 368
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 369 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 427
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 428 FI--ESEEGSGRGAALVS 443
>gi|18079297|ref|NP_524848.1| Hexokinase A CG3001-PA, isoform A [Drosophila melanogaster]
gi|7291070|gb|AAF46507.1| CG3001-PA, isoform A [Drosophila melanogaster]
gi|17862118|gb|AAL39536.1| LD09907p [Drosophila melanogaster]
Length = 541
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/435 (22%), Positives = 193/435 (44%), Gaps = 48/435 (11%)
Query: 26 LLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG 84
+L ++++GL + +++ + ++LP + K + +D GGTNFR +++ +
Sbjct: 116 ILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGK-FLALDLGGTNFRVLLIHLQENN 174
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
++ S + +P + + FD IAE L E ++ + F FS+ ++
Sbjct: 175 DFQMESRI-YAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLG 233
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G +K + + + + L A++R+G +I ++NDT L S +
Sbjct: 234 LTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAW--- 290
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIV-------CESGKSNKIP 251
+ + IG ++GTG N+ Y+E + +L E K +++ ++G + +
Sbjct: 291 --KNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFV- 347
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FSPRVNKMLLNSCD 310
+++FD+ + +S + E+M SG Y+GEL + L + GI F+ + +++L
Sbjct: 348 RTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGL 407
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIE----AHSVSEDYVKIYSICKCFFERAGRLSAAVIA 366
F T+ +S ++ + ++E ++ D + IC+C +RA L +A IA
Sbjct: 408 FFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIA 467
Query: 367 AACIKTGKGKSPDKP-ICISADGSMFLKGFLIKERIFKSLHTCLTE------KRGIYFVL 419
K D+P + + DGS++ R H + E K GI F L
Sbjct: 468 TLINKM------DEPTVTVGVDGSVY--------RFHPKFHNLMVEKISQLIKPGITFDL 513
Query: 420 KTNDEAVTLGTALAA 434
+++ G AL A
Sbjct: 514 MLSEDGSGRGAALVA 528
>gi|56428895|gb|AAV91306.1| hexokinase A [Drosophila santomea]
gi|56428897|gb|AAV91307.1| hexokinase A [Drosophila yakuba]
Length = 430
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/435 (22%), Positives = 193/435 (44%), Gaps = 48/435 (11%)
Query: 26 LLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG 84
+L ++++GL + +++ + ++LP + K + +D GGTNFR +++ +
Sbjct: 15 ILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGK-FLALDLGGTNFRVLLIHLQENN 73
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
++ S + +P + + FD IAE L E ++ + F FS+ ++
Sbjct: 74 DFQMESRI-YAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLG 132
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G +K + + + + L A++R+G +I ++NDT L S +
Sbjct: 133 LTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAW--- 189
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIV-------CESGKSNKIP 251
+ + IG ++GTG N+ Y+E + +L E K +++ ++G + +
Sbjct: 190 --KNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFV- 246
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FSPRVNKMLLNSCD 310
+++FD+ + +S + E+M SG Y+GEL + L + GI F+ + +++L
Sbjct: 247 RTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGL 306
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIE----AHSVSEDYVKIYSICKCFFERAGRLSAAVIA 366
F T+ +S ++ + ++E ++ D + IC+C +RA L +A IA
Sbjct: 307 FFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIA 366
Query: 367 AACIKTGKGKSPDKP-ICISADGSMFLKGFLIKERIFKSLHTCLTE------KRGIYFVL 419
K D+P + + DGS++ R H + E K GI F L
Sbjct: 367 TLINKM------DEPTVTVGVDGSVY--------RFHPKFHNLMVEKISQLIKPGITFDL 412
Query: 420 KTNDEAVTLGTALAA 434
+++ G AL A
Sbjct: 413 MLSEDGSGRGAALVA 427
>gi|24640843|ref|NP_727350.1| Hexokinase A CG3001-PB, isoform B [Drosophila melanogaster]
gi|10716937|gb|AAG21970.1|AF257650_1 hexokinase-A [Drosophila yakuba]
gi|10719419|gb|AAG22049.1|AF257609_1 hexokinase-A [Drosophila simulans]
gi|10719421|gb|AAG22050.1|AF257610_1 hexokinase-A [Drosophila simulans]
gi|10719423|gb|AAG22051.1|AF257611_1 hexokinase-A [Drosophila simulans]
gi|10719425|gb|AAG22052.1|AF257612_1 hexokinase-A [Drosophila simulans]
gi|10719427|gb|AAG22053.1|AF257613_1 hexokinase-A [Drosophila simulans]
gi|10719429|gb|AAG22054.1|AF257614_1 hexokinase-A [Drosophila simulans]
gi|10719431|gb|AAG22055.1|AF257615_1 hexokinase-A [Drosophila simulans]
gi|10719433|gb|AAG22056.1|AF257616_1 hexokinase-A [Drosophila simulans]
gi|10719435|gb|AAG22057.1|AF257617_1 hexokinase-A [Drosophila simulans]
gi|10719437|gb|AAG22058.1|AF257618_1 hexokinase-A [Drosophila simulans]
gi|10719439|gb|AAG22059.1|AF257619_1 hexokinase-A [Drosophila simulans]
gi|10719441|gb|AAG22060.1|AF257620_1 hexokinase-A [Drosophila simulans]
gi|10719443|gb|AAG22061.1|AF257621_1 hexokinase-A [Drosophila simulans]
gi|10719445|gb|AAG22062.1|AF257622_1 hexokinase-A [Drosophila simulans]
gi|10765435|gb|AAG23046.1|AF257522_1 hexokinase-A [Drosophila melanogaster]
gi|10765437|gb|AAG23047.1|AF257523_1 hexokinase-A [Drosophila melanogaster]
gi|10765439|gb|AAG23048.1|AF257524_1 hexokinase-A [Drosophila melanogaster]
gi|10765441|gb|AAG23049.1|AF257525_1 hexokinase-A [Drosophila melanogaster]
gi|10765443|gb|AAG23050.1|AF257526_1 hexokinase-A [Drosophila melanogaster]
gi|10765445|gb|AAG23051.1|AF257527_1 hexokinase-A [Drosophila melanogaster]
gi|10765447|gb|AAG23052.1|AF257528_1 hexokinase-A [Drosophila melanogaster]
gi|10765449|gb|AAG23053.1|AF257529_1 hexokinase-A [Drosophila melanogaster]
gi|10765451|gb|AAG23054.1|AF257530_1 hexokinase-A [Drosophila melanogaster]
gi|10765453|gb|AAG23055.1|AF257531_1 hexokinase-A [Drosophila melanogaster]
gi|10765455|gb|AAG23056.1|AF257532_1 hexokinase-A [Drosophila melanogaster]
gi|10765457|gb|AAG23057.1|AF257533_1 hexokinase-A [Drosophila melanogaster]
gi|10765459|gb|AAG23058.1|AF257534_1 hexokinase-A [Drosophila melanogaster]
gi|10765461|gb|AAG23059.1|AF257535_1 hexokinase-A [Drosophila melanogaster]
gi|10765463|gb|AAG23060.1|AF257536_1 hexokinase-A [Drosophila melanogaster]
gi|10765465|gb|AAG23061.1|AF257537_1 hexokinase-A [Drosophila melanogaster]
gi|10765467|gb|AAG23062.1|AF257538_1 hexokinase-A [Drosophila melanogaster]
gi|10765469|gb|AAG23063.1|AF257539_1 hexokinase-A [Drosophila melanogaster]
gi|22832009|gb|AAN09253.1| CG3001-PB, isoform B [Drosophila melanogaster]
Length = 448
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 97/435 (22%), Positives = 193/435 (44%), Gaps = 48/435 (11%)
Query: 26 LLEDMKKGLESEAESVSSMD-MIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG 84
+L ++++GL + +++ + ++LP + K + +D GGTNFR +++ +
Sbjct: 23 ILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGK-FLALDLGGTNFRVLLIHLQENN 81
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
++ S + +P + + FD IAE L E ++ + F FS+ ++
Sbjct: 82 DFQMESRI-YAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLG 140
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G +K + + + + L A++R+G +I ++NDT L S +
Sbjct: 141 LTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAW--- 197
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIV-------CESGKSNKIP 251
+ + IG ++GTG N+ Y+E + +L E K +++ ++G + +
Sbjct: 198 --KNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFV- 254
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FSPRVNKMLLNSCD 310
+++FD+ + +S + E+M SG Y+GEL + L + GI F+ + +++L
Sbjct: 255 RTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGL 314
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIE----AHSVSEDYVKIYSICKCFFERAGRLSAAVIA 366
F T+ +S ++ + ++E ++ D + IC+C +RA L +A IA
Sbjct: 315 FFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIA 374
Query: 367 AACIKTGKGKSPDKP-ICISADGSMFLKGFLIKERIFKSLHTCLTE------KRGIYFVL 419
K D+P + + DGS++ R H + E K GI F L
Sbjct: 375 TLINKM------DEPTVTVGVDGSVY--------RFHPKFHNLMVEKISQLIKPGITFDL 420
Query: 420 KTNDEAVTLGTALAA 434
+++ G AL A
Sbjct: 421 MLSEDGSGRGAALVA 435
>gi|6981022|ref|NP_036866.1| hexokinase 1 [Rattus norvegicus]
gi|6226638|sp|P05708|HXK1_RAT Hexokinase-1 (Hexokinase type I) (HK I) (Brain form hexokinase)
gi|3207508|gb|AAC20075.1| hexokinase [Rattus norvegicus]
Length = 918
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 93/397 (23%), Positives = 172/397 (43%), Gaps = 29/397 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQ---NHDKNIFSGI-IEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC- 369
++S K++ + K I + + +E V D V + IC R+ L AA + A
Sbjct: 338 DVSAIEKDKEGIQNAKEILTRLGVEPSDV--DCVSVQHICTIVSFRSANLVAATLGAILN 395
Query: 370 -IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 396 RLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 431
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 491 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 551 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 608
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 609 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 665
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 666 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 715
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 716 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 774
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 775 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 830
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 831 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 865
>gi|5542103|pdb|1BG3|A Chain A, Rat Brain Hexokinase Type I Complex With Glucose And
Inhibitor Glucose-6-Phosphate
gi|5542104|pdb|1BG3|B Chain B, Rat Brain Hexokinase Type I Complex With Glucose And
Inhibitor Glucose-6-Phosphate
Length = 919
Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats.
Identities = 93/397 (23%), Positives = 172/397 (43%), Gaps = 29/397 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKEQ---NHDKNIFSGI-IEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC- 369
++S K++ + K I + + +E V D V + IC R+ L AA + A
Sbjct: 338 DVSAIEKDKEGIQNAKEILTRLGVEPSDV--DCVSVQHICTIVSFRSANLVAATLGAILN 395
Query: 370 -IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
++ KG +P + DGS++ R K+L
Sbjct: 396 RLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKTL 431
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 492 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 551
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 552 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 609
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 610 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 666
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 667 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 716
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 717 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 775
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 776 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 831
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 832 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 866
>gi|74149550|dbj|BAE36411.1| unnamed protein product [Mus musculus]
Length = 670
Score = 80.1 bits (196), Expect = 2e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 243 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 302
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 303 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 360
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 361 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 417
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 418 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 467
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 468 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 526
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 527 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 582
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 583 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 617
>gi|6754206|ref|NP_034568.1| hexokinase 1 [Mus musculus]
gi|1850140|gb|AAB57759.1| hexokinase [Mus musculus]
Length = 945
Score = 80.1 bits (196), Expect = 2e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 518 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 577
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 578 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 635
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 636 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 692
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 693 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 742
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 743 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 801
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 802 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 857
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 858 AQLCGAGMAAVVQKIRENRGLDHLNVTVGVDGTLY 892
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 92/421 (21%), Positives = 171/421 (40%), Gaps = 54/421 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 49 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 108
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 109 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 168
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 169 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 225
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 226 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 281
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 282 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 341
Query: 315 EISLF-------------------LKEQNHDKNIFSGIIEAHSV---------SEDYVKI 346
+++ ++ + DK G+ A + +D V +
Sbjct: 342 DVAAIETGWELSPDRRWYQAYMRCTQDTHRDK---EGVQNAKEILTRLGVEPSHDDCVSV 398
Query: 347 YSICKCFFERAGRLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKS 404
+C R+ L AA + A ++ KG +P + DGS++ R K+
Sbjct: 399 QHVCTIVSFRSANLVAATLGAILNRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKT 457
Query: 405 L 405
L
Sbjct: 458 L 458
>gi|146417809|ref|XP_001484872.1| hypothetical protein PGUG_02601 [Pichia guilliermondii ATCC 6260]
gi|146390345|gb|EDK38503.1| hypothetical protein PGUG_02601 [Pichia guilliermondii ATCC 6260]
Length = 469
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 110/430 (25%), Positives = 181/430 (42%), Gaps = 46/430 (10%)
Query: 14 DYKIDIEY---AASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIID 67
D+ ID E+ A + DM GL S+ ++ +M MIP T +P K+ + D
Sbjct: 15 DFAIDKEFLIKATQKFVSDMDAGLSSKEQTRENMPMIP---TFVTSLPNGKEKGLYLAAD 71
Query: 68 AGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDE---- 122
GGTNFR + E+ S FK P L + T E F +A + DE
Sbjct: 72 LGGTNFRVCSIDLHGDHTFELKQSKFKIP-EDLMSDNTAENLFKYLALKVGFFLDEHHNE 130
Query: 123 ---SDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKK 179
S + F FS+ + G I+ +K LP + + E L Q K+
Sbjct: 131 ISGSLKLGFTFSFPVNQTALNKGTLIRWTKGFDLPECVNKDVVE-LLQTCLDALKLKVDV 189
Query: 180 IIMVNDTAAVLQSGIFSET-DDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKTTEFYDKP 237
+ + NDT L S +S + ++ +G + GTG N AY E I+KL + +
Sbjct: 190 VALANDTVGTLLSRAYSNNPSETNANTVVGAIFGTGTNGAYFETLDNIKKLDSDTVGENV 249
Query: 238 Q--IIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAG 291
+I E G + +P +K+D+I+ + + + E+ SG +LGEL + L
Sbjct: 250 SGMVINTEWGSFDNTLDILPSTKYDEIVDKQTANPGYHLFEKRISGMFLGELLRVTLVEL 309
Query: 292 SAEG-----IFSPRVNKM---LLNSCDFSTEEISLFLKEQNHD----KNIFSGIIEAHSV 339
EG ++ R + L S+E +S + + D + I ++ +
Sbjct: 310 FKEGHIFTDLYKSRGGSLPHRLAEPWQLSSEVLSYMQIDDSTDLKMSELILENVLRLPTT 369
Query: 340 SEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKP--ICISADGSM--FLKGF 395
+ + I + + RA LSA +AA I+ K + D P DGS+ F GF
Sbjct: 370 KVERIFIQQLTQAISNRAAYLSAIPLAAILIRV-KDQYKDDPKDFEFGCDGSVVEFYPGF 428
Query: 396 LIKERIFKSL 405
+E++ K++
Sbjct: 429 --REKVLKAI 436
>gi|39582982|emb|CAE73047.1| Hypothetical protein CBG20417 [Caenorhabditis briggsae]
Length = 552
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 85/319 (26%), Positives = 147/319 (46%), Gaps = 30/319 (9%)
Query: 24 SILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDK---KVIIIDAGGTNFRAGIVYF 80
S + ++M +GLES E S++ M+P + ++P K K + +D GGTN R ++
Sbjct: 66 SHMSDNMDRGLESGLER-STIAMLP---SFVPELPNGKERGKFVAMDLGGTNLRVMLMEL 121
Query: 81 DKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAI 134
+ G P F MP T E+ FD IA+ L L +E + F FSY
Sbjct: 122 EP-GEPMRTKQFNTRMPNAAMHGTGEKLFDYIAKALCDFLIERELAEECLPVGFTFSYPC 180
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
++ +K + + + L A+ R G K+ + ++NDT + +
Sbjct: 181 DQTGLRSATLLRWTKGVTATGCVGEDVVQLLEDAIKRDGRVKVNIVALINDTVGTMVAAA 240
Query: 195 FSETDDQGFDSHIGFVLGTGLNSAYIEYGK--IEKL--KTTEFYDKPQIIVCE------S 244
+ + G IG ++GTG N++Y+E K + L T E+ K II E +
Sbjct: 241 Y----EAGGHCDIGVIIGTGTNASYMESSKKIVHGLANATEEYNHKTMIIDTEWGGFGDN 296
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNK 303
G+++ I +++DKI+ S+ L+++ +G +GEL + L R + +F+ +K
Sbjct: 297 GEADYI-FTRYDKIVDSKSDHPGVNSLDKLIAGMCMGELVRLVLERLCENKVLFNGIGSK 355
Query: 304 MLLNSCDFSTEEISLFLKE 322
ML F T+ IS L +
Sbjct: 356 MLRTRNTFPTKYISEILHD 374
>gi|148700158|gb|EDL32105.1| hexokinase 1, isoform CRA_c [Mus musculus]
Length = 813
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 386 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 445
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 446 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 503
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 504 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 560
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 561 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 610
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 611 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 669
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 670 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 725
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 726 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 760
Score = 69.7 bits (169), Expect = 4e-10, Method: Composition-based stats.
Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 30/317 (9%)
Query: 108 FFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKI 161
FD +AE L +KD+ + F FS+ + I +K K + +
Sbjct: 21 LFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADV 80
Query: 162 NEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE 221
+ L +A+ ++G + +VNDT + + + DDQ +G ++GTG N+ Y+E
Sbjct: 81 VKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DDQ--QCEVGLIIGTGTNACYME 135
Query: 222 YGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCS 276
++ + E + I E G S + +++FD+ L S + E+M S
Sbjct: 136 --ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVS 193
Query: 277 GRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQ---NHDKNIFS- 331
G Y+GEL + L + E +F R+ LL F+T +++ ++ + K I +
Sbjct: 194 GMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDKEGVQNAKEILTR 253
Query: 332 -GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--IKTGKGKSPDKPICISADG 388
G+ +H +D V + +C R+ L AA + A ++ KG +P + DG
Sbjct: 254 LGVEPSH---DDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKG-TPRLRTTVGVDG 309
Query: 389 SMFLKGFLIKERIFKSL 405
S++ R K+L
Sbjct: 310 SLYKMHPQYSRRFHKTL 326
>gi|47169425|pdb|1V4T|A Chain A, Crystal Structure Of Human Glucokinase
Length = 451
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 15 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 74
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 75 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 134
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 135 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 194
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 195 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 244
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 245 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 304
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 305 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 364
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 365 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 423
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 424 FI--ESEEGSGRGAALVS 439
>gi|148700156|gb|EDL32103.1| hexokinase 1, isoform CRA_a [Mus musculus]
Length = 945
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 93/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 518 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 577
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+ K
Sbjct: 578 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQ 635
Query: 137 FPDGGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC + L A+ R+ + + +VNDT + +
Sbjct: 636 TSLDCGILITWTKGFKAT---DCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 692
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 693 AYEEP-----SCEIGLIVGTGSNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 742
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 743 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 801
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 802 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 857
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 858 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 892
Score = 74.7 bits (182), Expect = 1e-11, Method: Composition-based stats.
Identities = 92/421 (21%), Positives = 171/421 (40%), Gaps = 54/421 (12%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 49 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQN 108
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L +KD+ + F FS+ +
Sbjct: 109 VSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKID 168
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 169 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 225
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 226 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 281
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + E +F R+ LL F+T
Sbjct: 282 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTS 341
Query: 315 EISLF-------------------LKEQNHDKNIFSGIIEAHSV---------SEDYVKI 346
+++ ++ + DK G+ A + +D V +
Sbjct: 342 DVAAIETGWELSPDRRWYQAYMRCTQDTHRDK---EGVQNAKEILTRLGVEPSHDDCVSV 398
Query: 347 YSICKCFFERAGRLSAAVIAAAC--IKTGKGKSPDKPICISADGSMFLKGFLIKERIFKS 404
+C R+ L AA + A ++ KG +P + DGS++ R K+
Sbjct: 399 QHVCTIVSFRSANLVAATLGAILNRLRDNKG-TPRLRTTVGVDGSLYKMHPQYSRRFHKT 457
Query: 405 L 405
L
Sbjct: 458 L 458
>gi|30585129|gb|AAP36837.1| Homo sapiens glucokinase (hexokinase 4, maturity onset diabetes of
the young 2) [synthetic construct]
gi|33303953|gb|AAQ02484.1| glucokinase [synthetic construct]
gi|61372871|gb|AAX43928.1| glucokinase [synthetic construct]
gi|61372877|gb|AAX43929.1| glucokinase [synthetic construct]
Length = 466
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 378
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 379 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 437
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 438 FI--ESEEGSGRGAALVS 453
>gi|109066687|ref|XP_001093035.1| PREDICTED: similar to glucokinase isoform 1 isoform 3 [Macaca
mulatta]
Length = 458
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 22 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 81
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 82 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 141
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 142 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 201
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 202 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 251
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 252 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 311
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 312 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRA 371
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 372 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 430
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 431 FI--ESEEGSGRGAALVS 446
>gi|4503951|ref|NP_000153.1| glucokinase isoform 1 [Homo sapiens]
gi|547696|sp|P35557|HXK4_HUMAN Glucokinase (Hexokinase-4) (Hexokinase type IV) (HK IV) (HK4)
(Hexokinase-D)
gi|179427|gb|AAA51824.1| glucokinase
gi|183235|gb|AAA52562.1| glucokinase
gi|2773376|gb|AAB97680.1| glucokinase [Homo sapiens]
gi|12804883|gb|AAH01890.1| Glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
[Homo sapiens]
gi|30582963|gb|AAP35711.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
[Homo sapiens]
gi|51094508|gb|EAL23764.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
[Homo sapiens]
gi|60655533|gb|AAX32330.1| glucokinase [synthetic construct]
gi|60655535|gb|AAX32331.1| glucokinase [synthetic construct]
gi|119581519|gb|EAW61115.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2),
isoform CRA_b [Homo sapiens]
gi|123994319|gb|ABM84761.1| glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
[synthetic construct]
Length = 465
Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 259 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 378
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 379 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 437
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 438 FI--ESEEGSGRGAALVS 453
>gi|152211827|gb|ABS31137.1| glucokinase [Homo sapiens]
Length = 465
Score = 79.7 bits (195), Expect = 3e-13, Method: Composition-based stats.
Identities = 97/438 (22%), Positives = 187/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH M ++ + T E FD I+E + D+ M + F
Sbjct: 89 VKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 148
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 149 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 208
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 209 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 258
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGI-FSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E + F
Sbjct: 259 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLPFHG 318
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 319 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 378
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 379 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 437
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 438 FI--ESEEGSGRGAALVS 453
>gi|67003900|gb|AAY60841.1| hexokinase [Solanum lycopersicum]
Length = 499
Score = 79.7 bits (195), Expect = 3e-13, Method: Composition-based stats.
Identities = 104/401 (25%), Positives = 168/401 (41%), Gaps = 39/401 (9%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M+ GL SE S M +I NLPT D+K + +D GGTNFR
Sbjct: 56 LKQVADAMTVEMQAGLASEGGSKLKM-LISYVDNLPTG---DEKGLFYALDLGGTNFRVM 111
Query: 77 IVYFD-------KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---- 125
V K V E+ S ++ M E+ + ++AE++ D+ +
Sbjct: 112 RVQLGGKEKRIVKHEVKEV-SIPQNVMTGSSSEVLFDFIATALAEFVATEGDDFHLPPGR 170
Query: 126 ---ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIM 182
+ F FS+ +K G IK +K + + + L +A+ R G ++ +
Sbjct: 171 QRELGFTFSFPVKQLSIASGTLIKWTKGFSIEDLVGQDVVGELAKAMERAGLD-VRVAAL 229
Query: 183 VNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIV 241
VNDT L G ++ D +LGTG N+AY+E I K +I
Sbjct: 230 VNDTVGTLAGGRYNNPDVIA-----AVILGTGTNAAYVERAHAIPKWHGLLPKSGEMVIN 284
Query: 242 CESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFS 298
E G +S+ +P +++D+ L S E E++ SG YLGE+ L R +F
Sbjct: 285 MEWGNFRSSHLPVTEYDQNLDIESLNPGEQIYEKIISGMYLGEILRRVLCRMAEEASLFG 344
Query: 299 PRVNKMLLNSCDFSTEEISLFLKEQNHD----KNIFSGIIEAHSVSEDYVKI-YSICKCF 353
V L T +++ +++ D N I+E + + KI +C
Sbjct: 345 DYVPSKLKVPFVLRTPDMAAMHHDESADLKVVGNKLKDILEVPNSTLKMRKIVVELCDII 404
Query: 354 FERAGRLSAAVIAAACIKTGKGKSPD---KPICISADGSMF 391
R RLSAA I K G+ D + I+ DG++F
Sbjct: 405 TSRGARLSAAGIVGILKKLGRDTFKDGEKQRSVIAVDGALF 445
>gi|109066691|ref|XP_001092803.1| PREDICTED: similar to glucokinase isoform 2 isoform 1 [Macaca
mulatta]
Length = 429
Score = 79.7 bits (195), Expect = 3e-13, Method: Composition-based stats.
Identities = 96/428 (22%), Positives = 183/428 (42%), Gaps = 34/428 (7%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M +GL E +S+ M+P + + + + +D GGTNFR +V + +
Sbjct: 3 KEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQ 62
Query: 88 ILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFP 138
KH M ++ + T E FD I+E + D+ M + F FS+ ++
Sbjct: 63 WSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHED 122
Query: 139 DGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSET 198
G + +K K + L A+ R+G ++ + MVNDT A + S + +
Sbjct: 123 IDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYED- 181
Query: 199 DDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNKIPQ 252
+G ++GTG N+ Y +E+++ E + + +C + G S ++ +
Sbjct: 182 ----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDE 232
Query: 253 S--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++D+++ E+S + E++ G+Y+GEL + L E +F ++ L
Sbjct: 233 FLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRG 292
Query: 310 DFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAA 367
F T +S + K I++ + + D + C+ RA + +A +A
Sbjct: 293 AFETRFVSQVESDTGDRKQIYNILSTLGLRPSATDCDIVRRACESVSTRAAHMCSAGLAG 352
Query: 368 ACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAV 426
+ + +S D I + DGS++ KER S+ LT I F+ ++E
Sbjct: 353 VINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEITFI--ESEEGS 409
Query: 427 TLGTALAA 434
G AL +
Sbjct: 410 GRGAALVS 417
>gi|39958811|ref|XP_364444.1| hexokinase [Magnaporthe grisea 70-15]
gi|145013251|gb|EDJ97892.1| hexokinase [Magnaporthe grisea 70-15]
Length = 477
Score = 79.7 bits (195), Expect = 4e-13, Method: Composition-based stats.
Identities = 107/416 (25%), Positives = 175/416 (42%), Gaps = 62/416 (14%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA-GIVYFDKKGVPE 87
++++GL E + M P W D + + +D GGTN R I D+K +
Sbjct: 36 ELERGLSVEGGDIP---MNPTWVMSFPDGYETGTFLALDMGGTNLRVCEITLTDQKSEFD 92
Query: 88 ILSFFKHPMPALDREMTNEEFFDSIAEYL---------EPLKDESDMISFCFSY-AIKIF 137
I+ K+ MP + ++E +D IA+ L +P K E + F FSY A + +
Sbjct: 93 IIQS-KYRMPEELKTGQSDELWDYIADCLLQFIETHHGDPKKIEKLPLGFTFSYPATQNY 151
Query: 138 PDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
D G + +K + + + L +ALS +G +K + ++NDT L + +++
Sbjct: 152 VDEGILQ-RWTKGFDIAGVEGKNVAPMLMKALSERG-VPVKLVALINDTTGTLIASAYTD 209
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFY-DKPQIIVCESGKSNK----IP 251
T IG + GTG N+AY+E G I KL + P I CE G + +P
Sbjct: 210 TQ-----MRIGCIFGTGCNAAYMEECGSIPKLAHMNLPPETPMAINCEWGAFDNQHKVLP 264
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSCDF 311
++ +D + E+S + E+M +G YLGE+ + L R+ F
Sbjct: 265 RTPYDVKIDEDSPRPGQQAFEKMIAGLYLGEIFRLILV--DLHDNHEVRI---------F 313
Query: 312 STEEISLFLKEQNHDKNIFSGI--------IEAHSVSEDYVK----------IYSICKCF 353
++IS + D + S I E + +D + I +
Sbjct: 314 KNQDISKLRRAYTLDSSFLSAIEDDPWENLSETLDLFQDKLNLVPNRNELELIRRTAELI 373
Query: 354 FERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCL 409
RA RLSA +AA C K + + ADGS+F K K+R ++L L
Sbjct: 374 GTRAARLSACGVAAICKKKNY-----RSCHVGADGSVFNKYPNFKQRGAQALREIL 424
>gi|156717562|ref|NP_001096321.1| hypothetical protein LOC100124905 [Xenopus tropicalis]
gi|134026094|gb|AAI35717.1| LOC100124905 protein [Xenopus tropicalis]
Length = 458
Score = 79.3 bits (194), Expect = 4e-13, Method: Composition-based stats.
Identities = 99/430 (23%), Positives = 188/430 (43%), Gaps = 44/430 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E +S+ M+P + D + + +D GGTNFR +V D +G
Sbjct: 33 EMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFLALDLGGTNFRVMLVKVGEDLEGQW 92
Query: 87 EILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIF 137
++ + KH M ++ + T E FD IAE + D+ +M + F FS+ ++
Sbjct: 93 KVET--KHKMYSIPEDAMTGTAEMLFDYIAECISDYLDQQNMKHKKLPLGFTFSFPVRHE 150
Query: 138 PDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K + L A+ R+G ++ + MVNDT A + S +
Sbjct: 151 DIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYE- 209
Query: 198 TDDQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNK 249
D H +G ++GTG N+ Y +E++ E + + +C + G + +
Sbjct: 210 ------DHHCEVGLIVGTGCNACY-----MEEMSNVELVEGEEGRMCVNTEWGAFGDTGE 258
Query: 250 IPQSK--FDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ + +D+++ E S + E+M G+Y+GEL + L E IF ++ L
Sbjct: 259 LEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENLIFGGESSEKLK 318
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSI---CKCFFERAGRLSAA 363
F T+ +S + + K + I+ V +++ C+ RA + ++
Sbjct: 319 TRGAFDTQFVSQIEADTSDFKQTLN-ILRTLGVQATIGDCHAVRLACESVSTRAAVMCSS 377
Query: 364 VIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTN 422
+AA + + + + I + DGS++ K++ ++H LT I F+ +
Sbjct: 378 GLAAILNRMHQSRRGELSRITVGVDGSVYKLHPSFKDKFHATVHK-LTSGCEITFI--QS 434
Query: 423 DEAVTLGTAL 432
+E G AL
Sbjct: 435 EEGSGRGAAL 444
>gi|1708366|sp|P50506|HXK_DEBOC Hexokinase
gi|1041966|gb|AAB34892.1| hexokinase [Debaryomyces occidentalis]
Length = 478
Score = 79.3 bits (194), Expect = 4e-13, Method: Composition-based stats.
Identities = 104/413 (25%), Positives = 176/413 (42%), Gaps = 59/413 (14%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIVYFDK 82
+ +++KGL + ++ MIP W D P K++ + ID GGTN R +V
Sbjct: 48 FISELEKGLSKQGGNIP---MIPGWV---MDFPTGKEMGDYLAIDLGGTNLRVVLVKLGG 101
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDE-------SDM-ISFCFSYAI 134
+ K +P R +EE ++ IAE L+ +E S++ + F FSY
Sbjct: 102 NRDFDTTQS-KFALPENMRTAKSEELWEFIAECLQKFVEEEFRNGVLSNLPLGFTFSYPA 160
Query: 135 KIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGI 194
G + +K + + + + QA K I+ + ++NDT L + +
Sbjct: 161 SQGSINEGYLQRWTKGFDIEGVEGHDVVP-MLQAAIEKRKVPIEVVALINDTTGTLVASM 219
Query: 195 FSETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFYD----KPQIIVCESGKSNK 249
+++ + + +G GTG N AY + I KL+ D P I CE G +
Sbjct: 220 YTDPE-----AKMGLFSGTGCNGAYYDVVDNIPKLEGKVPDDIKSSSPMAINCEYGAFDN 274
Query: 250 ----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKML 305
+P++K+D + E S + E+M SG YLGE+ + L +++ +++
Sbjct: 275 EHIILPRTKYDIQIDEESPRPGQQAFEKMISGYYLGEVLRLILLDLTSK--------QLI 326
Query: 306 LNSCDFSTEEISLFLK-------EQNHDKN------IFSGIIEAHSVSEDYVKIYSICKC 352
D S ++ L E++ +N +F I+ + S + I + +
Sbjct: 327 FKDQDLSKLQVPFILDTSIPARIEEDPFENLSDVQELFQEILGIQTTSPERKIIRRLAEL 386
Query: 353 FFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
ER+ RLS IAA C K G K +ADGS++ K KER K L
Sbjct: 387 IGERSARLSICGIAAICKKRGY-----KTAHCAADGSVYNKYPGFKERAAKGL 434
>gi|27808608|gb|AAO24584.1| At2g19860 [Arabidopsis thaliana]
gi|110743636|dbj|BAE99655.1| hexokinase [Arabidopsis thaliana]
Length = 502
Score = 79.3 bits (194), Expect = 4e-13, Method: Composition-based stats.
Identities = 112/438 (25%), Positives = 173/438 (39%), Gaps = 36/438 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDK 82
A + +M GL SE S M +I NLP+ + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASEGGSKLKM-LISYVDNLPSG-DETGFFYALDLGGTNFRVMRVLLGG 116
Query: 83 KGVPEILSFFKH-PMPALDREMTNEEFFDSIAE-------------YLEPLKDESDMISF 128
K + FK +P + E FD I + +L P + + F
Sbjct: 117 KHDRVVKREFKEESIPPHLMTGKSHELFDFIVDVLAKFVATEGEDFHLPPGRQRE--LGF 174
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ +K G I +K + D + L +A+ R G + +VNDT
Sbjct: 175 TFSFPVKQLSLSSGTLINWTKGFSIDDTVDKDVVGELVKAMERVGLDMLVAA-LVNDTIG 233
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG-- 245
L G ++ D + +LGTG N+AY+E I K +I E G
Sbjct: 234 TLAGGRYTSPD-----VVVAVILGTGTNAAYVERAHAIPKWHGLLPKSGEMVINMEWGNF 288
Query: 246 KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPRVNKM 304
+S+ +P +++D L +S E LE++ SG YLGE L + L+ F V
Sbjct: 289 RSSHLPLTEYDHSLDVDSLNPGEQILEKIISGMYLGEILRRVLLKMAEEAAFFGDIVPPK 348
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVKIY-SICKCFFERAGR 359
L T +S + + D + I+E + S K+ S+C R R
Sbjct: 349 LKIPFIIRTPNMSAMHSDTSPDLKVVGSKLKDILEVQTSSLKMRKVVISLCNIIASRGAR 408
Query: 360 LSAAVIAAACIKTGKGKSPD---KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
LSAA I K G+ + D + I+ DG +F E + SL L ++
Sbjct: 409 LSAAGIYGILKKIGRDATKDGEAQKSVIAMDGGLFEHYTQFSESMKSSLKELLGDEVSES 468
Query: 417 FVLKTNDEAVTLGTALAA 434
+ +++ +G AL A
Sbjct: 469 VEVILSNDGSGVGAALLA 486
>gi|30694182|ref|NP_175220.2| hexokinase, putative [Arabidopsis thaliana]
gi|118582046|sp|Q9FZG4|HXKL1_ARATH Probable hexokinase-like 1 protein
gi|145651802|gb|ABP88126.1| At1g47840 [Arabidopsis thaliana]
Length = 493
Score = 79.3 bits (194), Expect = 5e-13, Method: Composition-based stats.
Identities = 107/440 (24%), Positives = 176/440 (40%), Gaps = 36/440 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDK 82
A+ + +DM+ GL E ++MI + + ++ +D GGTNFR V
Sbjct: 62 ANAIADDMRDGLAVEGGG--DLEMILTFVDALPSGNEEGLFYALDLGGTNFRVRSVQLGG 119
Query: 83 KGVPEILSFFKHPMPALDREM--TNEEFFDSIAEYLEPL------------KDESDMISF 128
K +L+ + + M T+EE F IA L + + F
Sbjct: 120 KK-ERVLATESEQISISQKLMIGTSEELFGFIASKLANFVAKEKPGRFLLEEGRKRELGF 178
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ +K G K +K K+ + + L +A+ G ++ +VND
Sbjct: 179 TFSFPVKQTSIDSGTLSKWTKGFKVSGMEGKNVVACLNEAMEAHGLD-MRVSALVNDGVG 237
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESGKS 247
L + + D +G +LGTG N+ Y+E I KL++ II E G
Sbjct: 238 TLAGARYWDED-----VMVGVILGTGTNACYVEQKHAIPKLRSKS-SSGTTIINTEWGGF 291
Query: 248 NKI-PQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIFSPRVNKML 305
+KI PQ+ FD + E S E+ E+M SG YLGE+ + L +F L
Sbjct: 292 SKILPQTIFDLEMDETSLNPGEHLYEKMISGMYLGEIVRRVLLHMCETSDLFGHFAPAKL 351
Query: 306 LNSCDFSTEEISLFLKEQNHDK-----NIFSGIIEAHSVSEDYVKIYSICKCFFERAGRL 360
TE + ++E N D +I ++ + ++ +C +R GRL
Sbjct: 352 STPLALRTEHLCK-MQEDNTDDLRDVGSILYDFLDVEANMNARRRVVEVCDTVVKRGGRL 410
Query: 361 SAAVIAAACIKTGKGKS---PDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYF 417
+ A I A K K K ++ DG+++ K ++ + +L L K +
Sbjct: 411 AGAGIVAILEKIEKDTKRMGSGKRTVVAMDGALYEKYPQYRQYMQDALVELLGHKLASHV 470
Query: 418 VLKTNDEAVTLGTALAAFLN 437
+K + LG AL A N
Sbjct: 471 AIKHTKDVSGLGAALLAATN 490
>gi|15224857|ref|NP_179576.1| ATHXK2 (HEXOKINASE 2); ATP binding / hexokinase [Arabidopsis
thaliana]
gi|11386884|sp|P93834|HXK2_ARATH Hexokinase-2
gi|1899025|gb|AAB49911.1| hexokinase 2
gi|3687232|gb|AAC62130.1| hexokinase (ATHXK2) [Arabidopsis thaliana]
Length = 502
Score = 79.3 bits (194), Expect = 5e-13, Method: Composition-based stats.
Identities = 112/438 (25%), Positives = 173/438 (39%), Gaps = 36/438 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDK 82
A + +M GL SE S M +I NLP+ + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASEGGSKLKM-LISYVDNLPSG-DETGFFYALDLGGTNFRVMRVLLGG 116
Query: 83 KGVPEILSFFKH-PMPALDREMTNEEFFDSIAE-------------YLEPLKDESDMISF 128
K + FK +P + E FD I + +L P + + F
Sbjct: 117 KHDRVVKREFKEESIPPHLMTGKSHELFDFIVDVLAKFVATEGEDFHLPPGRQRE--LGF 174
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ +K G I +K + D + L +A+ R G + +VNDT
Sbjct: 175 TFSFPVKQLSLSSGTLINWTKGFSIDDTVDKDVVGELVKAMERVGLDMLVAA-LVNDTIG 233
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG-- 245
L G ++ D + +LGTG N+AY+E I K +I E G
Sbjct: 234 TLAGGRYTNPD-----VVVAVILGTGTNAAYVERAHAIPKWHGLLPKSGEMVINMEWGNF 288
Query: 246 KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPRVNKM 304
+S+ +P +++D L +S E LE++ SG YLGE L + L+ F V
Sbjct: 289 RSSHLPLTEYDHSLDVDSLNPGEQILEKIISGMYLGEILRRVLLKMAEEAAFFGDIVPPK 348
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVKIY-SICKCFFERAGR 359
L T +S + + D + I+E + S K+ S+C R R
Sbjct: 349 LKIPFIIRTPNMSAMHSDTSPDLKVVGSKLKDILEVQTSSLKMRKVVISLCNIIASRGAR 408
Query: 360 LSAAVIAAACIKTGKGKSPD---KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
LSAA I K G+ + D + I+ DG +F E + SL L ++
Sbjct: 409 LSAAGIYGILKKIGRDATKDGEAQKSVIAMDGGLFEHYTQFSESMKSSLKELLGDEVSES 468
Query: 417 FVLKTNDEAVTLGTALAA 434
+ +++ +G AL A
Sbjct: 469 VEVILSNDGSGVGAALLA 486
>gi|60592784|ref|NP_001012686.1| hexokinase 1 [Bos taurus]
gi|33332343|gb|AAQ11378.1| hexokinase 1 [Bos taurus]
gi|154426122|gb|AAI51302.1| Hexokinase 1 [Bos taurus]
Length = 917
Score = 79.0 bits (193), Expect = 5e-13, Method: Composition-based stats.
Identities = 88/399 (22%), Positives = 169/399 (42%), Gaps = 33/399 (8%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNQA 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L ++ + + F FS+ +
Sbjct: 105 VHMESEVYDTPENIMHGSGSQLFDHVAECLGDFMEKKKIKDKKLPVGFTFSFPCRQSRID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAILITWTKRFKASGVEGTDVVKLLDKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKIP 251
Q +G ++GTG N+ Y+E +L+ + + + +C + G I
Sbjct: 222 Q--QCEVGLIIGTGTNACYME-----ELRHIDLVEGDEGRMCVNTEWGAFGDDGALEDI- 273
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCD 310
+++FD+ + S + E+M SG YLGEL + L + EG +F R+ LL
Sbjct: 274 RTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGK 333
Query: 311 FSTEEISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAA- 367
F+T ++S K + H+ + +D V + +C R+ L AA + A
Sbjct: 334 FNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVAVQHVCTIVSFRSANLVAATLGAI 393
Query: 368 -ACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ ++ KG +P + DGS++ R K+L
Sbjct: 394 LSRLRDNKG-TPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Score = 72.8 bits (177), Expect = 5e-11, Method: Composition-based stats.
Identities = 88/392 (22%), Positives = 169/392 (43%), Gaps = 49/392 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M+ GL + + + M+P + D ++ + +D GGTNFR +V K+ V
Sbjct: 494 EMELGLGKQTHDKAVVKMLPSFVRSTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRSV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPD 139
+ P+ + + T EE FD I + D + + F FS+ K
Sbjct: 554 EMHNKIYAIPIEIM--QGTGEELFDHIVSCISDFLDYMGIKGPKMPLGFTFSFPCKQTSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G I +K K DC + L +A+ R+ + + +VNDT + + +
Sbjct: 612 DAGILITWTKGFKAT---DCVGHDVATLLREAIKRREEFDLDVVAVVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E +G ++GTG N+ Y +E++K E + Q +C ++G
Sbjct: 669 EP-----TCEVGLIVGTGSNACY-----MEEMKNVETLEGNQGQMCINMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++ +DK++ E S + E+M SG YLGE+ L + G +F ++++ L
Sbjct: 719 DDI-RTIYDKLVDEFSLNSGKQRYEKMISGMYLGEIVRNILIDFAKRGFLFRGQISEPLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ +L + D+ + + +S +D + + ++C +RA +L
Sbjct: 778 TRGLFQTK----YLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 834 CGAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 865
>gi|7662683|gb|AAC33586.2| glucokinase [Oncorhynchus mykiss]
Length = 471
Score = 79.0 bits (193), Expect = 5e-13, Method: Composition-based stats.
Identities = 99/434 (22%), Positives = 194/434 (44%), Gaps = 46/434 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV 85
++ +M +GL E +S+ M+P + + + + +D GGTNFR +V K G
Sbjct: 42 MMREMDRGLRVETHQEASVKMLPTYVCSTPEGSEVGDFLALDLGGTNFRVMLV---KVGE 98
Query: 86 PEILSF---FKHPMPALDREM---TNEEFFDSIAEYL------EPLKDESDMISFCFSYA 133
E + KH M ++ + T E FD IAE + + +K + + F FS+
Sbjct: 99 DEERGWKVETKHQMYSISEDAMTGTAEMLFDYIAECISDFLNRQHIKHKKLPLGFTFSFP 158
Query: 134 IKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
++ G + +K K + L A+ R+G ++ + MVNDT A + S
Sbjct: 159 VRHENIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISC 218
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKS 247
+ + +G ++GTG N+ Y+E +++T E + + +C + G +
Sbjct: 219 YYEDRS-----CEVGMIVGTGCNACYME-----EMRTVELVEGEEGRMCVNTEWGAFGAN 268
Query: 248 NKIPQSK--FDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSPRVNKM 304
++ + + +D+++ E S + E++ SG+Y+GE + + L+ + E +F+ + +
Sbjct: 269 GELEEFRLEYDRVVDETSLNPGQQLYEKLISGKYMGELVRLVLLKLVNEELLFNGEASDL 328
Query: 305 LLNSCDFSTEEISLFLKEQNHDKNIFS-----GIIEAHSVSEDYVKIYSICKCFFERAGR 359
L F T +S + K I++ G++ + + D V++ C+ RA
Sbjct: 329 LKTRGSFETRYVSQIEGDSGDRKQIYNILSTLGVLPSE-LDCDIVRL--ACESVSTRAAH 385
Query: 360 LSAAVIAAACIKTGKGKSPDK-PICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFV 418
+ A +A + + +SP I + DGS++ ++R K + LT I F+
Sbjct: 386 MCGAGLAGVINRMRERRSPAVLKITVGIDGSVYKLHPCFQDRFHKVVRE-LTPHCDITFI 444
Query: 419 LKTNDEAVTLGTAL 432
++E G AL
Sbjct: 445 --QSEEGSGRGAAL 456
>gi|74219346|dbj|BAE26802.1| unnamed protein product [Mus musculus]
Length = 915
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 89/389 (22%), Positives = 173/389 (44%), Gaps = 46/389 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+++ GL+ + S++++ M+P + D + K + +D GGTNFR +V ++ V
Sbjct: 494 ELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMY 553
Query: 89 LSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDGGG 142
F P+ + + T EE FD IA++L+ LK + F FS+ + G
Sbjct: 554 NKIFAIPLEIM--QGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKG 611
Query: 143 QAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+ +K K DC+ + + L +A+ R+ + + +VNDT + + + +
Sbjct: 612 TLVGWTKGFKAT---DCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDP- 667
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKI 250
IG + GTG N Y +E+++ E D + +C ++G + I
Sbjct: 668 ----RCEIGLIAGTGSNVCY-----MEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDI 718
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++++DK + E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 -RTQYDKEVDEGSLNAGKQRYEKMTSGTYLGEIVRRILIDLTRQGLLFRGQISERLRTRG 777
Query: 310 DFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
F T+ FL + D+ + + S ED + + +C RA ++ A
Sbjct: 778 IFETK----FLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGA 833
Query: 364 VIAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + + + + DG+++
Sbjct: 834 GMAAIVEKRREDQGLQHFKVTVGVDGTLY 862
Score = 66.6 bits (161), Expect = 3e-09, Method: Composition-based stats.
Identities = 79/407 (19%), Positives = 165/407 (40%), Gaps = 24/407 (5%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+K++D F + ++ A E M+KGL + +S+ M+P + D ++
Sbjct: 19 IKKVDRFLYHMRLSDETLVDIMARFQAE-MEKGLGKDTNPTASVKMLPTFVRAIPDGSEN 77
Query: 61 KKVIIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
+ + +D GG+ FR V ++G + + +PMP E FD +A+ L
Sbjct: 78 GEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADF 137
Query: 120 KDESDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKG 173
++ + F FS+ + G + +K+ K + D + L A+ +
Sbjct: 138 MKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHK 197
Query: 174 WKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF 233
+ + +V+DT + + + + + +G ++GTG N+ Y+E + + E
Sbjct: 198 DLDVDILALVDDTVGTMMTCAYDDP-----NCEVGVIIGTGTNACYME--DMSNIDLVEG 250
Query: 234 YDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
+ I E G + + +++FD+ L S + E+M SG Y+GEL + L
Sbjct: 251 DEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLIL 310
Query: 289 RAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIE--AHSVSEDYVK 345
+ G +F + L T+ ++ + N +++ D +
Sbjct: 311 LKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIA 370
Query: 346 IYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+ +C R+ L AA +A + + K + + DG+++
Sbjct: 371 VQHVCTIVSFRSANLCAAALATILTRLRENKKLARLRTTVGMDGTLY 417
>gi|21703836|ref|NP_663394.1| hexokinase domain containing 1 [Mus musculus]
gi|81902330|sp|Q91W97|HKDC1_MOUSE Putative hexokinase HKDC1 (Hexokinase domain-containing protein 1)
gi|16740725|gb|AAH16235.1| Hexokinase domain containing 1 [Mus musculus]
gi|148700155|gb|EDL32102.1| hexokinase domain containing 1 [Mus musculus]
Length = 915
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 89/389 (22%), Positives = 173/389 (44%), Gaps = 46/389 (11%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+++ GL+ + S++++ M+P + D + K + +D GGTNFR +V ++ V
Sbjct: 494 ELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMY 553
Query: 89 LSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDGGG 142
F P+ + + T EE FD IA++L+ LK + F FS+ + G
Sbjct: 554 NKIFAIPLEIM--QGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKG 611
Query: 143 QAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+ +K K DC+ + + L +A+ R+ + + +VNDT + + + +
Sbjct: 612 TLVGWTKGFKAT---DCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDP- 667
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKI 250
IG + GTG N Y +E+++ E D + +C ++G + I
Sbjct: 668 ----RCEIGLIAGTGSNVCY-----MEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDI 718
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++++DK + E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 -RTQYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRG 777
Query: 310 DFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLSAA 363
F T+ FL + D+ + + S ED + + +C RA ++ A
Sbjct: 778 IFETK----FLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGA 833
Query: 364 VIAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + + + + DG+++
Sbjct: 834 GMAAIVEKRREDQGLQHFKVTVGVDGTLY 862
Score = 68.6 bits (166), Expect = 8e-10, Method: Composition-based stats.
Identities = 80/407 (19%), Positives = 165/407 (40%), Gaps = 24/407 (5%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+K++D F + ++ A E M+KGL + +S+ M+P + D ++
Sbjct: 19 IKKVDRFLYHMRLSDETLVDIMARFQAE-MEKGLGKDTNPTASVKMLPTFVRAIPDGSEN 77
Query: 61 KKVIIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYLEPL 119
+ + +D GG+ FR V ++G + + +PMP E FD +A+ L
Sbjct: 78 GEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADF 137
Query: 120 KDESDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKG 173
++ + F FS+ + G + +K+ K + D + L A+ +
Sbjct: 138 MKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHK 197
Query: 174 WKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF 233
+ + +VNDT + + + + + +G ++GTG N+ Y+E + + E
Sbjct: 198 DLDVDILALVNDTVGTMMTCAYDDP-----NCEVGVIIGTGTNACYME--DMSNIDLVEG 250
Query: 234 YDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
+ I E G + + +++FD+ L S + E+M SG Y+GEL + L
Sbjct: 251 DEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLIL 310
Query: 289 RAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIE--AHSVSEDYVK 345
+ G +F + L T+ ++ + N +++ D +
Sbjct: 311 LKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIA 370
Query: 346 IYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+ +C R+ L AA +A + + K + + DG+++
Sbjct: 371 VQHVCTIVSFRSANLCAAALATILTRLRENKKLARLRTTVGMDGTLY 417
>gi|68437695|ref|XP_702631.1| PREDICTED: hypothetical protein [Danio rerio]
gi|45501264|gb|AAH67330.1| Hexokinase 1 [Danio rerio]
Length = 918
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 88/402 (21%), Positives = 170/402 (42%), Gaps = 29/402 (7%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR---AGIVYFDKKGV 85
+M+ GL + +++ M+P + D + I +D GG+NFR + + K+ V
Sbjct: 46 EMENGLARDTNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSNFRILRVKVSHEKKQTV 105
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPD 139
++ P + + FD +AE L + +KD+ + F FS+
Sbjct: 106 QMESQIYETPEDII--HGSGSRLFDHVAECLGDFMEKQKIKDKKLPVGFTFSFPCSQSKL 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+ +K K+ + + + L +A+ ++G + + +VNDT + + F D
Sbjct: 164 DEAVLLTWTKRFKVNGVEGMDVVKLLNKAIKKRGDYEADIMAVVNDTVGTMMTCGF---D 220
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSK 254
DQ +G ++GTG N+ Y+E ++ + E + I E G + + +++
Sbjct: 221 DQ--RCEVGIIIGTGTNACYME--ELRHMDMVEGDEGRMCINTEWGAFGDDGTLEDIRTE 276
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFST 313
FD+ + S + E+M SG Y+GEL + L + EG +F R+ LL T
Sbjct: 277 FDREIDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTKGKIET 336
Query: 314 EEISLFLKEQ---NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACI 370
+ +S K + K I + + +D + + +C R+ L AA + A
Sbjct: 337 KHVSAIEKSKEGLTKAKEILTR-LGVEPSEDDCIAVQHVCAIVSFRSANLIAATLGAILT 395
Query: 371 KTGKGK-SPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
+ K +P + DGS++ R+ K++ + E
Sbjct: 396 RLKDNKNTPRLRTTVGIDGSLYKMHPQYARRLHKTVRRLVPE 437
Score = 71.6 bits (174), Expect = 9e-11, Method: Composition-based stats.
Identities = 87/391 (22%), Positives = 166/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+++ GL ++ +++ M+P + D ++ + +D GGTNFR +V + G
Sbjct: 494 EIQNGLSKSTQNTATVKMLPTYVRSTPDGSENGDFLALDLGGTNFRVLLVKI-RSGKRRT 552
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + +P + T EE FD I + D M + F FS+ +
Sbjct: 553 VEMHNKIYAIPIEVMQGTGEELFDHIVYCISDFLDYMGMKNARLPLGFTFSFPCRQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINE--GLF-QALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K DC+ + GL + + R+ + + +VNDT + + + E
Sbjct: 613 AGLLVNWTKGFKAT---DCEGEDVVGLLREGIKRREEFDLDVVAIVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G + GTG N+ Y +E+++ E + +C ++G +
Sbjct: 670 P-----TCEVGLIAGTGSNACY-----MEEMRNIETVSGEEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++K+D + + S + E+MCSG YLGE+ L + G +F ++++ L
Sbjct: 720 DI-RTKYDDAVDDLSLNAGKQKYEKMCSGMYLGEIVRNILIDLTKRGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI--IEAH----SVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + I H S +D + + +C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRSILQHLGLDSTCDDSIIVKEVCGAVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D I + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDHLDITVGVDGTLY 865
>gi|126343367|ref|XP_001364147.1| PREDICTED: similar to Hexokinase domain containing 1 [Monodelphis
domestica]
Length = 917
Score = 79.0 bits (193), Expect = 6e-13, Method: Composition-based stats.
Identities = 91/392 (23%), Positives = 179/392 (45%), Gaps = 49/392 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL+ E + ++++ M+P + D + K + +D GGTNFR +V ++ V
Sbjct: 494 EMEYGLKKETQPLATVKMLPTYVCAMPDGTEKGKYLALDLGGTNFRVLLVKIRSGRRSVR 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDM-ISFCFSYAIKIFPD 139
F P+ + + T EE FD IA++L+ +K S + + F FS+ K
Sbjct: 554 MYNKIFAIPLEIM--QGTGEELFDHIVQCIADFLDYMGIKGASKLPLGFTFSFPCKQNCL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G ++ +K K DC+ + + L +A+ R+ ++ + ++NDT + + +
Sbjct: 612 DKGILVEWTKGFKAT---DCEGEDVVDMLREAIKRRNEFELDVVAVLNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
+ IG + GTG N Y +E+++ E + + I+C ++G
Sbjct: 669 DP-----ACEIGLIAGTGSNVCY-----MEEMRNIELVEGDEGIMCINTEWGGFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
++I ++++D + E S + E+M SG YLGE+ L + G +F ++++ L
Sbjct: 719 DEI-RTQYDVEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKHGLLFRGQISERLR 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ + + S ED + + +C RA +L
Sbjct: 778 TRGIFETK----FLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + ++ I + DG+++
Sbjct: 834 CGAGLAAIVEKRREDRGLERLAITVGVDGTLY 865
Score = 69.3 bits (168), Expect = 4e-10, Method: Composition-based stats.
Identities = 74/337 (21%), Positives = 138/337 (40%), Gaps = 22/337 (6%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+M+KGL + + + M+P + D + + + +D GG+ FR V ++G P +
Sbjct: 46 EMEKGLGKDTNPTACVKMLPTFVRAIPDGSEKGEFLALDLGGSKFRVLTVRVSEEGKPNV 105
Query: 89 -LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDGG 141
+ +P P + E FD +A+ D+ + FS+ +
Sbjct: 106 HMESQIYPTPKEIIHGSGSELFDYVADCAADFVKTRDLAHKKLPLGLTFSFPCQQSKLEE 165
Query: 142 GQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQ 201
G + +K+ K+ + D + L +AL R + + +VNDT A + + + +
Sbjct: 166 GILLSWTKKFKVRGVQDTDVVSSLTRALRRHQDVDVDVLALVNDTVATMMTCAYDDP--- 222
Query: 202 GFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIP-----QSKFD 256
+G ++GTG N+ Y+E + + E + I E G + +++FD
Sbjct: 223 --RCEVGVIIGTGTNACYME--DMSNIDLVEGDEGRMAINTEWGAFGEDGALEDIRTEFD 278
Query: 257 KILSENSNLKNEYFLERMCSGRYLGELCS-IALRAGSAEGIFSPRVNKMLLNSCDFSTEE 315
+ L S + E+M SG Y+GEL I L+ A +F + L T
Sbjct: 279 RELDLGSINPGKQLFEKMISGLYIGELVRLILLKMTKAGLLFQGEKSSALHTKGKIETRH 338
Query: 316 ISLFLKEQNHDKNIFSGIIE--AHSVSEDYVKIYSIC 350
++L K + +N + E ED V + +C
Sbjct: 339 VALMEKYKEGLQNTREILRELGLEPSEEDCVAVQHVC 375
>gi|71983705|ref|NP_001021106.1| F14B4.2a [Caenorhabditis elegans]
gi|3875864|emb|CAA99826.1| Hypothetical protein F14B4.2a [Caenorhabditis elegans]
Length = 500
Score = 79.0 bits (193), Expect = 7e-13, Method: Composition-based stats.
Identities = 92/389 (23%), Positives = 165/389 (42%), Gaps = 38/389 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
+ M++GL + + V+ + M+P + + + + + +D GGTNFR + K
Sbjct: 62 KSMEQGLATSTKKVA-VKMLPTYVDSVPNGTESGDFLALDLGGTNFRVLHIKLQGKETKM 120
Query: 88 ILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM-------ISFCFSYAIKIFPDG 140
F+ P + T E FD IA + E+D+ + F FS+ +
Sbjct: 121 TGKIFRVPESIM--RGTGEALFDHIAGCMAKFMGENDLKDAQKLPLGFTFSFPCEQEGLT 178
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
G+ + +K K + + L +A R+ I + ++NDT L + F E
Sbjct: 179 KGKLVTWTKGFKASGVEGVDVVTLLHEACHRRKDIDIDVVALLNDTVGTLMACAFQENSC 238
Query: 201 QGFDSHIGFVLGTGLNSAYIE-YGKIEKLK--TTEFYDKPQ--IIVCESGK-----SNKI 250
Q IG ++GTG N+ Y+E +I KL E P+ II E G +
Sbjct: 239 Q-----IGVIVGTGTNACYMERLDRIPKLAGYVDEHGVTPEEMIINTEWGAFGDDGALDF 293
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++++D+++ S ++ E+M SG Y+GE + L + +G +F + + + C
Sbjct: 294 LRTEWDEVVDRESINPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGNSDAISVPHC 353
Query: 310 ---DFSTEEISLFLKEQNHDKNIFSGIIEAHSV----SEDYVKIYSICKCFFERAGRLSA 362
F +E S L++ + I+E V + D + +C RA L+A
Sbjct: 354 FPTKFVSEIDSDLLEDDDRTFQKTYQILEDIGVEMITANDCANVAYVCSLISTRAAHLTA 413
Query: 363 AVIAAACIKTGKGKSPDKPICISADGSMF 391
A IA + K K + + DGS++
Sbjct: 414 AGIAMLLNRMNK-----KHVTVGVDGSVY 437
>gi|85114646|ref|XP_964736.1| hypothetical protein [Neurospora crassa OR74A]
gi|28926528|gb|EAA35500.1| glucokinase [Neurospora crassa OR74A]
gi|38567331|emb|CAE76619.1| probable glucokinase [Neurospora crassa]
Length = 530
Score = 78.6 bits (192), Expect = 8e-13, Method: Composition-based stats.
Identities = 117/459 (25%), Positives = 180/459 (39%), Gaps = 80/459 (17%)
Query: 13 FDYKI-DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGT 71
FDY D+ L M +GLE + +SM IP + + + + +D GGT
Sbjct: 14 FDYSDEDVNKGVVEFLRQMAEGLEKDG---ASMSQIPTYVTAVPNGTEKGLYMAVDLGGT 70
Query: 72 NFRAGIVY----------FDKKGVP----------EILSFFKHPMPALDREMTNEEFFDS 111
NFR + + K +P E+ +F + R E F
Sbjct: 71 NFRVCSIQLNGDTTFRLTYTKVAIPRELMVAKTAEELFAFLAKQVEIFLRTHHGEHFEAH 130
Query: 112 IAEYL-----EPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEG 164
I + E KDE+ + F FS+ ++ G I+ +K +P +G K
Sbjct: 131 IRRRMTMSSPEGFKDENVFRLGFTFSFPVQQLGINKGTLIRWTKGFDIPDAVG--KDVCA 188
Query: 165 LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YG 223
L Q K +K +VNDT L + +S G + +G + GTG N AY+E
Sbjct: 189 LLQTEIDKLHLPVKVAALVNDTVGTLMARSYSSPGKSG--AILGAIFGTGTNGAYVEKLS 246
Query: 224 KIEKLKTTEFYDKP---QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCS 276
I+K E YDK +I E G + +P + +D L + E+ S
Sbjct: 247 NIKKPLAGE-YDKSTGEMVINTEWGSFDNQLKVLPNTPWDVQLDLATPNPGIQMYEKRVS 305
Query: 277 GRYLGE---LCSIALRAGSAEGIF-------------------SPRVNKMLLNSCDF--- 311
G YLGE L I L +F SP + L++
Sbjct: 306 GMYLGEILRLTVIDLLKNPDVALFKDDNSSYNDWKSTTNIAEHSPIYKQWGLDTSVLSVA 365
Query: 312 ---STEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAA 368
ST E+S+ +E + +I++ + ED +I RA RLSA IAA
Sbjct: 366 AADSTPELSILRQELEANLHIYAPSL------EDAQAFKAIAGAIGRRAARLSAVAIAAI 419
Query: 369 CIKTGKGKSP--DKPICISADGSMFLKGFLIKERIFKSL 405
++TGK P D+PI I DGS+ ++ I+++L
Sbjct: 420 VLQTGKLNDPEQDEPIDIGVDGSLVEHYPYFRDMIYEAL 458
>gi|50307177|ref|XP_453567.1| HXK_KLULA [Kluyveromyces lactis]
gi|38605692|sp|P33284|HXK_KLULA Hexokinase
gi|49642701|emb|CAH00663.1| HXK_KLULA [Kluyveromyces lactis NRRL Y-1140]
Length = 485
Score = 78.2 bits (191), Expect = 9e-13, Method: Composition-based stats.
Identities = 106/420 (25%), Positives = 184/420 (43%), Gaps = 73/420 (17%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIVYFDK 82
+ ++ KGL + ++ MIP W + P K+ + +D GGTN R +V
Sbjct: 48 FISELDKGLSKKGGNIP---MIPGWV---VEYPTGKETGDFLALDLGGTNLRVVLVKLGG 101
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGG 142
+ K+ +P R T+E+ + IA+ L+ DE +PDG
Sbjct: 102 NHDFDTTQN-KYRLPDHLRTGTSEQLWSFIAKCLKEFVDE-------------WYPDGVS 147
Query: 143 QAIKLSKEIKLPYIGDCKINEGLFQALSRKGW---------------KKIKK-------I 180
+ + L P KIN G+ Q + KG+ ++I+K +
Sbjct: 148 EPLPLGFTFSYP-ASQKKINSGVLQRWT-KGFDIEGVEGHDVVPMLQEQIEKLNIPINVV 205
Query: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY----GKIEKLKTTEF-YD 235
++NDT L + ++ TD Q + +G ++GTG+N AY + K+E L + D
Sbjct: 206 ALINDTTGTLVASLY--TDPQ---TKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPD 260
Query: 236 KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAG 291
P I CE G + +P++K+D I+ E S + E+M SG YLGE+ + L
Sbjct: 261 SPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDL 320
Query: 292 SAEG-IFSPR-VNKM----LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVK 345
G IF + ++K+ ++++ S E F ++ D ++F + + +
Sbjct: 321 YDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTD-DLFKTNLNIETTVVERKL 379
Query: 346 IYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
I + + RA RL+ ++A C K G K I+ADGS+F + KE+ ++L
Sbjct: 380 IRKLAELVGTRAARLTVCGVSAICDKRGY-----KTAHIAADGSVFNRYPGYKEKAAQAL 434
>gi|71983713|ref|NP_001021107.1| F14B4.2b [Caenorhabditis elegans]
gi|50507743|emb|CAH04733.1| Hypothetical protein F14B4.2b [Caenorhabditis elegans]
Length = 495
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/389 (23%), Positives = 165/389 (42%), Gaps = 38/389 (9%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
+ M++GL + + V+ + M+P + + + + + +D GGTNFR + K
Sbjct: 57 KSMEQGLATSTKKVA-VKMLPTYVDSVPNGTESGDFLALDLGGTNFRVLHIKLQGKETKM 115
Query: 88 ILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM-------ISFCFSYAIKIFPDG 140
F+ P + T E FD IA + E+D+ + F FS+ +
Sbjct: 116 TGKIFRVPESIM--RGTGEALFDHIAGCMAKFMGENDLKDAQKLPLGFTFSFPCEQEGLT 173
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
G+ + +K K + + L +A R+ I + ++NDT L + F E
Sbjct: 174 KGKLVTWTKGFKASGVEGVDVVTLLHEACHRRKDIDIDVVALLNDTVGTLMACAFQENSC 233
Query: 201 QGFDSHIGFVLGTGLNSAYIE-YGKIEKLK--TTEFYDKPQ--IIVCESGK-----SNKI 250
Q IG ++GTG N+ Y+E +I KL E P+ II E G +
Sbjct: 234 Q-----IGVIVGTGTNACYMERLDRIPKLAGYVDEHGVTPEEMIINTEWGAFGDDGALDF 288
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
++++D+++ S ++ E+M SG Y+GE + L + +G +F + + + C
Sbjct: 289 LRTEWDEVVDRESINPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGNSDAISVPHC 348
Query: 310 ---DFSTEEISLFLKEQNHDKNIFSGIIEAHSV----SEDYVKIYSICKCFFERAGRLSA 362
F +E S L++ + I+E V + D + +C RA L+A
Sbjct: 349 FPTKFVSEIDSDLLEDDDRTFQKTYQILEDIGVEMITANDCANVAYVCSLISTRAAHLTA 408
Query: 363 AVIAAACIKTGKGKSPDKPICISADGSMF 391
A IA + K K + + DGS++
Sbjct: 409 AGIAMLLNRMNK-----KHVTVGVDGSVY 432
>gi|118092591|ref|XP_421579.2| PREDICTED: similar to Hexokinase domain containing 1 [Gallus
gallus]
Length = 917
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/392 (23%), Positives = 173/392 (44%), Gaps = 49/392 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+++ GL+ E + +++ M+P + D + K + +D GGTNFR +V ++ V
Sbjct: 494 ELEYGLKRETQDRATVKMLPTYVCGTPDGTEKGKYLALDLGGTNFRVLLVKIRSGRRRSV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
F P+ + + T EE FD IA++LE +K + F FS+ +
Sbjct: 554 RMYNKIFAIPLEIM--QGTGEELFDHIVQCIADFLEYMGIKGARLPLGFTFSFPCRQASI 611
Query: 140 GGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G + +K K DC+ + + L +A+ R+ + + +VNDT + + +
Sbjct: 612 DKGTLVGWTKGFKAT---DCEGEDVVDMLREAIRRRNEFDLDIVAVVNDTVGTMMTCGYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
+ + IG + GTG N Y +E +K E D + +C ++G
Sbjct: 669 DP-----NCEIGLIAGTGSNVCY-----MEDMKNIEIVDGNEGKMCINTEWGGFGDNGCI 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ I ++K+DK + E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DNI-RTKYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISESLR 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRL 360
F T+ FL + D+ + + S +D + + +C RA +L
Sbjct: 778 KRGIFETK----FLSQIESDRLALLQVRRILQQLGLDSTCDDSIIVKEVCGAVSRRAAQL 833
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + + I + DG+++
Sbjct: 834 CGAGLAAIVEKKRENRGAEHLQITVGVDGTLY 865
Score = 69.7 bits (169), Expect = 4e-10, Method: Composition-based stats.
Identities = 79/311 (25%), Positives = 137/311 (44%), Gaps = 30/311 (9%)
Query: 29 DMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIIIDAGGTNFRA--GIVYFDKKGV 85
+M KGL + +++ M+P + ++LP D + + +D GG+ FRA V+ D K
Sbjct: 46 EMVKGLGRDTNPTATVKMLPSFVRSLP-DGSEKGDFLAVDLGGSQFRALKVKVFNDGKQS 104
Query: 86 PEILSFFKHPMPALDREMTNEEFF----DSIAEYLEP--LKDESDMISFCFSYAIKIFPD 139
++ S F +P P + + E F D +++++E LK E + F FS+ K
Sbjct: 105 SQLESEF-YPTPKEVIQGSGAELFSYVADCLSDFMESRNLKHEKLPLGFTFSFPCKQTKL 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
G + +K K + + L AL + + + MVNDT + +
Sbjct: 164 EEGILLSWTKHFKARGVQGTDVVSSLRNALQKHKDIDVDVLAMVNDTVGTMMTC------ 217
Query: 200 DQGFDS---HIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIP----- 251
G+D IG ++GTG N+ Y+E ++ + E + I E G
Sbjct: 218 --GYDDPRCEIGLIIGTGTNACYME--EMRHINLVEGDEGRMCINTEWGAFGDDGALDDL 273
Query: 252 QSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCD 310
+++FD+ L S + E+M S YLGEL + L + EG +F+ +V+ LL
Sbjct: 274 RTEFDRELDLGSLNPGKQLFEKMISSLYLGELVRLILLKMTKEGLLFNGKVSAALLTKGK 333
Query: 311 FSTEEISLFLK 321
+ +S K
Sbjct: 334 IEMKHVSAMEK 344
>gi|149038694|gb|EDL92983.1| hexokinase 1, isoform CRA_d [Rattus norvegicus]
Length = 757
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 330 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 389
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 390 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 447
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 448 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 504
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 505 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 554
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 555 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 613
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 614 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 669
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 670 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 704
Score = 59.3 bits (142), Expect = 5e-07, Method: Composition-based stats.
Identities = 52/203 (25%), Positives = 92/203 (45%), Gaps = 13/203 (6%)
Query: 126 ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
+ F FS+ + I +K K + + + L +A+ ++G + +VND
Sbjct: 45 VGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVND 104
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESG 245
T + + + DDQ +G ++GTG N+ Y+E ++ + E + I E G
Sbjct: 105 TVGTMMTCGY---DDQ--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWG 157
Query: 246 K-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
S + +++FD+ L S + E+M SG Y+GEL + L + EG +F
Sbjct: 158 AFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEG 217
Query: 300 RVNKMLLNSCDFSTEEISLFLKE 322
R+ LL F+T ++S KE
Sbjct: 218 RITPELLTRGKFNTSDVSAIEKE 240
>gi|54606886|ref|NP_998417.1| hexokinase 1 [Danio rerio]
gi|28856173|gb|AAH48065.1| Hexokinase 1 [Danio rerio]
Length = 918
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 88/402 (21%), Positives = 169/402 (42%), Gaps = 29/402 (7%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR---AGIVYFDKKGV 85
+M+ GL + ++ M+P + D + I +D GG+NFR + + K+ V
Sbjct: 46 EMENGLARDTNPTATAKMLPTFVRSIPDGSEKGDFIALDLGGSNFRILRVKVSHEKKQTV 105
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPD 139
++ P + + FD +AE L + +KD+ + F FS+
Sbjct: 106 QMESQIYETPEDII--HGSRSRLFDHVAECLGDFMEKQKIKDKKLPVGFTFSFPCSQSKL 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+ +K K+ + + + L +A+ ++G + + +VNDT + + F D
Sbjct: 164 DEAVLLTWTKRFKVNGVEGMDVVKLLNKAIKKRGDYEADIMAVVNDTVGTMMTCGF---D 220
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSK 254
DQ +G ++GTG N+ Y+E ++ + E + I E G + + +++
Sbjct: 221 DQ--RCEVGIIIGTGTNACYME--ELRHMDMVEGDEGRMCINTEWGAFGDDGTLEDIRTE 276
Query: 255 FDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFST 313
FD+ + S + E+M SG Y+GEL + L + EG +F R+ LL T
Sbjct: 277 FDREIDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTKGKIET 336
Query: 314 EEISLFLKEQ---NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACI 370
+ +S K + K I + + +D + + +C R+ L AA + A
Sbjct: 337 KHVSAIEKSKEGLTKAKEILTR-LGVEPSEDDCIAVQHVCAIVSFRSANLIAATLGAILT 395
Query: 371 KTGKGK-SPDKPICISADGSMFLKGFLIKERIFKSLHTCLTE 411
+ K +P + DGS++ R+ K++ + E
Sbjct: 396 RLKDNKNTPRLRTTVGIDGSLYKMHPQYARRLHKTVRRLVPE 437
Score = 71.6 bits (174), Expect = 9e-11, Method: Composition-based stats.
Identities = 87/391 (22%), Positives = 166/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEI 88
+++ GL ++ +++ M+P + D ++ + +D GGTNFR +V + G
Sbjct: 494 EIQNGLSKSTQNTATVKMLPTYVRSTPDGSENGDFLALDLGGTNFRVLLVKI-RSGKRRT 552
Query: 89 LSFFK--HPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + +P + T EE FD I + D M + F FS+ +
Sbjct: 553 VEMHNKIYAIPIEVMQGTGEELFDHIVYCISDFLDYMGMKNARLPLGFTFSFPCRQTSLD 612
Query: 141 GGQAIKLSKEIKLPYIGDCKINE--GLF-QALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K DC+ + GL + + R+ + + +VNDT + + + E
Sbjct: 613 AGLLVNWTKGFKAT---DCEGEDVVGLLREGIKRREEFDLDVVAIVNDTVGTMMTCAYEE 669
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G + GTG N+ Y +E+++ E + +C ++G +
Sbjct: 670 P-----TCEVGLIAGTGSNACY-----MEEMRNIETVSGEEGRMCVNMEWGAFGDNGCLD 719
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++K+D + + S + E+MCSG YLGE+ L + G +F ++++ L
Sbjct: 720 DI-RTKYDDAVDDLSLNAGKQKYEKMCSGMYLGEIVRNILIDLTKRGFLFRGQISETLKT 778
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI--IEAH----SVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + I H S +D + + +C RA +L
Sbjct: 779 RGIFETK----FLSQIESDRLALLQVRSILQHLGLDSTCDDSIIVKEVCGAVSRRAAQLC 834
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D I + DG+++
Sbjct: 835 GAGMAAVVDKIRENRGLDHLDITVGVDGTLY 865
>gi|183227|gb|AAB59563.1| glucokinase
Length = 464
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 96/438 (21%), Positives = 186/438 (42%), Gaps = 34/438 (7%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 28 DLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 87
Query: 78 VYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDESDM------ISF 128
V + + KH ++ + T E FD I+E + D+ M + F
Sbjct: 88 VKVGEGEEGQWSVKTKHQTYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGF 147
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAA 188
FS+ ++ G + +K K + L A+ R+G ++ + MVNDT A
Sbjct: 148 TFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVA 207
Query: 189 VLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES---- 244
+ S + + +G ++GTG N+ Y +E+++ E + + +C +
Sbjct: 208 TMISCYYED-----HQCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWG 257
Query: 245 --GKSNKIPQS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
G S ++ + ++D+++ E+S + E++ G+Y+GEL + L E +F
Sbjct: 258 AFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHG 317
Query: 300 RVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS--GIIEAHSVSEDYVKIYSICKCFFERA 357
++ L F T +S + K I++ + + D + C+ RA
Sbjct: 318 EASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRA 377
Query: 358 GRLSAAVIAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIY 416
+ +A +A + + +S D I + DGS++ KER S+ LT I
Sbjct: 378 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPSCEIT 436
Query: 417 FVLKTNDEAVTLGTALAA 434
F+ ++E G AL +
Sbjct: 437 FI--ESEEGSGRGAALVS 452
>gi|72134844|ref|XP_798648.1| PREDICTED: similar to hexokinase I [Strongylocentrotus purpuratus]
gi|115954217|ref|XP_001196458.1| PREDICTED: similar to hexokinase I [Strongylocentrotus purpuratus]
Length = 391
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 87/357 (24%), Positives = 165/357 (46%), Gaps = 37/357 (10%)
Query: 66 IDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREM---TNEEFFDSIAEYLEPLKDE 122
+D GG+NFR +V + V + A+ +E+ T ++ FD IA+ L K E
Sbjct: 9 LDLGGSNFRVLLVQLLEGEVK-----MESKTYAIAKEIMVGTGDQLFDYIADCLNEFKTE 63
Query: 123 SDM------ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKK 176
+ + F FS+ K G + +K + + + L +A R+G
Sbjct: 64 QGLGNKSLPLGFTFSFPCKQLSLKSGILVTWTKGFTAAGVEGKNVVDLLMEACKRRG-VD 122
Query: 177 IKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF-YD 235
I I +VNDT L S +++ ++++G +LGTG N+ Y+E + K+ T E +
Sbjct: 123 IDVIALVNDTTGTLMSCAYTD-----HNAYVGLILGTGTNACYME--DVNKVGTWEGDGN 175
Query: 236 KPQIIV-------CESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIA 287
Q IV + G + I ++++D+ + E S + + E+M SG YLGE+ +
Sbjct: 176 ARQTIVNMEWGAFGDDGVLDDI-RTEYDRNVDETSLNRGKQQYEKMISGMYLGEISRQVM 234
Query: 288 LRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVS---EDYV 344
++ ++ +F+ +K L F T + +++++ + I+ ++ ED
Sbjct: 235 VKLVQSKLLFNGVSSKELDTPGKFETRFTTDIENDKSNNGTDVAKILTDLNLKPSLEDIE 294
Query: 345 KIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERI 401
+ IC +RA RL+ A +AA + + P+ + I DG+++ K L K+ +
Sbjct: 295 LVRVICHSVAKRAARLAVAGLAAVTKRVQRDDRPE--VTIGIDGTLYKKHPLFKQEM 349
>gi|150007890|ref|YP_001302633.1| hexokinase type III [Parabacteroides distasonis ATCC 8503]
gi|149936314|gb|ABR43011.1| hexokinase type III [Parabacteroides distasonis ATCC 8503]
Length = 402
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 76/298 (25%), Positives = 132/298 (44%), Gaps = 24/298 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDK 82
AS E +++GL+ E + IP + + P + K +++D GGTN+R V +
Sbjct: 17 ASSFREKVEEGLKHENAEIQC---IPTFIS-PKTSDINGKALVLDLGGTNYRVATVDLGQ 72
Query: 83 KGVPEILSFFKHPMPALDREM--------TNEEFFDSIAEYLEPLKDESDM-ISFCFSYA 133
G P I HP ++M T EE F +A+ + +K + +M I +CFSY
Sbjct: 73 -GSPTI-----HPNNGWKKDMSIMKSPGYTREELFKELADMIVGIKRDEEMPIGYCFSYP 126
Query: 134 IKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
+ G + ++ +K + + + + + L L+ K I ++NDT A L +G
Sbjct: 127 AESVLSGDAKLLRWTKGVDIKEMVGQLVGKPLLDYLNEHCKIKFTGIKVLNDTIASLFAG 186
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSA-YIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIPQ 252
+ D +D++IG ++GTG N A +I KI+KL + + ESG +
Sbjct: 187 L----TDNSYDAYIGLIVGTGTNMATFIPADKIKKLDPSYNIQGLVPVNLESGNFHPPFL 242
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSCD 310
+ D + S + E+ SG YLG++ E F + ++N D
Sbjct: 243 TTVDDTVDAISGSLGKQRFEKAVSGMYLGDILKATFPLDEFENKFDAQKLTAIMNYPD 300
>gi|121533847|ref|ZP_01665673.1| Hexokinase [Thermosinus carboxydivorans Nor1]
gi|121307358|gb|EAX48274.1| Hexokinase [Thermosinus carboxydivorans Nor1]
Length = 436
Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats.
Identities = 75/255 (29%), Positives = 114/255 (44%), Gaps = 30/255 (11%)
Query: 42 SSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKG---VPEILSF-FKHPMP 97
S + M+P + + PT + + + I +D GGTN R +V G V + L+ K P
Sbjct: 42 SCLKMLPSFLSRPTGL-EQGRFIALDFGGTNIRTLLVDLHGDGRLSVRQTLAASLKDPTA 100
Query: 98 ALDREM----TNEEF-FDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGGQAIKL--SKE 150
D +E F F + +D + F FSY + G +AI L +KE
Sbjct: 101 GYDYTAPTVHADELFAFLAAQVATVTAAGSADGLGFTFSYPCR--QTGANRAILLHWTKE 158
Query: 151 IKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE--TDDQGFDSHIG 208
I + + E L AL+R+G + ++NDT L + + + TD IG
Sbjct: 159 IATAGVEGKDVGELLGAALARRGLGHLAPAAIINDTVGTLLAAAYQDPWTD-------IG 211
Query: 209 FVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIPQSKFDKILSENSNLKNE 268
+ GTG N+ Y+E + P II ESG + +P + FD L S+ +
Sbjct: 212 SICGTGHNTCYLEL-------SPPAAPAPMIINMESGNFDAMPLTPFDAALDAASDKPGQ 264
Query: 269 YFLERMCSGRYLGEL 283
LE+M +GRYLGEL
Sbjct: 265 QRLEKMAAGRYLGEL 279
>gi|115386740|ref|XP_001209911.1| glucokinase [Aspergillus terreus NIH2624]
gi|114190909|gb|EAU32609.1| glucokinase [Aspergillus terreus NIH2624]
Length = 492
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 108/429 (25%), Positives = 174/429 (40%), Gaps = 62/429 (14%)
Query: 13 FDYKID-IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDA 68
FDY + ++ + +M++GL E ++S IP + T +P + + +D
Sbjct: 16 FDYPAEEVQRGVKEYIREMEEGLSKEGATLSQ---IPTYV---TSVPNGTEKGLYLAVDL 69
Query: 69 GGTNFRA------GIVYFD----KKGVP----------EILSFFKHPMPALDREMTNEEF 108
GGTNFR G F K +P ++ F + + R NE F
Sbjct: 70 GGTNFRVCSIDLHGDTTFSLTQSKMMIPRELMASGSSKDLFHFLARQIESFLRIHHNEHF 129
Query: 109 FDSIAEYLE-PLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQ 167
L+ ++ E + F FS+ ++ G I+ +K +P + L
Sbjct: 130 EAHERRRLQGDVEQELFDLGFTFSFPVRQMGINKGTLIRWTKGFNIPDAVGHDVCALLQN 189
Query: 168 ALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIE 226
A+ G ++ +VNDT L + ++ + G + +G + GTG N AY+E KI
Sbjct: 190 AIDDLGLP-VRVAALVNDTVGTLMARSYTSPGETG--TFLGAIFGTGTNGAYLEKLDKIT 246
Query: 227 KLKTTEF--YDKP---QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSG 277
K+ T E YDK II E G + +P + +D+ L SN E+ SG
Sbjct: 247 KMATIEHSDYDKSTGEMIINAEWGSFDNHLSVLPNTLYDQQLDAESNNPGVQMFEKRVSG 306
Query: 278 RYLGELC-----------SIALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD 326
+LGE+ S+ SA + P N L T +SL +++
Sbjct: 307 MFLGEILRRVILHMYQNESLDFLKSSASDVVVPE-NSNLFRQWGVDTSFLSLAEADKSST 365
Query: 327 KNIFSGIIEAHSVSE-----DYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKP 381
++ H E D I ++ +RA RLSA +AA I TGK +S D
Sbjct: 366 LEQTKTALKDHFKIENPSDRDCKAIQTVVHAIGKRAARLSAVPLAATLISTGKLQS-DDL 424
Query: 382 ICISADGSM 390
+ I DGS+
Sbjct: 425 VDIGVDGSL 433
>gi|149038698|gb|EDL92987.1| hexokinase 1, isoform CRA_h [Rattus norvegicus]
Length = 848
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 421 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 480
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 481 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 538
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 539 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 595
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 596 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 645
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 646 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 704
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 705 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 760
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 761 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 795
Score = 71.2 bits (173), Expect = 1e-10, Method: Composition-based stats.
Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 20/308 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 31 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 90
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 91 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 150
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 151 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 207
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 208 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 263
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 264 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 323
Query: 315 EISLFLKE 322
++S KE
Sbjct: 324 DVSAIEKE 331
>gi|149038691|gb|EDL92980.1| hexokinase 1, isoform CRA_a [Rattus norvegicus]
Length = 866
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 439 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 498
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 499 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 556
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 557 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 613
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 614 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 663
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 664 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 722
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 723 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 778
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 779 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 813
Score = 71.2 bits (173), Expect = 1e-10, Method: Composition-based stats.
Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 20/308 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 49 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 108
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 109 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 168
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 169 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 225
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 226 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 281
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 282 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 341
Query: 315 EISLFLKE 322
++S KE
Sbjct: 342 DVSAIEKE 349
>gi|149038700|gb|EDL92989.1| hexokinase 1, isoform CRA_j [Rattus norvegicus]
Length = 846
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 419 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 478
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 479 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 536
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 537 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 593
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 594 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 643
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 644 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 702
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 703 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 758
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 759 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 793
Score = 71.2 bits (173), Expect = 1e-10, Method: Composition-based stats.
Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 20/308 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 29 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 88
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 89 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 148
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 149 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 205
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 206 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 261
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 262 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 321
Query: 315 EISLFLKE 322
++S KE
Sbjct: 322 DVSAIEKE 329
>gi|149038692|gb|EDL92981.1| hexokinase 1, isoform CRA_b [Rattus norvegicus]
Length = 861
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 434 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 493
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 494 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 551
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 552 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 608
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 609 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 658
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 659 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 717
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 718 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 773
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 774 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 808
Score = 71.2 bits (173), Expect = 1e-10, Method: Composition-based stats.
Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 20/308 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 44 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 103
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 104 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 163
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 164 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 220
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 221 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 276
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 277 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 336
Query: 315 EISLFLKE 322
++S KE
Sbjct: 337 DVSAIEKE 344
>gi|156538374|ref|XP_001605294.1| PREDICTED: similar to ENSANGP00000028361 [Nasonia vitripennis]
Length = 493
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 84/382 (21%), Positives = 164/382 (42%), Gaps = 42/382 (10%)
Query: 51 KNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFD 110
++LP K + +D GGTNFR ++ D + + P + T + FD
Sbjct: 101 QDLPNGTEKGN-FLALDLGGTNFRVLLITLDGQSFDMKSKIYAIPQSLM--LGTGRQLFD 157
Query: 111 SIAE----YLEPLKDESDMISFCFSYAIKIFPDG--GGQAIKLSKEIKLPYIGDCKINEG 164
IA+ +++ LK E +++ F+++ + G G ++ +K + + +
Sbjct: 158 HIAQCLALFVKDLKLEQEVLPLGFTFSFPLSQQGLTKGLLVRWTKGFNCSGVVEQDVVAL 217
Query: 165 LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK 224
L A++R+ KI ++NDT L S + + +G ++GTG N+ Y+E +
Sbjct: 218 LEDAIARRNDVKIDVCAILNDTTGTLMSCAWKNKN-----CRVGLIVGTGSNACYVEKTE 272
Query: 225 IEKLKTTEFY--DKPQIIV-------CESGKSNKIPQSKFDKILSENSNLKNEYFLERMC 275
+ Y KP +++ E G + + ++FD+ + ENS ++ E+M
Sbjct: 273 NVECAIPGQYAAHKPHMLINTEWGAFGEQGTLDFV-LTEFDRDIDENSINPSKQLFEKMI 331
Query: 276 SGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTEEISLFLKEQNHD----KNIF 330
SG Y+GEL + L + G +F+ + + L F T+ +S + + I
Sbjct: 332 SGMYMGELARLVLEKLTNNGLLFNGKCSCDLRKRGKFFTKYVSEIESDPKGKYANCREIL 391
Query: 331 SGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSM 390
+ + ++ +D + +C RA L++A IA +K G+ + + DGS+
Sbjct: 392 AELGIRNATDQDCENVRYVCSVVSRRAAHLASAGIATLLVKMGENN-----VTVGVDGSV 446
Query: 391 FLKGFLIKERIFKSLHTCLTEK 412
+ R H + EK
Sbjct: 447 Y--------RFHPHFHDLMVEK 460
>gi|149038695|gb|EDL92984.1| hexokinase 1, isoform CRA_e [Rattus norvegicus]
Length = 735
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 308 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 367
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 368 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 425
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 426 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 482
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 483 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 532
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 533 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 591
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 592 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 647
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 648 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 682
Score = 57.0 bits (136), Expect = 3e-06, Method: Composition-based stats.
Identities = 50/198 (25%), Positives = 90/198 (45%), Gaps = 13/198 (6%)
Query: 126 ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVND 185
+ F FS+ + I +K K + + + L +A+ ++G + +VND
Sbjct: 45 VGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVND 104
Query: 186 TAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESG 245
T + + + DDQ +G ++GTG N+ Y+E ++ + E + I E G
Sbjct: 105 TVGTMMTCGY---DDQ--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWG 157
Query: 246 K-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSP 299
S + +++FD+ L S + E+M SG Y+GEL + L + EG +F
Sbjct: 158 AFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEG 217
Query: 300 RVNKMLLNSCDFSTEEIS 317
R+ LL F+T ++S
Sbjct: 218 RITPELLTRGKFNTSDVS 235
>gi|147781819|emb|CAN74362.1| hypothetical protein [Vitis vinifera]
Length = 533
Score = 77.8 bits (190), Expect = 1e-12, Method: Composition-based stats.
Identities = 107/423 (25%), Positives = 173/423 (40%), Gaps = 49/423 (11%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
M+ + DF + Y +++ A + +M GL SE S M +I NLPT D
Sbjct: 38 MEIVKDFEEDCATSYS-KLKHVADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG---D 92
Query: 61 KKVII--IDAGGTNFRAGIVYFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAE--- 114
+K + +D GGTNFR V + G F + +P + + FD IA
Sbjct: 93 EKGLFYALDLGGTNFRVLRVQLGGRDGHIVNQEFVEVSIPPNLMVKSTDALFDYIATELA 152
Query: 115 ----------YLEPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEG 164
+L P + + F FS+ + G IK +K + +
Sbjct: 153 KFVAKEGPGFHLPPGRQRE--LGFTFSFPVMQTSINSGNLIKWTKGFSIDDTFGRDVVAE 210
Query: 165 LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK 224
L +A+ RKG ++ +VNDT L G + D + +LGTG N+AY+E +
Sbjct: 211 LTKAMERKG-VDMRVSALVNDTIGTLAGGRYFNDD-----VVVAVILGTGSNAAYVERAQ 264
Query: 225 -IEKLKTTEFYDKPQIIVCESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLG 281
I K + +I E G +S+ +P +++D+ + +S E E++ SG YLG
Sbjct: 265 AIPKWQGLLPKSGDMVINMEWGNFRSSHLPLTEYDRAMDIDSLNPGEQIFEKLVSGMYLG 324
Query: 282 E-LCSIALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGII-----E 335
E L + LR F V L T ++S +HD ++ ++ E
Sbjct: 325 EILRRVLLRMAEEAAFFGATVPPKLKIPFILRTPDMS----SMHHDTSVNLKVVGIKMKE 380
Query: 336 AHSVSEDYVKIYSI----CKCFFERAGRLSAAVIAAACIKTGKGK---SPDKPICISADG 388
+S+ +K+ I C R RL+AA I K G+ + I+ DG
Sbjct: 381 ILGISDTPLKMRKIVVQLCNIVATRGARLAAAAIFGVLKKMGRDTVRPGEKQKTVIAMDG 440
Query: 389 SMF 391
+F
Sbjct: 441 GLF 443
>gi|45387411|gb|AAS60196.1| hexokinase 4b [Nicotiana tabacum]
Length = 498
Score = 77.8 bits (190), Expect = 2e-12, Method: Composition-based stats.
Identities = 106/403 (26%), Positives = 166/403 (41%), Gaps = 51/403 (12%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD- 81
A + +M GL SE S M +I NLPT + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DETGLFYALDLGGTNFRVMRVQLGG 116
Query: 82 ------KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYL-EPLKDESD---------- 124
K+ V E+ S K+ M +++ FD IA L + + E D
Sbjct: 117 KEKRIVKQEVKEV-SIPKNVMAG----SSSDALFDFIATTLVKFVATEGDDFHLPPGRQR 171
Query: 125 MISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ +K G IK +K + + L +A+ R G ++ ++N
Sbjct: 172 ELGFTFSFPVKQLSIASGTLIKWTKGFSIDDAVGQDVVRELTKAMERVGLD-VRVAALIN 230
Query: 185 DTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCE 243
DT L G ++ D +LGTG N+AY+E I K +I E
Sbjct: 231 DTVGTLAGGRYNNPDVIA-----AVILGTGTNAAYVERANTIPKWHGLLPKSGDMVINME 285
Query: 244 SG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-----LCSIALRAGSAEGI 296
G +S+ +P +++D+ L S E E+M SG YLGE LC +A A +
Sbjct: 286 WGNFRSSHLPVTEYDQSLDAESLNPGEQIYEKMISGMYLGEILRRVLCRMAEEASFFDDY 345
Query: 297 FSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICK 351
P++ + T+++S +++ D + I+E + + K I +C
Sbjct: 346 VPPKLKTPFI----LRTQDMSAMHHDKSADLKVVGDKLKDILEVPNSTWKMRKIIVELCD 401
Query: 352 CFFERAGRLSAAVIAAACIKTGKGKSPD---KPICISADGSMF 391
R RLSAA I K G+ D + I+ DG++F
Sbjct: 402 IITSRGARLSAAGIVGILKKLGRDTLKDGEKQRSVIAVDGALF 444
>gi|121704084|ref|XP_001270306.1| glucokinase GlkA, putative [Aspergillus clavatus NRRL 1]
gi|119398450|gb|EAW08880.1| glucokinase GlkA, putative [Aspergillus clavatus NRRL 1]
Length = 492
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 106/431 (24%), Positives = 179/431 (41%), Gaps = 79/431 (18%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDAGGTNFRA 75
I+ + +M +GL E ++S IP + T +P + + +D GGTNFR
Sbjct: 23 IQLGVKEFIREMSEGLTKEHTTLSQ---IPTYV---TSVPNGTEKGLYLAVDLGGTNFRV 76
Query: 76 ------GIVYFD----KKGVP----------EILSFFKHPMPALDREMTNEEFFDSIAEY 115
G F+ K +P ++ F + + R NE F +
Sbjct: 77 CSIDLHGDTTFNLTQSKIMIPREMMASGTSKDLFLFLARQIESFLRIHHNEHFEAHLRRR 136
Query: 116 LEPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGD--CKINEGLFQALSR 171
+P +E + F FS+ ++ G I+ +K +P +G C + + L+
Sbjct: 137 RDPDHEEELFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGHDVCALLQNAIDELNL 196
Query: 172 KGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLKT 230
++ +VNDT L + ++ + G + IG + GTG N AY+E +I KL+T
Sbjct: 197 P----VRVAALVNDTVGTLMARSYTSPGETG--TFIGAIFGTGTNGAYVEKLNRITKLQT 250
Query: 231 TEFYD-----KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLG 281
E + I+ E G + +P +K+D+ L E SN E+ SG +LG
Sbjct: 251 MEHSNYETCTGEMIVNTEWGSFDNHLSVLPNTKWDQELDEESNNPGIQMFEKRVSGMFLG 310
Query: 282 ELCSIAL---RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFS------- 331
E+ AL + G+F+P ++ D E S ++ D + S
Sbjct: 311 EILRRALIDMHQDKSVGLFTPS------DTSDVVVPENSPIYRQWGIDTSFLSLVEADKT 364
Query: 332 -GIIEAHSVSEDYVKIY--SICKCFF---------ERAGRLSAAVIAAACIKTGKGKSPD 379
+ E + +D++KI S+ C +RA RLSA +AA I TGK + +
Sbjct: 365 EAMEEVKAALKDHLKIERPSMDDCRVVQILVHAVGKRAARLSAIPLAAILISTGKIE--E 422
Query: 380 KPICISADGSM 390
+ I DGS+
Sbjct: 423 DMVDIGVDGSL 433
>gi|313225|emb|CAA43855.1| hexakinase [Kluyveromyces lactis]
Length = 485
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 106/420 (25%), Positives = 184/420 (43%), Gaps = 73/420 (17%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV---IIIDAGGTNFRAGIVYFDK 82
+ ++ KGL + ++ MIP W + P K+ + +D GGTN R +V
Sbjct: 48 FISELDKGLSKKGGNIP---MIPGWV---VEYPTGKETGDFLALDLGGTNLRVVLVKLGG 101
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGG 142
+ K+ +P R T+E+ + IA+ L+ DE +PDG
Sbjct: 102 NHDFDTTQN-KYRLPDHLRTGTSEQLWSFIAKCLKEFVDE-------------WYPDGVS 147
Query: 143 QAIKLSKEIKLPYIGDCKINEGLFQALSRKGW---------------KKIKK-------I 180
+ + L P KIN G+ Q + KG+ ++I+K +
Sbjct: 148 EPLPLGFTFSYP-ASQKKINSGVLQRWT-KGFDIEGVEGHDVVPMLQEQIEKLNIPINVV 205
Query: 181 IMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEY----GKIEKLKTTEF-YD 235
++NDT L + ++ TD Q + +G ++GTG+N AY + K+E L + D
Sbjct: 206 RLINDTTGTLVASLY--TDPQ---TKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPD 260
Query: 236 KPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAG 291
P I CE G + +P++K+D I+ E S + E+M SG YLGE+ + L
Sbjct: 261 SPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDL 320
Query: 292 SAEG-IFSPR-VNKM----LLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVK 345
G IF + ++K+ ++++ S E F ++ D ++F + + +
Sbjct: 321 YDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTD-DLFKTNLNIETTVVERKL 379
Query: 346 IYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
I + + RA RL+ ++A C K G K I+ADGS+F + KE+ ++L
Sbjct: 380 IRKLAELVGTRAARLTVCGVSAICDKRGY-----KTAHIAADGSVFNRYPGYKEKAAQAL 434
>gi|116192959|ref|XP_001222292.1| hypothetical protein CHGG_06197 [Chaetomium globosum CBS 148.51]
gi|88182110|gb|EAQ89578.1| hypothetical protein CHGG_06197 [Chaetomium globosum CBS 148.51]
Length = 528
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 115/444 (25%), Positives = 181/444 (40%), Gaps = 79/444 (17%)
Query: 13 FDYK-IDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKK---VIIIDA 68
F+Y D+ A L M +GL A+ +SM IP + T +P + + +D
Sbjct: 14 FEYSDSDVNKAVQEFLRQMDEGL---AKDGTSMSQIPTYV---TGVPNGTEKGLYMAVDL 67
Query: 69 GGTNFRAGIVY----------FDKKGVP----------EILSFFKHPMPALDREMTNEEF 108
GGTNFR + ++K +P E+ +F + E E+F
Sbjct: 68 GGTNFRVCSIQLLGNSTFTHTYNKVAIPKHLMVAKTAQELFAFLASEIKKFLEEHHTEDF 127
Query: 109 FDSI-----AEYLEPLKDESDM-ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKI 161
+ +DE + F FS+ +K F G I+ +K +P +G K
Sbjct: 128 EHHVRRRKTVSSPNGFRDEHIFRMGFTFSFPVKQFGINKGTLIRWTKGFDIPDAVG--KD 185
Query: 162 NEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE 221
L Q K +K +VNDT L + ++ QG S +G + GTG N AY+E
Sbjct: 186 VCALLQEEIDKLHLPVKVAALVNDTVGTLMARSYAAPGKQG--SVLGAIFGTGTNGAYVE 243
Query: 222 YGKIEKLKTT--EFYDKP---QIIVCESG----KSNKIPQSKFDKILSENSNLKNEYFLE 272
K+ KLK YD+ +I E G + N +P +K+D L + S E
Sbjct: 244 --KLSKLKKPLGGEYDQSTGEMVINTEWGSFDNQLNVLPSTKWDIALEKESLNPGFQMYE 301
Query: 273 RMCSGRYLGELCSIAL--------------------RAGSAEGIF--SPRVNKMLLNSCD 310
+ SG +LGE+ +A+ GS I S + L++
Sbjct: 302 KRVSGMFLGEILRLAIIDLLNNPNVSFFKDENSSSNDRGSVTIISKDSGLYKQWGLDTAI 361
Query: 311 FSTEEISLFLKEQNHDKNIFSGIIEAHSVS-EDYVKIYSICKCFFERAGRLSAAVIAAAC 369
ST E+ E + + +E ++ + ED + I + RA RLSA I A
Sbjct: 362 MSTAELDQD-PELSGLRQALENTLEVYAPAYEDALAFKKIAQAIGRRAARLSAVAIGAII 420
Query: 370 IKTGKGKSP---DKPICISADGSM 390
++TGK + P D+PI + DGS+
Sbjct: 421 LQTGKLEDPEYKDEPIDVGVDGSL 444
>gi|62702157|gb|AAX93084.1| unknown [Homo sapiens]
Length = 344
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 74/310 (23%), Positives = 141/310 (45%), Gaps = 34/310 (10%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++M+KGL + +++ M+P + D + + + +D GGTNFR V G+ +
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLE------PLKDESDMISFCFSYAIKIFPDG 140
+ + + +P + + FD IAE L +KD+ + F FS+
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
+ +K K + + + +A+ R+G I + +VNDT + +
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTC------- 217
Query: 201 QGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
G+D H IG ++GTG N+ Y +E+++ + + + +C + G N
Sbjct: 218 -GYDDHNCEIGLIVGTGSNACY-----MEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLN 271
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNKMLLN 307
I +++FD+ + S + E+M SG Y+GEL + L + E +F +++ LLN
Sbjct: 272 DI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLN 330
Query: 308 SCDFSTEEIS 317
+ F T++IS
Sbjct: 331 TGRFETKDIS 340
>gi|149038693|gb|EDL92982.1| hexokinase 1, isoform CRA_c [Rattus norvegicus]
Length = 839
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 412 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 471
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 472 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 529
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 530 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 586
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 587 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 636
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 637 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 695
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 696 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 751
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 752 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 786
Score = 68.9 bits (167), Expect = 7e-10, Method: Composition-based stats.
Identities = 71/307 (23%), Positives = 134/307 (43%), Gaps = 20/307 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 44 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 103
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 104 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 163
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 164 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 220
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 221 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 276
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 277 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 336
Query: 315 EISLFLK 321
++S K
Sbjct: 337 DVSAIEK 343
>gi|149038696|gb|EDL92985.1| hexokinase 1, isoform CRA_f [Rattus norvegicus]
Length = 862
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 435 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 494
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 495 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 552
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 553 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 609
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 610 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 659
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 660 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 718
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 719 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 774
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 775 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 809
Score = 70.9 bits (172), Expect = 2e-10, Method: Composition-based stats.
Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 20/308 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EISLFLKE 322
++S KE
Sbjct: 338 DVSAIEKE 345
>gi|115464965|ref|NP_001056082.1| Os05g0522500 [Oryza sativa (japonica cultivar-group)]
gi|75287587|sp|Q5W676|HXK5_ORYSJ Hexokinase-5 (Hexokinase I)
gi|13991925|gb|AAK51559.1|AF372831_1 hexokinase I [Oryza sativa]
gi|55168165|gb|AAV44032.1| hexokinase 1 [Oryza sativa (japonica cultivar-group)]
gi|55733815|gb|AAV59322.1| hexokinase [Oryza sativa (japonica cultivar-group)]
gi|73918011|gb|AAZ93622.1| hexokinase 5 [Oryza sativa (japonica cultivar-group)]
gi|113579633|dbj|BAF17996.1| Os05g0522500 [Oryza sativa (japonica cultivar-group)]
gi|125594926|gb|EAZ34985.1| hypothetical protein OsJ_018468 [Oryza sativa (japonica
cultivar-group)]
Length = 507
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/337 (27%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 18 DIEYAASI-----------LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIII 66
D+E+A S ++ +M++GL ++ ++ M +I NLPT + +
Sbjct: 52 DVEHALSTPTALLRGISDAMVTEMERGLRGDSHAMVKM-LITYVDNLPTG-NEQGLFYAL 109
Query: 67 DAGGTNFRAGIVYFDKKGVPEILSFFKH-PMPALDREMTNEEFFDSIAEYLEPLKD-ESD 124
D GGTNFR V K + ++ +P T+ E FD IA L D E D
Sbjct: 110 DLGGTNFRVLRVQLGGKEKRVVQQQYEEVSIPPHLMVGTSMELFDFIASALSKFVDTEGD 169
Query: 125 ----------MISFCFSYAIKIFPDGGGQAIKLSKEIKL-PYIGDCKINEGLFQALSRKG 173
+ F FS+ + G IK +K + +G+ ++E L +A+ R+G
Sbjct: 170 DFHLPEGRQRELGFTFSFPVSQTSISSGTLIKWTKGFSINDAVGEDVVSE-LGKAMERQG 228
Query: 174 WKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTE 232
+K +VNDT L G +++ +LGTG N+AY+E I K
Sbjct: 229 LD-MKIAALVNDTVGTLAGGRYADNSVVA-----AIILGTGTNAAYVENANAIPKWTGLL 282
Query: 233 FYDKPQIIVCESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALR 289
+I E G KS+K+P S+FDK + S E E++ SG YLGE+ I L+
Sbjct: 283 PRSGNMVINTEWGSFKSDKLPLSEFDKAMDFESLNPGEQIYEKLISGMYLGEIVRRILLK 342
Query: 290 AGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD 326
+F V L T ++S + +HD
Sbjct: 343 LAHDAALFGDVVPSKLEQPFVLRTPDMSAMHHDSSHD 379
>gi|149690291|ref|XP_001502742.1| PREDICTED: similar to hexokinase domain containing 1 [Equus
caballus]
Length = 916
Score = 77.4 bits (189), Expect = 2e-12, Method: Composition-based stats.
Identities = 91/391 (23%), Positives = 176/391 (45%), Gaps = 48/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+++ GL+ + S++++ M+P + D + K + +D GGTNFR +V ++ V
Sbjct: 494 ELEYGLKRDTHSLATVKMLPTYVCGMPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVR 553
Query: 87 EILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPDG 140
F P+ + + T EE FD IA++L+ LK + F FS+ +
Sbjct: 554 MYNKIFAIPLEIM--QGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQASID 611
Query: 141 GGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC+ + + L +A+ R+ + + +VNDT + + + +
Sbjct: 612 KGTLIGWTKGFKAT---DCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYED 668
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+ IG + GTG N Y +E+++ E + + +C ++G +
Sbjct: 669 P-----NCEIGLIAGTGSNLCY-----MEEMRNIELVEGDEGKMCINTEWGGFGDNGCID 718
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++++DK + E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 719 DI-RTQYDKEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRT 777
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + S ED + + +C RA +L
Sbjct: 778 RGIFETK----FLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLC 833
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + ++ I + DG+++
Sbjct: 834 GAGLAAIVEKRREDQGLERLRITVGVDGTLY 864
Score = 61.6 bits (148), Expect = 1e-07, Method: Composition-based stats.
Identities = 69/309 (22%), Positives = 133/309 (43%), Gaps = 20/309 (6%)
Query: 1 MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKD 60
+K++D F + ++ A E M+KGL + +S+ M+P + D ++
Sbjct: 19 IKKVDRFLYHMRLSDETLLDIMARFQAE-MQKGLGKDTNPTASVKMLPTFVRAIPDGSEN 77
Query: 61 KKVIIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAEYL--- 116
+ + +D GG+ FR V ++G + + +P P E F+ +A+ L
Sbjct: 78 GEFLSLDLGGSKFRVLKVQVSEEGKRNVQMESQFYPTPNEIIRGNGIELFEYVADCLADF 137
Query: 117 ---EPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKG 173
+ LK + + FS+ + G + +K+ K + D + L +A+ R
Sbjct: 138 MNTKGLKHKRLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSCLTRAMKRHK 197
Query: 174 WKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEF 233
+ + +VNDT + + + DD + +G ++GTG N+ Y+E + + E
Sbjct: 198 DINVDTLALVNDTVGTMMTCAY---DDPYCE--VGVIIGTGTNACYME--DMSNIDLVEG 250
Query: 234 YDKPQIIVCESGK-----SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
+ I E G + + +++FD+ L S + E+M SG YLGEL + L
Sbjct: 251 DEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLIL 310
Query: 289 RAGSAEGIF 297
+ G+
Sbjct: 311 LKMAKAGLL 319
>gi|149038701|gb|EDL92990.1| hexokinase 1, isoform CRA_k [Rattus norvegicus]
Length = 824
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 397 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 456
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 457 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 514
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 515 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 571
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 572 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 621
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 622 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 680
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 681 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 736
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 737 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 771
Score = 68.6 bits (166), Expect = 7e-10, Method: Composition-based stats.
Identities = 71/307 (23%), Positives = 134/307 (43%), Gaps = 20/307 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 29 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 88
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 89 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 148
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 149 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 205
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 206 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 261
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 262 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 321
Query: 315 EISLFLK 321
++S K
Sbjct: 322 DVSAIEK 328
>gi|73953342|ref|XP_536376.2| PREDICTED: similar to Hexokinase, type I (HK I) (Brain form
hexokinase) [Canis familiaris]
Length = 1073
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 87/395 (22%), Positives = 166/395 (42%), Gaps = 25/395 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +++ M+P + D + I +D GG++FR V + +
Sbjct: 201 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNQN 260
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +AE L ++ + + F FS+ +
Sbjct: 261 VHMESEIYDTPENIVHGSGSQLFDHVAECLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 320
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
G I +K+ K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 321 EGILITWTKKFKASGVEGMDVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 377
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 378 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 433
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ + S + E+M SG YLGEL + L + E +F R+ LL T
Sbjct: 434 DREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKESLLFEGRITPELLTRGKLKTS 493
Query: 315 EISLFLKEQN--HDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAAC--I 370
++S K + H+ + +D + + +C R+ L AA + A +
Sbjct: 494 DVSAIEKNKEGLHNAKEILTRLGVEPSDDDCISVQHVCTIVSFRSANLVAATLGAILNRL 553
Query: 371 KTGKGKSPDKPICISADGSMFLKGFLIKERIFKSL 405
+ KG +P + DGS++ R K+L
Sbjct: 554 RDNKG-TPRLRTTVGVDGSLYKTHPQYARRFHKTL 587
Score = 72.4 bits (176), Expect = 6e-11, Method: Composition-based stats.
Identities = 88/391 (22%), Positives = 168/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M GL + + + M+P + D + + +D GGTNFR +V KK
Sbjct: 650 EMDMGLRKQTHEKAVVKMLPSFVRSTPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTV 709
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ K
Sbjct: 710 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPKMPLGFTFSFPCKQTSLD 768
Query: 141 GGQAIKLSKEIKLPYIGDCKINEG---LFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC N+ L +A+ R+ + + +VNDT + + + E
Sbjct: 769 AGILITWTKGFKAT---DCVGNDVATLLREAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 825
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + +C ++G +
Sbjct: 826 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMLEGNDGRMCINMEWGAFGDNGCLD 875
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D+++ E S + E+M SG YLGE+ L + +G +F ++++ L
Sbjct: 876 DI-RTIYDRLVDEYSLNAGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKT 934
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ +L + D+ + + +S +D + + ++C +RA +L
Sbjct: 935 RGIFQTK----YLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLC 990
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 991 GAGMAAVVDKIRENRGLDHLNVTVGVDGTLY 1021
>gi|145247326|ref|XP_001395912.1| glucokinase glkA-Aspergillus niger
gi|134080646|emb|CAK41311.1| glucokinase glkA-Aspergillus niger
Length = 495
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 103/429 (24%), Positives = 176/429 (41%), Gaps = 59/429 (13%)
Query: 13 FDY-KIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGT 71
FDY +++ + + ++ +GL E ++S IP + + + + +D GGT
Sbjct: 16 FDYPAAEVQRGVTEYIREIDEGLSKEHTTLSQ---IPTYVTAVPNGTEKGLYLAVDLGGT 72
Query: 72 NFRA------GIVYFD----KKGVP----------EILSFFKHPMPALDREMTNEEFFDS 111
NFR G F K +P ++ F + + R N+ F
Sbjct: 73 NFRVCSIDLHGDTTFSLTQSKIMIPRETMASGTAKDLFLFLARQIESFLRIHHNDHFEAH 132
Query: 112 IAEYLEPLKD-ESDM--ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQA 168
+ E + E D+ + F FS+ ++ G I+ +K +P + L A
Sbjct: 133 LRRRNEKNGNCEEDLFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGKDVCALLQNA 192
Query: 169 LSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEK 227
+ G ++ +VNDT L + ++ + G + +G + GTG N AY+E +I K
Sbjct: 193 IDDLGLP-VRVAALVNDTVGTLMARSYTSPGETG--TFLGAIFGTGTNGAYVEKLDRITK 249
Query: 228 LKTTEF--YDKP---QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGR 278
L+T E YDK II E G + +P + +D+ L +SN E+ SG
Sbjct: 250 LQTIEHSEYDKTTGEMIINAEWGSFDNHLSVLPNTIYDQQLDADSNNPGIQMFEKRVSGM 309
Query: 279 YLGELCSIA------------LRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD 326
+LGE+ LRAG A + P+ L T +SL ++ +
Sbjct: 310 FLGEILRRVMLDMQRNESLGFLRAGGASTVSVPQ-ESSLYRQWGIDTSLLSLVEADKTEN 368
Query: 327 KNIFSGIIEAH-----SVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKP 381
++ H ++D I ++ +RA RLSA +AA + TGK + D
Sbjct: 369 MEQIKVALKDHLKIERPTTDDCKAIQTVVHAIGKRAARLSAVPLAAILLSTGKLQK-DDL 427
Query: 382 ICISADGSM 390
+ I DGS+
Sbjct: 428 VDIGVDGSL 436
>gi|45387409|gb|AAS60195.1| hexokinase 4a [Nicotiana tabacum]
Length = 498
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 106/403 (26%), Positives = 162/403 (40%), Gaps = 51/403 (12%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFD- 81
A + +M GL SE S M +I NLPT + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG-DETGLFYALDLGGTNFRVMRVQLGG 116
Query: 82 ------KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESD----------- 124
K+ V E+ S K+ M +++ FD IA L D
Sbjct: 117 KEKRIVKQEVKEV-SIPKNVMAG----SSSDALFDFIATALVKFVATEDDDFRLPPGRQR 171
Query: 125 MISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVN 184
+ F FS+ +K G IK +K + + L +A+ R G ++ +VN
Sbjct: 172 ELGFTFSFPVKQLSIASGTLIKWTKGFSIDDTVGQDVVRELTKAMERVGLD-VRVAALVN 230
Query: 185 DTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCE 243
DT L G ++ D +LGTG N+AY+E I K +I E
Sbjct: 231 DTVGTLAGGRYNNPDVIA-----AVILGTGTNAAYVERANTIPKWHGLLPKSGDMVINME 285
Query: 244 SG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-----LCSIALRAGSAEGI 296
G +S+ +P +++D+ L S E E+M SG YLGE LC +A A +
Sbjct: 286 WGNFRSSHLPVTEYDQSLDTESLNPGEQIYEKMISGMYLGEILRRVLCRMAEEASFFDDY 345
Query: 297 FSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICK 351
P++ + T ++S +++ D + I+E + + K I +C
Sbjct: 346 VPPKLKTPFI----LRTPDMSAMHHDKSADLKVVGDKLKDILEVPNSTWKMRKIIVELCD 401
Query: 352 CFFERAGRLSAAVIAAACIKTGKGKSPD---KPICISADGSMF 391
R RLSAA I K G+ D + I+ DG++F
Sbjct: 402 IITSRGARLSAAGIVGILKKLGRDTLKDGEKQRSVIAVDGALF 444
>gi|2495217|sp|Q92407|HXKG_ASPNG Glucokinase (Glucose kinase) (GLK)
gi|1619590|emb|CAA67949.1| glucokinase [Aspergillus niger]
Length = 495
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 103/429 (24%), Positives = 176/429 (41%), Gaps = 59/429 (13%)
Query: 13 FDY-KIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGT 71
FDY +++ + + ++ +GL E ++S IP + + + + +D GGT
Sbjct: 16 FDYPAAEVQRGVTEYIREIDEGLSKEHTTLSQ---IPTYVTAVPNGTEKGLYLAVDLGGT 72
Query: 72 NFRA------GIVYFD----KKGVP----------EILSFFKHPMPALDREMTNEEFFDS 111
NFR G F K +P ++ F + + R N+ F
Sbjct: 73 NFRVCSIDLHGDTTFSLTQSKIMIPRETMASGTAKDLFLFLARQIESFLRIHHNDHFEAH 132
Query: 112 IAEYLEPLKD-ESDM--ISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQA 168
+ E + E D+ + F FS+ ++ G I+ +K +P + L A
Sbjct: 133 LRRRNEKNGNCEEDLFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGKDVCALLQNA 192
Query: 169 LSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEK 227
+ G ++ +VNDT L + ++ + G + +G + GTG N AY+E +I K
Sbjct: 193 IDDLGLP-VRVAALVNDTVGTLMARSYTSPGETG--TFLGAIFGTGTNGAYVEKLDRITK 249
Query: 228 LKTTEF--YDKP---QIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGR 278
L+T E YDK II E G + +P + +D+ L +SN E+ SG
Sbjct: 250 LQTIEHSEYDKTTGEMIINAEWGSFDNHLSVLPNTIYDQQLDADSNNPGIQMFEKRVSGM 309
Query: 279 YLGELCSIA------------LRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD 326
+LGE+ LRAG A + P+ L T +SL ++ +
Sbjct: 310 FLGEILRRVMLDMQRNESLGFLRAGGASTVSVPQ-ESSLYRQWGIDTSLLSLVEADKTEN 368
Query: 327 KNIFSGIIEAH-----SVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKP 381
++ H ++D I ++ +RA RLSA +AA + TGK + D
Sbjct: 369 MEQIKVALKDHLKIERPTTDDCKAIQTVVHAIGKRAARLSAVPLAAILLSTGKLQK-DDL 427
Query: 382 ICISADGSM 390
+ I DGS+
Sbjct: 428 VDIGVDGSL 436
>gi|50512098|gb|AAT77511.1| hexokinase [Nicotiana sylvestris]
Length = 383
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 90/318 (28%), Positives = 136/318 (42%), Gaps = 30/318 (9%)
Query: 19 IEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAG 76
++ A + +M GL SE S M +I NLPT D+ + +D GGTNFR
Sbjct: 55 LKQVADAMTVEMHAGLASEGGSKLKM-LITYVDNLPTG---DEAGVFYALDLGGTNFRVL 110
Query: 77 IVYFD-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM---------- 125
V K G F + +P T+E FD IA L E +
Sbjct: 111 RVQLGGKDGGIVHQEFAEASIPPNLMVGTSEALFDYIAAELAKFVAEEEEKFQQPPGKQR 170
Query: 126 -ISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMV 183
+ F FS+ + G ++ +K + +G + E L +A+ RKG ++ +V
Sbjct: 171 ELGFTFSFPVMQTSINSGTIMRWTKGFSIDDAVGQDVVGE-LTKAMKRKG-VDMRVSALV 228
Query: 184 NDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVC 242
NDT L G ++ D + +LGTG N+AY+E + I K +I
Sbjct: 229 NDTVGTLAGGKYTHND-----VAVAVILGTGTNAAYVERVQAIPKWHGPVPKSGEMVINM 283
Query: 243 ESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGE-LCSIALRAGSAEGIFSP 299
E G +S+ +P +++D L NS + E+M SG YLGE L + LR GIF
Sbjct: 284 EWGNFRSSHLPLTQYDHALDTNSLNPGDQIFEKMTSGMYLGEILRRVLLRVAEDAGIFGD 343
Query: 300 RVNKMLLNSCDFSTEEIS 317
V L + T ++S
Sbjct: 344 EVPPKLKSPFVLRTPDMS 361
>gi|11066213|gb|AAG28503.1|AF196966_1 hexokinase [Citrus sinensis]
Length = 498
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 114/439 (25%), Positives = 179/439 (40%), Gaps = 38/439 (8%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVII--IDAGGTNFRAGIVYF 80
A + +M GL SE S M +I NLPT D+K + +D GGTNFR V
Sbjct: 59 ADAMTVEMHAGLASEGGSKLKM-LISYVDNLPTG---DEKGLFYALDLGGTNFRVLRVQL 114
Query: 81 D-KKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL---KDESDMIS--------F 128
++G F + +P ++ E FD IA L + E +S F
Sbjct: 115 GGREGRVVKQEFEEVSIPPHLMTGSSHELFDYIAAALAKFVATEGEGFHVSPGRQRELGF 174
Query: 129 CFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQALSRKGWKKIKKIIMVNDTA 187
FS+ ++ G IK +K + +G+ + E L +A+ R G ++ +VNDT
Sbjct: 175 TFSFPVRQTSIASGDLIKWTKGFSIEDTVGEDVVGE-LTKAMERIGLD-MRVAALVNDTI 232
Query: 188 AVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQIIVCESG- 245
L G + D + +LGTG N+AY+E I K +I E G
Sbjct: 233 GTLAGGRYHNKD-----AIAAVILGTGTNAAYVERAHAIPKWHGLLPKSGEMVINMEWGN 287
Query: 246 -KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIAL-RAGSAEGIFSPRVNK 303
+S+ +P +++D+ L S E E++ SG YLGE+ L R F V
Sbjct: 288 FRSSHLPLTEYDEALDTESLNPGEQIFEKIISGMYLGEIVRRVLCRMAEEANFFGDTVPP 347
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNI----FSGIIEAHSVSEDYVK-IYSICKCFFERAG 358
L T +S + + D + I+E + S K + +C R
Sbjct: 348 KLKIPFILRTPHMSAMHHDTSPDLRVVGKKLKDILEISNTSLKMRKLVVELCDIVATRGA 407
Query: 359 RLSAAVIAAACIKTGKGKSPD---KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGI 415
RLSAA I K G+ D + I+ DG +F + ++ L E+
Sbjct: 408 RLSAAGIVGILKKLGRDTVRDGEKQKSVIALDGGLFEHYTKFSACMQSTVKELLGEEVSE 467
Query: 416 YFVLKTNDEAVTLGTALAA 434
V++ +++ +G AL A
Sbjct: 468 TVVIEHSNDGSGIGAALLA 486
>gi|149038699|gb|EDL92988.1| hexokinase 1, isoform CRA_i [Rattus norvegicus]
Length = 826
Score = 77.0 bits (188), Expect = 2e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 399 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 458
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 459 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 516
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 517 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 573
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 574 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 623
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 624 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 682
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 683 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 738
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 739 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 773
Score = 68.6 bits (166), Expect = 8e-10, Method: Composition-based stats.
Identities = 71/307 (23%), Positives = 134/307 (43%), Gaps = 20/307 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 31 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 90
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 91 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 150
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 151 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 207
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 208 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 263
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 264 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 323
Query: 315 EISLFLK 321
++S K
Sbjct: 324 DVSAIEK 330
>gi|149038697|gb|EDL92986.1| hexokinase 1, isoform CRA_g [Rattus norvegicus]
Length = 840
Score = 76.6 bits (187), Expect = 3e-12, Method: Composition-based stats.
Identities = 92/395 (23%), Positives = 170/395 (43%), Gaps = 49/395 (12%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DK 82
L +M+ GL E S +++ M+P + D + + +D GGTNFR +V K
Sbjct: 413 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 472
Query: 83 KGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKI 136
+ V + P+ + + T +E FD I + D + + F FS+
Sbjct: 473 RTVEMHNKIYSIPLEIM--QGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQ 530
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCK---INEGLFQALSRKGWKKIKKIIMVNDTAAVLQSG 193
G I +K K DC+ + L A+ R+ + + +VNDT + +
Sbjct: 531 TNLDCGILISWTKGFKAT---DCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTC 587
Query: 194 IFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ES 244
+ E IG ++GTG N+ Y +E++K E + Q +C ++
Sbjct: 588 AYEEP-----TCEIGLIVGTGTNACY-----MEEMKNVEMVEGNQGQMCINMEWGAFGDN 637
Query: 245 GKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNK 303
G + I ++ FDK++ E S + E+M SG YLGE+ L + +G +F ++++
Sbjct: 638 GCLDDI-RTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISE 696
Query: 304 MLLNSCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERA 357
L F T+ FL + D+ + + +S +D + + ++C +RA
Sbjct: 697 PLKTRGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 752
Query: 358 GRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
+L A +AA K + + D + + DG+++
Sbjct: 753 AQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLY 787
Score = 68.6 bits (166), Expect = 9e-10, Method: Composition-based stats.
Identities = 70/303 (23%), Positives = 133/303 (43%), Gaps = 20/303 (6%)
Query: 28 EDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPE 87
++MK GL + +S+ M+P + D + I +D GG++FR V + +
Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104
Query: 88 I-LSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
+ + + P + + FD +A+ L ++ + + F FS+ +
Sbjct: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKID 164
Query: 141 GGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDD 200
I +K K + + + L +A+ ++G + +VNDT + + + DD
Sbjct: 165 EAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY---DD 221
Query: 201 QGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGK-----SNKIPQSKF 255
Q +G ++GTG N+ Y+E ++ + E + I E G S + +++F
Sbjct: 222 Q--QCEVGLIIGTGTNACYME--ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEF 277
Query: 256 DKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDFSTE 314
D+ L S + E+M SG Y+GEL + L + EG +F R+ LL F+T
Sbjct: 278 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTS 337
Query: 315 EIS 317
++S
Sbjct: 338 DVS 340
>gi|147820969|emb|CAN74594.1| hypothetical protein [Vitis vinifera]
Length = 483
Score = 76.6 bits (187), Expect = 3e-12, Method: Composition-based stats.
Identities = 88/366 (24%), Positives = 160/366 (43%), Gaps = 55/366 (15%)
Query: 99 LDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGD 158
++RE N EF P+K + F FS+ +K G IK +K + +
Sbjct: 115 VEREAQNSEF--------SPVKRRE--LGFTFSFPVKQTSVSSGILIKWTKRFSVKDMVG 164
Query: 159 CKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSA 218
++E L A++R G ++ ++VNDT L G +++ D + ++GTG N+
Sbjct: 165 KDVSECLQHAMTRNGLD-MRVAVLVNDTVGTLALGHYNDPD-----TVAAVIIGTGTNAC 218
Query: 219 YIEYG----KIEKLKTTEFYDKPQIIVCESGK--SNKIPQSKFDKILSENSNLKNEYFLE 272
Y+E K + L TT ++ E G S+ +P++ +D L +S N+ E
Sbjct: 219 YLERTDAIIKCQGLLTTS---GGMVVNMEWGNFWSSHLPRTSYDIDLDGDSPNPNDQGFE 275
Query: 273 RMCSGRYLGELCS-IALRAGSAEGIFSPRVNKM----LLNS-------CDFSTE--EISL 318
+M SG YLG++ + LR IF P +++ +L++ D S E E++
Sbjct: 276 KMISGMYLGDIVRRVILRMSQESDIFGPVSSRLSMPFILSTPSMADMHADESPELMEVAR 335
Query: 319 FLKEQNHDKNI----------FSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAA 368
LKE ++ ++ + I I K + GR + +A+
Sbjct: 336 ILKEDLQIPDVPLKVRKLVVKVCDVVTRRAARLAAAGIVGILK----KIGRDGSGGVASG 391
Query: 369 CIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAVTL 428
+ GK + ++ DGS++ + + KE + ++L L E+ Y +LK ++ +
Sbjct: 392 RSRGSDGKM--RRTVVAMDGSLYTRYTMFKEYLHEALCEILGEEVAQYVILKVTEDGSGI 449
Query: 429 GTALAA 434
G AL A
Sbjct: 450 GAALLA 455
>gi|39581300|emb|CAE72321.1| Hypothetical protein CBG19465 [Caenorhabditis briggsae]
Length = 494
Score = 76.3 bits (186), Expect = 3e-12, Method: Composition-based stats.
Identities = 94/393 (23%), Positives = 165/393 (41%), Gaps = 41/393 (10%)
Query: 25 ILLE-DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKK 83
+L+E M++GL + +V M+P + + + + + +D GGTNFR + + K
Sbjct: 56 VLMEKSMEQGLSGKKAAVK---MLPTYVDAVPNGTEKGDFLALDLGGTNFRVLHIKLEGK 112
Query: 84 GVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM-------ISFCFSYAIKI 136
F+ P + T E FD IA+ + +E+++ + F FS+ +
Sbjct: 113 ETKMTGKIFRVPESIM--RGTGEALFDHIADCMAKFMEENNLKDATKLPLGFTFSFPCEQ 170
Query: 137 FPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G+ + +K K + + L A R+ I + ++NDT L + F
Sbjct: 171 DGLTRGKLVTWTKGFKASGVEGADVVTLLRDACHRRKDIDIDVVALLNDTVGTLMACAFQ 230
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIE-YGKIEKLK--TTEFYDKPQ--IIVCESGK----- 246
E Q IG ++GTG N+ Y+E +I KL E P+ II E G
Sbjct: 231 ENTCQ-----IGVIVGTGTNACYMERLDRIPKLAGYVDEHNVTPEEMIINTEWGAFGDDG 285
Query: 247 SNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKML 305
+ ++K+D + S ++ E+M SG Y+GE + L + +G +F + +
Sbjct: 286 ALSFLRTKWDDAVDRESINPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGHSDAIS 345
Query: 306 LNSC---DFSTEEISLFLKEQNHDKNIFSGIIEAHSV----SEDYVKIYSICKCFFERAG 358
C F +E S L++ + I+E V + D + +C RA
Sbjct: 346 TPHCFPTKFVSEIDSDLLEDDDRTFQKTYQILEDIGVEMITANDCANVAYVCSLISTRAA 405
Query: 359 RLSAAVIAAACIKTGKGKSPDKPICISADGSMF 391
L+AA IA + K K + + DGS++
Sbjct: 406 HLTAAGIAMLLNRINK-----KHVTVGVDGSVY 433
>gi|154297364|ref|XP_001549109.1| hexokinase [Botryotinia fuckeliana B05.10]
gi|120564541|gb|ABM30191.1| hexokinase [Botryotinia fuckeliana]
gi|150858591|gb|EDN33783.1| hexokinase [Botryotinia fuckeliana B05.10]
Length = 491
Score = 76.3 bits (186), Expect = 4e-12, Method: Composition-based stats.
Identities = 100/392 (25%), Positives = 172/392 (43%), Gaps = 41/392 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA-GIVYFDKKG 84
+ ++ KGL E S+ M P W D + + +D GGTN R I+ D+K
Sbjct: 48 FVSELTKGLTVEGGSIP---MNPTWCMAFPDGYETGTFLALDMGGTNLRVCEIILTDEKS 104
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIA----EYLEPLKDESDM----ISFCFSY-AIK 135
+I+ K+ MP + +E ++ IA +++E D+ + F FSY A +
Sbjct: 105 EFDIIQS-KYRMPEELKTGEADELWEYIADCLQQFIESHHHGEDLGTLSLGFTFSYPATQ 163
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIF 195
+ D G + +K + + I AL+++G IK ++NDT L + +
Sbjct: 164 NYIDEGILQ-RWTKGFDIAGVEGENIVPMFEAALAKRG-VPIKLTALINDTTGTLIASAY 221
Query: 196 SETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFY-DKPQIIVCESGKSNK---- 249
++T + IG + GTG N+AY+E G I KL D P I CE G +
Sbjct: 222 TDTAMK-----IGCIFGTGCNAAYMENCGSIPKLAHMNLPPDTPMAINCEWGAFDNEHKV 276
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIA---LRAGSAEGIFSPRVNKMLL 306
+P++ +D I+ ++S + E+M +G YLGEL + L +F + + L
Sbjct: 277 LPRTPYDIIIDKDSPRPGQQAFEKMIAGLYLGELFRLVLVDLHDNKDIHMFEGQDIEKLR 336
Query: 307 NSCDFSTEEISLFLKEQ----NHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSA 362
+ + +SL ++ + ++F + + + I + + RA RLSA
Sbjct: 337 KAYTLDSSFLSLVEEDPWENLSETADLFQNKLSIRATVPELELIRRLAELIGTRAARLSA 396
Query: 363 AVIAAACIKTGKGKSPDKPIC-ISADGSMFLK 393
+AA K + C + ADGS+F K
Sbjct: 397 CGVAAI------AKKKNYETCHVGADGSVFNK 422
>gi|47227723|emb|CAG09720.1| unnamed protein product [Tetraodon nigroviridis]
Length = 894
Score = 76.3 bits (186), Expect = 4e-12, Method: Composition-based stats.
Identities = 86/414 (20%), Positives = 175/414 (42%), Gaps = 42/414 (10%)
Query: 4 IDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKV 63
+D + R ++ +E + E M KGL + +++ M+P + D + +
Sbjct: 1 VDKYLHRFQLSHEDLMEISVRFRRE-MDKGLCRDTSPTAAVRMLPTFVRSTPDGTEHGEF 59
Query: 64 IIIDAGGTNFRAGIVYFDKKGVPEI-LSFFKHPMPALDREMTNEEFFDSIAE----YLEP 118
+ +D GG+NFR +V G ++ + + +P + + E FD IA+ ++E
Sbjct: 60 LALDLGGSNFRVLLVKVMADGEQKVEMENQVYAIPEHLMKGSGTELFDHIADCLANFMEK 119
Query: 119 L--KDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKK 176
+ K++ + F FS+ + + +K K + + E L +++ ++G
Sbjct: 120 MGIKEKKLPLGFTFSFPCQQTKLDESVLLSWTKAFKSSGVEGKDVVELLRKSIKKRGDFD 179
Query: 177 IKKIIMVNDTAAVLQSGIFSETDDQGFDSH---IGFVLGTGLNSAYIEYGKIEKLKTTEF 233
+ ++NDT + + G+D H IG ++GTG N+ Y +E+++ E
Sbjct: 180 ADVMAVINDTVGTMMTC--------GYDDHLCEIGLIVGTGTNACY-----MEQMRNIEV 226
Query: 234 YDKPQIIVC---------ESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC 284
+ + +C + G + ++ D+ + S E+M SG YLGEL
Sbjct: 227 LEGDEGRMCVNTEWGAFGDDGALEDL-RTDLDREIDAGSLNPGRQLFEKMVSGLYLGELV 285
Query: 285 SIAL-RAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHD-----KNIFSGIIEAHS 338
+ L + + +F + LL + F T I + + + + + G ++
Sbjct: 286 RLILVKMAKEQLLFQGKSTAELLTTGSFKTSHICTIDVDNDEEGLASAEKVLRG-LKISP 344
Query: 339 VSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
SED + +C+ R+ L AA + A + K+ +K I DGS++
Sbjct: 345 TSEDCAAVRRVCQIVSTRSAHLCAATLVAILRQIRDNKAAEKLRTTIGVDGSVY 398
Score = 72.4 bits (176), Expect = 6e-11, Method: Composition-based stats.
Identities = 85/388 (21%), Positives = 169/388 (43%), Gaps = 42/388 (10%)
Query: 30 MKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEIL 89
M +GL SS+ M+P + D + + +D GG+NFR +V + G +
Sbjct: 476 MLEGLSEHTHKDSSVKMLPTYVRSTPDGTEQGDFLAVDLGGSNFRVLLVQI-QSGTKRSV 534
Query: 90 SFFK--HPMPALDREMTNEEFFDSI----AEYLE--PLKDESDMISFCFSYAIKIFPDGG 141
+ + + +P + T EE FD I A +LE L S + F FS+
Sbjct: 535 NLHQKIYHIPQETLQGTGEELFDHIVQCMASFLEYMGLSGASLPLGFTFSFPCHQSRLDQ 594
Query: 142 GQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQ 201
G ++ +K K + L +A++R+ + + +VNDT + + + +
Sbjct: 595 GILLRWTKGFKASGCEGRDVIMLLKEAVNRRKEFDLNFVAVVNDTVGTMMTCGYEDP--- 651
Query: 202 GFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKIPQ 252
+G ++GTG N Y +E++ + D + +C ++G+ +
Sbjct: 652 --RCEVGLIVGTGTNVCY-----MEEVGNMDLVDGDEGRMCVNMEWGAFGDAGELDDF-S 703
Query: 253 SKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSCDF 311
++FD+++ + S + E+M SG YLGE+ L + G +F ++++ L F
Sbjct: 704 TQFDRLVDDCSTNPGKQRYEKMISGMYLGEIVRNVLMHFTDRGLLFRGKLSERLKMRGIF 763
Query: 312 STEEISLFLKEQNHD-------KNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAV 364
+T+ FL + D ++I + +S +D V + +C RA +L A
Sbjct: 764 ATK----FLAQIESDRLAMRQVRSILQHLGLTNSTCDDSVLVKEVCSVVSRRAAQLCGAG 819
Query: 365 IAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + ++ ++ + + DG+++
Sbjct: 820 LAAVVDKMRENRNLNQLSVTVGVDGTLY 847
>gi|204380|gb|AAA41239.1| glucokinase (EC 2.7.1.1)
gi|149047656|gb|EDM00326.1| glucokinase, isoform CRA_d [Rattus norvegicus]
Length = 448
Score = 75.9 bits (185), Expect = 5e-12, Method: Composition-based stats.
Identities = 99/431 (22%), Positives = 187/431 (43%), Gaps = 37/431 (8%)
Query: 18 DIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGI 77
D++ S + ++M +GL E +S+ M+P + + + + +D GGTNFR +
Sbjct: 29 DLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVML 88
Query: 78 VYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIF 137
V + + KH M ++ D++ E +K + + F FS+ ++
Sbjct: 89 VKVGEGEAGQWSVKTKHQMYSIPE--------DAMTGTAEMMKHKKLPLGFTFSFPVRHE 140
Query: 138 PDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K I L A+ R+G ++ + MVNDT A + S + +
Sbjct: 141 DLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYED 200
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNKIP 251
+G ++GTG N+ Y +E+++ E + + +C + G S ++
Sbjct: 201 R-----QCEVGMIVGTGCNACY-----MEEMQNVELVEGDEGRMCVNTEWGAFGDSGELD 250
Query: 252 QS--KFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNS 308
+ ++D+++ E+S + E++ G+Y+GEL + L E +F ++ L
Sbjct: 251 EFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTR 310
Query: 309 CDFSTEEISLFLKEQNHDK---NIFSGIIEAHSVSE-DYVKIYSICKCFFERAGRLSAAV 364
F T +S + K NI S + SV++ D V+ C+ RA + +A
Sbjct: 311 GAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVR--RACESVSTRAAHMCSAG 368
Query: 365 IAAACIKTGKGKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTND 423
+A + + +S D I + DGS++ KER S+ LT I F+ ++
Sbjct: 369 LAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR-LTPNCEITFI--ESE 425
Query: 424 EAVTLGTALAA 434
E G AL +
Sbjct: 426 EGSGRGAALVS 436
>gi|125527545|gb|EAY75659.1| hypothetical protein OsI_003506 [Oryza sativa (indica
cultivar-group)]
Length = 502
Score = 75.9 bits (185), Expect = 5e-12, Method: Composition-based stats.
Identities = 107/444 (24%), Positives = 182/444 (40%), Gaps = 49/444 (11%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA------- 75
A + +M+ GL +E S M ++ +LP+ K +D GGTNFR
Sbjct: 61 ADAMAAEMRAGLAAEGGSDLQM-LVTYVDSLPSGGEKGM-FYALDLGGTNFRVLRVQLGG 118
Query: 76 ---GIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL-----------KD 121
I+ D +G+ S +H M + ++ E FD +A L +
Sbjct: 119 KERRIIKQDSEGI----SIPQHLMSS-----SSHELFDFVAAALAKFVASEGEDCHLPEG 169
Query: 122 ESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKII 181
+ F FS+ +K G IK +K + + + L A+ R+G +K
Sbjct: 170 TQRELGFTFSFPVKQKSLASGTLIKWTKSFAIDEMVGKDVVAELNMAIRRQGLD-MKVTA 228
Query: 182 MVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGK-IEKLKTTEFYDKPQII 240
+VNDT L +G + + D+ +LGTG N+AYI++ I K + +I
Sbjct: 229 LVNDTVGTLAAGRYVD-----HDTIAAVILGTGSNAAYIDHADAIPKWHGSLPKSGNMVI 283
Query: 241 VCESG--KSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELC-SIALRAGSAEGIF 297
E G KS+ +P ++FD+ L S + E+M SG Y+GEL I L+ IF
Sbjct: 284 NMEWGNFKSSHLPLTEFDQELDAESLNPGKQVYEKMISGMYMGELVRRILLKMAQETRIF 343
Query: 298 SPRVNKMLLNSCDFSTEEISLFLKEQNHD----KNIFSGIIEAHSVSEDYVK-IYSICKC 352
+ L T ++ + + + D N ++ S K + +C+
Sbjct: 344 GDNIPPKLERPYILRTLDMLIMHHDTSSDLRTVANKLKEVLGIEYTSFTTRKLVLDVCEA 403
Query: 353 FFERAGRLSAAVIAAACIKTGK-GKSPD-KPICISADGSMFLKGFLIKERIFKSLHTCLT 410
R RL+AA I K G+ SP + I+ DG ++ + + +L L
Sbjct: 404 IATRGARLAAAGIYGIIQKLGQHSDSPSTRRSVIAVDGGVYKYYTFFSQCMESTLSDMLG 463
Query: 411 EKRGIYFVLKTNDEAVTLGTALAA 434
++ ++K ++ +G AL A
Sbjct: 464 QELAPSVMIKHVNDGSGVGAALLA 487
>gi|155008468|gb|ABS89273.1| hexokinase 1b [Gadus morhua]
Length = 918
Score = 75.5 bits (184), Expect = 6e-12, Method: Composition-based stats.
Identities = 83/388 (21%), Positives = 172/388 (44%), Gaps = 41/388 (10%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+++ GL + ++++ M+P + D ++ + +D GGTNFR +V ++ V
Sbjct: 494 EIQNGLSKSTQEIATVKMLPTFVQSTPDGSENGDFLALDLGGTNFRVLLVKIRSGKRRTV 553
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPD 139
+ PM + + T EE FD I + + D M + F FS+ +
Sbjct: 554 EMNNKIYAIPMEVM--QGTGEELFDHIVQCISDFLDYMGMKNTRLPLGFTFSFPCQQTSL 611
Query: 140 GGGQAIKLSKEIKLPYIGDCKINE--GLFQ-ALSRKGWKKIKKIIMVNDTAAVLQSGIFS 196
G + +K K DC+ + GL + A+ R+ + + +VNDT + + +
Sbjct: 612 DAGVLVTWTKGFKAT---DCEGEDVVGLLRDAIRRREEFDLDVVAIVNDTVGTMMTCAYE 668
Query: 197 ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKS 247
E +G + GTG N+ Y +E++K E + + +C ++G
Sbjct: 669 EP-----TCEVGLIAGTGSNACY-----MEEMKNIEMIEGDEGRMCVNMEWGAFGDNGCL 718
Query: 248 NKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLL 306
+ + ++++D+ + + S + E+MCSG YLGE+ L + +G +F ++++ L
Sbjct: 719 DDM-RTEYDRTVDDLSLNPGKQRYEKMCSGMYLGEIVRNILIDLTRKGFLFRGQISETLK 777
Query: 307 NSCDFSTEEISLFLKEQNHDKNIFSGI--IEAHSVSEDYVKIYSICKCFFERAGRLSAAV 364
F T+ +S ++ + S + + S +D + + +C RA ++ A
Sbjct: 778 TRGIFETKYLSQIESDRLALLQVRSILQHLGLDSTCDDSIIVKKVCGAVSHRAAQICGAG 837
Query: 365 IAAACIKTGKGKSPDK-PICISADGSMF 391
+AA K + + D + + DG+++
Sbjct: 838 MAAVVDKIRENRGLDHLDVTVGVDGTLY 865
Score = 74.3 bits (181), Expect = 2e-11, Method: Composition-based stats.
Identities = 83/392 (21%), Positives = 165/392 (42%), Gaps = 49/392 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFR---AGIVYFDKKGV 85
++ +GL + +++ M+P + + D + I +D GG+ FR + + K+ V
Sbjct: 46 ELARGLGQDTNPTATLKMLPTFVHSIPDGSEKGDFIALDLGGSAFRILRVRVSHEKKQTV 105
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYL------EPLKDESDMISFCFSYAIKIFPD 139
+ P + T FD +AE L +KD+ + FS+ +
Sbjct: 106 QMESEIYDTPEDIIHGNGT--RLFDHVAECLGNFMEKHNIKDKRLPVGLTFSFPCQQTKL 163
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
G + +K K + + + L +A+ ++G + +VNDT + + F D
Sbjct: 164 DEGYLLTWTKRFKASGVEGMDVVQLLNKAIKKRGDYDADIMAVVNDTVGTMMTCGF---D 220
Query: 200 DQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSNKI 250
DQ +G ++GTG N+ Y+E +L+ + + + +C + G+ I
Sbjct: 221 DQ--RCEVGIIVGTGTNACYME-----ELRHIDLVEGDEGRMCVNTEWGAFGDDGRLEDI 273
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLNSC 309
+++FD+ + S + E+M SG Y+GEL + L + EG +F R+ LL
Sbjct: 274 -RTEFDREIDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTKG 332
Query: 310 DFSTEEISLFLKEQNHDKNIFSGIIEAHSV---------SEDYVKIYSICKCFFERAGRL 360
T+ +S K + G+ +A + ++D + + +C R+ L
Sbjct: 333 KLDTKHVSAIEKSK-------EGLTKAKEILIRLGVEPSADDCIAVQHVCAIVSFRSASL 385
Query: 361 SAAVIAAACIKTGKGKSPDK-PICISADGSMF 391
AA + A ++ + K + + DGS++
Sbjct: 386 IAATLGAILLRLKENKGVARLRTTVGIDGSLY 417
>gi|156062314|ref|XP_001597079.1| hypothetical protein SS1G_01273 [Sclerotinia sclerotiorum 1980]
gi|154696609|gb|EDN96347.1| hypothetical protein SS1G_01273 [Sclerotinia sclerotiorum 1980]
Length = 491
Score = 75.5 bits (184), Expect = 6e-12, Method: Composition-based stats.
Identities = 100/391 (25%), Positives = 170/391 (43%), Gaps = 39/391 (9%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRA-GIVYFDKKG 84
+ ++ KGL E S+ M P W D + + +D GGTN R I+ D+K
Sbjct: 48 FVSELTKGLTVEGGSIP---MNPTWCMSFPDGYETGTFLALDMGGTNLRVCEIILTDEKS 104
Query: 85 VPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPL--------KDESDMISFCFSY-AIK 135
+I+ K+ MP + +E ++ IA+ L+ K + + F FSY A +
Sbjct: 105 EFDIMQS-KYRMPEELKTGDADELWEYIADCLQQFIESHHQGEKLDKLSLGFTFSYPATQ 163
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIF 195
+ D G + +K + + + AL+++G IK ++NDT L + +
Sbjct: 164 NYIDEGILQ-RWTKGFDIEGVEGENVVPMFEAALAKRG-VPIKLTALINDTTGTLIASAY 221
Query: 196 SETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFY-DKPQIIVCESGKSNK---- 249
++T + IG + GTG N+AY+E G I KL D P I CE G +
Sbjct: 222 TDTSMK-----IGCIFGTGCNAAYMENCGSIPKLAHMNLPPDTPMAINCEWGAFDNEHKV 276
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIA---LRAGSAEGIFSPRVNKMLL 306
+P++ +D I+ ++S + E+M +G YLGEL + L IF + + L
Sbjct: 277 LPRTPYDIIIDKDSPRPGQQAFEKMIAGLYLGELFRLVLVDLHDNKDIHIFEGQDIEKLR 336
Query: 307 NSCDFSTEEISLF----LKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSA 362
+ + +SL + + ++F + + + I + + RA RLSA
Sbjct: 337 KAYTLDSSFLSLVEEDPFENLSETADLFQNKLGIVTTVPELELIRRLAELIGTRAARLSA 396
Query: 363 AVIAAACIKTGKGKSPDKPICISADGSMFLK 393
+AA K G + + ADGS+F K
Sbjct: 397 CGVAAIAKKKGY-----ETCHVGADGSVFNK 422
>gi|148236406|ref|NP_001079298.1| glucokinase [Xenopus laevis]
gi|1262840|emb|CAA63761.1| glucokinase [Xenopus laevis]
gi|1589157|prf||2210326A glucokinase
Length = 458
Score = 75.5 bits (184), Expect = 7e-12, Method: Composition-based stats.
Identities = 71/281 (25%), Positives = 127/281 (45%), Gaps = 35/281 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M++GL E +S+ M+P + D + + +D GGTNFR +V D +G
Sbjct: 33 EMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFLALDLGGTNFRVMLVKVGEDLEGQW 92
Query: 87 EILSFFKHPM---PALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIF 137
++ + KH M P T E FD IAE + D+ +M + F FS+ ++
Sbjct: 93 KVET--KHKMYSIPVDAMTGTAEMLFDYIAECISDYLDQQNMKHKKLPLGFTFSFPVRHE 150
Query: 138 PDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G + +K K + L A+ R+G ++ + MVNDT A + S +
Sbjct: 151 DIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYE- 209
Query: 198 TDDQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCES------GKSNK 249
D H +G ++GTG N+ Y +E++ E + + +C + G + +
Sbjct: 210 ------DHHCEVGLIVGTGCNACY-----MEEMSNVELVEGEEGRMCVNTEWGAFGDTGE 258
Query: 250 IPQSK--FDKILSENSNLKNEYFLERMCSGRYLGELCSIAL 288
+ + +D+++ E S + E+M G+Y+GEL + L
Sbjct: 259 LEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVL 299
>gi|149239002|ref|XP_001525377.1| glucokinase GLK1 [Lodderomyces elongisporus NRRL YB-4239]
gi|146450870|gb|EDK45126.1| glucokinase GLK1 [Lodderomyces elongisporus NRRL YB-4239]
Length = 474
Score = 75.5 bits (184), Expect = 7e-12, Method: Composition-based stats.
Identities = 107/438 (24%), Positives = 189/438 (43%), Gaps = 58/438 (13%)
Query: 14 DYKIDIEY---AASILLEDMKKGLESEAESVSSMDMIPLW-KNLPTDIPKDKKVIII-DA 68
D+ ID ++ A+ E M+ GL++ + + M MIP + +LPT K+K + + D
Sbjct: 17 DFYIDDDFLIKASQYFEESMRAGLQAPEQDRAHMPMIPTYVTSLPTG--KEKGLFLAADL 74
Query: 69 GGTNFRAGIVYFDKKGVPEI---LSFFKHPMPALDREMTNEEF---FDSIAEYLE----- 117
GGTNFR + D KG S F+ P+ + + ++ F IA +L+
Sbjct: 75 GGTNFR--VCSVDLKGDHTFDLKQSKFRIPLDLMKGDHADDLFRFLATKIAAFLDENHQD 132
Query: 118 -------PLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLP-YIGDCKINEGLFQAL 169
PLK + F FS+ + G ++ +K +P +G + L QA
Sbjct: 133 CRVKGSKPLK-----LGFTFSFPVDQTALNRGTLLRWTKSFDIPDTVGRDVVQ--LLQAN 185
Query: 170 SRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGF-DSHIGFVLGTGLNSAYIE-YGKIEK 227
+ + + NDT L S ++ + ++ IG + GTG N AY E + +I K
Sbjct: 186 LTVLEVNVDVVALANDTVGTLLSRSYANNPEYTHANTVIGLIFGTGTNGAYYESFDRIPK 245
Query: 228 LKTTEFYDKPQIIVCESGKSNK----IPQSKFDKILSENSNLKNEYFLERMCSGRYLGEL 283
LK K +I E G + +P + +DKI+ + K + E+ SG +LGE+
Sbjct: 246 LKNKPEGAKGMVINTEWGSFDNELKILPNTLYDKIVDSETANKGYHMFEKRVSGLFLGEI 305
Query: 284 CSIALRAGSAEGIFSPRVNK--------MLLNSCDFSTEEISLFLKEQN----HDKNIFS 331
+AL +G+ + K L+ +E +S + + + I
Sbjct: 306 LRVALLDLFEKGLIFQELYKERGGSLPHRLITPWQLDSEVLSYIQIDDSTALKMSELILQ 365
Query: 332 GIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPD-KPICISADGSM 390
+ + +++ V I I + +RA +L+A IA +T + D + + DGS+
Sbjct: 366 NTLRLPTTADERVVIQRITRAISKRAAQLAAIPIATIIRETKDLYADDERDFEVGCDGSV 425
Query: 391 --FLKGFLIKERIFKSLH 406
F GF ++ I K+ +
Sbjct: 426 IEFYPGF--RDEIMKAFN 441
>gi|157071924|gb|EAA36437.2| hexokinase [Neurospora crassa OR74A]
Length = 489
Score = 75.1 bits (183), Expect = 8e-12, Method: Composition-based stats.
Identities = 106/409 (25%), Positives = 171/409 (41%), Gaps = 42/409 (10%)
Query: 26 LLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGV 85
+ +++KGL + S+ M P W D + + +D GGTN R V +
Sbjct: 38 FVHELEKGLSVQGGSIP---MNPTWVMSFPDGNETGTYLALDMGGTNLRVCQVTLTETKS 94
Query: 86 PEILSFFKHPMPALDREMTNEEFFDSIAEYL---------EPLKDESDMISFCFSY-AIK 135
+ K+ MP + EE ++ IA+ L +P K ++ + F FSY A +
Sbjct: 95 EFDIIQSKYRMPEELKTGDAEELWEYIADCLMQFIETHHGDPTKLDALPLGFTFSYPATQ 154
Query: 136 IFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIF 195
+ D G + +K + + + AL R+G IK ++NDT L + +
Sbjct: 155 NYIDEGILQ-RWTKGFDIAGVEGHNVVPMFEAALQRRG-VPIKLTALINDTTGTLIASAY 212
Query: 196 SETDDQGFDSHIGFVLGTGLNSAYIEY-GKIEKLKTTEFY-DKPQIIVCESGKSNK---- 249
++ IG + GTG N+AY+E G I KL D P I CE G +
Sbjct: 213 TDPK-----MRIGCIFGTGCNAAYMENCGSIPKLAHMNLPPDMPMAINCEWGAFDNEHKV 267
Query: 250 IPQSKFDKILSENSNLKNEYFLERMCSGRYLGE---LCSIALRAGSAEGIFSPRVNKMLL 306
+P++ +D I+ ++S + E+M +G YLGE L + L IF + L
Sbjct: 268 LPRTPYDVIIDKDSPRPGQQSFEKMVAGLYLGEIFRLVLVDLHDNQEIKIFPGQDIAKLR 327
Query: 307 NSCDFSTEEISLFLKEQNHDKN------IFSGIIEAHSVSEDYVKIYSICKCFFERAGRL 360
+ +S + L L E++ +N +F + + I + RA RL
Sbjct: 328 KA--YSLDSSFLSLIEEDPFENLSETFELFQTKLGLTPTGPELELIRRTAELIGTRAARL 385
Query: 361 SAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCL 409
SA +AA K G K + ADGS+F K K R ++L L
Sbjct: 386 SACGVAAISKKKGY-----KQCHVGADGSVFNKYPNFKARGAQALREIL 429
>gi|204615|gb|AAA41334.1| hexokinase type II
Length = 516
Score = 75.1 bits (183), Expect = 8e-12, Method: Composition-based stats.
Identities = 91/391 (23%), Positives = 167/391 (42%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF---DKKGV 85
+M++GL E +V+ + M+P + D + + +D GGTNFR +V ++GV
Sbjct: 93 EMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGV 152
Query: 86 PEILSFFKHPMPALDREMTNEEFFD----SIAEYLE--PLKDESDMISFCFSYAIKIFPD 139
+ P + T EE FD IA++LE +K S + F FS+ +
Sbjct: 153 EMHNKIYSIPQEVM--HGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSL 210
Query: 140 GGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETD 199
+K +K K + L +A+ R+ + + +VNDT + + +
Sbjct: 211 DQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYE--- 267
Query: 200 DQGFDSH--IGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
D H +G ++GTG N+ Y +E+++ E D + +C ++G +
Sbjct: 268 ----DPHCEVGLIVGTGSNACY-----MEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLD 318
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
+ ++ FD + E S + E+M SG YLGE+ L + G +F R+++ L
Sbjct: 319 DL-RTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKT 377
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D + + S +D + + +C RA +L
Sbjct: 378 RGIFETK----FLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLC 433
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D + + DG+++
Sbjct: 434 GAGMAAVVDKIRENRGLDNLKVTVGVDGTLY 464
>gi|118727370|ref|ZP_01575973.1| Hexokinase [Clostridium cellulolyticum H10]
gi|118663260|gb|EAV69918.1| Hexokinase [Clostridium cellulolyticum H10]
Length = 431
Score = 75.1 bits (183), Expect = 8e-12, Method: Composition-based stats.
Identities = 78/273 (28%), Positives = 124/273 (45%), Gaps = 32/273 (11%)
Query: 23 ASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVY--- 79
A + E M+K L E + + M+P + PT + + ID GGTNFR
Sbjct: 26 AMLFKETMEKSLNGEK---TCLKMLPSYIGKPTG-KEQGTFMTIDMGGTNFRCTKYKINN 81
Query: 80 --FDKKGVPEILSFFKHPMPALDREMTNEE-----FFDSIAEYLEPLKDESDMISFCFSY 132
F+K G + K L + ++E+ + I E LEP +ES + FS+
Sbjct: 82 GNFEKVGEIKQKLINKEKNYDLTKSDSDEKQLFGFMAECIGELLEP--EESLYLGNTFSF 139
Query: 133 AIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQS 192
+ I+ +KEI + IN+ L Q+L K +K + ++NDT L
Sbjct: 140 PCRQEGINDAYLIQWTKEITTSGVVGQNINKLLEQSLKEKNIN-VKPVAILNDTVGTLLV 198
Query: 193 GIFS-ETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSN-KI 250
++S +T D IG ++GTG N+ Y+E + I+ ESG N +
Sbjct: 199 AMYSYQTAD------IGSIMGTGHNTCYLE-------NNHPLNGQKMIVNIESGNYNVGL 245
Query: 251 PQSKFDKILSENSNLKNEYFLERMCSGRYLGEL 283
P +K+D+I+ +NS + LE+M SG Y+G L
Sbjct: 246 PVTKYDEIIDKNSQIPGAQLLEKMVSGYYMGSL 278
>gi|34670|emb|CAA47379.1| hexokinase type 1 [Homo sapiens]
Length = 631
Score = 75.1 bits (183), Expect = 8e-12, Method: Composition-based stats.
Identities = 87/391 (22%), Positives = 171/391 (43%), Gaps = 47/391 (12%)
Query: 29 DMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYF--DKKGVP 86
+M+ GL + + + + M+P + D ++ + +D GGTNFR +V KK
Sbjct: 208 EMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTV 267
Query: 87 EILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDM------ISFCFSYAIKIFPDG 140
E+ + + +P + T EE FD I + D + + F FS+ +
Sbjct: 268 EMHNKI-YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLD 326
Query: 141 GGQAIKLSKEIKLPYIGDC---KINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSE 197
G I +K K DC + L A+ R+ + + +VNDT + + + E
Sbjct: 327 AGILITWTKGFKAT---DCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEE 383
Query: 198 TDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVC---------ESGKSN 248
+G ++GTG N+ Y +E++K E + Q +C ++G +
Sbjct: 384 P-----TCEVGLIVGTGSNACY-----MEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLD 433
Query: 249 KIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEG-IFSPRVNKMLLN 307
I ++ +D++++E S + E+M SG YLGE+ L + +G +F ++++ +
Sbjct: 434 DI-RTHYDRLVNEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETMKT 492
Query: 308 SCDFSTEEISLFLKEQNHDKNIFSGI------IEAHSVSEDYVKIYSICKCFFERAGRLS 361
F T+ FL + D+ + + +S +D + + ++C RA +L
Sbjct: 493 RGIFETK----FLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLC 548
Query: 362 AAVIAAACIKTGKGKSPDK-PICISADGSMF 391
A +AA K + + D+ + + DG+++
Sbjct: 549 GAGMAAVVDKIRENRGLDRLNVTVGVDGTLY 579
Database: nr
Posted date: Sep 17, 2007 11:41 AM
Number of letters in database: 999,999,834
Number of sequences in database: 2,976,859
Database: /nucleus1/users/jsaw/ncbi/db/nr.01
Posted date: Sep 17, 2007 11:48 AM
Number of letters in database: 894,087,890
Number of sequences in database: 2,493,262
Lambda K H
0.320 0.138 0.400
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,606,137,828
Number of Sequences: 5470121
Number of extensions: 69267382
Number of successful extensions: 171079
Number of sequences better than 1.0e-05: 441
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 438
Number of HSP's that attempted gapping in prelim test: 169540
Number of HSP's gapped (non-prelim): 650
length of query: 437
length of database: 1,894,087,724
effective HSP length: 136
effective length of query: 301
effective length of database: 1,150,151,268
effective search space: 346195531668
effective search space used: 346195531668
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 131 (55.1 bits)