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Actinobacillus actinomycetemcomitans Search Results

Record: 1 of 1  
MiniMap IGR0596 IGR0595 IGR0594 IGR0597 IGR0593 AA00924 lysA, - AA00923 imp, - AA00919 AA00925 cyaY, - AA00926 gptA, - AA00915 AA00921 recQ, - AA00927 gyrB, - AA00929 AA00924 lysA, - AA00923 imp, - AA00919 AA00925 cyaY, - AA00926 gptA, - AA00915 AA00921 recQ, - AA00927 gyrB, - AA00929 AA00924 lysA, - AA00923 imp, - AA00919 tagI, - AA00920 tagI, - AA00920 cyaY, - AA00926 gptA, - AA00915 AA00921 recQ, - AA00927 gyrB, - AA00929 AA00918 AA00918 AA00925


Gene ID:AA00923

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
lysA  

Definition:
diaminopimelate decarboxylase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
635380

Gene Stop:
634133

Gene Length:
1248

Molecular Weight*:
50361

pI*:


Net Charge*:


EC:
4.1.1.20  

Functional Class:
Amino acid biosynthesis; Aspartate family  

Gene Ontology:
Biological process
  GO:0009089    lysine biosynthetic process via diaminopimelate

Molecular function
  GO:0003824    catalytic activity
  GO:0008836    diaminopimelate decarboxylase activity


Pathway: pathway table
Lysine biosynthesis

Secondary Evidence:
Stragier,P., Danos,O. and Patte,J.C.
Regulation of diaminopimelate decarboxylase synthesis in
Escherichia coli. II. Nucleotide sequence of the lysA gene and
its regulatory region.
J. Mol. Biol. 168 (2), 321-331 (1983)
PubMed: 6350601.

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|42628962|ref|ZP_00154513.1|  COG0019: Diaminopimelate dec...   713   0.0  
 gi|145634864|ref|ZP_01790572.1|  diaminopimelate decarboxyla...   711   0.0  
 gi|15603289|ref|NP_246363.1|  LysA [Pasteurella multocida su...   709   0.0  
 gi|145637736|ref|ZP_01793388.1|  diaminopimelate decarboxyla...   707   0.0  
 gi|145632076|ref|ZP_01787811.1|  diaminopimelate decarboxyla...   707   0.0  
 gi|68249326|ref|YP_248438.1|  diaminopimelate decarboxylase ...   707   0.0  
 gi|16272667|ref|NP_438885.1|  diaminopimelate decarboxylase ...   705   0.0  
 gi|145630464|ref|ZP_01786244.1|  diaminopimelate decarboxyla...   698   0.0  
 gi|152977874|ref|YP_001343503.1|  diaminopimelate decarboxyl...   694   0.0  
 gi|52426139|ref|YP_089276.1|  LysA protein [Mannheimia succi...   693   0.0


InterPro Summary:  InterProScan

InterPro
IPR000183
Domain
Orn/DAP/Arg decarboxylase 2
PR01179 [57-75]T 8.1e-27 PR01179 ODADCRBXLASE[77-89]T 8.1e-27 PR01179 ODADCRBXLASE[190-203]T 8.1e-27 PR01179 ODADCRBXLASE[271-290]T 8.1e-27 PR01179 ODADCRBXLASE[370-383]T 8.1e-27 PR01179 ODADCRBXLASE ODADCRBXLASE
PF00278 [285-391]T 1.4e-32 PF00278 Orn_DAP_Arg_deC Orn_DAP_Arg_deC
PF02784 [33-282]T 9.4e-110 PF02784 Orn_Arg_deC_N Orn_Arg_deC_N
PS00878 [57-75]? NA PS00878 ODR_DC_2_1 ODR_DC_2_1
PS00879 [228-241]? NA PS00879 ODR_DC_2_2 ODR_DC_2_2
InterPro
IPR002986
Domain
Diaminopimelate decarboxylase
PR01181 [75-92]T 2.4e-32 PR01181 DAPDCRBXLASE[164-173]T 2.4e-32 PR01181 DAPDCRBXLASE[299-317]T 2.4e-32 PR01181 DAPDCRBXLASE[380-402]T 2.4e-32 PR01181 DAPDCRBXLASE DAPDCRBXLASE
TIGR01048 [4-413]T 8e-253 TIGR01048 lysA: diaminopimelate decarboxylase lysA: diaminopimelate decarboxylase
noIPR
unintegrated
unintegrated
G3DSA:3.20.20.10 [34-281]T 4.4e-75 G3DSA:3.20.20.10 no description no description
PTHR11482 [10-416]T 7.6e-146 PTHR11482 ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE
PTHR11482:SF5 [10-416]T 7.6e-146 PTHR11482:SF5 DIAMINOPIMELATE DECARBOXYLASE DIAMINOPIMELATE DECARBOXYLASE


COGS Summary:  COGS Search
No hits to the COGs database.
Blocks Summary:  Blocks Search

Significant hit ( 6.9e-71) to 7/7 blocks of the IPB000183 family, which is described as "Orn/DAP/Arg decarboxylases family 2". Interpro entry for IPR000183.
    IPB000183A    57-101    1e-21
    IPB000183B    158-172    7.2e-06
    IPB000183C    193-204    0.00023
    IPB000183D    226-245    3.9e-06
    IPB000183E    271-294    6.1e-12
    IPB000183F    339-348    0.054
    IPB000183G    361-381    1.2e-09

 ProDom Summary:  Protein Domain Search

Residues 21 to 202 match (6e-07) PD:PD552258 which is described as PROTEOME DECARBOXYLASE COMPLETE DIAMINOPIMELATE LYASE

Paralogs:  Local Blast Search

AA00923 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search

Residues 285 to 392 (E-value = 5.6e-47) place AA00923 in the Orn_DAP_Arg_deC family which is described as Pyridoxal-dependent decarboxylase, C-terminal sheet domain (PF00278)


 Top PDB Hits:


Gene Protein Sequence:
MDFFQYQYDRLMVENLPVKQLAEEFGTPLYVYSKAALEHHWYAFENAFGN
HPHLVCFAVKSNPNIAILNIMARLGSGFDIVSQGELERVLAAGGEAHKVV
FSGVAKSRREIARALEVGIRCFNIESEAELLRINQVAGDIGKIAPISLRV
NPDVDAHTHPYISTGLKENKFGVSVEQAREVYKLATTLPNIEIVGMDCHI
GSQLTELQPFLDAADRLIMLMEQLKQDSIQLKHLDLGGGLGVTYTDETPP
HPTEYAKALWEKLSAFNELEIIVEPGRAITANAGILVTKVEYLKSNESRN
FAIVDAGMNDMIRPALYQAYMNILEIDRTLAREEKIYDVVGPICETSDFL
GKQRKLAIAEGDYLAQRSAGAYGASMSSNYNSRPRTAEVMVDGDNAYLIR
RREALNELWRLESLLP

Gene Nucleotide Sequence:  Sequence Viewer
ATGGACTTTTTCCAATATCAATATGATCGACTTATGGTGGAAAATCTGCC
GGTCAAACAACTTGCCGAGGAGTTCGGCACGCCCTTATATGTTTATTCCA
AAGCCGCTCTTGAGCACCACTGGTATGCTTTTGAGAACGCCTTTGGAAAC
CATCCGCACTTAGTGTGTTTCGCCGTGAAATCCAATCCGAATATTGCTAT
TTTGAACATCATGGCAAGACTGGGTTCCGGCTTTGACATTGTGTCCCAAG
GAGAATTGGAACGGGTGCTTGCCGCCGGCGGTGAGGCGCATAAAGTGGTG
TTTTCCGGCGTGGCGAAATCCCGCCGGGAAATCGCCCGCGCGCTGGAAGT
GGGCATTCGTTGCTTTAACATAGAATCGGAAGCAGAATTGTTACGCATTA
ATCAAGTCGCTGGCGACATAGGCAAAATCGCACCCATATCTTTACGCGTC
AATCCTGATGTGGACGCCCACACCCACCCTTACATTTCCACCGGTTTAAA
AGAAAATAAGTTCGGTGTGAGTGTGGAACAGGCACGTGAGGTGTATAAAT
TAGCCACAACGCTGCCGAATATTGAAATTGTCGGTATGGATTGTCACATC
GGTTCGCAACTCACGGAATTACAACCATTTTTAGATGCCGCCGATCGGTT
AATCATGCTCATGGAACAGTTAAAACAGGACAGCATTCAGTTGAAACATT
TGGATTTGGGCGGCGGTTTAGGCGTCACTTACACCGACGAAACGCCACCA
CACCCGACGGAATACGCCAAAGCCCTGTGGGAAAAATTAAGTGCGTTCAA
CGAGTTGGAAATTATCGTTGAGCCCGGTCGCGCCATCACCGCCAATGCGG
GGATTTTGGTGACCAAAGTGGAATATTTAAAATCCAACGAAAGCCGTAAT
TTCGCCATTGTAGATGCGGGCATGAACGACATGATTCGCCCGGCGTTATA
TCAGGCTTATATGAACATTCTGGAAATCGACCGCACTTTAGCGCGCGAAG
AGAAAATTTATGACGTGGTGGGGCCGATTTGCGAAACCTCGGATTTCCTC
GGCAAACAACGTAAACTTGCCATTGCGGAAGGGGATTATTTAGCCCAACG
CTCTGCGGGAGCTTATGGCGCCAGTATGTCTTCCAACTACAATTCCCGCC
CGAGAACGGCGGAGGTTATGGTGGACGGCGACAACGCCTATTTAATCCGC
CGCCGTGAAGCGTTAAATGAATTGTGGCGACTGGAAAGTTTGTTGCCA

Los Alamos National Laboratory • Est 1943

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