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Section Contents
 
References
 
Case Contents
 
Table of Contents
Cover Page
How to Use the Course
Initial Check
Nitrates and Nitrites
Who Is At Risk?
U.S. Standards
Biological Fate
Physiological Effects
Clinical Evaluation
Diagnostic Tests
Treatment
More Information
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Agency for Toxic Substances and Disease Registry 
Case Studies in Environmental Medicine (CSEM) 

Nitrate/Nitrite Toxicity
Literature Cited


References

  1. Agency for Toxic Substances and Disease Registry. Case studies in environmental medicine: taking an exposure history. Atlanta: US Department of Health and Human Services; 2001.
  2. Mackerness CW, Keevil CW. Origin and significance of nitrite in water. In: Hill MJ, editor. Nitrates and nitrites in food and water. Chichester, England: Ellis Horwood; 1991.
  3. Shuval HI, Gruener N. Epidemiological and toxicological aspects of nitrates and nitrites in the environment. Am J Public Health 1992; 62(8):1045-52.
  4. National Research Council, Committee on Toxicology. Nitrate and nitrite in drinking water. Washington, DC: National Academies Press; 1995.
  5. US Census Bureau. The American housing survey for the United States, 2003. Washington, DC: US Department of Commerce; 2004.
  6. Centers for Disease Control and Prevention. A survey of the quality of water drawn from domestic wells in nine Midwest states. Atlanta: US Department of Health and Human Services; 1995.
  7. US Geological Survey. The quality of our nations waters: nutrients and pesticides. Circular 1225. Reston, VA: US Department of the Interior; 1999.
  8. US Environmental Protection Agency. National pesticide survey: project summary. Washington, DC: US Environmental Protection Agency; 1990.
  9. Nolan BT, Hitt KJ, Ruddy BC. Probability of nitrate contamination of recently recharged ground waters in the conterminous United States. Environ Sci Technol 36(10):2138-45.
  10. Johnson CJ, Kross BC. Continuing importance of nitrate contamination of groundwater and wells in rural areas. Am J Ind Med 1990;18(4): 449-56.
  11. Kross BC, Ayebo AD, Fourtes LJ. Methemoglobinemia: nitrate toxicity in rural America. Am Fam Physician 1992;46:183-88.
  12. Centers for Disease Control and Prevention. Methemoglobinemia attributable to nitrite contamination of potable water through boiler fluid additives'-New Jersey, 1992-1996. MMWR 1997;46(09):202-4.
  13. Sanchez-Echaniz J. , Benito-Fernandez J, Mintegui-Raso S. Methemoglobinemia and consumption of vegetables in infants. Pediatrics 2001;107(5):1024-8.
  14. Dusdieker LB, Getchell JP, Liarakos TM, Hausler WJ, Dungy CI. Nitrate in baby foods: adding to the nitrate mosaic. Arch Pediatric Adolesc Med 1994;148: 490-94.
  15. Rowley GA. Carrots from the Everglades. N Engl J Med 1973;289(2):109.
  16. Keating JP, Lell ME, Strauss AW, Zarkowsky H, Smith GE. Infantile methemoglobinemia caused by carrot juice. N Engl J Med 1973;288(16):824-6.
  17. Vittozzi L. Toxicology of nitrates and nitrites. Food Addit Contam 1992; 9(5):579-85.
  18. Chan TY, Food-borne nitrates and nitrites as a cause of methemoglobinemia. Southeast Asian J Trop Med Public Health 1996;27(1):189-92.
  19. Saito T, Takeichi S, Osawa M, Yukawa N, Huang X-L. A case of fatal methemoglobinemia of unknown origin but presumably due to ingestion of nitrate. Int J Legal Med 2000;113(3):164-7.
  20. Coleman MD, Coleman NA. Drug-induced methaemoglobinaemia. Treatment issues. Drug Saf 1996;14(6):394-405.
  21. Dusdieker LB, Dungy CI. Nitrates and babies: A dangerous combination. Contemp Pediatr 1996;13(11):91-102.
  22. Agency for Toxic Substances and Disease Registry. Interaction profile for cyanide, fluoride, nitrate, and uranium. Atlanta: US Department of Health and Human Services; 2004.
  23. Smith RP. Toxic responses of the blood. In: Amdur MO, Doull J, Klaassen CD, editors. Casarett and Doulls toxicology: the basic science of poisons. New York: Pergamon Press; 1991. p. 257-81.
  24. Lebby T, Roco JJ, Arcinue EL. Infantile methemoglobinemia associated with acute diarrheal illness. Am J Emerg Med 1993;11:471-2.
  25. Gebara B. , Goetting MM. Life-threatening methemoglobinemia in infants with diarrhea and acidosis. Clin Pediatr 1994;33:370-3.
  26. Avery AA. Infantile methemoglobinemia: reexamining the role of drinking water nitrates. Environ Health Perspect 1999;107(7):583-6.
  27. Zeman CL, Kross B, Vlad M. A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania. Environ Health Perspect 2002;110(8):817-22.
  28. Croen, LA, Todoroff K, Shaw GM. Maternal exposure to nitrate from drinking water and diet and risk of neural tube defects. Am J Epidemiol 2001;153:325-31.
  29. Spontaneous abortions possibly related to ingestion of nitrate-contaminated well water-LaGrange County, Indiana, 1991-1994. MMWR 1996;45:569-72.
  30. US Environmental Protection Agency. Consumer factsheet on: nitrates/nitrites. Washington, DC: US Environmental Protection Agency; 2004. Available from URL: http://www.epa.gov/safewater/dwh/c-ioc/nitrates.html.
  31. Mensinga TT, Speijers GJA, Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev 2003;22(1):41-51.
  32. Abadin HG, Murray HE, Wheeler JS. The use of hematological effects in the development of minimal risk levels. Regul Toxicol Pharmacol 1998;28(1):61-6.
  33. Fan AM, Steinberg VE. Health implications of nitrate and nitrite in drinking water: An update on methemoglobinemia occurrence and reproductive and development toxicity. Regul Toxicol Pharmacol 1996;23(11):35-43.
  34. US Environmental Protection Agency. Integrated Risk Information System (IRIS) database. Nitrate (CASRN 14797-55-8). Washington, DC: US Environmental Protection Agency. 2002. Available at URL: http://www.epa.gov/iris/.
  35. Walker R. The metabolism of dietary nitrites and nitrates. Biochem Soc Trans 1996;24(3):780-5.
  36. US Environmental Protection Agency. Criteria document for nitrate/nitrite. Washington, DC: US Environmental Protection Agency; 1990.
  37. McKnight GM, Duncan CW, Leifert C, Golden MH. Dietary nitrate in man: Friend or foe? Br J Nutr 1999; 81(5):349-58.
  38. Lundberg JO, Weitzberg E, Cole JA, Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol 2004;2(7):593-602.
  39. Hill MJ. Nitrate toxicity: myth or reality? Br J Nutr 1999;81(5):343-4.
  40. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 1999;34(5):646-56.
  41. Harris JC, Rumack BH, Peterson RG, McGuire BM. Methemoglobinemia resulting from absorption of nitrates. JAMA 1979;242(26):2869-71.
  42. American Academy of Pediatrics Committee on Nutrition. Infant methemoglobinemia: the role of dietary nitrate. Pediatrics 1970;46(3):475-8.
  43. Comly HH. Cyanosis in infants caused by nitrates in well water. JAMA 1945;129:112.
  44. Reynolds KA. The prevalence of nitrate contamination in the United States. Water Conditioning and Purification 2002; 44(1). Available from URL: http://www.wcponline.com/ArchiveNewsView.cfm?pkArticleID=1330&AT=T.
  45. Knobeloch L, Salna B, Hogan A, Postle J, Anderson H. Blue babies and nitrate-contaminated well water. Environ Health Perspect 2000; 108(7):675-8.
  46. Shearer LA, Goldsmith JR, Young C, Kearns OA, Tamplin BR. Methemoglobin levels in infants in an area with high nitrate water supply. Am J Public Health 1972;62(9):1174-80.
  47. Jaffe ER, Hultquist DE. Cytochrome b5 reductase deficiency and enzymopenic hereditary methemoglobinemia. In: Scriver CR, Beaudet AL, Sly WS, editors. The metabolic and molecular basis of inherited disease. 7th ed. New York: McGraw-Hill; 1995. p. 2267-80.
  48. Bradberry SM. Occupational methaemoglobinaemia: mechanisms of production, features, diagnosis and management including the use of methylene blue. Toxicol Rev 2003;22(1):13-27.
  49. Osterhoudt KC. Methemoglobinemia. In: Ford MD, Delaney KA, Ling LJ, Erickson T, editors. Clinical toxicology. 1st ed. Philadelphia: WB Saunders Company; 2001. p. 214-6.
  50. Tabacova S, Balabaeva L, Little RE. Maternal exposure to exogenous nitrogen compounds and complications of pregnancy. Arch Environ Health 1997;52(5):341-7.
  51. Bruning-Fann CS, Kaneene JB. The effects of nitrate, nitrite and N-nitroso compounds on human health: a review. Vet Hum Toxicol 1993;35(6):521-38.
  52. Kostraba JN, Gay EC, Rewers M, Hamman RF. Nitrate levels in community drinking waters and risk of IDDM. An ecological analysis. Diabetes Care 1992;15(11):1505-8.
  53. Virtanen SM, Jaakkola L, Rasanen L, Ylonen K, Aro A, Lounamaa R, et al. Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Childhood Diabetes in Finland Study Group. Diabet Med 1994;11(7):656-62.
  54. Parslow RC, McKinney PA, Law GR, Staines A, Williams R, Bodansky HJ. Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia 1997; 40(5):550-6.
  55. Tricker AR, Preussmann R. Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat Res 1991;259:277-89.
  56. Cantor KP. Drinking water and cancer. Cancer Causes Control 1997; 8:292-308.
  57. Eichholzer M. , Gutzwiller F. Dietary nitrates, nitrites, and N-nitroso compounds and cancer risk: a review of the epidemiologic evidence. Nutr Rev 1998; 56:95-105.
  58. Barrett JH, Parslow RC, McKinney PA, Law GR, Forman D. Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England. Cancer Causes Control 1998;9:153-9.
  59. Ward MH, Mark SD, Cantor KP, Weisenburger DD, Correa-Villasenor A, Zahm SH. Drinking water nitrate and the risk of non-Hodgkins lymphoma. Epidemiology 1996; 7(5):465-71.
  60. Van Loon AJ, Botterweck AA, Goldbohm RA, Brants HA, van Klaveren JD, van den Brandt PA. Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study. Br J Cancer 1998; 78:129-35.
  61. Xu G, Song P, Reed PI. The relationship between gastric mucosal changes and nitrate intake via drinking water in a high-risk population for gastric cancer in Moping County, China. Eur J Cancer Prev 1992; 1(6):437-43.
  62. Dabney BJ, Zelarney PT, Hall AH. Evaluation and treatment of patients exposed to systemic asphyxiants. Emerg Care Q 1990; 6(3):65-80.
  63. Rehman HU. Methemoglobinemia. West J Med 2001;175:193-6.
  64. Zorc JJ, Kanic Z. A cyanotic infant: true blue or otherwise? Pediatr Ann 2001;30(10):597-601.
  65. Mack RB. The "blue" people with "chocolate" blood'-methemoglobinemia. N C Med J 1982;43(4):292-3.
  66. Geffner ME, Powars DR, Choctaw WT. Acquired methemoglobinemia. West J Med 1981;134(1):7-10.
  67. Wentworth P, Roy M, Wilson B, Padusenko J, Smeaton A, Burchell N. Toxic methemoglobinemia in a 2-year-old child. Lab Med 1999;30(5):311-5.
  68. Henretig FM, Gribetz B, Kearney T. Interpretation of color change in blood with varying degree of methemoglobinemia. Clin Toxicol 1988; 26(5-6):293-301.
  69. Ralston AC, Webb RK, Runciman WB. Potential error in pulse oximetry: III. Effects of interference, dyes, dyshaemoglobins and other pigments. Anaesthesia 1991;46:291-5.
  70. Avner JR, Henretig FM, McAneney CM. Acquired methemoglobinemia'-the relationship of cause to course of illness. Am J Dis Child 1990;144:1229-30.
  71. Park CM, Nagel RL. Sulfhemoglobinemia: clinical and molecular aspects. N Engl J Med 1984;310:1579-84.
  72. Matthews PJ. Co-oximetry. Resp Care Clin N Am 1995; 1:47-68.
  73. Mansouri A, Lurie AA. Concise review: Methemoglobinemia. Am J Hematol 1993;42:7-12.
  74. Olsen ML, McEvoy GK. Methemoglobinemia induced by topical anesthetics. Am J Hosp Pharmacol 1981;38:89-93.
  75. Reigart JR, Trammel HL, Lindsey JM. Repetitive doses of activated charcoal in dapsone poisoning in a child. J Toxicol Clin Toxicol 1982;19(10):1061-6.
  76. Price D. Methoglobinemia. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, editors. Goldfranks toxicologic emergencies. 6th ed. Old Tappan, NJ: Appleton & Lange 1998. p. 1507-23.
  77. Berlin G, Brodin B, Hilden J. Acute dapsone intoxication: a case treated with continuous infusion of methylene blue, forced diuresis, and plasma exchange. J Toxicol Clin Toxicol 1985;22:537-48.
  78. Goluboff N, Wheaton R. Methylene blue induced cyanosis and acute hemolytic anemia complicating the treatment of methemoglobinemia. J Pediatr 1961;58:86-9.
  79. Kirsch IR, Cohen HJ. Heinz body hemolytic anemia from the use of methylene blue in neonates. J Pediatr 1980;96:276-8.
  80. Rosen PJ, Johnson C, McGehee WG, Beutler E. Failure of methylene blue treatment in toxic methemoglobinemia. Ann Intern Med 1971;75:83-6.
  81. Harvey JW, Keitt AS. Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia. Br J Haematol 1983;54:29-41.
  82. Harrison MR. Toxic methemoglobinemia: a case of acute nitrobenzene and aniline poisoning treated by exchange transfusion. Anaesthesia 1977;32:270-2.
  83. Mier RJ. Treatment of aniline poisoning with exchange transfusion. Clin Toxicol 1988;26:357-64.
  84. Wright RO, Woolf AD, Shannon MW, Magnani B. N-acetylcysteine reduces methemoglobin in an in-vitro model of glucose-6-phosphate dehydrogenase deficiency. Acad Emerg Med 1998;5(3):225-9.

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Revised 2007-09-24.