BONAPACE CR, LORENZ KR, BOSSO JA, WHITE RL; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 403.

Med. Univ. of South Carolina, Charleston, SC

BACKGROUND: Rate and extent of change of decreases in bacterial susceptibility (S) are largely unknown. Further, such assessment may be more readily made with MICs rather than categorical data.METHODS: We assessed S trends for 8 FQ (ciprofloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, ofloxacin, sitafloxacin, trovafloxacin) using studies published from 1982-2000. Using >/=3 studies and >/=3 years of data, linear regression of log-MIC[50] and MIC[90] was performed for each organism/drug combination.RESULTS: Literature was evaluated for trends with 8 FQ and 70 organisms. Final analysis involved 152,406 isolates. Positive slopes from the regression analysis, indicating increasing MICs over time, were detected in 57%, 71%, and 76% of possible instances for NA, E, and A. In a subset of data reflecting steepest + slopes (>/=0.5), the median increase in MIC[90] over time was 32-fold. Gram-negative (GN) aerobes were associated with the most positive slopes (74% of possible instances) and Gram-positive (GP) anaerobic cocci with the least (20%). Slopes of >/=0.5 were more often associated with GN aerobes (13 of 23 cases). With FQ, the steepest positive slopes were detected in the 1990s, usually with newer agents. Of the GP organisms evaluated, the highest slope was observed with S. aureus and ciprofloxacin while with GN organisms the highest slope was with P. aeruginosa and trovafloxacin.CONCLUSIONS: We detected increases in MIC[50] and MIC[90] of FQ over time against numerous pathogens. Increases were greatest for drugs that have been used for the longest period of time; the steepest slopes often involved newer agents and occurred in the decade of the 90s, suggesting either inherent differences in these newer FQ or a cumulative effect of FQ use over time on susceptibility.KEYWORDS: Fluoroquinolone; Resistance; Surveillance

Publication Types:

• Meeting Abstracts

Keywords:

• Americas
• Asia
• Aza Compounds
• Bacteria, Aerobic
• Ciprofloxacin
• Europe
• Fluoroquinolones
• Microbial Sensitivity Tests
• Naphthyridines
• Ofloxacin
• Quinolines
• gatifloxacin
• gemifloxacin
• moxifloxacin
• sitafloxacin
• trovafloxacin

Other ID:

• GWAIDS0009490

UI: 102246988

From Meeting Abstracts