Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine deaminase	F	Contig10	442	COG1001	36	0.008
Adenine deaminase	F	Contig10	542	COG1001	44	4e-05
Adenine deaminase	F	Contig10	678	COG1001	47	4e-06
Adenine deaminase	F	Contig10	864	COG1001	39	5e-04
Adenosine deaminase	F	Contig10	442	COG1816	43	5e-05
Adenylate cyclase class 2 (thermophilic)	F	Contig10	1270	COG1437	119	1e-28
adenylate kinase	F	Contig10	513	COG2019	168	1e-43
Aspartate carbamoyltransferase regulatory subunit	F	Contig7	1515	COG1781	156	5e-40
Deoxynucleoside kinase	F	Contig9	1592	COG1428	34	0.009
Deoxyribose-phosphate aldolase	F	Contig10	1206	COG0274	37	0.001
dGTP triphosphohydrolase	F	Contig9	1641	COG0232	50	5e-07
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig10	904	COG0537	126	7e-31
Exopolyphosphatase	F	Contig10	405	COG0248	45	3e-06
IMP cyclohydrolase	F	Contig10	1077	COG3363	208	3e-55
Orotate phosphoribosyltransferase homologs	F	Contig10	1280	COG0856	40	3e-04
Orotate phosphoribosyltransferase homologs	F	Contig10	322	COG0856	55	4e-09
Orotate phosphoribosyltransferase homologs	F	Contig10	452	COG0856	35	0.003
Orotate phosphoribosyltransferase homologs	F	Contig10	815	COG0856	51	7e-08
Orotate phosphoribosyltransferase homologs	F	Contig10	901	COG0856	41	1e-04
Predicted nucleotide kinase	F	Contig10	863	COG4088	144	6e-36
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig10	308	COG1936	102	2e-23
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig10	513	COG1936	37	6e-04
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig9	1592	COG1936	47	8e-07

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig10	923	COG0015	524	1.0e-150
Adenylosuccinate lyase	F	Contig9	1673	COG0015	117	2e-27
Adenylosuccinate synthase	F	Contig9	1605	COG0104	378	1.0e-106
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig10	509	COG0138	46	8e-06
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig10	1162	COG0027	44	1e-05
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig10	508	COG0027	57	2e-09
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig10	509	COG0027	69	1e-12
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig10	763	COG0027	595	1.0e-171
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig10	979	COG0027	47	4e-06
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig10	1280	COG0034	624	1.0e-180
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig10	128	COG0034	132	9e-32
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig10	472	COG0034	89	9e-19
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig10	815	COG0034	37	7e-04
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig10	901	COG0034	41	1e-04
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig9	1663	COG0034	44	9e-06
GMP synthase - Glutamine amidotransferase domain	F	Contig10	102	COG0518	34	0.007
GMP synthase - Glutamine amidotransferase domain	F	Contig10	1151	COG0518	53	3e-08
GMP synthase - Glutamine amidotransferase domain	F	Contig10	239	COG0518	63	3e-11
GMP synthase - Glutamine amidotransferase domain	F	Contig10	950	COG0518	54	5e-09
GMP synthase - Glutamine amidotransferase domain	F	Contig8	1555	COG0518	115	2e-27
GMP synthase - Glutamine amidotransferase domain	F	Contig9	1617	COG0518	167	4e-43
GMP synthase PP-ATPase domain/subunit	F	Contig10	1016	COG0519	440	1.0e-125
GMP synthase PP-ATPase domain/subunit	F	Contig10	1022	COG0519	42	6e-05
GMP synthase PP-ATPase domain/subunit	F	Contig10	1071	COG0519	59	2e-10
GMP synthase PP-ATPase domain/subunit	F	Contig10	1084	COG0519	40	3e-04
GMP synthase PP-ATPase domain/subunit	F	Contig10	1150	COG0519	39	6e-04
GMP synthase PP-ATPase domain/subunit	F	Contig10	124	COG0519	38	0.002
GMP synthase PP-ATPase domain/subunit	F	Contig10	240	COG0519	39	5e-04
GMP synthase PP-ATPase domain/subunit	F	Contig9	1627	COG0519	37	0.002
IMP dehydrogenase/GMP reductase	F	Contig10	74	COG0516	136	3e-33
Phosphoribosylamine-glycine ligase	F	Contig10	218	COG0151	38	0.003
Phosphoribosylamine-glycine ligase	F	Contig10	482	COG0151	49	6e-07
Phosphoribosylamine-glycine ligase	F	Contig10	508	COG0151	53	4e-08
Phosphoribosylamine-glycine ligase	F	Contig10	509	COG0151	61	2e-10
Phosphoribosylamine-glycine ligase	F	Contig10	763	COG0151	54	1e-08
Phosphoribosylamine-glycine ligase	F	Contig10	922	COG0151	448	1.0e-127
Phosphoribosylamine-glycine ligase	F	Contig10	979	COG0151	68	2e-12
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	1090	COG0150	42	5e-05
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	1340	COG0150	35	0.008
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	311	COG0150	41	1e-04
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	627	COG0150	35	0.006
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	65	COG0150	41	3e-04
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	77	COG0150	74	1e-14
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig10	940	COG0150	44	4e-05
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig9	1580	COG0150	359	1.0e-100
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig10	246	COG0026	40	2e-04
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig10	482	COG0026	36	0.006
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig10	508	COG0026	50	5e-07
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig10	509	COG0026	58	3e-09
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig10	763	COG0026	226	3e-60
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig10	979	COG0026	58	2e-09
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig9	1639	COG0026	36	0.004
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig10	533	COG0152	277	6e-76
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig10	46	COG0041	185	1e-48
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig10	549	COG0041	63	3e-11
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig10	102	COG0047	34	0.006
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig10	1205	COG0047	312	1e-86
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component	F	Contig10	534	COG1828	99	6e-23
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	1090	COG0046	38	0.001
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	1340	COG0046	38	0.001
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	311	COG0046	63	3e-11
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	627	COG0046	58	1e-09
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	65	COG0046	57	4e-09
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	77	COG0046	82	6e-17
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig10	940	COG0046	776	0.0
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig9	1580	COG0046	36	0.004
Phosphoribosylpyrophosphate synthetase	F	Contig10	1280	COG0462	37	0.003
Phosphoribosylpyrophosphate synthetase	F	Contig10	322	COG0462	47	6e-07
Phosphoribosylpyrophosphate synthetase	F	Contig10	815	COG0462	46	1e-06
Phosphoribosylpyrophosphate synthetase	F	Contig10	901	COG0462	277	8e-76

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig10	1280	COG0503	41	1e-04
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig10	322	COG0503	60	8e-11
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig10	452	COG0503	170	7e-44
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig10	815	COG0503	128	4e-31
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig10	901	COG0503	45	6e-06
Formyltetrahydrofolate hydrolase	F	Contig10	532	COG0788	39	5e-05
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig10	901	COG0634	55	6e-09
Purine nucleoside phosphorylase	F	Contig9	1621	COG0005	239	1e-64

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig9	1592	COG0563	47	1e-06
Aspartate carbamoyltransferase catalytic chain	F	Contig10	105	COG0540	384	1.0e-108
Aspartate carbamoyltransferase catalytic chain	F	Contig10	1312	COG0540	154	5e-39
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	1162	COG0458	74	1e-14
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	1182	COG0458	35	0.008
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	246	COG0458	50	1e-07
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	29	COG0458	43	3e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	482	COG0458	43	5e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	508	COG0458	554	1.0e-159
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	509	COG0458	253	3e-68
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	763	COG0458	62	9e-11
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig10	979	COG0458	107	3e-24
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig9	1639	COG0458	49	5e-07
Carbamoylphosphate synthase small subunit	F	Contig10	1017	COG0505	41	2e-04
Carbamoylphosphate synthase small subunit	F	Contig10	239	COG0505	485	1.0e-138
Carbamoylphosphate synthase small subunit	F	Contig8	1555	COG0505	91	7e-20
Carbamoylphosphate synthase small subunit	F	Contig9	1617	COG0505	69	3e-13
CTP synthase (UTP-ammonia lyase)	F	Contig10	1017	COG0504	884	0.0
CTP synthase (UTP-ammonia lyase)	F	Contig9	1617	COG0504	34	0.008
Cytidylate kinase	F	Contig10	513	COG1102	42	3e-05
Cytidylate kinase	F	Contig9	1592	COG1102	210	4e-56
Cytidylate kinase	F	Contig9	1592	COG0283	45	4e-06
Dihydroorotase and related cyclic amidohydrolase	F	Contig10	542	COG0044	58	1e-09
Dihydroorotase and related cyclic amidohydrolase	F	Contig10	629	COG0044	312	4e-86
Dihydroorotase and related cyclic amidohydrolase	F	Contig10	678	COG0044	57	4e-09
Dihydroorotase and related cyclic amidohydrolase	F	Contig10	864	COG0044	52	8e-08
Dihydroorotase	F	Contig10	629	COG0418	53	4e-08
Dihydroorotate dehydrogenase	F	Contig10	1153	COG0167	35	0.004
Dihydroorotate dehydrogenase	F	Contig10	21	COG0167	39	7e-04
Dihydroorotate dehydrogenase	F	Contig10	221	COG0167	305	2e-84
Dihydroorotate dehydrogenase	F	Contig10	74	COG0167	49	1e-06
Dihydroorotate dehydrogenase	F	Contig10	894	COG0167	41	2e-05
Dihydroorotate dehydrogenase	F	Contig9	1642	COG0167	36	0.004
Dihydroorotate dehydrogenase	F	Contig9	1665	COG0167	55	2e-08
Dihydroorotate dehydrogenase	F	Contig9	1679	COG0167	37	0.002
Orotate phosphoribosyltransferase	F	Contig10	322	COG0461	169	1e-43
Orotate phosphoribosyltransferase	F	Contig10	452	COG0461	53	9e-09
Orotate phosphoribosyltransferase	F	Contig10	815	COG0461	74	7e-15
Orotate phosphoribosyltransferase	F	Contig10	901	COG0461	45	8e-06
Orotidine-5'-phosphate decarboxylase	F	Contig10	659	COG0284	149	1e-37
Uridylate kinase	F	Contig10	150	COG0528	50	2e-07
Uridylate kinase	F	Contig10	348	COG0528	43	2e-05
Uridylate kinase	F	Contig10	555	COG0528	56	7e-09
Uridylate kinase	F	Contig10	943	COG0528	189	2e-49

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytosine deaminase and related metal-dependent hydrolase	F	Contig10	442	COG0402	162	6e-41
Cytosine deaminase and related metal-dependent hydrolase	F	Contig10	542	COG0402	47	5e-06
Cytosine deaminase and related metal-dependent hydrolase	F	Contig10	678	COG0402	50	3e-07
Cytosine deaminase and related metal-dependent hydrolase	F	Contig10	864	COG0402	317	9e-88
Thymidine phosphorylase	F	Contig10	976	COG0213	312	7e-86
Thymidine phosphorylase	F	Contig8	1557	COG0213	49	4e-07
Uracil phosphoribosyltransferase	F	Contig10	815	COG0035	34	0.009
Uracil phosphoribosyltransferase	F	Contig10	901	COG0035	39	4e-04
Uracil phosphoribosyltransferase	F	Contig9	1598	COG0035	203	7e-54
Uridine kinase	F	Contig9	1592	COG0572	34	0.007

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	Contig10	1123	COG2022	36	0.003
Uncharacterized protein of thiazole biosynthesis	F	Contig10	1279	COG2022	39	3e-04
Uncharacterized protein of thiazole biosynthesis	F	Contig9	1642	COG2022	44	1e-05

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	Contig10	374	COG0717	132	2e-32
Deoxycytidine deaminase	F	Contig9	1588	COG0717	99	1e-22
dUTPase	F	Contig10	374	COG0756	40	1e-04
Nucleoside diphosphate kinase	F	Contig10	47	COG0105	182	9e-48
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig10	642	COG1328	36	7e-04
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig9	1626	COG1328	633	0.0
Thymidylate kinase	F	Contig10	397	COG0125	153	1e-38
Thymidylate kinase	F	Contig10	513	COG0125	44	7e-06
Thymidylate synthase	F	Contig10	441	COG0207	119	1e-28

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Xanthine/uracil permease	F	Contig10	404	COG2233	54	3e-08
Xanthine/uracil permease	F	Contig9	1597	COG2233	282	5e-77
Xanthosine triphosphate pyrophosphatase	F	Contig9	1637	COG0127	163	9e-42

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