R = Retrieve links to Related sequences (neighbors).
Use the 
icon (if present) to retrieve links to the Sequence Retrieval System (SRS).
Use the 
icon (if present) to retrieve links to the Ligand Enzyme and Chemical Compound Database .
Use the 
icon (if present) to retrieve links to the Protein Data Bank database.
WARNING: Descriptions of 380 database sequences were not reported due to the
limiting value of parameter V = 50.
>gi|9759328|dbj|BAB09837.1| (AB005246) protein disulphide isomerase-like
protein [Arabidopsis thaliana]
Length = 597
Frame 2 hits (HSPs): ___________ __________________
__________________________________________________
Database sequence: | | | | | 597
0 150 300 450
Plus Strand HSPs:
Score = 938 (330.2 bits), Expect = 2.9e-93, P = 2.9e-93
Identities = 167/208 (80%), Positives = 193/208 (92%), Frame = +2
Query: 35 AAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGEVTTDK 214
AAKSFKGKLIFV V++DNED GKPV+EYFG+SGN PK++GYTGN+D KK+ DGE+ +DK
Sbjct: 354 AAKSFKGKLIFVSVDLDNEDYGKPVAEYFGVSGNGPKLIGYTGNEDPKKYFFDGEIQSDK 413
Query: 215 IKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGH 394
IK FGEDF+ DKLKPFYKSDP+PE ND DVKIVVG+NFDEIVLD+SKDVLLE+YAPWCGH
Sbjct: 414 IKIFGEDFLNDKLKPFYKSDPIPEKNDEDVKIVVGDNFDEIVLDDSKDVLLEVYAPWCGH 473
Query: 395 CQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFDPITVD 574
CQ+LEP+YNKLAKHLR+IDSLVI KMDGTTNEHP+AK +GFPT+LFFPAGNK+ +PITVD
Sbjct: 474 CQALEPMYNKLAKHLRSIDSLVITKMDGTTNEHPKAKAEGFPTILFFPAGNKTSEPITVD 533
Query: 575 TDRTVVAFYKFLKKHASIPFKLQKPTST 658
TDRTVVAFYKFL+KHA+IPFKL+KP ST
Sbjct: 534 TDRTVVAFYKFLRKHATIPFKLEKPAST 561
Score = 208 (73.2 bits), Expect = 6.3e-15, P = 6.3e-15
Identities = 48/110 (43%), Positives = 67/110 (60%), Frame = +2
Query: 275 PVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDS 454
P PE ++ DV ++ NF +++ + ++ VL+E YAPWCGHCQSL P Y A L+ D
Sbjct: 96 PTPEIDEKDVVVIKERNFTDVI-ENNQYVLVEFYAPWCGHCQSLAPEYAAAATELKE-DG 153
Query: 455 LVIAKMDGTT-NEHPRA-KPDGFPTLLFFPAGNKSFDPITVD-TDRTVVAFYK 604
+V+AK+D T NE + + GFPTLLFF G P T T T+V + K
Sbjct: 154 VVLAKIDATEENELAQEYRVQGFPTLLFFVDGEHK--PYTGGRTKETIVTWVK 204
>gi|7437396|pir||T06724 protein disulfide-isomerase homolog F28P10.60 -
Arabidopsis thaliana >gi|4678297|emb|CAB41088.1| (AL049655) protein
disulfide-isomerase-like protein [Arabidopsis thaliana]
Length = 566
Frame 2 hits (HSPs): ___________ __________________
__________________________________________________
Database sequence: | | | | | 566
0 150 300 450
Plus Strand HSPs:
Score = 830 (292.2 bits), Expect = 8.2e-82, P = 8.2e-82
Identities = 154/210 (73%), Positives = 178/210 (84%), Frame = +2
Query: 26 LKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGEVT 205
L+ AKSFKGK +FVYV+MDNED G+ VS +FG++G APKVL YTGN+D +KF+LDGE+T
Sbjct: 341 LREVAKSFKGKFVFVYVQMDNEDYGEAVSGFFGVTGAAPKVLVYTGNEDMRKFILDGELT 400
Query: 206 TDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPW 385
+ IK EDF+ DKLKPFYKSDP+PE+NDGDVK++VGNNFDEIVLDESKDVLLE
Sbjct: 401 VNNIKTLAEDFLADKLKPFYKSDPLPENNDGDVKVIVGNNFDEIVLDESKDVLLE----- 455
Query: 386 CGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFDPI 565
HCQS EPIYNKL K+L+ IDSLV+AKMDGT+NEHPRAK DGFPT+LFFP GNKSFDPI
Sbjct: 456 --HCQSFEPIYNKLGKYLKGIDSLVVAKMDGTSNEHPRAKADGFPTILFFPGGNKSFDPI 513
Query: 566 TVDTDRTVVAFYKFLKKHASIPFKLQKPTS 655
VD DRTVV YKFLKKHASIPFKL+KP +
Sbjct: 514 AVDVDRTVVELYKFLKKHASIPFKLEKPAT 543
Score = 173 (60.9 bits), Expect = 3.4e-11, P = 3.4e-11
Identities = 44/121 (36%), Positives = 65/121 (53%), Frame = +2
Query: 263 YKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLR 442
Y+ +P+P ++ DV ++ +NF E V + S ++E YAPWCG CQ+L P Y A L+
Sbjct: 88 YEEEPLPPVDEKDVAVLTKDNFTEFVGNNSF-AMVEFYAPWCGACQALTPEYAAAATELK 146
Query: 443 NIDSLVIAKMDGTTNEHPRAKPD--GFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+ +L AK+D T K + GFPT+ F G T + +RT +LKK
Sbjct: 147 GLAAL--AKIDATEEGDLAQKYEIQGFPTVFLFVDGEMRK---TYEGERTKDGIVTWLKK 201
Query: 617 HAS 625
AS
Sbjct: 202 KAS 204
>gi|5902592|gb|AAD55566.1|AF110784_1 (AF110784) protein disulfide isomerase
precursor [Volvox carteri f. nagariensis]
Length = 524
Frame 2 hits (HSPs): __________ _____________________
__________________________________________________
Database sequence: | | | | | 524
0 150 300 450
Plus Strand HSPs:
Score = 509 (179.2 bits), Expect = 8.5e-48, P = 8.5e-48
Identities = 102/212 (48%), Positives = 140/212 (66%), Frame = +2
Query: 29 KXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGNA-PKVLGYTGNDDGKKFVLDGEVT 205
K A FKGKL+FV V + E+ PV+ +FG+ G A P +LG+ + KK+ L T
Sbjct: 300 KTVASKFKGKLVFVTVNNEGEEAD-PVTNFFGLKGAASPVLLGFY-MEKNKKYKLQEPFT 357
Query: 206 TDKIKAFGEDFVEDKLKPFYKSDPVPES--NDGDVKIVVGNNFDEIVLDESKDVLLEIYA 379
+ ++ F E ++ +P YKS P+PE DG V +VVG + D +VLD +KDVLLE+YA
Sbjct: 358 LEAVEKFAESILDGTAQPEYKSQPIPEDPYEDG-VHVVVGKSVDSVVLDPTKDVLLEVYA 416
Query: 380 PWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFD 559
PWCGHC+ L+PIY KLAK + + S+VIAKMDGT NEHP GFPTL+FFPAG +
Sbjct: 417 PWCGHCKKLDPIYKKLAKRFKKVSSVVIAKMDGTENEHPLVDVKGFPTLIFFPAGEDA-T 475
Query: 560 PITVDT-DRTVVAFYKFLKKHASIPFKLQKPTSTSE 664
PI + DRT+ + KF+K +A +P++L K +S E
Sbjct: 476 PIPFEGGDRTLKSLTKFIKANAKVPYELPKKSSAEE 511
Score = 190 (66.9 bits), Expect = 4.3e-13, P = 4.3e-13
Identities = 41/93 (44%), Positives = 55/93 (59%), Frame = +2
Query: 272 DPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNI- 448
D P +D DV +V NFD++V +SK L+E YAPWCGHC+SL+P Y A L+ +
Sbjct: 38 DEAPADDDKDVVVVTTKNFDDVV-KKSKFALVEFYAPWCGHCKSLKPQYAAAATTLKKVA 96
Query: 449 DSLVIAKMDGTTNEHPRAK--PDGFPTLLFFPAG 544
V+AK+D T E K G+PTL +F G
Sbjct: 97 PDAVLAKVDATVEESLAGKFGIQGYPTLKWFVDG 130
>gi|7437394|pir||T07927 protein disulfide-isomerase (EC 5.3.4.1) RB60 -
Chlamydomonas reinhardtii >gi|2708314|gb|AAC49896.1| (AF027727)
protein disulfide isomerase RB60 [Chlamydomonas reinhardtii]
>gi|4104541|gb|AAD02069.1| (AF036939) protein disulfide isomerase
[Chlamydomonas reinhardtii]
Length = 532
Frame 2 hits (HSPs): _________ _____________________
__________________________________________________
Database sequence: | | | | | 532
0 150 300 450
Plus Strand HSPs:
Score = 499 (175.7 bits), Expect = 9.7e-47, P = 9.7e-47
Identities = 102/212 (48%), Positives = 143/212 (67%), Frame = +2
Query: 29 KXAAKSFKGKLIFVYVEMDNE-DVGKPVSEYFGISG-NAPKVLGYTGNDDGKKFVLDGEV 202
+ A+K FKG+L+FV V +NE D PV+ +FG+ G +P +LG+ + KKF ++GE
Sbjct: 304 REASKKFKGQLVFVTV--NNEGDGADPVTNFFGLKGATSPVLLGFF-MEKNKKFRMEGEF 360
Query: 203 TTDKIKAFGEDFVEDKLKPFYKSDPVPES--NDGDVKIVVGNNFDEIVLDESKDVLLEIY 376
T D + F E V+ + KS+ +PE DG KIV G + +VLDE+KDVLLE+Y
Sbjct: 361 TADNVAKFAESVVDGTAQAVLKSEAIPEDPYEDGVYKIV-GKTVESVVLDETKDVLLEVY 419
Query: 377 APWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSF 556
APWCGHC+ LEPIY KLAK + +DS++IAKMDGT NEHP + GFPT+LF+PAG+
Sbjct: 420 APWCGHCKKLEPIYKKLAKRFKKVDSVIIAKMDGTENEHPEIEVKGFPTILFYPAGSDR- 478
Query: 557 DPITVDT-DRTVVAFYKFLKKHASIPFKLQKPTSTSE 664
PI + DR++ + KF+K +A IP++L K S +
Sbjct: 479 TPIVFEGGDRSLKSLTKFIKTNAKIPYELPKKGSDGD 515
Score = 179 (63.0 bits), Expect = 6.8e-12, P = 6.8e-12
Identities = 43/95 (45%), Positives = 58/95 (61%), Frame = +2
Query: 281 PESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNI--DS 454
P+ +D DV +V N+DE V +SK L+E YAPWCGHC++L+P Y K A L+ D+
Sbjct: 44 PKDDDVDVTVVTVKNWDETV-KKSKFALVEFYAPWCGHCKTLKPEYAKAATALKAAAPDA 102
Query: 455 LVIAKMDGTTNEHPRAK--PDGFPTLLFFPAGNKSFD 559
L IAK+D T E K G+PTL +F G + D
Sbjct: 103 L-IAKVDATQEESLAQKFGVQGYPTLKWFVDGELASD 138
>gi|2144546|pir||ISCHSS protein disulfide-isomerase (EC 5.3.4.1) precursor -
chicken
Length = 515
Frame 2 hits (HSPs): ____________ _____________________
Annotated Domains: ____________ __________ _
__________________________________________________
Database sequence: | | | | | 515
0 150 300 450
__________________
Annotated Domains:
Entrez domain: signal sequence 1..22
Entrez domain: thioredoxin homology #label TX1 37..124
Entrez domain: thioredoxin homology #label TX2 380..465
Entrez region: endoplasmic reticulum retention 512..515
PROSITE THIOREDOXIN: Thioredoxin family active s 394..412
PROSITE THIOREDOXIN: Thioredoxin family active s 50..68
__________________
Plus Strand HSPs:
Score = 409 (144.0 bits), Expect = 3.3e-37, P = 3.3e-37
Identities = 84/198 (42%), Positives = 127/198 (64%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA +FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + +
Sbjct: 279 NFKTAAGNFKGKILFIFIDSDHSD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 337
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T DKIK F F+E K+KP S +PE D VK++VG NF+E+ DE+K+V +E
Sbjct: 338 DLTADKIKEFCNKFLEGKIKPHLMSQDLPEDWDKQPVKVLVGKNFEEVAFDENKNVFVEF 397
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + R+ +++VIAKMD T NE K FPTL FFPAG+
Sbjct: 398 YAPWCGHCKQLAPIWDKLGETYRDHENIVIAKMDSTANEVEAVKIHSFPTLKFFPAGSGR 457
Query: 554 FDPITVDTDRTVVAFYKFLK 613
+ I + +RT+ F KFL+
Sbjct: 458 -NVIDYNGERTLEGFKKFLE 476
Score = 154 (54.2 bits), Expect = 6.1e-08, P = 6.1e-08
Identities = 43/116 (37%), Positives = 65/116 (56%), Frame = +2
Query: 269 SDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNI 448
++P+ E DG V ++ NF++ L + +L+E YAPWCGHC++L P Y K A L+
Sbjct: 22 AEPL-EEEDG-VLVLRAANFEQ-ALAAHRHLLVEFYAPWCGHCKALAPEYAKAAAQLKAE 78
Query: 449 DSLV-IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
S + +AK+D T E A+ G+PT+ FF G+K+ P R +LKK
Sbjct: 79 GSEIRLAKVDAT-EEAELAQQFGVRGYPTIKFFRNGDKAA-PREYTAGREADDIVSWLKK 136
>gi|129727|sp|P09102|PDI_CHICK PROTEIN DISULFIDE ISOMERASE (PDI) (PROLYL
4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE BINDING
PROTEIN) (RETINA COGNIN) (R-COGNIN)
Length = 493
Frame 2 hits (HSPs): ____________ _____________________
Annotated Domains: _______________________________________________ _
__________________________________________________
Database sequence: | | | | | 493
0 150 300 450
__________________
Annotated Domains:
DOMO DM00054: THIOREDOXINFAMILY 7..110
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 112..347
DOMO DM00054: THIOREDOXINFAMILY 349..452
Entrez other site: PREVENT SECRETION FROM ER. 490..493
PFAM thiored: Thioredoxin 6..117
PFAM thiored: Thioredoxin 349..458
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 27..35
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 35..44
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 78..89
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 9..79
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 81..113
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 116..345
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 351..418
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 420..460
PROSITE THIOREDOXIN: Thioredoxin family active s 28..46
PROSITE THIOREDOXIN: Thioredoxin family active s 372..390
__________________
Plus Strand HSPs:
Score = 409 (144.0 bits), Expect = 3.3e-37, P = 3.3e-37
Identities = 84/198 (42%), Positives = 127/198 (64%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA +FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + +
Sbjct: 257 NFKTAAGNFKGKILFIFIDSDHSD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 315
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T DKIK F F+E K+KP S +PE D VK++VG NF+E+ DE+K+V +E
Sbjct: 316 DLTADKIKEFCNKFLEGKIKPHLMSQDLPEDWDKQPVKVLVGKNFEEVAFDENKNVFVEF 375
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + R+ +++VIAKMD T NE K FPTL FFPAG+
Sbjct: 376 YAPWCGHCKQLAPIWDKLGETYRDHENIVIAKMDSTANEVEAVKIHSFPTLKFFPAGSGR 435
Query: 554 FDPITVDTDRTVVAFYKFLK 613
+ I + +RT+ F KFL+
Sbjct: 436 -NVIDYNGERTLEGFKKFLE 454
Score = 153 (53.9 bits), Expect = 7.7e-08, P = 7.7e-08
Identities = 43/115 (37%), Positives = 64/115 (55%), Frame = +2
Query: 272 DPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNID 451
+P+ E DG V ++ NF++ L + +L+E YAPWCGHC++L P Y K A L+
Sbjct: 1 EPL-EEEDG-VLVLRAANFEQ-ALAAHRHLLVEFYAPWCGHCKALAPEYAKAAAQLKAEG 57
Query: 452 SLV-IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
S + +AK+D T E A+ G+PT+ FF G+K+ P R +LKK
Sbjct: 58 SEIRLAKVDAT-EEAELAQQFGVRGYPTIKFFRNGDKAA-PREYTAGREADDIVSWLKK 114
>gi|63739|emb|CAA31502.1| (X13110) prolyl-4-hydroxylase (AA 5 - 494) [Gallus
gallus]
Length = 490
Frame 2 hits (HSPs): ____________ _____________________
__________________________________________________
Database sequence: | | | | | 490
0 150 300 450
Plus Strand HSPs:
Score = 409 (144.0 bits), Expect = 3.3e-37, P = 3.3e-37
Identities = 84/198 (42%), Positives = 127/198 (64%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA +FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + +
Sbjct: 254 NFKTAAGNFKGKILFIFIDSDHSD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 312
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T DKIK F F+E K+KP S +PE D VK++VG NF+E+ DE+K+V +E
Sbjct: 313 DLTADKIKEFCNKFLEGKIKPHLMSQDLPEDWDKQPVKVLVGKNFEEVAFDENKNVFVEF 372
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + R+ +++VIAKMD T NE K FPTL FFPAG+
Sbjct: 373 YAPWCGHCKQLAPIWDKLGETYRDHENIVIAKMDSTANEVEAVKIHSFPTLKFFPAGSGR 432
Query: 554 FDPITVDTDRTVVAFYKFLK 613
+ I + +RT+ F KFL+
Sbjct: 433 -NVIDYNGERTLEGFKKFLE 451
Score = 152 (53.5 bits), Expect = 1.0e-07, P = 1.0e-07
Identities = 42/111 (37%), Positives = 61/111 (54%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV- 460
E DG V ++ NF++ L + +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 1 EEEDG-VLVLRAANFEQ-ALAAHRHLLVEFYAPWCGHCKALAPEYAKAAAQLKAEGSEIR 58
Query: 461 IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+AK+D T E A+ G+PT+ FF G+K+ P R +LKK
Sbjct: 59 LAKVDAT-EEAELAQQFGVRGYPTIKFFRNGDKAA-PREYTAGREADDIVSWLKK 111
>gi|12733115 ref|XP_011568.1| similar to protein disulfide isomerase related
protein (calcium-binding protein, intestinal-related) (H. sapiens)
[Homo sapiens]
Length = 365
Frame 2 hits (HSPs): ___________________________
__________________________________________________
Database sequence: | | | | 365
0 150 300
Plus Strand HSPs:
Score = 408 (143.6 bits), Expect = 4.3e-37, P = 4.3e-37
Identities = 84/189 (44%), Positives = 118/189 (62%), Frame = +2
Query: 65 FVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGE-VTTDKIKAFGEDFV 241
+ + D ED V + G+S + V ++ GKKF ++ E +D ++ F F
Sbjct: 168 YTFAIADEEDYAGEVKD-LGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFK 226
Query: 242 EDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYN 421
+ KLKP KS PVP++N G VK+VVG FD IV+D KDVL+E YAPWCGHC+ LEP+YN
Sbjct: 227 KGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYN 286
Query: 422 KLAKHLRNIDSLVIAKMDGTTNEHP--RAKPDGFPTLLFFPAGNKSFDPITVDT-DRTVV 592
LAK + LVIAKMD T N+ P R K +GFPT+ F P+G+K +P+ + DR +
Sbjct: 287 SLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKK-NPVKFEGGDRDLE 345
Query: 593 AFYKFLKKHAS 625
KF+++HA+
Sbjct: 346 HLSKFIEEHAT 356
>gi|7495584|pir||T34092 hypothetical protein C07A12.4 - Caenorhabditis elegans
>gi|1109873|gb|AAC69237.1| (U41542) Similar to protein disulfide
isomerase; coded for by C. elegans cDNA CEESB65F; coded for by C.
elegans cDNA CEESH23FB; coded for by C. elegans cDNA CEESH23FC;
coded for by C. elegans cDNA CEESN70F; coded for by C. elegans cDNA
CEESO88F; coded >
Length = 493
Frame 2 hits (HSPs): _________ _____________________
__________________________________________________
Database sequence: | | | | | 493
0 150 300 450
Plus Strand HSPs:
Score = 407 (143.3 bits), Expect = 5.5e-37, P = 5.5e-37
Identities = 86/198 (43%), Positives = 126/198 (63%), Frame = +2
Query: 20 QHLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGNA-PKVLGYTGNDDGKKFVLD- 193
Q K AAK FKGK++FVY+ D E+ + + E+FG+ + P + + +D KF D
Sbjct: 269 QEFKNAAKQFKGKVLFVYINTDVEENAR-IMEFFGLKKDELPAIRLISLEEDMTKFKPDF 327
Query: 194 GEVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLE 370
E+TT+ I F +++++ +KP S+ +PE D + VKI+VG NF+++ D +K+VL+E
Sbjct: 328 EEITTENISKFTQNYLDGSVKPHLMSEDIPEDWDKNPVKILVGKNFEQVARDNTKNVLVE 387
Query: 371 IYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAG-N 547
YAPWCGHC+ L P ++KL + + +S+VIAKMD T NE K FPT+ FFPAG N
Sbjct: 388 FYAPWCGHCKQLAPTWDKLGEKFADDESIVIAKMDSTLNEVEDVKIQSFPTIKFFPAGSN 447
Query: 548 KSFDPITVDTDRTVVAFYKFLK 613
K D DRT+ F KFL+
Sbjct: 448 KVVD---YTGDRTIEGFTKFLE 466
Score = 158 (55.6 bits), Expect = 1.4e-08, P = 1.4e-08
Identities = 33/84 (39%), Positives = 53/84 (63%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDS-LVIAKMD 475
+V ++ +NFDE++ + ++ +L+E YAPWCGHC+SL P Y K A L+ S + + K+D
Sbjct: 24 NVIVLTKDNFDEVI-NGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDIKLGKLD 82
Query: 476 GTTNEHPRAKPD--GFPTLLFFPAG 544
T + +K + G+PTL F G
Sbjct: 83 ATVHGEVSSKFEVRGYPTLKLFRNG 107
>gi|422699|pir||A47300 cell adhesion protein retina cognin - chicken (fragment)
>gi|289822|gb|AAA49054.1| (L11147) prolyl 4-hydroxylase [Gallus
gallus]
Length = 378
Frame 2 hits (HSPs): ___________________________
Annotated Domains: _____________ _
__________________________________________________
Database sequence: | | | | 378
0 150 300
__________________
Annotated Domains:
Entrez domain: thioredoxin homology #label TX2 242..327
Entrez region: endoplasmic reticulum retention 375..378
PROSITE THIOREDOXIN: Thioredoxin family active s 256..274
__________________
Plus Strand HSPs:
Score = 406 (142.9 bits), Expect = 7.0e-37, P = 7.0e-37
Identities = 84/198 (42%), Positives = 126/198 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA +FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + +
Sbjct: 141 NFKTAAGNFKGKILFIFIDSDHSD-NQRILEFFGLKKQECPAVRLITLEEEMTKYKPESD 199
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T DKIK F F+E K KP S +PE D VK++VG NF+E+ DE+K+V +E
Sbjct: 200 DLTADKIKEFCNKFLEGKTKPHLMSQDLPEDWDKQPVKVLVGKNFEEVAFDENKNVFVEF 259
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + R+ +++VIAKMD T NE K FPTL FFPAG+
Sbjct: 260 YAPWCGHCKQLAPIWDKLGETYRDHENIVIAKMDSTANEVEAVKIHSFPTLKFFPAGSGR 319
Query: 554 FDPITVDTDRTVVAFYKFLK 613
+ I + +RT+ F KFL+
Sbjct: 320 -NVIDYNGERTLEGFKKFLE 338
>gi|7437386|pir||S71862 protein disulfide-isomerase (EC 5.3.4.1) precursor -
Caenorhabditis elegans (fragment)
Length = 491
Frame 2 hits (HSPs): _________ _____________________
__________________________________________________
Database sequence: | | | | | 491
0 150 300 450
Plus Strand HSPs:
Score = 404 (142.2 bits), Expect = 1.1e-36, P = 1.1e-36
Identities = 86/198 (43%), Positives = 125/198 (63%), Frame = +2
Query: 20 QHLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGNA-PKVLGYTGNDDGKKFVLD- 193
Q K AAK FKGK++FVY+ D E+ + + E+FG+ + P + + +D KF D
Sbjct: 267 QEFKNAAKQFKGKVLFVYINTDVEENAR-IMEFFGLKKDELPAIRLISLEEDMTKFKPDF 325
Query: 194 GEVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLE 370
E+TT+ I F +++++ +KP S+ +PE D + VKI+VG NF+++ D +K+VL+E
Sbjct: 326 EEITTENISKFTQNYLDGSVKPHLMSEDIPEDWDKNPVKILVGKNFEQVARDNTKNVLVE 385
Query: 371 IYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAG-N 547
YAPWCGHC+ L P ++KL + +S+VIAKMD T NE K FPT+ FFPAG N
Sbjct: 386 FYAPWCGHCKQLAPTWDKLGGKFADDESIVIAKMDSTLNEVEDVKIQSFPTIKFFPAGSN 445
Query: 548 KSFDPITVDTDRTVVAFYKFLK 613
K D DRT+ F KFL+
Sbjct: 446 KVVD---YTGDRTIEGFTKFLE 464
Score = 158 (55.6 bits), Expect = 1.4e-08, P = 1.4e-08
Identities = 33/84 (39%), Positives = 53/84 (63%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDS-LVIAKMD 475
+V ++ +NFDE++ + ++ +L+E YAPWCGHC+SL P Y K A L+ S + + K+D
Sbjct: 22 NVIVLTKDNFDEVI-NGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDIKLGKLD 80
Query: 476 GTTNEHPRAKPD--GFPTLLFFPAG 544
T + +K + G+PTL F G
Sbjct: 81 ATVHGEVSSKFEVRGYPTLKLFRNG 105
>gi|4758304 ref|NP_004902.1| protein disulfide isomerase related protein
(calcium-binding protein, intestinal-related) [Homo sapiens]
>gi|11420164 ref|XP_004775.1| protein disulfide isomerase related
protein (calcium-binding protein, intestinal-related) [Homo
sapiens] >gi|119530|sp|P13667|ER72_HUMAN PROTEIN DISULFIDE
ISOMERASE-RELATED PROTEIN ERP-72 PRECURSOR (ERP72)
>gi|87320|pir||A23723 protein disulfide-isomerase (EC 5.3.4.1)
ERp72 precursor - human >gi|181508|gb|AAA58460.1| (J05016) protein
disulfide isomerase-related protein [Homo sapiens]
>gi|12653313|gb|AAH00425.1|AAH00425 (BC000425) protein disulfide
isomerase related protein (calcium-binding protein,
intestinal-related) [Homo sapiens]
Length = 645
Frame 2 hits (HSPs): ___________________ ________________
__________________________________________________
Database sequence: | | | | | | 645
0 150 300 450 600
Plus Strand HSPs:
Score = 408 (143.6 bits), Expect = 1.2e-36, P = 1.2e-36
Identities = 84/189 (44%), Positives = 118/189 (62%), Frame = +2
Query: 65 FVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGE-VTTDKIKAFGEDFV 241
+ + D ED V + G+S + V ++ GKKF ++ E +D ++ F F
Sbjct: 448 YTFAIADEEDYAGEVKD-LGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFK 506
Query: 242 EDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYN 421
+ KLKP KS PVP++N G VK+VVG FD IV+D KDVL+E YAPWCGHC+ LEP+YN
Sbjct: 507 KGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYN 566
Query: 422 KLAKHLRNIDSLVIAKMDGTTNEHP--RAKPDGFPTLLFFPAGNKSFDPITVDT-DRTVV 592
LAK + LVIAKMD T N+ P R K +GFPT+ F P+G+K +P+ + DR +
Sbjct: 567 SLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKK-NPVKFEGGDRDLE 625
Query: 593 AFYKFLKKHAS 625
KF+++HA+
Sbjct: 626 HLSKFIEEHAT 636
Score = 163 (57.4 bits), Expect = 3.5e-09, P = 3.5e-09
Identities = 36/85 (42%), Positives = 51/85 (60%), Frame = +2
Query: 308 IVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHL-RNIDSLVIAKMDGT- 481
++ NFDE+V D + +L+E YAPWCGHC+ L P Y K AK L + + +AK+D T
Sbjct: 181 VLTKENFDEVVND-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATA 239
Query: 482 -TNEHPRAKPDGFPTLLFFPAGNKSFD 559
T+ R G+PTL F G + +D
Sbjct: 240 ETDLAKRFDVSGYPTLKIFRKG-RPYD 265
Score = 161 (56.7 bits), Expect = 7.3e-09, P = 7.3e-09
Identities = 46/128 (35%), Positives = 71/128 (55%), Frame = +2
Query: 230 EDFVEDKLKPFYKSDPVPESNDGDVK----IVVGN--NFDEIVLDESKDVLLEIYAPWCG 391
E+ +ED+ + + D E +D +VK ++V N NFD V D+ VLLE YAPWCG
Sbjct: 35 ENAIEDEEEEEEEDDD-EEEDDLEVKEENGVLVLNDANFDNFVADKDT-VLLEFYAPWCG 92
Query: 392 HCQSLEPIYNKLAKHLRNIDSLV-IAKMDGTTNEHPRAKPD--GFPTLLFFPAGNKSFDP 562
HC+ P Y K+A L++ D + +AK+D T+ ++ D G+PT+ G ++ D
Sbjct: 93 HCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKG-QAVDY 151
Query: 563 ITVDTDRTVVA 595
T +VA
Sbjct: 152 EGSRTQEEIVA 162
>gi|4505567 ref|NP_000909.1| procollagen-proline, 2-oxoglutarate 4-dioxygenase
(proline 4-hydroxylase), beta polypeptide (protein disulfide
isomerase; thyroid hormone binding protein p55); v-erb-a avian
erythroblastic leukemia viral oncogene homolog 2-like [Homo
sapiens] >gi|35655|emb|CAA28775.1| (X05130) prolyl 4-hydroxylase
beta subunit (AA 1-491) [Homo sapiens]
Length = 508
Frame 2 hits (HSPs): ____________ _____________________
__________________________________________________
Database sequence: | | | | | 508
0 150 300 450
Plus Strand HSPs:
Score = 393 (138.3 bits), Expect = 1.7e-35, P = 1.7e-35
Identities = 83/198 (41%), Positives = 126/198 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA+SFKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E
Sbjct: 274 NFKTAAESFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESE 332
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T ++I F F+E K+KP S +PE D VK++VG NF+++ DE K+V +E
Sbjct: 333 ELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEF 392
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K GFPTL FFPA S
Sbjct: 393 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHGFPTLGFFPA---S 449
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 450 ADRTVIDYNGERTLDGFKKFLE 471
Score = 133 (46.8 bits), Expect = 2.7e-05, P = 2.7e-05
Identities = 41/112 (36%), Positives = 58/112 (51%), Frame = +2
Query: 281 PESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV 460
PE D V ++ +NF E L K +E +APWCGHC++L P Y K A L+ S +
Sbjct: 20 PEEED-HVLVLRKSNFAE-ALAAHKYPPVEFHAPWCGHCKALAPEYAKAAGKLKAEGSEI 77
Query: 461 -IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 78 RLAKVDAT-EESDLAQQYGVRGYPTIKFFRNGDTA-SPKEYTAGREADDIVNWLKK 131
>gi|129726|sp|P05307|PDI_BOVIN PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI)
(PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE
BINDING PROTEIN) (P55) >gi|68464|pir||ISBOSS protein
disulfide-isomerase (EC 5.3.4.1) precursor - bovine
>gi|163497|gb|AAA30690.1| (M17596) PDI (E.C.5.3.4.1) [Bos taurus]
Length = 510
Frame 2 hits (HSPs): ___________ _____________________
Annotated Domains: _______________________________________________ _
__________________________________________________
Database sequence: | | | | | 510
0 150 300 450
__________________
Annotated Domains:
Entrez other site: PREVENT SECRETION FROM ER. 507..510
PFAM thiored: Thioredoxin 25..136
PFAM thiored: Thioredoxin 368..477
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 46..54
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 54..63
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 97..108
PRODOM PD054060: PDI_BOVIN 1..26
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 28..98
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 100..132
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 135..364
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 370..437
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 439..480
PROSITE THIOREDOXIN: Thioredoxin family active s 391..409
PROSITE THIOREDOXIN: Thioredoxin family active s 47..65
__________________
Plus Strand HSPs:
Score = 391 (137.6 bits), Expect = 2.7e-35, P = 2.7e-35
Identities = 83/198 (41%), Positives = 125/198 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG- 196
+ K AA+SFKGK++F++++ D+ D + + E+FG+ P V T ++ K+ +
Sbjct: 276 NFKKAAESFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 334
Query: 197 EVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
E+T +KI F F+E K+KP S +P+ D VK++VG NF+E+ DE K+V +E
Sbjct: 335 ELTAEKITEFCHRFLEGKIKPHLMSQELPDDWDKQPVKVLVGKNFEEVAFDEKKNVFVEF 394
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA S
Sbjct: 395 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA---S 451
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 452 ADRTVIDYNGERTLDGFKKFLE 473
Score = 153 (53.9 bits), Expect = 8.1e-08, P = 8.1e-08
Identities = 43/112 (38%), Positives = 60/112 (53%), Frame = +2
Query: 281 PESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV 460
P+ D V ++ NFDE L K +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 22 PDEED-HVLVLHKGNFDE-ALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEI 79
Query: 461 -IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 80 RLAKVDAT-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKK 133
>gi|129731|sp|P04785|PDI_RAT PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI)
(PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE
BINDING PROTEIN) (THYROXINE DEIODINASE) (IODOTHYRONINE
5'-MONODEIODINASE) (5'-MD)
Length = 509
Frame 2 hits (HSPs): _____________ ____________________
__________________________________________________
Database sequence: | | | | | 509
0 150 300 450
Plus Strand HSPs:
Score = 391 (137.6 bits), Expect = 2.7e-35, P = 2.7e-35
Identities = 83/198 (41%), Positives = 124/198 (62%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG- 196
+ K AA+ FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ +
Sbjct: 276 NFKKAAEGFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 334
Query: 197 EVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
E+T +KI F F+E K+KP S +PE D VK++VG NF+E+ DE K+V +E
Sbjct: 335 ELTAEKITQFCHHFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDEKKNVFVEF 394
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA S
Sbjct: 395 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA---S 451
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 452 ADRTVIDYNGERTLDGFKKFLE 473
Score = 142 (50.0 bits), Expect = 2.2e-06, P = 2.2e-06
Identities = 43/127 (33%), Positives = 63/127 (49%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV- 460
E D +V ++ +NF E L +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 23 EEED-NVLVLKKSNFAE-ALAAHNYLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIR 80
Query: 461 IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIP 631
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 81 LAKVDAT-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPA 138
Query: 632 FKLQKPTSTSE 664
T+ +E
Sbjct: 139 ATTLSDTAAAE 149
>gi|202549|gb|AAA40620.1| (M21018) iodothyronine 5' monodeiodinase [Rattus
norvegicus]
Length = 482
Frame 2 hits (HSPs): _____________ ______________________
__________________________________________________
Database sequence: | | | | | 482
0 150 300 450
Plus Strand HSPs:
Score = 391 (137.6 bits), Expect = 2.7e-35, P = 2.7e-35
Identities = 83/198 (41%), Positives = 124/198 (62%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG- 196
+ K AA+ FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ +
Sbjct: 249 NFKKAAEGFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 307
Query: 197 EVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
E+T +KI F F+E K+KP S +PE D VK++VG NF+E+ DE K+V +E
Sbjct: 308 ELTAEKITQFCHHFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDEKKNVFVEF 367
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA S
Sbjct: 368 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA---S 424
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 425 ADRTVIDYNGERTLDGFKKFLE 446
Score = 139 (48.9 bits), Expect = 4.7e-06, P = 4.7e-06
Identities = 41/122 (33%), Positives = 60/122 (49%), Frame = +2
Query: 302 VKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-IAKMDG 478
V ++ +NF E L +L+E YAPWCGHC++L P Y K A L+ S + +AK+D
Sbjct: 1 VLVLKKSNFAE-ALAAHNYLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIRLAKVDA 59
Query: 479 TTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKLQKP 649
T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 60 T-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPAATTLSD 117
Query: 650 TSTSE 664
T+ +E
Sbjct: 118 TAAAE 122
>gi|6981324 ref|NP_037130.1| protein disulfide isomerase (Prolyl
4-hydroxylase, beta polypeptide) [Rattus norvegicus]
>gi|68461|pir||ISRTSS protein disulfide-isomerase (EC 5.3.4.1)
precursor [validated] - rat >gi|56872|emb|CAA26675.1| (X02918)
precursor [Rattus norvegicus] >gi|224672|prf||1110240A
isomerase,protein disulfide [Rattus norvegicus]
Length = 508
Frame 2 hits (HSPs): _____________ _____________________
__________________________________________________
Database sequence: | | | | | 508
0 150 300 450
Plus Strand HSPs:
Score = 391 (137.6 bits), Expect = 2.7e-35, P = 2.7e-35
Identities = 83/198 (41%), Positives = 124/198 (62%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG- 196
+ K AA+ FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ +
Sbjct: 275 NFKKAAEGFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESD 333
Query: 197 EVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
E+T +KI F F+E K+KP S +PE D VK++VG NF+E+ DE K+V +E
Sbjct: 334 ELTAEKITQFCHHFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDEKKNVFVEF 393
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA S
Sbjct: 394 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA---S 450
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 451 ADRTVIDYNGERTLDGFKKFLE 472
Score = 136 (47.9 bits), Expect = 1.2e-05, P = 1.2e-05
Identities = 42/127 (33%), Positives = 62/127 (48%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV- 460
E D +V ++ +NF E +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 23 EEED-NVLVLKKSNFAEPAAHNY--LLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIR 79
Query: 461 IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIP 631
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 80 LAKVDAT-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPA 137
Query: 632 FKLQKPTSTSE 664
T+ +E
Sbjct: 138 ATTLSDTAAAE 148
>gi|68462|pir||ISMSSS protein disulfide-isomerase (EC 5.3.4.1) precursor -
mouse >gi|387509|gb|AAA39906.1| (J05185) protein disulfide
isomerase [Mus musculus]
Length = 509
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: __ _________ __________ _
__________________________________________________
Database sequence: | | | | | 509
0 150 300 450
__________________
Annotated Domains:
Entrez domain: signal sequence 1..19
Entrez domain: thioredoxin homology #label TX1 34..121
Entrez domain: thioredoxin homology #label TX2 377..462
Entrez region: endoplasmic reticulum retention 506..509
PROSITE THIOREDOXIN: Thioredoxin family active s 391..409
PROSITE THIOREDOXIN: Thioredoxin family active s 47..65
__________________
Plus Strand HSPs:
Score = 389 (136.9 bits), Expect = 4.4e-35, P = 4.4e-35
Identities = 83/196 (42%), Positives = 123/196 (62%), Frame = +2
Query: 29 KXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG-EV 202
K AA+ FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E+
Sbjct: 278 KRAAEGFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDEL 336
Query: 203 TTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEIYA 379
T +KI F F+E K+KP S VPE D VK++VG NF+E+ DE K+V +E YA
Sbjct: 337 TAEKITEFCHRFLEGKIKPHLMSQEVPEDWDKQPVKVLVGANFEEVAFDEKKNVFVEFYA 396
Query: 380 PWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFD 559
PWCGHC+ L PI++KL + ++ ++++IAKMD T NE K FPTL FFPA S D
Sbjct: 397 PWCGHCKQLAPIWDKLGETYKDHENIIIAKMDSTANEVEAVKVHSFPTLKFFPA---SAD 453
Query: 560 PITVDT--DRTVVAFYKFLK 613
+D +RT+ F KFL+
Sbjct: 454 RTVIDYNGERTLDGFKKFLE 473
Score = 151 (53.2 bits), Expect = 1.5e-07, P = 1.5e-07
Identities = 44/127 (34%), Positives = 65/127 (51%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV- 460
E D +V ++ +NF+E L K +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 23 EEED-NVLVLKKSNFEE-ALAAHKYLLVEFYAPWCGHCKALAPEYAKAAAKLKAEGSEIR 80
Query: 461 IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIP 631
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 81 LAKVDAT-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPA 138
Query: 632 FKLQKPTSTSE 664
T+ +E
Sbjct: 139 ATTLSDTAAAE 149
>gi|129729|sp|P09103|PDI_MOUSE PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI)
(PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE
BINDING PROTEIN) (P55) (ERP59) >gi|54777|emb|CAA29759.1| (X06453)
thyroid hormone binding protein [Mus musculus]
Length = 509
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: __________________________________________________
__________________________________________________
Database sequence: | | | | | 509
0 150 300 450
__________________
Annotated Domains:
Entrez other site: PREVENT SECRETION FROM ER. 506..509
PFAM thiored: Thioredoxin 25..136
PFAM thiored: Thioredoxin 368..477
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 46..54
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 54..63
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 97..108
PRODOM PD027371: PDI(2) 1..26
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 28..98
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 100..132
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 135..364
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 370..437
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 439..480
PRODOM PD019288: PDI(2) GSBP(1) 482..508
PROSITE THIOREDOXIN: Thioredoxin family active s 391..409
PROSITE THIOREDOXIN: Thioredoxin family active s 47..65
__________________
Plus Strand HSPs:
Score = 389 (136.9 bits), Expect = 4.4e-35, P = 4.4e-35
Identities = 83/196 (42%), Positives = 123/196 (62%), Frame = +2
Query: 29 KXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG-EV 202
K AA+ FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E+
Sbjct: 278 KRAAEGFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDEL 336
Query: 203 TTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEIYA 379
T +KI F F+E K+KP S VPE D VK++VG NF+E+ DE K+V +E YA
Sbjct: 337 TAEKITEFCHRFLEGKIKPHLMSQEVPEDWDKQPVKVLVGANFEEVAFDEKKNVFVEFYA 396
Query: 380 PWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFD 559
PWCGHC+ L PI++KL + ++ ++++IAKMD T NE K FPTL FFPA S D
Sbjct: 397 PWCGHCKQLAPIWDKLGETYKDHENIIIAKMDSTANEVEAVKVHSFPTLKFFPA---SAD 453
Query: 560 PITVDT--DRTVVAFYKFLK 613
+D +RT+ F KFL+
Sbjct: 454 RTVIDYNGERTLDGFKKFLE 473
Score = 150 (52.8 bits), Expect = 2.1e-07, P = 2.1e-07
Identities = 44/127 (34%), Positives = 65/127 (51%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV- 460
E D +V ++ +NF+E L K +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 23 EEED-NVLVLKKSNFEE-ALAAHKYLLVEFYAPWCGHCKALAPEYAKRAAKLKAEGSEIR 80
Query: 461 IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIP 631
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 81 LAKVDAT-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPA 138
Query: 632 FKLQKPTSTSE 664
T+ +E
Sbjct: 139 ATTLSDTAAAE 149
>gi|2507460|sp|P07237|PDI_HUMAN PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI)
(PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE
BINDING PROTEIN) (P55) >gi|2144545|pir||ISHUSS protein
disulfide-isomerase (EC 5.3.4.1) precursor - human
>gi|190384|gb|AAC13652.1| (M22806) prolyl 4-hydroxylase
beta-subunit [Homo sapiens]
Length = 508
Frame 2 hits (HSPs): ____________ _____________________
Annotated Domains: _______________________________________________ _
__________________________________________________
Database sequence: | | | | | 508
0 150 300 450
__________________
Annotated Domains:
Entrez Repetitive region 28..109
Entrez Repetitive region 372..450
Entrez Repetitive region 275..362
Entrez Repetitive region 172..263
Entrez other site: PREVENT SECRETION FROM ER. 505..508
PFAM thiored: Thioredoxin 23..134
PFAM thiored: Thioredoxin 366..475
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 44..52
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 52..61
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 95..106
PRODOM PD054053: PDI_HUMAN 1..24
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 26..96
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 98..130
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 133..362
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 368..435
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 437..478
PROSITE THIOREDOXIN: Thioredoxin family active s 389..407
PROSITE THIOREDOXIN: Thioredoxin family active s 45..63
__________________
Plus Strand HSPs:
Score = 389 (136.9 bits), Expect = 4.4e-35, P = 4.4e-35
Identities = 82/198 (41%), Positives = 125/198 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA+SFKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E
Sbjct: 274 NFKTAAESFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESE 332
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T ++I F F+E K+KP S +PE D VK++VG NF+++ DE K+V +E
Sbjct: 333 ELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEF 392
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA S
Sbjct: 393 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA---S 449
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 450 ADRTVIDYNGERTLDGFKKFLE 471
Score = 148 (52.1 bits), Expect = 3.8e-07, P = 3.8e-07
Identities = 43/112 (38%), Positives = 60/112 (53%), Frame = +2
Query: 281 PESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV 460
PE D V ++ +NF E L K +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 20 PEEED-HVLVLRKSNFAE-ALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEI 77
Query: 461 -IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 78 RLAKVDAT-EESDLAQQYGVRGYPTIKFFRNGDTA-SPKEYTAGREADDIVNWLKK 131
>gi|12740731 ref|XP_008588.2| procollagen-proline, 2-oxoglutarate 4-dioxygenase
(proline 4-hydroxylase), beta polypeptide (protein disulfide
isomerase; thyroid hormone binding protein p55) [Homo sapiens]
Length = 517
Frame 2 hits (HSPs): ____________ ____________________
__________________________________________________
Database sequence: | | | | | 517
0 150 300 450
Plus Strand HSPs:
Score = 389 (136.9 bits), Expect = 4.4e-35, P = 4.4e-35
Identities = 82/198 (41%), Positives = 125/198 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA+SFKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E
Sbjct: 283 NFKTAAESFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESE 341
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEI 373
+T ++I F F+E K+KP S +PE D VK++VG NF+++ DE K+V +E
Sbjct: 342 ELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEF 401
Query: 374 YAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKS 553
YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA S
Sbjct: 402 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA---S 458
Query: 554 FDPITVDT--DRTVVAFYKFLK 613
D +D +RT+ F KFL+
Sbjct: 459 ADRTVIDYNGERTLDGFKKFLE 480
Score = 133 (46.8 bits), Expect = 2.8e-05, P = 2.8e-05
Identities = 41/109 (37%), Positives = 58/109 (53%), Frame = +2
Query: 296 GD-VKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-IAK 469
GD V ++ +NF E L K +L+E APWCGHC++L P Y K A L+ S + +AK
Sbjct: 32 GDHVLVLRKSNFAE-ALAAHKYLLVEFDAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAK 90
Query: 470 MDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 91 VDAT-EESDLAQQYGVRGYPTIKFFRNGDTA-SPKEYTAGREADDIVNWLKK 140
>gi|729433|sp|P38657|PDA3_BOVIN PROTEIN DISULFIDE ISOMERASE A3 PRECURSOR
(DISULFIDE ISOMERASE ER-60) (ERP60) (58 KDA MICROSOMAL PROTEIN)
(P58) (ERP57) >gi|303524|dbj|BAA03760.1| (D16235) PLC alpha [Bos
taurus] >gi|1585552|prf||2201353A glucose-regulated protein
ERp57/GRP58 [Homo sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: ______________________________________________ _
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
__________________
Annotated Domains:
BLOCKS BL00194: Thioredoxin family proteins. 49..61
DOMO DM00054: THIOREDOXINFAMILY 25..126
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 128..373
DOMO DM00054: THIOREDOXINFAMILY 375..479
Entrez other site: PREVENT SECRETION FROM ER (B 502..505
PFAM thiored: Thioredoxin 24..133
PFAM thiored: Thioredoxin 375..485
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 48..56
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 56..65
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 96..107
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 26..95
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 97..129
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 133..372
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 376..447
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 449..484
PROSITE THIOREDOXIN: Thioredoxin family active s 398..416
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 386 (135.9 bits), Expect = 9.2e-35, P = 9.2e-35
Identities = 84/189 (44%), Positives = 119/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F ED+ + LK + KS+P+P
Sbjct: 314 FGLESTTGEIPVVAVRTAK--GEKFVMQEEFSRDGKALERFLEDYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + LR ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLRKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +LK+ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKQNPKKYEGGRELSDFISYLKREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 159 (56.0 bits), Expect = 1.1e-08, P = 1.1e-08
Identities = 43/118 (36%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G +S D RT LKK A S+P K
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEESG---AYDGPRTADGIVSHLKKQAGPASVPLK 140
Query: 638 LQK 646
++
Sbjct: 141 SEE 143
>gi|1083063|pir||JC2385 protein disulfide-isomerase (EC 5.3.4.1) ER60 precursor
- bovine
Length = 488
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: ____________ __________ _
__________________________________________________
Database sequence: | | | | | 488
0 150 300 450
__________________
Annotated Domains:
Entrez domain: signal sequence 1..24
Entrez domain: thioredoxin homology #label TX1 33..118
Entrez domain: thioredoxin homology #label TX2 367..453
Entrez region: endoplasmic reticulum retention 485..488
PROSITE THIOREDOXIN: Thioredoxin family active s 381..399
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 386 (135.9 bits), Expect = 9.2e-35, P = 9.2e-35
Identities = 84/189 (44%), Positives = 119/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F ED+ + LK + KS+P+P
Sbjct: 297 FGLESTTGEIPVVAVRTAK--GEKFVMQEEFSRDGKALERFLEDYFDGNLKRYLKSEPIP 354
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + LR ++VI
Sbjct: 355 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLRKDPNIVI 414
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +LK+ A+ P +
Sbjct: 415 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKQNPKKYEGGRELSDFISYLKREATNPPVI 473
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 474 QEEKPKKKKKAQ 485
Score = 159 (56.0 bits), Expect = 1.0e-08, P = 1.0e-08
Identities = 43/118 (36%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G +S D RT LKK A S+P K
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEESG---AYDGPRTADGIVSHLKKQAGPASVPLK 140
Query: 638 LQK 646
++
Sbjct: 141 SEE 143
>gi|129730|sp|P21195|PDI_RABIT PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI)
(PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE
BINDING PROTEIN) (P55) >gi|109143|pir||A38362 protein
disulfide-isomerase (EC 5.3.4.1) precursor - rabbit
>gi|165739|gb|AAA31476.1| (J05602) multifunctional thyroid hormone
binding protein [Oryctolagus cuniculus]
Length = 509
Frame 2 hits (HSPs): ___________ ____________________
Annotated Domains: __________________________________________________
__________________________________________________
Database sequence: | | | | | 509
0 150 300 450
__________________
Annotated Domains:
Entrez other site: PREVENT SECRETION FROM ER. 506..509
PFAM thiored: Thioredoxin 24..135
PFAM thiored: Thioredoxin 367..476
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 45..53
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 53..62
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 96..107
PRODOM PD054057: PDI_RABIT 1..25
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 27..97
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 99..131
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 134..363
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 369..436
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 438..479
PRODOM PD054115: PDI_RABIT 481..508
PROSITE THIOREDOXIN: Thioredoxin family active s 390..408
PROSITE THIOREDOXIN: Thioredoxin family active s 46..64
__________________
Plus Strand HSPs:
Score = 383 (134.8 bits), Expect = 1.9e-34, P = 1.9e-34
Identities = 81/196 (41%), Positives = 119/196 (60%), Frame = +2
Query: 29 KXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDG-EV 202
K AA+ FKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E+
Sbjct: 277 KQAAEGFKGKILFIFIDSDHAD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDEL 335
Query: 203 TTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLEIYA 379
T + I F + F+E K+KP S +PE D VK++VG NF+E+ DE K+V +E YA
Sbjct: 336 TAEGITEFCQRFLEGKIKPHLMSQELPEDWDRQPVKVLVGKNFEEVAFDEKKNVFVEFYA 395
Query: 380 PWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFD 559
PWCGHC+ L PI++KL + + +VIAKMD T NE K FPTL FFPAG
Sbjct: 396 PWCGHCKQLAPIWDKLGETYKEHQDIVIAKMDSTANEVEAVKVHSFPTLKFFPAG-PGRT 454
Query: 560 PITVDTDRTVVAFYKFLK 613
I + +RT+ F KFL+
Sbjct: 455 VIDYNGERTLDGFKKFLE 472
Score = 146 (51.4 bits), Expect = 6.9e-07, P = 6.9e-07
Identities = 42/111 (37%), Positives = 60/111 (54%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV- 460
E D +V ++ +NF E L K +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 22 EEED-NVLVLKSSNFAE-ELAAHKHLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSDIR 79
Query: 461 IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 80 LAKVDAT-EESDLAQQYGVRGYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKK 132
>gi|423647|pir||S32476 protein disulfide-isomerase (EC 5.3.4.1) ERp72 precursor
- rat
Length = 643
Frame 2 hits (HSPs): __________ _______ ________________
Annotated Domains: __ _______ _______ _______ _
__________________________________________________
Database sequence: | | | | | | 643
0 150 300 450 600
__________________
Annotated Domains:
Entrez domain: (or 1-27) signal sequence 1..22
Entrez domain: thioredoxin homology #label TX1 68..152
Entrez domain: thioredoxin homology #label TX2 183..267
Entrez domain: thioredoxin homology #label TX3 531..618
Entrez region: endoplasmic reticulum retention 640..643
PROSITE THIOREDOXIN: Thioredoxin family active s 196..214
PROSITE THIOREDOXIN: Thioredoxin family active s 545..563
PROSITE THIOREDOXIN: Thioredoxin family active s 81..99
__________________
Plus Strand HSPs:
Score = 388 (136.6 bits), Expect = 2.0e-34, P = 2.0e-34
Identities = 81/189 (42%), Positives = 116/189 (61%), Frame = +2
Query: 65 FVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGE-VTTDKIKAFGEDFV 241
+ + D ED V + G+S + V ++ GKKFV++ E +D ++ F F
Sbjct: 446 YTFAIADEEDYATEVKD-LGLSESGEDVNAAILDESGKKFVMEPEEFDSDALREFVMAFK 504
Query: 242 EDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYN 421
+ KLKP KS PVP++N G V++VVG FD IV+D KDVL+E YAPWCGHC+ LEP+Y
Sbjct: 505 KGKLKPVIKSQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYT 564
Query: 422 KLAKHLRNIDSLVIAKMDGTTNE--HPRAKPDGFPTLLFFPAGNKSFDPITVDT-DRTVV 592
L K + LVIAKMD T N+ + R K +GFPT+ F P+G+K +PI + +R +
Sbjct: 565 SLGKKYKGQKDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKK-NPIKFEGGNRDLE 623
Query: 593 AFYKFLKKHAS 625
KF+ +HA+
Sbjct: 624 HLSKFIDEHAT 634
Score = 163 (57.4 bits), Expect = 3.5e-09, P = 3.5e-09
Identities = 39/109 (35%), Positives = 58/109 (53%), Frame = +2
Query: 272 DPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNID 451
D + + V ++ NFD V D+ VLLE YAPWCGHC+ P Y K+A L++ D
Sbjct: 52 DDLEVKEENGVWVLNDENFDNFVADKDT-VLLEFYAPWCGHCKQFAPEYEKIASTLKDND 110
Query: 452 S-LVIAKMDGTTNEHPRAKPD--GFPTLLFFPAGNKSFDPITVDTDRTVVA 595
+ +AK+D T+ +K D G+PT+ G ++ D T +VA
Sbjct: 111 PPIAVAKIDATSASMLASKFDVSGYPTIKILKKG-QAVDYDGSRTQEEIVA 160
Score = 159 (56.0 bits), Expect = 1.6e-08, P = 1.6e-08
Identities = 35/80 (43%), Positives = 49/80 (61%), Frame = +2
Query: 323 NFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHL-RNIDSLVIAKMDGT--TNEH 493
NFD++V + + +L+E YAPWCGHC+ L P Y K AK L + + +AK+D T T+
Sbjct: 184 NFDDVV-NNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLA 242
Query: 494 PRAKPDGFPTLLFFPAGNKSFD 559
R G+PTL F G + FD
Sbjct: 243 KRFDVSGYPTLKIFRKG-RPFD 263
>gi|119531|sp|P08003|ER72_MOUSE PROTEIN DISULFIDE ISOMERASE-RELATED PROTEIN
ERP-72 PRECURSOR (ERP72) >gi|68466|pir||ISMSER protein
disulfide-isomerase (EC 5.3.4.1) ERp72 precursor - mouse
>gi|200283|gb|AAA39907.1| (J05186) protein disulfide
isomerase-related protein [Mus musculus]
Length = 638
Frame 2 hits (HSPs): ___________________ ________________
Annotated Domains: ________________________________________________
__________________________________________________
Database sequence: | | | | | | 638
0 150 300 450 600
__________________
Annotated Domains:
BLOCKS BL00194: Thioredoxin family proteins. 191..203
Entrez glycosylation site: POTENTIAL. 36
Entrez Domain: ASP/GLU-RICH (ACIDIC). 39..50
Entrez other site: PREVENT SECRETION FROM ER. 635..638
PFAM thiored: Thioredoxin 54..162
PFAM thiored: Thioredoxin 169..277
PFAM thiored: Thioredoxin 517..629
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 190..198
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 198..207
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 241..252
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 59..124
PRODOM PD019287: ER72(3) 126..171
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 173..239
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 242..276
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 278..513
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 518..580
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 590..628
PROSITE THIOREDOXIN: Thioredoxin family active s 191..209
PROSITE THIOREDOXIN: Thioredoxin family active s 540..558
PROSITE THIOREDOXIN: Thioredoxin family active s 76..94
__________________
Plus Strand HSPs:
Score = 385 (135.5 bits), Expect = 4.1e-34, P = 4.1e-34
Identities = 81/189 (42%), Positives = 115/189 (60%), Frame = +2
Query: 65 FVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGE-VTTDKIKAFGEDFV 241
+ + D ED V + G+S + V ++ GKKF ++ E +D ++ F F
Sbjct: 441 YTFAIADEEDYATEVKD-LGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFK 499
Query: 242 EDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYN 421
+ KLKP KS PVP++N G VK+VVG FD IV+D KDVL+E YAPWCGHC+ LEPIY
Sbjct: 500 KGKLKPVIKSQPVPKNNKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYT 559
Query: 422 KLAKHLRNIDSLVIAKMDGTTNE--HPRAKPDGFPTLLFFPAGNKSFDPITVDT-DRTVV 592
L K + LVIAKMD T N+ + + K +GFPT+ F P+G+K +PI + +R +
Sbjct: 560 SLGKKYKGQKDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKK-NPIKFEGGNRDLE 618
Query: 593 AFYKFLKKHAS 625
KF+ +HA+
Sbjct: 619 HLSKFIDEHAT 629
Score = 165 (58.1 bits), Expect = 1.2e-09, P = 1.2e-09
Identities = 46/133 (34%), Positives = 67/133 (50%), Frame = +2
Query: 197 EVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIY 376
E T+D A E+ ED D + + V ++ NFD V D+ VLLE Y
Sbjct: 29 EDTSDTENATEEEEEED-------DDDLEVKEENGVWVLNDGNFDNFVADKDT-VLLEFY 80
Query: 377 APWCGHCQSLEPIYNKLAKHLRNIDS-LVIAKMDGTTNEHPRAKPD--GFPTLLFFPAGN 547
APWCGHC+ P Y K+A L++ D + +AK+D T+ +K D G+PT+ G
Sbjct: 81 APWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKILKKG- 139
Query: 548 KSFDPITVDTDRTVVA 595
++ D T +VA
Sbjct: 140 QAVDYDGSRTQEEIVA 155
Score = 160 (56.3 bits), Expect = 1.1e-08, P = 1.1e-08
Identities = 35/81 (43%), Positives = 50/81 (61%), Frame = +2
Query: 320 NNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHL-RNIDSLVIAKMDGT--TNE 490
+NFD++V + + +L+E YAPWCGHC+ L P Y K AK L + + +AK+D T T+
Sbjct: 178 DNFDDVV-NNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDL 236
Query: 491 HPRAKPDGFPTLLFFPAGNKSFD 559
R G+PTL F G + FD
Sbjct: 237 AKRFDVSGYPTLKIFRKG-RPFD 258
>gi|729436|sp|P38659|ER72_RAT PROTEIN DISULFIDE ISOMERASE-RELATED PROTEIN
ERP-72 PRECURSOR (ERP72) (CALCIUM-BINDING PROTEIN 2) (CABP2)
>gi|393203|gb|AAA19217.1| (M86870) calcium-binding protein [Rattus
norvegicus]
Length = 643
Frame 2 hits (HSPs): __________ _______ ________________
Annotated Domains: ______________________________________________
__________________________________________________
Database sequence: | | | | | | 643
0 150 300 450 600
__________________
Annotated Domains:
Entrez other site: PREVENT SECRETION FROM ER. 640..643
PFAM thiored: Thioredoxin 59..167
PFAM thiored: Thioredoxin 174..282
PFAM thiored: Thioredoxin 522..634
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 195..203
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 203..212
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 246..257
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 65..129
PRODOM PD019287: ER72(3) 131..176
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 180..244
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 247..281
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 283..518
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 523..585
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 595..633
PROSITE THIOREDOXIN: Thioredoxin family active s 196..214
PROSITE THIOREDOXIN: Thioredoxin family active s 545..563
PROSITE THIOREDOXIN: Thioredoxin family active s 81..99
__________________
Plus Strand HSPs:
Score = 384 (135.2 bits), Expect = 5.5e-34, P = 5.5e-34
Identities = 80/189 (42%), Positives = 115/189 (60%), Frame = +2
Query: 65 FVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGNDDGKKFVLDGE-VTTDKIKAFGEDFV 241
+ + D ED V + G+S + V ++ GKKF ++ E +D ++ F F
Sbjct: 446 YTFAIADEEDYATEVKD-LGLSESGEDVNAAILDESGKKFAMEPEEFDSDALREFVMAFK 504
Query: 242 EDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYN 421
+ KLKP KS PVP++N G V++VVG FD IV+D KDVL+E YAPWCGHC+ LEP+Y
Sbjct: 505 KGKLKPVIKSQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYT 564
Query: 422 KLAKHLRNIDSLVIAKMDGTTNE--HPRAKPDGFPTLLFFPAGNKSFDPITVDT-DRTVV 592
L K + LVIAKMD T N+ + R K +GFPT+ F P+G+K +PI + +R +
Sbjct: 565 SLGKKYKGQKDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKK-NPIKFEGGNRDLE 623
Query: 593 AFYKFLKKHAS 625
KF+ +HA+
Sbjct: 624 HLSKFIDEHAT 634
Score = 163 (57.4 bits), Expect = 3.5e-09, P = 3.5e-09
Identities = 39/109 (35%), Positives = 58/109 (53%), Frame = +2
Query: 272 DPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNID 451
D + + V ++ NFD V D+ VLLE YAPWCGHC+ P Y K+A L++ D
Sbjct: 52 DDLEVKEENGVWVLNDENFDNFVADKDT-VLLEFYAPWCGHCKQFAPEYEKIASTLKDND 110
Query: 452 S-LVIAKMDGTTNEHPRAKPD--GFPTLLFFPAGNKSFDPITVDTDRTVVA 595
+ +AK+D T+ +K D G+PT+ G ++ D T +VA
Sbjct: 111 PPIAVAKIDATSASMLASKFDVSGYPTIKILKKG-QAVDYDGSRTQEEIVA 160
Score = 159 (56.0 bits), Expect = 1.6e-08, P = 1.6e-08
Identities = 35/80 (43%), Positives = 49/80 (61%), Frame = +2
Query: 323 NFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHL-RNIDSLVIAKMDGT--TNEH 493
NFD++V + + +L+E YAPWCGHC+ L P Y K AK L + + +AK+D T T+
Sbjct: 184 NFDDVV-NNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLA 242
Query: 494 PRAKPDGFPTLLFFPAGNKSFD 559
R G+PTL F G + FD
Sbjct: 243 KRFDVSGYPTLKIFRKG-RPFD 263
>gi|1085373|pir||S55507 protein disulfide-isomerase (EC 5.3.4.1) ER60 precursor
- human >gi|860986|emb|CAA89996.1| (Z49835) protein disulfide
isomerase [Homo sapiens] >gi|1588744|prf||2209333A protein
disulfide isomerase [Homo sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: ____________ __________ _
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
__________________
Annotated Domains:
Entrez domain: signal sequence 1..24
Entrez domain: thioredoxin homology #label TX1 33..118
Entrez domain: thioredoxin homology #label TX2 384..470
Entrez region: endoplasmic reticulum retention 502..505
PROSITE THIOREDOXIN: Thioredoxin family active s 398..416
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 375 (132.0 bits), Expect = 1.3e-33, P = 1.3e-33
Identities = 81/189 (42%), Positives = 118/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +D+ + LK + KS+P+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNPKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 41/118 (34%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|2507461|sp|P30101|PDA3_HUMAN PROTEIN DISULFIDE ISOMERASE A3 PRECURSOR
(DISULFIDE ISOMERASE ER-60) (ERP60) (58 KDA MICROSOMAL PROTEIN)
(P58) (ERP57) >gi|2134675|pir||S68363 protein disulfide-isomerase
(EC 5.3.4.1) ER60 precursor - human >gi|1147739|gb|AAC50331.1|
(U42068) P58 [Homo sapiens] >gi|1699219|gb|AAB37397.1|
H-ERp60=protein disulphide isomerase isoform/multifunctional
endoplasmic reticulum luminal polypeptide [human, heart, Peptide,
505 aa] >gi|1585496|prf||2201310A microsomal protein P58 [Homo
sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: ______________________________________________ _
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
__________________
Annotated Domains:
BLOCKS BL00194: Thioredoxin family proteins. 49..61
Entrez other site: PREVENT SECRETION FROM ER (B 502..505
PFAM thiored: Thioredoxin 24..133
PFAM thiored: Thioredoxin 375..485
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 48..56
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 56..65
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 96..107
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 26..95
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 97..129
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 133..372
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 376..447
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 449..484
PROSITE THIOREDOXIN: Thioredoxin family active s 398..416
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 375 (132.0 bits), Expect = 1.3e-33, P = 1.3e-33
Identities = 81/189 (42%), Positives = 118/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +D+ + LK + KS+P+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNPKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 41/118 (34%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|7437388|pir||JC5704 protein disulfide-isomerase (EC 5.3.4.1) ER60 precursor
- human >gi|1208427|dbj|BAA11928.1| (D83485) ER-60 protease [Homo
sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
Plus Strand HSPs:
Score = 375 (132.0 bits), Expect = 1.3e-33, P = 1.3e-33
Identities = 81/189 (42%), Positives = 118/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +D+ + LK + KS+P+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNPKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 41/118 (34%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|4885359 ref|NP_005304.1| glucose regulated protein, 58kD [Homo sapiens]
>gi|2245365|gb|AAC51518.1| (U75885) ER-60 protein [Homo sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
Plus Strand HSPs:
Score = 375 (132.0 bits), Expect = 1.3e-33, P = 1.3e-33
Identities = 81/189 (42%), Positives = 118/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +D+ + LK + KS+P+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNPKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 41/118 (34%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|12738722 ref|XP_007536.2| glucose regulated protein, 58kD [Homo sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
Plus Strand HSPs:
Score = 375 (132.0 bits), Expect = 1.3e-33, P = 1.3e-33
Identities = 81/189 (42%), Positives = 118/189 (62%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +D+ + LK + KS+P+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNPKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 126 (44.4 bits), Expect = 0.00019, P = 0.00019
Identities = 39/118 (33%), Positives = 59/118 (50%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +A CGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAYRCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|86248|pir||A30007 dolichyl-diphosphooligosaccharide--protein
glycotransferase (EC 2.4.1.119) glycosylation site-binding chain
precursor - chicken
Length = 508
Frame 2 hits (HSPs): ______________ _____________________
Annotated Domains: ____________ __________ _
__________________________________________________
Database sequence: | | | | | 508
0 150 300 450
__________________
Annotated Domains:
Entrez domain: signal sequence 1..17
Entrez domain: thioredoxin homology #label TX1 31..118
Entrez domain: thioredoxin homology #label TX2 376..461
Entrez region: endoplasmic reticulum retention 505..508
PROSITE THIOREDOXIN: Thioredoxin family active s 390..408
__________________
Plus Strand HSPs:
Score = 374 (131.7 bits), Expect = 1.7e-33, P = 1.7e-33
Identities = 78/199 (39%), Positives = 126/199 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+LK AA FKGK++FV+++ D+ D + + E+FG+ P V T +++ K+ + E
Sbjct: 274 NLKKAADGFKGKILFVFIDSDHTD-NQRILEFFGLKKEECPAVRLITLDEELTKYKPETE 332
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKS-DPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLE 370
+T +K+ F F+E K+KP S +P+PE D VK++VG N++E+ DE K+V +E
Sbjct: 333 ELTAEKLTQFCHHFLEGKIKPHLMSNEPLPEDWDKQPVKVLVGKNYEEVAFDEKKNVFIE 392
Query: 371 IYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNK 550
YAPWCGHC+ L P++++L + ++ +++VIAKM+ T NE K FPTL FFPA +
Sbjct: 393 FYAPWCGHCKQLAPMWDRLGEAYKDDENIVIAKMESTANEVEAIKVHSFPTLKFFPASAE 452
Query: 551 SFDPITVDTDRTVVAFYKFLK 613
I + +RT+ + KFL+
Sbjct: 453 R-TVIDYNGERTLDGYKKFLE 472
Score = 122 (42.9 bits), Expect = 0.00055, P = 0.00055
Identities = 39/127 (30%), Positives = 57/127 (44%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
E D +V + +NF E + S + +E YAPWCGHC++L P Y K L+ S +
Sbjct: 20 EEQD-NVLVAKKSNFLEPLAAHSY-LAVEFYAPWCGHCKALAPDYAKAGGKLKAEGSEIK 77
Query: 464 AKMDGTTNEHPRAKPDG---FPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPF 634
A T E A+ G +PT+ FF G+ + P R +LKK
Sbjct: 78 AAKVEATEESDLAQQYGVRAYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPAA 136
Query: 635 KLQKPTSTSE 664
T+ +E
Sbjct: 137 TTLSDTAAAE 146
>gi|1346187|sp|P12244|GSBP_CHICK DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE-PROTEIN
GLYCOTRANSFERASE PRECURSOR (GLYCOSYLATION SITE-BINDING CHAIN)
(GSBP) >gi|727149|gb|AAA64295.1| (M22594) glycosylation
site-binding protein [Gallus gallus]
Length = 508
Frame 2 hits (HSPs): ______________ _____________________
Annotated Domains: __________________________________________________
__________________________________________________
Database sequence: | | | | | 508
0 150 300 450
__________________
Annotated Domains:
BLOCKS BL00194: Thioredoxin family proteins. 390..402
DOMO DM00054: THIOREDOXINFAMILY 23..126
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 128..365
DOMO DM00054: THIOREDOXINFAMILY 367..469
DOMO DM03864: PROTEINDISULFIDE-ISOMERASE 471..507
Entrez other site: PREVENT SECRETION FROM ER. 505..508
PFAM thiored: Thioredoxin 22..133
PFAM thiored: Thioredoxin 367..476
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 389..397
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 397..406
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 437..448
PRODOM PD054049: GSBP_CHICK 1..23
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 25..95
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 98..129
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 132..363
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 369..434
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 438..479
PRODOM PD019288: PDI(2) GSBP(1) 481..507
PROSITE THIOREDOXIN: Thioredoxin family active s 390..408
__________________
Plus Strand HSPs:
Score = 374 (131.7 bits), Expect = 1.7e-33, P = 1.7e-33
Identities = 78/199 (39%), Positives = 126/199 (63%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+LK AA FKGK++FV+++ D+ D + + E+FG+ P V T +++ K+ + E
Sbjct: 274 NLKKAADGFKGKILFVFIDSDHTD-NQRILEFFGLKKEECPAVRLITLDEELTKYKPETE 332
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKS-DPVPESNDGD-VKIVVGNNFDEIVLDESKDVLLE 370
+T +K+ F F+E K+KP S +P+PE D VK++VG N++E+ DE K+V +E
Sbjct: 333 ELTAEKLTQFCHHFLEGKIKPHLMSNEPLPEDWDKQPVKVLVGKNYEEVAFDEKKNVFIE 392
Query: 371 IYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNK 550
YAPWCGHC+ L P++++L + ++ +++VIAKM+ T NE K FPTL FFPA +
Sbjct: 393 FYAPWCGHCKQLAPMWDRLGEAYKDDENIVIAKMESTANEVEAIKVHSFPTLKFFPASAE 452
Query: 551 SFDPITVDTDRTVVAFYKFLK 613
I + +RT+ + KFL+
Sbjct: 453 R-TVIDYNGERTLDGYKKFLE 472
Score = 109 (38.4 bits), Expect = 0.018, P = 0.018
Identities = 38/127 (29%), Positives = 56/127 (44%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
E D +V + +NF E + S + +E YAP CGHC++L P Y K L+ S +
Sbjct: 20 EEQD-NVLVAKKSNFLEPLAAHSY-LAVEFYAPLCGHCKALAPDYAKAGGKLKAEGSEIK 77
Query: 464 AKMDGTTNEHPRAKPDG---FPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPF 634
A T E A+ G +PT+ FF G+ + P R +LKK
Sbjct: 78 AAKVEATEESDLAQQYGVRAYPTIKFFKNGDTA-SPKEYTAGREADDIVNWLKKRTGPAA 136
Query: 635 KLQKPTSTSE 664
T+ +E
Sbjct: 137 TTLSDTAAAE 146
>gi|4115422|dbj|BAA36352.1| (AB022013) protein disulphide isomerase like
protein [Antheraea pernyi]
Length = 231
Frame 2 hits (HSPs): _________________________________________
__________________________________________________
Database sequence: | | | | | | 231
0 50 100 150 200
Plus Strand HSPs:
Score = 370 (130.2 bits), Expect = 4.5e-33, P = 4.5e-33
Identities = 76/185 (41%), Positives = 118/185 (63%), Frame = +2
Query: 83 DNEDVGKPVSEYFGIS---GNAPKVLGYTGNDDGKKFVLDGEVTTDKIKAFGEDFVEDKL 253
D +D ++E FGI G+ P V G + DG K+V+ E + + + AF +D ++ KL
Sbjct: 28 DKDDFVHELNE-FGIDFSKGDKPVVAGR--DVDGNKYVMKSEFSIENLVAFAKDLIDGKL 84
Query: 254 KPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAK 433
+PF KS+ VPE+NDG VK+ VG NF E+V D +D L+E YAPWCGHCQ L P++ +L +
Sbjct: 85 EPFIKSEAVPENNDGPVKVAVGKNFKELVSDSGRDALVEFYAPWCGHCQKLTPVWEELGE 144
Query: 434 HLRNIDSLVIAKMDGTTNEHPRAKPD--GFPTLLFFPAGNKSFDPITVDTDRTVVAFYKF 607
L++ + + I K+D T N+ P+++ D GFPT+ + P + S P+ + RT+ F K+
Sbjct: 145 KLKD-EEVDIVKIDATANDWPKSQFDVSGFPTIYWKPK-DSSKKPVRYNGGRTLEDFIKY 202
Query: 608 LKKHASIPFK 637
+ + AS K
Sbjct: 203 VSEQASSELK 212
>gi|339647|gb|AAA61169.1| (J02783) thyroid hormone binding protein precursor
[Homo sapiens]
Length = 508
Frame 2 hits (HSPs): ____________ _____________________
__________________________________________________
Database sequence: | | | | | 508
0 150 300 450
Plus Strand HSPs:
Score = 369 (129.9 bits), Expect = 5.8e-33, P = 5.8e-33
Identities = 81/198 (40%), Positives = 123/198 (62%), Frame = +2
Query: 23 HLKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLDGE 199
+ K AA+SFKGK++F++++ D+ D + + E+FG+ P V T ++ K+ + E
Sbjct: 274 NFKTAAESFKGKILFIFIDSDHTD-NQRILEFFGLKKEECPAVRLITLEEEMTKYKPESE 332
Query: 200 -VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGD---VKIVVGNNFDEIVLDESKDVLL 367
+T ++I F F+E K+KP S + D D VK+ VG NF+++ DE K+V +
Sbjct: 333 ELTAERITEFCHRFLEGKIKPHLMSQE--RAGDWDKQPVKVPVGKNFEDVAFDEKKNVFV 390
Query: 368 EIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGN 547
E YAPWCGHC+ L PI++KL + ++ +++VIAKMD T NE K FPTL FFPA
Sbjct: 391 EFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPA-- 448
Query: 548 KSFDPITVDT--DRTVVAFYKFLK 613
S D +D +RT+ F KFL+
Sbjct: 449 -SADRTVIDYNGERTLDGFKKFLE 471
Score = 148 (52.1 bits), Expect = 3.8e-07, P = 3.8e-07
Identities = 43/112 (38%), Positives = 60/112 (53%), Frame = +2
Query: 281 PESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV 460
PE D V ++ +NF E L K +L+E YAPWCGHC++L P Y K A L+ S +
Sbjct: 20 PEEED-HVLVLRKSNFAE-ALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEI 77
Query: 461 -IAKMDGTTNEHPRAKP---DGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
+AK+D T E A+ G+PT+ FF G+ + P R +LKK
Sbjct: 78 RLAKVDAT-EESDLAQQYGVRGYPTIKFFRNGDTA-SPKEYTAGREADDIVNWLKK 131
>gi|7303555|gb|AAF58609.1| (AE003824) CG8983 gene product [Drosophila
melanogaster]
Length = 488
Frame 2 hits (HSPs): __________ _____________________
__________________________________________________
Database sequence: | | | | | 488
0 150 300 450
Plus Strand HSPs:
Score = 369 (129.9 bits), Expect = 5.8e-33, P = 5.8e-33
Identities = 77/200 (38%), Positives = 118/200 (59%), Frame = +2
Query: 38 AKSFKGKLIFVYVEMDNEDVGKPVSEY-FGISGNAPKVLGYTGNDDGKKFVLDGEVTTDK 214
AK F G++ F D D ++EY + G+ P VL ++ K+ L E + +
Sbjct: 280 AKEFVGQINFAIASKD--DFQHELNEYGYDFVGDKPVVLAR--DEKNLKYALKDEFSVEN 335
Query: 215 IKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGH 394
++ F E + ++L+P+ KS+P+PESND VK+ V NFD++V++ KD L+E YAPWCGH
Sbjct: 336 LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGH 395
Query: 395 CQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNE-HPRAKPDGFPTLLFFPAGNKSFDPITV 571
C+ L PIY +LA+ L++ D + I KMD T N+ P GFPTL + P K+ P++
Sbjct: 396 CKKLSPIYEELAEKLQDED-VAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKN-KPVSY 453
Query: 572 DTDRTVVAFYKFLKKHASIPFK 637
+ R V F K++ K A+ K
Sbjct: 454 NGGREVDDFLKYIAKEATTELK 475
Score = 118 (41.5 bits), Expect = 0.0015, P = 0.0015
Identities = 31/90 (34%), Positives = 50/90 (55%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-IAKMD 475
DV + +G++ L + + L+ YAPWCGHC+ L+P Y K A+ +++ D + +AK+D
Sbjct: 22 DV-LELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAKVD 80
Query: 476 GT-TNEHPRAK--PDGFPTLLFFPAGNKSFD 559
T + +K G+PTL F S D
Sbjct: 81 CTEAGKETCSKYSVSGYPTLKIFRQDEVSQD 111
>gi|303618|dbj|BAA03759.1| (D16234) PLC alfa [Homo sapiens]
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
Plus Strand HSPs:
Score = 368 (129.5 bits), Expect = 7.4e-33, P = 7.4e-33
Identities = 81/189 (42%), Positives = 116/189 (61%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F + + LK + KSDP+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQGYFGGNLKRYLKSDPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK +P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNPKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 41/118 (34%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|7437389|pir||S68280 protein disulfide-isomerase (EC 5.3.4.1) ERp60
precursor - fruit fly (Drosophila melanogaster)
>gi|1699220|gb|AAB37398.1| D-ERp60=protein disulphide isomerase
isoform/multifunctional endoplasmic reticulum luminal polypeptide
[Drosophila melanogaster, Peptide, 489 aa]
Length = 489
Frame 2 hits (HSPs): __________ _____________________
__________________________________________________
Database sequence: | | | | | 489
0 150 300 450
Plus Strand HSPs:
Score = 368 (129.5 bits), Expect = 7.4e-33, P = 7.4e-33
Identities = 77/200 (38%), Positives = 118/200 (59%), Frame = +2
Query: 38 AKSFKGKLIFVYVEMDNEDVGKPVSEY-FGISGNAPKVLGYTGNDDGKKFVLDGEVTTDK 214
AK F G++ F D D ++EY + G+ P VL ++ K+ L E + +
Sbjct: 281 AKEFVGQINFAIASKD--DFQHELNEYGYDFVGDKPVVLAR--DEKNLKYALKDEFSVEN 336
Query: 215 IKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGH 394
++ F E + ++L+P+ KS+P+PESND VK+ V NFD++V++ KD L+E YAPWCGH
Sbjct: 337 LQDFVEKLLANELEPYIKSEPIPESNDAPVKVAVAKNFDDLVINNGKDTLIEFYAPWCGH 396
Query: 395 CQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNE-HPRAKPDGFPTLLFFPAGNKSFDPITV 571
C+ L PIY +LA+ L++ D + I KMD T N+ P GFPTL + P K+ P++
Sbjct: 397 CKKLTPIYEELAQKLQDED-VAIVKMDATANDVPPEFNVRGFPTLFWLPKDAKN-KPVSY 454
Query: 572 DTDRTVVAFYKFLKKHASIPFK 637
+ R V F K++ K A+ K
Sbjct: 455 NGGREVDDFLKYIAKEATTELK 476
Score = 122 (42.9 bits), Expect = 0.00052, P = 0.00052
Identities = 32/92 (34%), Positives = 51/92 (55%), Frame = +2
Query: 293 DGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-IAK 469
D DV + +G++ L + + L+ YAPWCGHC+ L+P Y K A+ +++ D + +AK
Sbjct: 21 DEDV-LELGDDDFATTLKQHETTLVMFYAPWCGHCKRLKPEYAKAAEIVKDDDPPIKLAK 79
Query: 470 MDGT-TNEHPRAK--PDGFPTLLFFPAGNKSFD 559
+D T + +K G+PTL F S D
Sbjct: 80 VDCTEAGKETCSKYSVSGYPTLKIFRQDEVSQD 112
>gi|627195|pir||A54757 protein disulfide-isomerase (EC 5.3.4.1) / ER
calcistorin precursor - sea urchin (Strongylocentrotus purpuratus)
>gi|521107|gb|AAA57472.1| (U06484) ERcalcistorin/PDI
[Strongylocentrotus purpuratus]
Length = 496
Frame 2 hits (HSPs): __________ _______________________
Annotated Domains: ________________________________________________
__________________________________________________
Database sequence: | | | | | 496
0 150 300 450
__________________
Annotated Domains:
DOMO DM00054: THIOREDOXINFAMILY 25..125
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 127..358
DOMO DM00054: THIOREDOXINFAMILY 360..461
DOMO DM03864: PROTEINDISULFIDE-ISOMERASE 463..496
Entrez domain: thioredoxin homology #label TX1 33..117
Entrez domain: thioredoxin homology #label TX2 369..453
PROSITE THIOREDOXIN: Thioredoxin family active s 383..401
PROSITE THIOREDOXIN: Thioredoxin family active s 46..64
__________________
Plus Strand HSPs:
Score = 366 (128.8 bits), Expect = 1.2e-32, P = 1.2e-32
Identities = 84/217 (38%), Positives = 120/217 (55%), Frame = +2
Query: 35 AAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLD-GEVTT 208
AA +FKG+++FV ++ E + + EYFG+ P V T + D KK+ E+TT
Sbjct: 272 AATTFKGEVLFVLIDAAAESNSR-ILEYFGLGDEEVPTVRLITLDGDMKKYKPTVPELTT 330
Query: 209 DKIKAFGEDFVEDKLKPFYKSDPVPES-NDGDVKIVVGNNFDEIVLDESKDVLLEIYAPW 385
+ + F DF + KLKP S+ VPE N V I+VG NF E+ LD +KDVL+E YAPW
Sbjct: 331 ESLSQFVIDFKDGKLKPHLMSESVPEDWNANPVTILVGENFAEVALDPTKDVLVEFYAPW 390
Query: 386 CGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFDPI 565
CGHC+ L PIY +L +H + + +VIAK+D T NE A FPTL F+ G +
Sbjct: 391 CGHCKQLAPIYEELGEHFKEREDVVIAKVDSTKNEVEDAVVRSFPTLKFWKKGENEM--V 448
Query: 566 TVDTDRTVVAFYKFLKKHASIPFKLQKPTSTSEXRFQGGA 685
DRT+ A +F++ I ++ + GA
Sbjct: 449 DYSGDRTLEAMIQFVESGGEIIAEVDDEDMEEDEEMDEGA 488
Score = 159 (56.0 bits), Expect = 1.0e-08, P = 1.0e-08
Identities = 37/87 (42%), Positives = 52/87 (59%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-IAKMD 475
DV ++ F + V E++ VL+E YAPWCGHC+SL P Y+ AK L++ S + +AK+D
Sbjct: 26 DVAVLTDAAFADYVA-ENEFVLVEFYAPWCGHCKSLAPQYSIAAKTLKDSGSSIKLAKVD 84
Query: 476 GTTNEHPRAKPD--GFPTLLFFPAGNKS 553
T K G+PTL FF +G S
Sbjct: 85 ATVETQLPGKYGVRGYPTLKFFRSGKDS 112
>gi|6679687 ref|NP_031978.1| glucose regulated protein, 58 kDa; endoplasmic
reticulum protein; phospholipase C, alpha [Mus musculus]
>gi|130232|sp|P27773|PDA3_MOUSE PROTEIN DISULFIDE ISOMERASE A3
PRECURSOR (DISULFIDE ISOMERASE ER-60) (ERP60) (58 KDA MICROSOMAL
PROTEIN) (P58) (ERP57) >gi|200397|gb|AAA39944.1| (M73329)
phospholipase C-alpha [Mus musculus]
Length = 504
Frame 2 hits (HSPs): ____________ ___________________
__________________________________________________
Database sequence: | | | | | 504
0 150 300 450
Plus Strand HSPs:
Score = 361 (127.1 bits), Expect = 4.1e-32, P = 4.1e-32
Identities = 76/183 (41%), Positives = 113/183 (61%), Frame = +2
Query: 128 SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVPESNDGD 301
+G P V T G+KFV+ E + D ++ F +++ + LK + KS+P+PESN+G
Sbjct: 319 TGEVPVVAIRTAK--GEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGP 376
Query: 302 VKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGT 481
VK+VV NFD+IV +E KDVL+E YAPWCGHC++LEP Y +L + L ++VIAKMD T
Sbjct: 377 VKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDAT 436
Query: 482 TNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKLQKPTST 658
N+ P + GFPT+ F PA NK P + R + F +L++ A+ P +Q+
Sbjct: 437 ANDVPSPYEVKGFPTIYFSPA-NKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPK 495
Query: 659 SEXRFQ 676
+ + Q
Sbjct: 496 KKKKAQ 501
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 42/117 (35%), Positives = 60/117 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + NF+ V D +L+E +APWCGHC+ L P Y A L+ + +AK+
Sbjct: 26 DVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKIVP---LAKV 82
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F AG ++ D RT LKK A S+P +
Sbjct: 83 DCTANTNTCNKYGVSGYPTLKIFRAGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 139
Query: 638 LQK 646
++
Sbjct: 140 TEE 142
>gi|12697536|emb|CAC28361.1| (AJ306291) putative protein disulfide isomerase
[Toxoplasma gondii]
Length = 472
Frame 2 hits (HSPs): ____________ _______________________
__________________________________________________
Database sequence: | | | | | 472
0 150 300 450
Plus Strand HSPs:
Score = 357 (125.7 bits), Expect = 1.1e-31, P = 1.1e-31
Identities = 86/204 (42%), Positives = 122/204 (59%), Frame = +2
Query: 26 LKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGNAPKVLGYTGND-DGKK--FVLDG 196
++ AAK + FV+++ D ++ G + NA + + G KK FVL
Sbjct: 263 VREAAKKLRDTRSFVWLDTD---------QFKGHAENALGITEFPGLVFQSKKGRFVLP- 312
Query: 197 EVTTD-----KIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDV 361
E TT KI F +D K+ KS+PVPE D VK+VVG NF+E+V+ + KDV
Sbjct: 313 EATTSLKDAAKISQFFDDVEAGKIDRSLKSEPVPEKQDEAVKVVVGKNFEEMVIQKDKDV 372
Query: 362 LLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPD--GFPTLLFF 535
+LEIYAPWCG+C+S EPIY + A+ +++D LV+AKMDGT NE P + FP++ F
Sbjct: 373 MLEIYAPWCGYCKSFEPIYKEFAEKYKDVDHLVVAKMDGTANETPLEEFSWSSFPSIFFV 432
Query: 536 PAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFK 637
AG K+ P+ + RTV +F+ KH S P K
Sbjct: 433 KAGEKT--PMKFEGSRTVEGLTEFVNKHGSKPLK 464
Score = 153 (53.9 bits), Expect = 7.1e-08, P = 7.1e-08
Identities = 39/105 (37%), Positives = 60/105 (57%), Frame = +2
Query: 302 VKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDS-LVIAKMDG 478
V ++ +NFD+ L ++ VL++ YAPWCGHC+ + P Y K AK L+ S +V+AK+D
Sbjct: 29 VTVLTASNFDD-TLKNNEIVLVKFYAPWCGHCKRMAPEYEKAAKTLKEKGSKIVLAKVDA 87
Query: 479 TTNEHPRAKPDG---FPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKK 616
T+ E A G +PTL F + P RT A ++++K
Sbjct: 88 TS-ETDIADKQGVREYPTLTLF----RKEKPEKYTGGRTAEAIVEWIEK 131
>gi|2135267|pir||S63994 protein disulfide-isomerase (EC 5.3.4.1) ER60 precursor
- human
Length = 505
Frame 2 hits (HSPs): _____________ ____________________
Annotated Domains: ___ ___
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
__________________
Annotated Domains:
PROSITE THIOREDOXIN: Thioredoxin family active s 398..416
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 357 (125.7 bits), Expect = 1.1e-31, P = 1.1e-31
Identities = 80/189 (42%), Positives = 115/189 (60%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F + + LK + KSDP+P
Sbjct: 314 FGLESTAGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQGYFGGNLKRYLKSDPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
ESNDG VK+VV NFDEIV +E+KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK + + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVRGFPTIYFSPA-NKKLNFKKYEGGRELSDFISYLQREATNPPVI 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 150 (52.8 bits), Expect = 2.0e-07, P = 2.0e-07
Identities = 41/118 (34%), Positives = 61/118 (51%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + +NF+ + D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQK 646
++
Sbjct: 141 TEE 143
>gi|3392892|emb|CAA12644.1| (AJ225804) protein disulphide isomerase [Fasciola
hepatica]
Length = 489
Frame 2 hits (HSPs): __________ ____ ____________________
__________________________________________________
Database sequence: | | | | | 489
0 150 300 450
Plus Strand HSPs:
Score = 356 (125.3 bits), Expect = 1.4e-31, P = 1.4e-31
Identities = 75/195 (38%), Positives = 115/195 (58%), Frame = +2
Query: 26 LKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGI-SGNAPKVLGYTGNDDGKKFVLDG-E 199
LK +AK FKGK F+ ++ D D + + E+FG+ S + P +D K+ D +
Sbjct: 276 LKESAKKFKGKAHFIIIDTDVAD-NQRILEFFGMTSADVPGYRMINLAEDMTKYKPDSSD 334
Query: 200 VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYA 379
T + I AF E+ + K KPF S +P + V+++VG N++E+V D SK V +E+YA
Sbjct: 335 FTEEAISAFVEEVLSGKRKPFLMSQEIPSPSSDPVRVLVGKNYNEVVSDLSKAVFVELYA 394
Query: 380 PWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFD 559
PWCGHC+ L PI+++L + + + L+IAKMD T NE FPTL ++P G S +
Sbjct: 395 PWCGHCKQLAPIWDELGEAYKTKEDLIIAKMDATANEAEGLSVQSFPTLKYYPKG--SSE 452
Query: 560 PITVDTDRTVVAFYKFL 610
PI +RT+ A +F+
Sbjct: 453 PIEYTGERTLEALKRFV 469
Score = 132 (46.5 bits), Expect = 6.8e-06, Sum P(2) = 6.8e-06
Identities = 32/90 (35%), Positives = 54/90 (60%), Frame = +2
Query: 284 ESNDGDVKI-VVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDS-L 457
ES D + + FD+ + + + ++ YAPWCGHC++++P Y + A L+ S +
Sbjct: 23 ESVDESAVVELTEETFDDEI-KKKEFAMVMFYAPWCGHCKAMKPEYARAAAQLKEEGSDI 81
Query: 458 VIAKMDGTTNEHPR-AKPD---GFPTLLFFPAG 544
+IAK+D T +H + AK G+PTL F+ +G
Sbjct: 82 MIAKVDAT--QHSKLAKSHNVTGYPTLKFYKSG 112
Score = 43 (15.1 bits), Expect = 6.8e-06, Sum P(2) = 6.8e-06
Identities = 11/38 (28%), Positives = 18/38 (47%), Frame = +2
Query: 533 FPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKLQK 646
F + +FD +D+ VV F KF + A +L +
Sbjct: 187 FVSSKDAFDHYKIDSKSRVVLFKKFDEGRADFDGELTR 224
>gi|422337|pir||S34275 protein disulfide-isomerase homolog precursor - fluke
(Schistosoma mansoni) >gi|312018|emb|CAA80520.1| (Z22933) protein
disulfide isomerase homologue [Schistosoma mansoni]
Length = 482
Frame 2 hits (HSPs): __________ _____________________
Annotated Domains: ________________________________________________
__________________________________________________
Database sequence: | | | | | 482
0 150 300 450
__________________
Annotated Domains:
DOMO DM00054: THIOREDOXINFAMILY 23..123
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 125..358
DOMO DM00054: THIOREDOXINFAMILY 360..460
DOMO DM03864: PROTEINDISULFIDE-ISOMERASE 462..482
Entrez domain: thioredoxin homology #label TX1 31..115
Entrez domain: thioredoxin homology #label TX2 369..452
Entrez region: endoplasmic reticulum retention 479..482
PROSITE THIOREDOXIN: Thioredoxin family active s 383..401
PROSITE THIOREDOXIN: Thioredoxin family active s 44..62
__________________
Plus Strand HSPs:
Score = 354 (124.6 bits), Expect = 2.3e-31, P = 2.3e-31
Identities = 75/196 (38%), Positives = 120/196 (61%), Frame = +2
Query: 26 LKXAAKSFKGKLIFVYVEMDNEDVGKPVSEYFGISGN-APKVLGYTGNDDGKKFVLD-GE 199
L A+ FKGKL +YV++D E+ V E+FG+S N AP ++ K+ D +
Sbjct: 270 LTEVARQFKGKLHVIYVDVDVEN-NLRVLEFFGLSKNDAPTYRIIELGEETTKYKPDTND 328
Query: 200 VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIYA 379
+ + F + ++ K+KPF S+ +P G VK++VG N++++V D+SKDV +++YA
Sbjct: 329 YSVSAMSDFVQRTIDGKVKPFLMSEEIPSDQTGAVKVLVGKNYNDVVKDKSKDVFVKLYA 388
Query: 380 PWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSFD 559
PWCGHC++L P++++L + +N D+ VIAKMD T NE K FPTL F+P ++ +
Sbjct: 389 PWCGHCKALAPVWDELGETFKNSDT-VIAKMDATVNEVEDLKVTSFPTLKFYPKNSE--E 445
Query: 560 PITVDTDRTVVAFYKFLK 613
I DR+ A KF++
Sbjct: 446 VIDYTGDRSFEALKKFVE 463
Score = 181 (63.7 bits), Expect = 3.4e-12, P = 3.4e-12
Identities = 37/85 (43%), Positives = 55/85 (64%), Frame = +2
Query: 287 SNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-I 463
+ + DV ++ NFD+++ +K VL+E YAPWCGHC++L P Y++ AK L+ SL+ +
Sbjct: 20 TEEDDVLVLNKKNFDDVI-KTNKFVLVEFYAPWCGHCKALAPEYSEAAKKLKEKGSLIKL 78
Query: 464 AKMDGTTNEHPRAK--PDGFPTLLFF 535
AK+D T E K G+PTL FF
Sbjct: 79 AKVDATVEEELALKHGEKGYPTLKFF 104
>gi|1352731|sp|Q10057|PDI1_SCHPO PUTATIVE PROTEIN DISULFIDE ISOMERASE C1F5.02
PRECURSOR >gi|7492861|pir||T38093 probable protein
disulfide-isomerase (EC 5.3.4.1) SPAC1F5.02 [similarity] - fission
yeast (Schizosaccharomyces pombe) >gi|1103729|emb|CAA92230.1|
(Z68136) putative protein disulphide isomerase precursor
[Schizosaccharomyces pombe]
Length = 492
Frame 2 hits (HSPs): _________ ________________
Annotated Domains: ________________________________________________
__________________________________________________
Database sequence: | | | | | 492
0 150 300 450
__________________
Annotated Domains:
BLOCKS BL00194: Thioredoxin family proteins. 377..389
DOMO DM00054: THIOREDOXINFAMILY 22..121
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 123..353
DOMO DM00054: THIOREDOXINFAMILY 355..456
Entrez glycosylation site: POTENTIAL. 161
Entrez glycosylation site: POTENTIAL. 257
Entrez other site: PREVENT SECRETION FROM ER (P 489..492
PFAM thiored: Thioredoxin 21..128
PFAM thiored: Thioredoxin 354..462
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 376..384
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 384..393
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 423..434
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 23..92
PRODOM PD113917: PDI1_SCHPO 94..127
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 129..353
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 356..417
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 424..460
PRODOM PD054118: PDI1_SCHPO 462..491
PROSITE THIOREDOXIN: Thioredoxin family active s 377..395
PROSITE THIOREDOXIN: Thioredoxin family active s 43..61
__________________
Plus Strand HSPs:
Score = 352 (123.9 bits), Expect = 3.7e-31, P = 3.7e-31
Identities = 69/150 (46%), Positives = 101/150 (67%), Frame = +2
Query: 197 EVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDVLLEIY 376
E+T + F DFV+ KL+P KS P+PES + D+ ++V +NFD+IV+DE+KDVL+E Y
Sbjct: 323 ELTAKAMTKFVGDFVDGKLQPKIKSQPIPESQE-DLVVLVADNFDDIVMDETKDVLVEFY 381
Query: 377 APWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDGTTNEHPRAKPDGFPTLLFFPAGNKSF 556
APWCGHC++L P Y KLA+ + ++V+AK+D T N+ GFPT++FF A +K
Sbjct: 382 APWCGHCKNLAPTYEKLAEEYSDDSNVVVAKIDATENDIS-VSISGFPTIMFFKANDK-V 439
Query: 557 DPITVDTDRTVVAFYKFLKKHASI-PFKLQK 646
+P+ + DRT+ F+ KHAS P K +K
Sbjct: 440 NPVRYEGDRTLEDLSAFIDKHASFEPIKKEK 470
Score = 110 (38.7 bits), Expect = 0.013, P = 0.013
Identities = 26/84 (30%), Positives = 45/84 (53%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMDG 478
+V V +E++ + K ++++ YAPWCGHC++L P Y A L D + + ++D
Sbjct: 23 EVPKVNKEGLNELITAD-KVLMVKFYAPWCGHCKALAPEYESAADELEK-DGISLVEVDC 80
Query: 479 TTNEHPRAKPD--GFPTLLFFPAGNK 550
T ++ G+PTL F G +
Sbjct: 81 TEEGDLCSEYSIRGYPTLNVFKNGKQ 106
>gi|1352384|sp|P11598|PDA3_RAT PROTEIN DISULFIDE ISOMERASE A3 PRECURSOR
(DISULFIDE ISOMERASE ER-60) (ERP60) (58 KDA MICROSOMAL PROTEIN)
(P58) (ERP57) (HIP-70) (Q-2)
Length = 505
Frame 2 hits (HSPs): ____________ ____________________
Annotated Domains: ______________________________________________ _
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
__________________
Annotated Domains:
Entrez other site: PREVENT SECRETION FROM ER (B 502..505
PFAM thiored: Thioredoxin 24..133
PFAM thiored: Thioredoxin 375..485
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 48..56
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 56..65
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 96..107
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 26..95
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 97..129
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 133..372
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 376..444
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 447..484
PROSITE THIOREDOXIN: Thioredoxin family active s 398..416
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 349 (122.9 bits), Expect = 7.6e-31, P = 7.6e-31
Identities = 76/189 (40%), Positives = 115/189 (60%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +++ + LK + KS+P+P
Sbjct: 314 FGLESTTGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIP 371
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
E+N+G VK+VV +FD+IV E KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 372 ETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK P + R + F +L++ A+ P +
Sbjct: 432 AKMDATANDVPSPYEVKGFPTIYFSPA-NKKLTPKKYEGGRELNDFISYLQREATNPPII 490
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 491 QEEKPKKKKKAQ 502
Score = 149 (52.5 bits), Expect = 2.8e-07, P = 2.8e-07
Identities = 42/117 (35%), Positives = 59/117 (50%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + NF+ V D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQ 643
+
Sbjct: 141 TE 142
>gi|91897|pir||A28807 protein disulfide-isomerase (EC 5.3.4.1) ER60 precursor -
rat >gi|56905|emb|CAA30916.1| (X12355) PI-PLC I (AA 1-504) [Rattus
norvegicus] >gi|226092|prf||1410285A phospholipase C I [Rattus
norvegicus]
Length = 504
Frame 2 hits (HSPs): ____________ ____________________
Annotated Domains: ____________ __________ _
__________________________________________________
Database sequence: | | | | | 504
0 150 300 450
__________________
Annotated Domains:
Entrez domain: signal sequence 1..24
Entrez domain: thioredoxin homology #label TX1 33..118
Entrez domain: thioredoxin homology #label TX2 383..469
Entrez region: endoplasmic reticulum retention 501..504
PROSITE THIOREDOXIN: Thioredoxin family active s 397..415
PROSITE THIOREDOXIN: Thioredoxin family active s 49..67
__________________
Plus Strand HSPs:
Score = 349 (122.9 bits), Expect = 7.6e-31, P = 7.6e-31
Identities = 76/189 (40%), Positives = 115/189 (60%), Frame = +2
Query: 119 FGI---SGNAPKVLGYTGNDDGKKFVLDGEVTTD--KIKAFGEDFVEDKLKPFYKSDPVP 283
FG+ +G P V T G+KFV+ E + D ++ F +++ + LK + KS+P+P
Sbjct: 313 FGLESTTGEIPVVAIRTAK--GEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIP 370
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
E+N+G VK+VV +FD+IV E KDVL+E YAPWCGHC++LEP Y +L + L ++VI
Sbjct: 371 ETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 430
Query: 464 AKMDGTTNEHPRA-KPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFKL 640
AKMD T N+ P + GFPT+ F PA NK P + R + F +L++ A+ P +
Sbjct: 431 AKMDATANDVPSPYEVKGFPTIYFSPA-NKKLTPKKYEGGRELNDFISYLQREATNPPII 489
Query: 641 QKPTSTSEXRFQ 676
Q+ + + Q
Sbjct: 490 QEEKPKKKKKAQ 501
Score = 148 (52.1 bits), Expect = 3.7e-07, P = 3.7e-07
Identities = 42/117 (35%), Positives = 59/117 (50%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD--VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKM 472
DV + NF+ V D +L+E +APWCGHC+ L P Y A L+ I + +AK+
Sbjct: 26 DVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKV 83
Query: 473 DGTTNEHPRAK--PDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHA---SIPFK 637
D T N + K G+PTL F G ++ D RT LKK A S+P +
Sbjct: 84 DCTANTNTCNKYGVTGYPTLKIFRDGEEAG---AYDGPRTADGIVSHLKKQAGPASVPLR 140
Query: 638 LQ 643
+
Sbjct: 141 TE 142
>gi|1709618|sp|P55059|PDI_HUMIN PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI)
>gi|625437|pir||JC2291 protein disulfide-isomerase (EC 5.3.4.1)
precursor - Humicola insolens >gi|712823|gb|AAC60578.1| (S74296)
protein disulfide isomerase, PDI {EC 5.3.4.1} [Humicola insolens,
KASI, Peptide, 505 aa] >gi|1089933|prf||2018168A protein disulfide
isomerase [Humicola insolens]
Length = 505
Frame 2 hits (HSPs): ___________ __________________
Annotated Domains: _________________________________________________
__________________________________________________
Database sequence: | | | | | 505
0 150 300 450
__________________
Annotated Domains:
DOMO DM00054: THIOREDOXINFAMILY 21..120
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 122..352
DOMO DM00054: THIOREDOXINFAMILY 354..458
DOMO DM04486: PREVENTSECRETIONFROMERSITE 460..504
Entrez other site: PREVENT SECRETION FROM ER (P 502..505
PFAM thiored: Thioredoxin 20..127
PFAM thiored: Thioredoxin 354..465
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 41..49
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 49..58
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 90..101
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 20..89
PRODOM PD113919: PDI(3) O74568(1) 91..126
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 128..352
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 355..420
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 427..467
PROSITE THIOREDOXIN: Thioredoxin family active s 377..395
PROSITE THIOREDOXIN: Thioredoxin family active s 42..60
__________________
Plus Strand HSPs:
Score = 349 (122.9 bits), Expect = 7.6e-31, P = 7.6e-31
Identities = 76/170 (44%), Positives = 110/170 (64%), Frame = +2
Query: 176 KKFVLDGE--VTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDE 349
+KF D E +T + IKAF +DFV K++P KS+P+PE +G V +VV N++EIVLD+
Sbjct: 313 QKFPFDQEKEITFEAIKAFVDDFVAGKIEPSIKSEPIPEKQEGPVTVVVAKNYNEIVLDD 372
Query: 350 SKDVLLEIYAPWCGHCQSLEPIYNKL-AKHLRNI--DSLVIAKMDGTTNEHPRAKPDGFP 520
+KDVL+E YAPWCGHC++L P Y +L A + ++ D +VIAK+D T N+ P + GFP
Sbjct: 373 TKDVLIEFYAPWCGHCKALAPKYEELGALYAKSEFKDRVVIAKVDATANDVPD-EIQGFP 431
Query: 521 TLLFFPAGNKSFDPITVDTDRTVVAFYKFL----KKHASIPFKLQKPTSTSE 664
T+ +PAG K P+T RTV KF+ K A+I ++ +S +E
Sbjct: 432 TIKLYPAGAKG-QPVTYSGSRTVEDLIKFIAENGKYKAAISEDAEETSSATE 482
Score = 125 (44.0 bits), Expect = 0.00024, P = 0.00024
Identities = 37/111 (33%), Positives = 60/111 (54%), Frame = +2
Query: 299 DVKIVVGNNFDEIVLDESKD-VLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVIAKMD 475
DV + + FD+ + ++ D VL E +APWCGHC++L P Y + A L+ ++ +AK+D
Sbjct: 22 DVVQLKKDTFDDFI--KTNDLVLAEFFAPWCGHCKALAPEYEEAATTLKE-KNIKLAKVD 78
Query: 476 GT--TNEHPRAKPDGFPTLLFFPAGNKSFDPITVDTDRTVVAFYKFLKKHASIP 631
T T+ + +G+PTL F G + P R A ++ K S+P
Sbjct: 79 CTEETDLCQQHGVEGYPTLKVF-RGLDNVSPYK--GQRKAAAITSYMIKQ-SLP 128
>gi|462019|sp|P34329|ER72_CAEEL PROBABLE ERP-72 PROTEIN HOMOLOG PRECURSOR
>gi|630536|pir||S44756 probable protein disulfide-isomerase (EC
5.3.4.1) - Caenorhabditis elegans >gi|289643|gb|AAA27952.1|
(L15188) homology with deoxycytidine kinase; coded for by C.
elegans cDNA CEL06D3 (GenBank: M75920); putative [Caenorhabditis
elegans]
Length = 664
Frame 2 hits (HSPs): _________________ ________________
Annotated Domains: __________________________________________________
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Database sequence: | | | | | | 664
0 150 300 450 600
__________________
Annotated Domains:
BLOCKS BL00194: Thioredoxin family proteins. 214..226
DOMO DM00054: THIOREDOXINFAMILY 82..185
DOMO DM00054: THIOREDOXINFAMILY 187..293
DOMO DM00799: PROTEINDISULFIDE-ISOMERASE 295..542
DOMO DM00054: THIOREDOXINFAMILY 544..649
Entrez other site: PREVENT SECRETION FROM ER. 661..664
PFAM thiored: Thioredoxin 81..185
PFAM thiored: Thioredoxin 192..300
PFAM thiored: Thioredoxin 544..655
PRINTS THIOREDOXIN1: Thioredoxin motif I - 6 213..221
PRINTS THIOREDOXIN2: Thioredoxin motif II - 6 221..230
PRINTS THIOREDOXIN3: Thioredoxin motif III - 6 264..275
PRODOM PD060585: ER72_CAEEL 1..82
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 84..146
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 149..181
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 194..263
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 265..294
PRODOM PD001708: PDI(15) ER60(5) CAQC(5) 301..542
PRODOM PD000175: THIO(41) PDI(30) ER72(12) 545..614
PRODOM PD000611: PDI(23) ER60(10) ER72(9) 617..653
PROSITE THIOREDOXIN: Thioredoxin family active s 103..121
PROSITE THIOREDOXIN: Thioredoxin family active s 214..232
PROSITE THIOREDOXIN: Thioredoxin family active s 567..585
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Plus Strand HSPs:
Score = 353 (124.3 bits), Expect = 1.6e-30, P = 1.6e-30
Identities = 90/206 (43%), Positives = 121/206 (58%), Frame = +2
Query: 26 LKXAAKSFKGKLIFVYVEMDNEDVGKPVSEY-FGISGNAPKVL--GYTGNDDGKKFVL-- 190
L A K K K F D E+ K + E G SG V+ GY DGKK+ +
Sbjct: 454 LNIAQKYQKDKYKFAVA--DEEEFAKELEELGLGDSGLEHNVVVFGY----DGKKYPMNP 507
Query: 191 ---DGEVTTDKIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLDESKDV 361
DGE+ + ++AF + K K KS P P+ + G VK VVG+NFD+IV DESKDV
Sbjct: 508 DEFDGELD-ENLEAFMKQISSGKAKAHVKSAPAPKDDKGPVKTVVGSNFDKIVNDESKDV 566
Query: 362 LLEIYAPWCGHCQSLEPIYNKLAKHLRNID-SLVIAKMDGTTNEHP-RAKPDGFPTLLFF 535
L+E YAPWCGHC+S E Y +LA+ L+ ++V+AKMD T N+ P + +GFPT+ F
Sbjct: 567 LIEFYAPWCGHCKSFESKYVELAQALKKTQPNVVLAKMDATINDAPSQFAVEGFPTIYFA 626
Query: 536 PAGNKSFDPITVDTDRTVVAFYKFLKKHASIPFK 637
PAG KS +PI +R + KF+ KH F+
Sbjct: 627 PAGKKS-EPIKYSGNRDLEDLKKFMTKHGVKSFQ 659
Score = 164 (57.7 bits), Expect = 2.0e-09, P = 2.0e-09
Identities = 47/127 (37%), Positives = 70/127 (55%), Frame = +2
Query: 179 KFVLDGEVTTD----KIKAFGEDFVEDKLKPFYKSDPVPESNDGDVKIVVGNNFDEIVLD 346
KF DG+ D + +A ++VE ++ P YK P PE +V + NFD+ +
Sbjct: 156 KFWKDGKGPNDYDGGRDEAGIVEWVESRVDPNYK--PPPE----EVVTLTTENFDDFI-S 208
Query: 347 ESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLV-IAKMDGTTNEHPRAK--PDGF 517
++ VL+E YAPWCGHC+ L P Y K A+ L+ S V + K+D T + K G+
Sbjct: 209 NNELVLVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGKVDATIEKDLGTKYGVSGY 268
Query: 518 PTLLFFPAGNKSFD 559
PT+ G + FD
Sbjct: 269 PTMKIIRNGRR-FD 281
Score = 145 (51.0 bits), Expect = 1.4e-06, P = 1.4e-06
Identities = 34/87 (39%), Positives = 51/87 (58%), Frame = +2
Query: 284 ESNDGDVKIVVGNNFDEIVLDESKDVLLEIYAPWCGHCQSLEPIYNKLAKHLRNIDSLVI 463
E ++G V ++ NFD L ++ VL++ YAPWCGHC+ L P Y K + + S+ +
Sbjct: 79 EMDEG-VVVLTDKNFDAF-LKKNPSVLVKFYAPWCGHCKHLAPEYEKASSKV----SIPL 132
Query: 464 AKMDGT--TNEHPRAKPDGFPTLLFFPAG 544
AK+D T T R + G+PTL F+ G
Sbjct: 133 AKVDATVETELGKRFEIQGYPTLKFWKDG 161
WARNING: HSPs involving 380 database sequences were not reported due to the
limiting value of parameter B = 50.
Parameters:
filter=none
matrix=BLOSUM62
V=50
B=50
E=10
gi
H=1
sort_by_pvalue
echofilter
ctxfactor=5.87
Query ----- As Used ----- ----- Computed ----
Frame MatID Matrix name Lambda K H Lambda K H
Std. 0 BLOSUM62 0.318 0.135 0.401
+3 0 BLOSUM62 0.318 0.135 0.401 0.351 0.149 0.485
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
+2 0 BLOSUM62 0.317 0.139 0.412 same same same
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
+1 0 BLOSUM62 0.318 0.135 0.401 0.367 0.162 0.736
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
-1 0 BLOSUM62 0.318 0.135 0.401 0.326 0.139 0.436
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
-2 0 BLOSUM62 0.318 0.135 0.401 0.347 0.153 0.553
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
-3 0 BLOSUM62 0.318 0.135 0.401 0.347 0.154 0.540
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
Query
Frame MatID Length Eff.Length E S W T X E2 S2
+3 0 233 230 10. 78 3 12 22 0.11 35
32 0.097 39
+2 0 233 228 10. 78 3 12 22 0.12 35
32 0.12 38
+1 0 234 230 10. 78 3 12 22 0.11 35
32 0.097 39
-1 0 234 229 10. 78 3 12 22 0.11 35
32 0.12 38
-2 0 233 230 10. 78 3 12 22 0.11 35
32 0.097 39
-3 0 233 230 10. 78 3 12 22 0.11 35
32 0.097 39
Statistics:
Database: /usr/local/dot5/sl_home/beauty/seqdb/blast/nr
Title: nr
Release date: unknown
Posted date: 4:06 PM CST Feb 28, 2001
Format: BLAST
# of letters in database: 197,782,623
# of sequences in database: 625,274
# of database sequences satisfying E: 430
No. of states in DFA: 599 (59 KB)
Total size of DFA: 263 KB (320 KB)
Time to generate neighborhood: 0.01u 0.01s 0.02t Elapsed: 00:00:00
No. of threads or processors used: 6
Search cpu time: 244.08u 0.91s 244.99t Elapsed: 00:00:52
Total cpu time: 244.19u 0.95s 245.14t Elapsed: 00:00:54
Start: Thu Jan 17 02:22:52 2002 End: Thu Jan 17 02:23:46 2002
WARNINGS ISSUED: 2
Annotated Domains Database: March 14, 2000
Release Date: March 14, 2000