Dried pig ear dog treats have been implicated in human salmonellosis cases in Canada. To determine whether similar pet treats available in the U.S. were also contaminated, one-hundred and fifty-eight, randomly sampled, imported dog treats made from dried pig ears and other animal parts, were assayed for Salmonella. Forty-nine percent (n=78) of dog treat samples were positive for Salmonella. Twenty-seven different Salmonella serotypes were recovered including Anatum (n=10), Typhimurium (n=7), and Infantis (n=7). The majority of Salmonella isolates were susceptible to the 17 antimicrobials tested, however, resistance was observed to tetracycline (26 %), streptomycin (23 %), sulfamethoxazole (19 %), and chloramphenicol (8 %). Twenty-eight Salmonella isolates were resistant to at least one antimicrobial, whereas 10 isolates displayed resistance to 4 antimicrobials.Two S. Typhimurium DT104 isolates displayed the characteristic penta-resistance phenotype (ACSSuT). One isolate (S. Brandenburg) was resistant to 8 antimicrobials including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline, cephalothin, gentamicin, and apramycin. Salmonella isolates were further screened for the presence of class 1 integrons via PCR. While the majority of Salmonella isolates assayed did not contain class 1 integrons, three Salmonella isolates displaying resistance patterns of ACSSuT or KACSSuT possessed two chromosomal integrons of 1 and 1.2 kb. In conclusion, this study indicates that animal derived dog treats available in the U.S. are a potential source of animal and human salmonella infections.