Delatour F, Prevot MH, Marquetty C, Gougerot-Pocidalo M; International Conference on AIDS.

Int Conf AIDS. 1992 Jul 19-24; 8: 72 (abstract no. PuB 7143).

Pharmacologie Clinique, INSERM U13, Paris, France.

OBJECTIVES: To determine whether the depletion of total glutathione concentration in plasma of HIV-seropositive patients is associated to disease progression, hepatic status, cellular and serologic markers and AZT treatment. METHODS: Total glutathione concentrations [GLU] were enzymatically determined in the plasma of 25 HIV-seronegative healthy controls and 59 HIV-seropositive patients (CDC group II/III n = 17, CDC group IVA/IVC2 n = 17, CDC group IVC1/IVD n = 25). The patients were investigated according to the previous group IV clinical manifestations, concomitant AZT treatment, lymphocyte markers, p24 antigenemia, hepatic enzymatic functions. They were followed up for the next six months. For statistical analysis, distributions were normalized by logarithmic transformation and the Student's t-test or Spearman's rank correlation coefficient were used. RESULTS: A significative difference was observed in [GLU] mean value between controls (9.77 +/- 1.59 microM/L) and each group: II/III (8.73 +/- 1.2 microM/L; p less than .05), IVA/C2 (7.4 +/- 1.11 microM/L; p less than .001), IVC1/D (7 +/- 2.0 microM/L; p less than .001). Groups II/III was significantly different from the two others. Furthermore [GLU] is correlated to CD4 cell counts (p less than .05), absolute lymphocyte counts (p less than .05) and the number of group IV clinical manifestations (p less than .01). A decreased [GLU] mean value was associated with an altered hepatic function (p less than .02), no difference was observed with concomitant AZT therapy or p24 positive antigenemia. Further group IV clinical manifestations appearing for the next 6 months do not seem to be linked to a low [GLU] value. CONCLUSIONS: Plasma total glutathione concentrations decreased mainly with HIV disease progression but does not seem to be a good individual parameter of the disease stage.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• CD4 Lymphocyte Count
• Disease Progression
• Glutathione
• HIV Infections
• HIV Seropositivity
• Humans
• Zidovudine

Other ID:

• 92404428

UI: 102202142

From Meeting Abstracts