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Chemical Name: 5-(3-Methyl-but-3-enyl)-3-(1-phenyl-1H-pyrrol-3-yl)-oxazolidin-2-one AIDS# 195988
CHEMICAL STRUCTURE Synonyms
 
C18 H20 N2 O2 MW: 296.37 CAS#
Company:  Calc. Log P: 5.34
Classes: ANTITUBERCULOUS AGENTS; ANTIMYCOBACTERIALS

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC27294
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC90
IVT MIC Result:  74 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID 9.8 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC35820 (STREPTOMYCIN-RESISTANT)
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC90
IVT MIC Result: >= 100 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID >100 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC35828 (PYRAZINAMIDE-RESISTANT)
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC50
IVT MIC Result:  50.3 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID 0.1 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC35828 (PYRAZINAMIDE-RESISTANT)
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC90
IVT MIC Result: > 100 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID >100 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC35837 (ETHAMBUTOL-RESISTANT)
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC50
IVT MIC Result:  23.8 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID 0.2 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC35837 (ETHAMBUTOL-RESISTANT)
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC90
IVT MIC Result:  100 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID 13 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: C.I.1104
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC90
IVT MIC Result:  77.8 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID 0.2 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC27294
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC50
IVT MIC Result:  19 uM
Inhibitory Activity: 1-SOME
ACTIVITY
IVT Positive Control: ISONIAZID 0.09 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: C.I.1104
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC50
IVT MIC Result:  10.5 uM
Inhibitory Activity: 1-SOME
ACTIVITY
IVT Positive Control: ISONIAZID 0.06 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: M.TB
Strain: ATCC35820 (STREPTOMYCIN-RESISTANT)
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC50
IVT MIC Result:  5.6 uM
Inhibitory Activity: 2-MODERATE
ACTIVITY
IVT Positive Control: ISONIAZID 1.3 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: MAC
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC90
IVT MIC Result:  32.8 uM
Inhibitory Activity: 0-INACTIVE
IVT Positive Control: ISONIAZID 4.7 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

AIDS#: 195988(click to go back)
IVT Organism: MAC
Cell Line: MT-4
Cytotox IC50: >100 uM
Cytotox Activity: 4-HIGH
ACTIVITY
IVT MIC Kind: MIC50
IVT MIC Result:  4 uM
Inhibitory Activity: 3-ACTIVE
IVT Positive Control: ISONIAZID 1.4 uM
Literature Reference: 11684 SBARDELLA, G; MAI, A; ARTICO, M; LODDO, R; SETZU, MG; LA COLLA, P, BIOORG MED CHEM LETT 14(6):1537-1541(2004).

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