Organism

8 Record(s) returned from your Search Criteria

Organism

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Chemical Name: N-{[3-(3-Fluoro-4-(1,4-thiazaperhydroin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide			Synonyms Oxazolidininone U-100480 PNU 100480 PNU-100480		AIDS# 045415
					Links to ChemID Plus by CAS# 168828-58-8
					Links to PubChem by AIDS# 045415

C16 H20 F N3 O3 S		MW: 353.42			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 8	PHIA (Flexible Bonds): 5.62	Calc. LogP (MDL QSAR): 1.65
Company: UPJOHN			Calc. LogP (KowWin): 2.12
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 43	TB Min MIC 0.0056 ug/mL	TB Min IC50 < 0.125 ug/mL	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 7	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; OXAZOLIDINES; ANTIMYCOBACTERIALS; THIOMORPHOLINES

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			3-ACTIVE					11684	View
Mycobacterium tuberculosis			4-HIGH ACTIVITY					11684	View
Mycobacterium avium(complex)			2-MODERATE ACTIVITY					11684	View
Mycobacterium avium(complex)			4-HIGH ACTIVITY					11684	View

Chemical Name: 5-(3-Methyl-but-3-enyl)-3-(1-phenyl-1H-pyrrol-3-yl)-oxazolidin-2-one			Synonyms		AIDS# 195988
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195988

C18 H20 N2 O2		MW: 296.37			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 3	PHIA (Flexible Bonds): 4.34	Calc. LogP (MDL QSAR): 3.12
Company:			Calc. LogP (KowWin): 5.34
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 12	TB Min MIC 5.6 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; ANTIMYCOBACTERIALS

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium tuberculosis			1-SOME ACTIVITY					11684	View
Mycobacterium tuberculosis			2-MODERATE ACTIVITY					11684	View
Mycobacterium avium(complex)			0-INACTIVE					11684	View
Mycobacterium avium(complex)			3-ACTIVE					11684	View

Chemical Name: 3-[1-(2-Fluoro-phenyl)-1H-pyrrol-3-yl]-5-(3-methyl-but-3-enyl)-oxazolidin-2-one			Synonyms		AIDS# 195989
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195989

C18 H19 F N2 O2		MW: 314.36			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 4	PHIA (Flexible Bonds): 4.52	Calc. LogP (MDL QSAR): 2.94
Company:			Calc. LogP (KowWin): 5.54
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 10	TB Min MIC 1.1 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; ANTIMYCOBACTERIALS

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium tuberculosis			1-SOME ACTIVITY					11684	View
Mycobacterium tuberculosis			2-MODERATE ACTIVITY					11684	View
Mycobacterium tuberculosis			3-ACTIVE					11684	View
Mycobacterium avium(complex)			2-MODERATE ACTIVITY					11684	View
Mycobacterium avium(complex)			3-ACTIVE					11684	View

Chemical Name: 3-[1-(3-Fluoro-phenyl)-1H-pyrrol-3-yl]-5-(3-methyl-but-3-enyl)-oxazolidin-2-one			Synonyms		AIDS# 195990
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195990

C18 H19 F N2 O2		MW: 314.36			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 4	PHIA (Flexible Bonds): 4.52	Calc. LogP (MDL QSAR): 2.89
Company:			Calc. LogP (KowWin): 5.54
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 12	TB Min MIC 0.9 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; ANTIMYCOBACTERIALS

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium tuberculosis			1-SOME ACTIVITY					11684	View
Mycobacterium tuberculosis			2-MODERATE ACTIVITY					11684	View
Mycobacterium tuberculosis			4-HIGH ACTIVITY					11684	View
Mycobacterium avium(complex)			0-INACTIVE					11684	View
Mycobacterium avium(complex)			3-ACTIVE					11684	View

Chemical Name: 3-[1-(4-Fluoro-phenyl)-1H-pyrrol-3-yl]-5-(3-methyl-but-3-enyl)-oxazolidin-2-one			Synonyms		AIDS# 195991
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195991

C18 H19 F N2 O2		MW: 314.36			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 4	PHIA (Flexible Bonds): 4.52	Calc. LogP (MDL QSAR): 2.98
Company:			Calc. LogP (KowWin): 5.54
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 10	TB Min MIC 0.8 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; ANTIMYCOBACTERIALS

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium tuberculosis			1-SOME ACTIVITY					11684	View
Mycobacterium tuberculosis			3-ACTIVE					11684	View
Mycobacterium tuberculosis			4-HIGH ACTIVITY					11684	View
Mycobacterium avium(complex)			2-MODERATE ACTIVITY					11684	View
Mycobacterium avium(complex)			3-ACTIVE					11684	View

Chemical Name: 3-[1-(3-Fluoro-4-morpholin-4-yl-phenyl)-1H-pyrrol-3-yl]-5-(3-methyl-but-3-enyl)-oxazolidin-2-one			Synonyms		AIDS# 195992
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195992

C22 H26 F N3 O3		MW: 399.46			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 6	PHIA (Flexible Bonds): 6.03	Calc. LogP (MDL QSAR): 2.67
Company:			Calc. LogP (KowWin): 5.33
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 12	TB Min MIC 4.9 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium tuberculosis			1-SOME ACTIVITY					11684	View
Mycobacterium tuberculosis			3-ACTIVE					11684	View
Mycobacterium avium(complex)			0-INACTIVE					11684	View
Mycobacterium avium(complex)			1-SOME ACTIVITY					11684	View

Chemical Name: 3-[1-(3-Fluoro-4-thiomorpholin-4-yl-phenyl)-1H-pyrrol-3-yl]-5-(3-methyl-but-3-enyl)-oxazolidin-2-one			Synonyms		AIDS# 195993
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195993

C22 H26 F N3 O2 S		MW: 415.53			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 6	PHIA (Flexible Bonds): 6.32	Calc. LogP (MDL QSAR): 3.48
Company:			Calc. LogP (KowWin): 6.18
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 6	TB Min MIC 9.8 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; ANTIMYCOBACTERIALS; THIOMORPHOLINES

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium tuberculosis			1-SOME ACTIVITY					11684	View
Mycobacterium tuberculosis			2-MODERATE ACTIVITY					11684	View
Mycobacterium avium(complex)			1-SOME ACTIVITY					11684	View
Mycobacterium avium(complex)			2-MODERATE ACTIVITY					11684	View

Chemical Name: 5-(3-Methyl-but-3-enyl)-3-(1-morpholin-4-yl-1H-pyrrol-3-yl)-oxazolidin-2-one			Synonyms		AIDS# 195994
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 195994

C16 H23 N3 O3		MW: 305.38			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 5	PHIA (Flexible Bonds): 4.85	Calc. LogP (MDL QSAR): 0.48
Company:			Calc. LogP (KowWin): 3.36
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 12	TB Min MIC > 100 uM	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes:

Anti-Opportunistic Infection Data Summary

IVT ORGANISM	ENZYME NAME	ENZYME ACTIVITY	INHIBITION ACTIVITY	IVT OTHER ACTIVITY	IVV ORGANISM	*MODEL*	IVV ACTIVITY	*LIT. REF. #*	ALL OI Data
Mycobacterium tuberculosis			0-INACTIVE					11684	View
Mycobacterium avium(complex)			0-INACTIVE					11684	View

NIAID Home / Anti-Opportunistic Infection Search / Anti-Opportunistic Infection Results / Alternate View