Tugwell P, Wells G, Shea B, Peterson J, Cranney A, Henry D, O'Connell D, Robertson J, Gillespie B; International Society of Technology Assessment in Health Care. Meeting.

Annu Meet Int Soc Technol Assess Health Care Int Soc Technol Assess Health Care Meet. 1997; 13: 125.

University of Ottawa, Clinical Epidemiology Unit, Ontario, Canada.

OBJECTIVES: The purpose of this systematic review was to determine the effectiveness of HRT on bone loss in postmenopausal women. It is thought that the use of HRT slows bone loss, and has a beneficial effect on the bone mineral density (BMD) of women, thus preveting fractures. METHODS: All randomized controlled (RCTs) in which treatment with HRT was compared to control. The primary outcome was BMD expressed as the percent of baseline. A comprehensive literature review was conducted using MEDLINE supplemented by manual reviews of bibliographies. Quality assessment and data extraction were conducted by two independent reviewers. RESULTS: Thirty-five RCTs were identified. Results vary by side and methods of bone measurement. In particular, for studies evaluating lumbar spine for unopposed and opposed estrogent, the pooled weighted mean difference of the percent of baseline BMD for primary prevention is 4.93 (95% CI 4.26, 5.6) based on 16 trials and for secondary prevention is 8.72 (95% CI 7.71, 9.74) based on 7 trials. Similarly, for femoral neck: 3.40 (95% CI (1.64, 5.11) on 2 trials and 2.32 (95% CI (-0.71, 5.35) on 1 trial. For forearm: 3.48 (95% CI 3.10, 8.70) on 14 trials and 3.07 (95% CI 0.61, 5.53) on 3 trials. CONCLUSIONS: The systematic review of RCTS has demonstrated that HRT is efficacious in halting bone loss in postmenopausal women.

Publication Types:

• Meeting Abstracts

Keywords:

• Bone Density
• Clinical Trials as Topic
• Dietary Supplements
• Estrogen Replacement Therapy
• Female
• Femur
• Fractures, Bone
• Heart
• Hormone Replacement Therapy
• Humans
• Lumbar Vertebrae
• Osteoporosis
• Randomized Controlled Trials as Topic
• Research Design
• United States
• hsrmtgs

Other ID:

• HTX/98601704

UI: 102233249

From Meeting Abstracts