Note from the Centers for Disease Control and Prevention (CDC) and the National Guideline Clearinghouse (NGC): On September 19, 2008 the CDC released updated guidelines on hepatitis B. For more information see the NGC summary Recommendations for Identification and Public Health Management of Persons with Chronic Hepatitis B Virus Infection.
Recommendations are followed by a strength of evidence rating (Strongly Recommended, Recommended, Indicated, Not Recommended), which are defined at the end of the "Major Recommendations" field.
Recommendations for Juvenile Correctional Facilities -- Hepatitis A Virus Infection
- Hepatitis A vaccination should be administered to all
juveniles in those states where routine vaccination is recommended (Refer to
Box 1 in the original guideline document). Strongly recommended.
- In all other states, hepatitis A vaccination of all
juveniles should be considered because of the high prevalence of risk factors
for hepatitis A virus (HAV) infection among this population. Indicated.
- Vaccination should be administered to those juveniles
with risk factors for HAV infection (see Box 1 in the original guideline document) or
for those at risk for severe adverse outcomes of infection (e.g., persons with
chronic liver disease). Strongly recommended.
- Vaccination should be initiated as soon as possible
after entry into incarceration or detention using the appropriate dosage and
schedule (standard practice) (Refer to Table 3 in the original guideline document).
- Tracking systems to ensure completion of vaccine
series within the correctional system should be established, and systems
should be established to facilitate completion of the vaccine series in the
community (standard practice).
- Vaccination information, including date of
administration, dose, and manufacturer should be included in the medical
record, and an immunization record should be given to juvenile, or their
parents or guardians, upon release (standard practice).
- Routine screening or prevaccination testing of
juveniles for markers of HAV infection should not be conducted. Not
recommended.
- Prevaccination testing should be considered for older
adolescents (e.g., >15 years) in certain population groups (i.e., American
Indians, Alaska Natives, and Hispanics) because of higher prevalence of
infection or previous infection. Indicated.
- Juveniles with signs or symptoms indicative of acute hepatitis should have appropriate diagnostic testing to differentiate acute hepatitis A, hepatitis B, or hepatitis C and to determine if the patients have chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (standard practice).
- Cases of acute hepatitis A should be reported to
the appropriate public health jurisdiction (e.g., county or state health
department) (standard practice).
- Identification of a case of hepatitis A in a
correctional facility should prompt an epidemiologic investigation by
correctional officials, in collaboration with the appropriate health
authorities, to identify the source of infection and contacts who might have
been exposed (standard practice).
- Unvaccinated close contacts of a confirmed case of hepatitis A should be administered postexposure prophylaxis with 1 dose of immune globulin (IG) (0.02 mL/kg body weight, intramuscular) as soon as possible, but not > 2 weeks after the last exposure. If the contact has indications for hepatitis A vaccination, vaccine should be administered either at the same or a later time (Box 3 in the original guideline document). Strongly recommended.
Recommendations for Juvenile Correctional Facilities -- Hepatitis B Virus Infection
Preventing Perinatal HBV Infection
- All pregnant incarcerated juveniles should be tested
for hepatitis B surface antigen (HBsAg) after their pregnancy is recognized,
even if previously vaccinated or tested. Because of the high risk of HBV
infection among this population, testing should be performed even if the
female was tested before incarceration. The HBsAg status of incarcerated
pregnant juveniles should be reported to the hospital where the juvenile will
deliver her infant, along with other prenatal medical information.
HBsAg-positive females should also be reported to the appropriate public
health authority. Strongly recommended.
- Infants born to HBsAg-positive mothers should receive hepatitis B immune globulin (HBIG) (0.5 mL) and the first dose of hepatitis B vaccine < 12 hours of birth. Strongly
recommended.
- Females admitted for delivery without HBsAg test results should have blood drawn for testing. While test results are pending, the infant should receive hepatitis B vaccine without HBIG within 12 hours of birth (Refer to Table 4 in the original guideline document for recommended dosages of licensed hepatitis B vaccines.) (standard practice).
- If the mother is later determined to be HBsAg-positive, her infant should receive HBIG as soon as possible, but <7 days after birth. If the infant does not
receive HBIG, the second dose of vaccine should be administered at 1 month
of age. The final dose should be administered at age 6 months. Strongly
recommended.
- If the mother is determined to be HBsAg-negative,
her infant should continue to receive hepatitis B vaccine as part of the
routine vaccination schedule. Strongly recommended.
- If the mother is never tested to determine her HBsAg status, the infant should continue to receive hepatitis B vaccine as part of the routine vaccination schedule. Strongly recommended.
- Case management should be established to ensure
appropriate postexposure prophylaxis and follow-up for children born to
incarcerated or recently released HBsAg-positive mothers, including completion
of the vaccine series at age 6 months and postvaccination testing during ages
9-15 months. Recommended.
- Infants born to HBsAg-negative mothers should receive
the first dose of hepatitis B vaccine before release from the hospital.
Strongly recommended.
- Previously unvaccinated HBsAg-negative pregnant
juveniles should be vaccinated; pregnancy is not a contraindication to
vaccination. Strongly recommended.
- Discharge planning for pregnant HBsAg-positive juveniles should include transfer of appropriate medical records to the hospital where the juvenile plans to deliver her infant, along with other prenatal medical information. Test results should also be provided to the patient and her parent or guardian (standard practice).
Hepatitis B Vaccination
Preexposure
- All juveniles who receive a medical evaluation in a correctional facility should be administered hepatitis B vaccine, unless they have proof of completion of the vaccine series or serologic evidence of immunity to infection. The vaccine series should be started for those juveniles who have never been vaccinated, irrespective of their length of stay, and the series should be completed for those incompletely immunized. Strongly recommended.
- For juveniles who do not receive medical evaluation
upon entry into correctional custody, vaccination should be considered for
those who lack proof of previous vaccination (standard practice).
- Catch-up vaccination of previously unvaccinated, already incarcerated juveniles should be considered in facilities in which routine hepatitis B vaccination of entering inmates is established (standard practice).
- An appropriate vaccination dose and schedule should
be selected to facilitate completion of the vaccine series while the juvenile
is in custody. For previously unvaccinated juveniles held in a correctional
facility for <6 months, the vaccine series should be initiated and
completed by using a 4-month schedule (0, 1-2, and 4 months). Recommended.
- Vaccination information, including date of
administration, dose, and manufacturer should be included in the medical
record, and an immunization record should be given to juveniles, or to their
parents or guardians, upon release (standard practice).
- Discharge planning should include transfer of immunization records to the person's medical home to ensure completion of the vaccine series for those juveniles not fully vaccinated while in the correctional facility, and for all fully vaccinated persons as well (standard practice).
Prevaccination and Postvaccination Testing
- Prevaccination serologic testing is not indicated. Indicated.
- As hepatitis B vaccination coverage among
adolescents increases, validation of immunization records or serologic
testing might become a cost-effective means to minimize overvaccination.
Indicated.
- Knowledge of state middle school hepatitis B vaccination requirements and performance of periodic vaccine coverage serologic surveys to determine the proportion of vaccinated or immune adolescents entering juvenile facilities should be used to define prevaccination screening policies (e.g., history or serologic testing) and the need for hepatitis B immunization among specific age groups (standard practice).
- Postvaccination testing should not be conducted for
healthy juveniles. Not recommended.
- For juveniles with special conditions (e.g., immunocompromised or HIV-infected), postvaccination testing for antibody to hepatitis B surface antigen (anti-HBs) should be conducted 1-2 months after completion of the vaccine series. Nonresponders in this category should be revaccinated. Strongly recommended.
Postexposure Prophylaxis
- After any percutaneous exposure (e.g., sharing injection-drug equipment or human bite) or mucosal exposure (e.g., sexual) to blood, unvaccinated juveniles should begin the vaccine series, and the exposure incident should be evaluated to determine if additional postexposure prophylaxis (i.e., HBIG) is required (Refer to the erratum, "Errata: Vol.52, No. RR-1"). Strongly recommended.
- The first dose of hepatitis B vaccine should be
administered immediately, and the remaining doses, 1 and 6 months later
(standard practice).
- For an exposed juvenile who has begun but not
completed the vaccine series, subsequent vaccine doses should be
administered as scheduled (standard practice).
- The person who was the source of the exposure should be tested for HBsAg, even if this person was previously vaccinated. If the source person is HBsAg-positive, HBIG should be administered to the exposed person as soon as possible and <7
days after the exposure (standard practice).
- Postexposure prophylaxis is not necessary for a fully vaccinated juvenile after exposure to HBV. Not recommended.
Serologic Testing for Hepatitis B Virus Infection
- Routine testing of juveniles for markers of HBV
infection (e.g., HBsAg, anti-HBs, antibody to hepatitis B core antigen
[anti-HBc]) is not recommended. Not recommended.
- Juveniles with signs or symptoms indicative of viral hepatitis should have appropriate diagnostic testing to differentiate acute hepatitis A, hepatitis B, or hepatitis C and to determine if the patient has chronic HBV or HCV infection (standard practice).
- Cases of acute hepatitis B should be reported to
the appropriate public health authority (standard practice).
- Cases of chronic HBV infection should be reported in those states that require reporting (standard practice).
- Identification of a case of acute hepatitis B should prompt an epidemiologic investigation by correctional officials, in collaboration with the appropriate health authorities, to identify the source of infection and provide appropriate postexposure prophylaxis (Refer to the erratum, "Errata: Vol.52, No. RR-1" and Box 6 in the original guideline document) to nonimmunized contacts at risk for infection (standard practice).
Chronic Hepatitis B Treatment
- Juveniles identified as having, or who are known to have chronic HBV infection during routine medical screening should be evaluated to determine the presence and extent of chronic liver disease and candidacy for antiviral therapy. Recommended.
- Lamivudine can be used to treat patients aged >2
years.
- The safety and efficacy of interferon and adefovir
in pediatric patients has not been established.
- Treatment of patients with chronic hepatitis B should be conducted in consultation with a pediatric specialist experienced with these treatment regimens.
- All long-term correctional facilities should
establish criteria for identification of inmates who might benefit from
treatment, on the basis of the latest treatment guidelines (standard
practice).
- Discharge planning for persons with chronic HBV infection should include referral to medical care, risk-reduction programs, and social services necessary to maintain behavior changes; vaccination of contacts should also be arranged before patient discharge (standard practice).
Recommendations for Juvenile Correctional Facilities -- Hepatitis C Virus Infection
Testing for Hepatitis C Virus Infection
- A history of risk factors for HCV infection should be
obtained from juveniles undergoing medical evaluations, and those with risk
factors should be tested for anti-HCV (see Box 7 in the original guideline document).
Routine testing of all juveniles for anti-HCV should not be conducted. Not
recommended.
- Juveniles with signs or symptoms indicative of viral
hepatitis should have appropriate diagnostic testing to differentiate acute
hepatitis A, hepatitis B, or hepatitis C and to determine if the patient has
chronic HBV or HCV infection (see Box 2 in the original guideline document) (standard practice).
- Cases of acute hepatitis C should be reported to the
appropriate public health authority (standard practice).
- Anti-HCV-positive persons should be reported if
required by state laws or regulations (standard practice).
- Identification of juveniles with acute hepatitis C,
including those incarcerated for >6 months, should prompt an epidemiologic
investigation by correctional officials, in collaboration with the appropriate
health authorities, to identify the source of the infection. Depending on the
results of the investigation, testing of contacts might be indicated (see Box
7 in the original guideline document) (standard practice).
- Juveniles who are anti-HCV-positive should receive further medical evaluation to determine if they are chronically infected (Box 2 of the original guideline document) (standard practice).
Postexposure Management for HCV
- After a percutaneous or permucosal exposure to blood,
the source person should be tested for anti-HCV. If the source person is
anti-HCV-positive, the exposed person should be tested for anti-HCV and ALT
activity at baseline and 4-6 months later. For earlier diagnosis, testing for
HCV ribonucleic acid (RNA) can be performed in 4-6 weeks. Recommended.
- IG and antiviral agents are not recommended for postexposure prophylaxis of hepatitis C. Not recommended.
Chronic Hepatitis C Treatment
- Juveniles identified as having chronic HCV infection
should be evaluated to determine the presence and extent of chronic liver
disease. Food and Drug Administration (FDA)-approved antiviral agents for
treatment of hepatitis C are not indicated for persons aged <18 years,
although participation in clinical trials might be possible. Although HCV
infection in juveniles can result in less severe disease, infected juveniles
should be monitored by a specialist familiar with this disease. Discharge
planning should also include drug and alcohol abuse treatment, risk-reduction
programs, and social services necessary to maintain behavior changes (standard
practice).
- Juveniles with chronic hepatitis C should receive hepatitis B vaccination and hepatitis A vaccination if not previously immunized or known to be susceptible to infection. Recommended.
Juvenile Health Education and Release Planning
- Prevention of HAV, HBV, and HCV infections should be
incorporated into health education programs (e.g., programs for preventing
HIV/AIDS) and include information concerning modes of disease transmission and
means for prevention, including risk-reduction and immunization (see Box 8 in
the original guideline document). Indicated.
- An integrated health education and risk reduction
program should be established in each facility and include a written plan of
health instruction completed by each inmate (standard practice).
- Such instruction should address a range of issues
relevant to the diverse developmental and cultural composition of correctional
populations, and should include basic skill development, literacy, and home
economics, as well as tools needed to avoid behaviors that result in
acquisition of HIV, hepatitis, and other bloodborne and sexually transmitted
infections (standard practice).
- Teachers should be trained professionals or inmate
peers with specific training to teach comprehensive life-skills programs,
including health education (standard practice).
- A system for periodic evaluation, updating and
improvement should exist (standard practice).
- Documentation of hepatitis A or hepatitis B
vaccination should be included in the medical record retained within the
correctional system, as well as in any medical record provided to other
health-care providers. In addition, vaccinated persons or their parents or
guardians should be provided a personal immunization record (standard
practice).
- Juvenile correctional health facilities should
establish links with community and public health facilities, and where
available, with immunization registries, to ensure tracking and completion of
hepatitis A and hepatitis B vaccine series (standard practice).
- Juveniles with chronic HBV or HCV infection should be:
- counseled, along with their parent or guardian,
regarding preventing transmission to household, sexual, and drug-use
contacts
- provided referral for hepatitis B vaccination of
contacts
- counseled regarding ways to reduce further liver
damage, including limiting alcohol and drug use, and afforded
substance-abuse treatment when appropriate
- provided aftercare that includes medical follow-up (standard practices)
Recommendations for Adult Correctional Facilities -- Hepatitis A Virus Infection
- Hepatitis A vaccination should be administered to
adults in groups at risk for HAV infection (e.g., men who have sex with men
[MSM] or drug users) or who are likely to experience severe adverse outcomes
of infection (e.g., persons with chronic liver disease) (Refer to Box 1 in the
original guideline document for other groups for whom vaccination is recommended.)
Strongly recommended.
- For persons at risk, the vaccination series should be
initiated as soon as possible after incarceration using the appropriate dosage
and schedule (see Table 3 in the original guideline document). Tracking systems to
ensure completion of the vaccine series within the correctional system should
be established, and systems should be developed to facilitate completion of
the second vaccine dose for those inmates who return to the community.
Strongly recommended.
- Prevaccination serologic testing to identify
susceptible persons should be considered if determined to be cost-effective
(see Box 5 of the original guideline document for method to determine
cost-effectiveness), and it does not compromise initiation of vaccination.
Inmates aged >40 years and those from regions of high endemicity should be
considered for prevaccination testing because of the high prevalence of past
HAV infection among these groups. Indicated.
- Routine screening of adults for anti-HAV should not
be conducted, except when used to identify susceptible persons for
vaccination. Not recommended.
- Vaccination information, including date of
administration, dose, and manufacturer should be included in the medical
record, and an immunization record should be given to the inmate upon release
(standard practice).
- Adults with signs or symptoms indicative of acute hepatitis should have appropriate diagnostic testing to differentiate acute hepatitis A, hepatitis B, or hepatitis C, and to determine if the patient has chronic HBV or HCV infection (see Box 2 of the original guideline document for specific diagnostic tests to be performed) (standard practice).
- Cases of hepatitis A should be reported to the
appropriate public health authority (standard practice).
- Identification of a case of hepatitis A in a
correctional facility should prompt an epidemiologic investigation by
correctional officials, in collaboration with the appropriate health
authorities, to identify the source of infection and contacts that might
have been exposed (standard practice).
- Unvaccinated or known susceptible close contacts of a confirmed case of hepatitis A should be administered postexposure prophylaxis with a single dose of IG (0.02 mL/kg body weight, intramuscular) as soon as possible, but not >2 weeks after the last exposure (see Box 3 of the original guideline document for additional guidelines on postexposure prophylaxis). Strongly recommended.
Recommendations for Adult Correctional Facilities -- Hepatitis B Virus Infection
Preventing Perinatal HBV Infection
- All pregnant women should be tested for HBsAg after
their pregnancy is recognized, even if previously vaccinated or tested.
Because of the high risk for HBV infection among this incarcerated population,
testing should be performed even if the woman was tested before incarceration.
The HBsAg status of a pregnant woman should be reported to the hospital where
she will deliver her infant, along with other prenatal medical information.
HBsAg-positive women should also be reported to the appropriate public health
authority. Strongly recommended.
- Infants born to HBsAg-positive mothers should receive HBIG (0.5 mL) and the first dose of hepatitis B vaccine <12 hours after birth (see Table 4 of the original
guideline document for recommended dosages of hepatitis B vaccines). Strongly
recommended.
- Females admitted for delivery without HBsAg test results should have blood drawn for testing. While test results are pending, the infant should receive hepatitis B vaccine without HBIG within 12 hours of birth (standard practice).
- If the mother is later determined to be HBsAg-positive, her infant should receive HBIG as soon as possible, but <7 days after birth. If the infant does not
receive HBIG, the second dose of vaccine should be administered at 1 month
of age. The final dose should be given at age 6 months. Strongly
recommended.
- If the mother is determined to be HBsAg-negative,
her infant should continue to receive hepatitis B vaccine as part of the
routine vaccination schedule. Strongly recommended.
- If the mother is never tested to determine her HBsAg status, the infant should continue to receive hepatitis B vaccine as part of the routine vaccination schedule. Strongly recommended.
- Case management should be established to ensure
appropriate postexposure prophylaxis and follow-up for children born to
incarcerated or recently released HBsAg-positive mothers, including completion
of the vaccine series at age 6 months and postvaccination testing during ages
9-15 months. Recommended.
- Infants born to HBsAg-negative mothers should receive
the first dose of hepatitis B vaccine before release from the hospital.
Strongly recommended.
- Previously unvaccinated HBsAg-negative pregnant women
should be vaccinated; pregnancy is not a contraindication to vaccination.
Strongly recommended.
- Discharge planning for pregnant HBsAg-positive women should include transfer of appropriate medical records to the hospital where the woman plans to deliver her infant, along with other prenatal medical information. Test results should also be provided to the patient (standard practice).
Hepatitis B Vaccination
Preexposure
- All adults who receive a medical evaluation in a correctional facility should be administered hepatitis B vaccine, unless they have proof of completion of the vaccine series or serologic evidence of immunity to infection. The vaccine series should be started for those who have never been vaccinated, irrespective of the length of their stay, and the series should be completed for those incompletely immunized. Strongly recommended.
- For persons who did not receive medical evaluation
upon entry into correctional custody, vaccination should be considered for
those who lack proof of previous vaccination or immunity. Recommended.
- Catch-up vaccination of already incarcerated, previously unvaccinated persons, or persons known to be susceptible to infection, should be considered in facilities in which routine hepatitis B vaccination of entering inmates is being established. Priority should be given to vaccination of contacts of known HBsAg-positive persons (e.g., cellmates or persons living in the same cell block or dormitory). Recommended.
- An appropriate vaccination dose and schedule should
be selected to facilitate completion of the vaccine series while the person is
in custody. For previously unvaccinated persons held in a correctional
facility for <6 months, the vaccine series should be initiated and
completed by using a 4-month schedule (0, 1-2, and 4 months) (Refer to Table 4
in the original guideline document). Recommended.
- Vaccination information, including date of
administration, dose, and manufacturer should be included in the medical
record, and an immunization record should be given to the incarcerated person
upon release (standard practice).
- Discharge planning should include transfer of immunization records to the person's medical home to ensure completion of the vaccine series for persons not fully vaccinated while in the correctional facility, and for all fully vaccinated persons as well (standard practice).
Prevaccination and Postvaccination Testing
- Prevaccination serologic testing should be considered for adult incarcerated populations and is likely to be cost-effective when the prevalence of immunity from prior infection and vaccination exceeds 25%-30%. Indicated.
- To assist correctional facilities in determining
whether to conduct prevaccination testing, periodic serologic surveys of
incoming inmates can be used to determine the prevalence of markers of
immunity to HBV infection (standard practice).
- Testing for anti-HBs provides the best measure of
immunity to HBV infection, because it detects infection or vaccine-induced
immunity (standard practice).
- When prevaccination testing is done, the first dose of vaccine should be administered at the same time the blood sample is obtained to ensure optimal vaccination coverage (see Box 5 of the original guideline document). Recommended.
- Postvaccination testing is not indicated for healthy
adults. Not recommended.
- For persons with special conditions (e.g., immunodeficiency, HIV infection, or chronic hemodialysis), or who are likely to be exposed to HBV (e.g., sex partner of HBsAg-positive person or health-care worker), postvaccination testing for anti-HBs is recommended 1-2 months after completion of the vaccination series. Nonresponders in this category should be revaccinated. Strongly recommended.
Postexposure Prophylaxis
- After any percutaneous (e.g., sharing injection-drug equipment or human bite) or mucosal (e.g., sexual) exposure to blood, an unvaccinated person should begin the vaccine series, and the exposure incident should be evaluated to determine if additional postexposure prophylaxis (i.e., HBIG) is required (see Table 5 in the erratum, "Errata: Vol.52, No. RR-1"). Strongly recommended.
- The first dose of hepatitis B vaccine should be
administered immediately, and the remaining doses 1 and 6 months later
(refer to Table 4 in the original guideline document for additional dosage
information) (standard practice).
- For an exposed person who has begun but not
completed the vaccine series, subsequent vaccine doses should be
administered as scheduled (standard practice).
- The person who was the source of the exposure should be tested for HBsAg, even if that person was previously vaccinated. If the source person is HBsAg-positive, HBIG (0.06 mL/kg body weight intramuscular) should be administered to the exposed person as soon as possible and <7 days after the exposure
(standard practice).
- Postexposure prophylaxis is not necessary for a fully vaccinated person after exposure to HBV. Not recommended.
Serologic Testing for Hepatitis B Virus Infection
- Correctional facilities should consider routine
testing of long-term inmates for chronic HBV infection (see Box 2 and Table 2
in the original guideline document), to facilitate rapid vaccination of contacts,
direct counseling for preventing secondary transmission, and ensure medical
evaluation of infected persons. If routine testing is not performed, testing
should be considered for inmates in groups with risk factors for chronic HBV
infection (e.g., injection-drug use, men who have sex with men or foreign-born
persons from countries with high rate of infection). Indicated.
- Residents of any facility with signs or symptoms indicative of viral hepatitis should have appropriate diagnostic testing to differentiate acute hepatitis A, hepatitis B, and hepatitis C and to determine if the patient has chronic HBV or HCV infection (see Box 2 in the original guideline document) (standard practice).
- Cases of acute hepatitis B should be reported to
the appropriate public health authority (standard practice).
- If an inmate is identified as having chronic HBV
infection, the case should be reported in those states where reporting is
required (standard practice).
- Identification of acute hepatitis B should prompt
an epidemiologic investigation by correctional officials, in collaboration
with the appropriate health authorities, to identify the source of infection
and provide appropriate postexposure prophylaxis to nonimmunized contacts at
risk for infection (standard practice).
- Persons diagnosed with acute hepatitis B should be observed for progressive liver dysfunction and evidence of acute liver failure (standard practice).
Chronic Hepatitis B Treatment
- Inmates identified as having chronic HBV infection
during medical screening should be evaluated to determine the presence and
extent of chronic liver disease and the potential benefit of antiviral
therapy. Therapies for treatment of hepatitis B include interferon, alpha,
lamivudine, and adefovir. Treatment of patients with chronic hepatitis B
should be conducted in consultation with a specialist experienced with these
treatment regimens (standard practice).
- All long-term correctional facilities should
establish criteria for identifying prisoners who might benefit from treatment,
on the basis of the latest treatment guidelines (standard practice).
- Discharge planning for persons with chronic HBV infection should include referral to medical care, risk-reduction programs, and social services necessary to maintain behavior changes; vaccination of contacts should also be arranged before patient discharge (standard practice).
Recommendations for Adult Correctional Facilities -- Hepatitis C Virus Infection
Testing for Hepatitis C Virus Infection
- All inmates should be asked questions regarding risk
factors for HCV infection during their entry medical evaluations, and all
inmates reporting risk factors for HCV infection should be tested for anti-HCV
(see Box 7 for list of persons for whom routine hepatitis C virus testing is
recommended) Recommended.
- The sensitivity of risk factor-based screening should be periodically determined by seroprevalence surveys, in combination with ascertainment of demographic and risk-factor information. Serologic testing of expanded groups of inmates or all inmates is recommended when:
- self-reported history of risk factors alone
identifies <75% of anti-HCV positive inmates
- the prevalence of risk factors for HCV infection, including injection-drug use, is known to be high (>75%), and a high prevalence exists (>20%) of HCV infection among inmates who deny risk factors (standard practices)
- Anti-HCV-positive persons should be reported if
required by state regulations (standard practice).
- Adults with signs or symptoms indicative of viral hepatitis should have appropriate diagnostic testing to differentiate acute hepatitis A, hepatitis B, or hepatitis C and to determine if the patient has chronic HBV or HCV infection (see Box 2 of the original guideline document) (standard practice).
- Cases of acute hepatitis C should be reported to
the appropriate public health authority (standard practice).
- Identification of an inmate with acute hepatitis C, including ones who have been incarcerated for >6 months, should prompt an epidemiologic investigation by correctional officials, in collaboration with the appropriate health authorities, to identify the source of the infection. Depending on the results of the investigation, testing of contacts might be indicated (see Box 7 of the original guideline document) (standard practice).
- Adults who test positive for anti-HCV should receive further medical evaluation to determine chronic infection and liver disease (standard practice).
Postexposure Management for HCV
- After a percutaneous or permucosal exposure to blood,
the source person should be tested for anti-HCV. If the source person is
anti-HCV-positive, the exposed person should be tested for anti-HCV and ALT
activity at baseline and 4-6 months later. For earlier diagnosis, testing for
HCV ribonucleic acid can be performed at 4-6 weeks. Recommended.
- IG and antiviral agents are not recommended for postexposure prophylaxis of hepatitis C. Not recommended.
Chronic Hepatitis C Treatment
- All anti-HCV-positive inmates should be evaluated for
evidence of chronic HCV infection, including the presence and extent of
chronic liver disease and candidacy for antiviral therapy. Treatment of
patients with chronic hepatitis C should be conducted in consultation with a
specialist familiar with these treatment regimens (standard practice).
- Inmates with chronic hepatitis C should receive
hepatitis B vaccination and hepatitis A vaccination if not previously
immunized or known to be susceptible to infection. Recommended.
- Correctional facilities or systems should establish criteria based on the latest treatment guidelines for the identification of prisoners who might benefit from antiviral treatment. For HCV-infected patients who are actively abusing substances (e.g., drugs or alcohol), appropriate substance-abuse treatment should be initiated to limit disease transmission, reinfection, and liver disease progression. Recommended.
Adult Health Education and Release Planning
- Prevention of HAV, HBV, and HCV infection should be
incorporated into health education programs (e.g., programs for preventing
HIV/AIDS) and include information concerning modes of disease transmission,
methods for prevention, including risk reduction and immunization, disease
outcomes, and options for treatment (see Box 8 for elements of a viral
hepatitis health education program). Indicated.
- An integrated health education and risk reduction
program should be established in each facility and include a written plan of
health instruction completed by each inmate (standard practice).
- Such instruction should address a range of issues
relevant to the diverse developmental and cultural composition of correctional
populations, and should include basic skill development, literacy, and home
economics, as well as tools needed to avoid behaviors that result in
acquisition of HIV, hepatitis, and other bloodborne and sexually transmitted
infections (standard practice).
- Teachers should be trained professionals or inmate
peers with specific training to teach comprehensive life-skills programs,
including health education (standard practice).
- A system for periodic evaluation, updating and
improvement should exist (standard practice).
- Documentation of hepatitis A or hepatitis B
vaccination should be included in the medical record retained within the
correctional system, as well as in any medical record provided to other
health-care providers. In addition, the vaccinated person should be provided a
personal immunization record (standard practice).
- Correctional health facilities should establish links
with community and public health facilities, and where available, with
immunization registries, to ensure tracking and completion of hepatitis A and
hepatitis B vaccine series (standard practice).
- Persons with chronic HBV or HCV infection should be
- counseled regarding preventing transmission to
household, sexual, and drug-use contacts, including risk reduction and
condom use
- provided referral for hepatitis B vaccination of
contacts
- counseled regarding ways to reduce further liver
damage, including limiting alcohol and drug use, and afforded
substance-abuse treatment when appropriate
- provided aftercare that includes medical follow-up (standard practices)
Preventing and Controlling Hepatitis Virus Infections Among Correctional Staff
Hepatitis A Virus Infection
- Hepatitis A is not occupationally acquired in the health-care or correctional setting, and neither routine screening nor routine vaccination of staff should be administered. Not recommended.
Infection Control Plan for HBV and HCV Prevention
- Measures to prevent occupational exposure to HBV and HCV among correctional workers should be integrated into each facility's bloodborne pathogen and infection control plan according to the requirements of the Occupational Safety and Health Administration (OSHA) or the respective state Occupational Safety and Health Administration. Elements of this plan should be coordinated with the infection control plan for correctional workers for all other infectious agents (e.g., HIV and Mycobacterium tuberculosis) (standard practice).
- The plan should cover all employees (including
inmates who are assigned work duties at a correctional facility) who could be
reasonably anticipated, as the result of job duties, to be exposed to blood,
bodily fluids, or other materials that might contain HBV or HCV (standard
practice).
- The plan should identify tasks, procedures, and job
classifications in which occupational exposure to potentially infectious
material occurs--without regard to personal protective clothing and
equipment. The plan must be accessible to employees and employee
representatives. The employer should review and update the plan at least
annually--more often if necessary to accommodate changes or recommendations
from appropriate agencies (standard practice).
- The plan should mandate standard (i.e., universal)
precautions for all contact with blood or body fluids. This should include
procedures used to prevent needle sticks, including use of safer needle
devices, to minimize splashing and spraying of potentially infectious
material, and to ensure appropriate disinfection and decontamination of
potentially contaminated surfaces and equipment, and appropriate disinfection
and disposal of infectious material and contaminated clothing. As a part of
the plan, correctional facilities should require employees to use appropriate
personal protective equipment (e.g., gloves, gowns, masks, mouthpieces, and
resuscitation bags) that are provided by the employer (standard practice).
- The plan should ensure that all workers are familiar
with all aspects of infection control, including bloodborne pathogens and
their transmission, the written exposure control plan, engineering and work
practice controls, personal protective equipment, hepatitis B vaccine,
response to emergencies involving blood, how to handle exposure incidents, the
postexposure evaluation and follow-up program, and signs/labels/color-coding
to alert persons to potentially infectious material (standard practice).
- Plan administrators should consider strategies to
overcome the unique barriers to an effective infection control plan in a
correctional environment. For example, potential inaccessibility of sharps
disposal containers might necessitate using specific safe-needle devices and
other strategies to minimize needle-stick injuries in correctional health-care
settings (standard practice).
- A work practices program should be established that includes standard operating procedures for all activities having exposure potential. No worker should engage in such tasks or activities before receiving training pertaining to the procedures, work practices, and protective equipment required for that task (standard practice).
Preexposure Hepatitis B Vaccination and Postexposure Management for HBV and HCV
- Hepatitis B vaccination should be administered to all
previously unvaccinated persons (e.g., correctional and medical staff) whose
work duties involve exposure to blood or other potentially infectious body
fluids. Strongly recommended.
- Prevaccination serologic screening is not indicated
for persons being vaccinated because of occupational risk, unless the hospital
or health-care organization considers screening cost-effective. Indicated.
- Staff with continued contact with patients or blood
and who are at ongoing risk for percutaneous injuries should be tested for
anti-HBs 1-2 months after completion of the 3-dose vaccination series. Staff
who do not respond to a primary vaccine series should complete a second 3-dose
vaccine series or be evaluated to determine if they are HBsAg-positive
(standard practice).
- For correctional workers who have no contact with
inmates and no routine exposure to blood and body fluids in the correctional
setting, timely postexposure prophylaxis should be provided if an exposure
occurs, rather than routine vaccination (standard practice).
- Evaluation for appropriate postexposure prophylaxis
for an employee who has had an exposure incident should be performed in a
timely fashion according to recommendations for HBV and HCV. Strongly
recommended.
- When an exposure to potentially infectious blood or
body fluid has occurred, a blood sample from the source person should be
tested for HBsAg and anti-HCV. If the source person cannot be identified or
tested, the respective postexposure protocol (i.e., HBV or HCV) should be
followed to evaluate the need for postexposure prophylaxis or follow-up
(standard practice).
- Appropriate postexposure prophylaxis and follow-up
for HBV infection after exposure is dependent on the HBsAg status of the
source person, as well as the immunization status of the exposed person
(Tables 2 and 4 in the original guideline document) (see Recommendations for Adult
Inmates) (standard practice).
- If the source person is anti-HCV positive, Centers for Disease Control and Prevention (CDC) guidelines for postexposure follow-up should be followed (see Recommendations for Adult Inmates) (standard practice).
HBV or HCV Serologic Testing
- Routine testing for HBV or HCV infection is not necessary for correctional workers, except as described for hepatitis B vaccination or postexposure management. Not recommended.
Definitions:
Note: The recommendations are rated, where applicable, on the basis of the strength of evidence indicating changes in outcomes attributable to the interventions. Where formal recommendations previously have been published, they are cited as supporting evidence and can be referred to for the original studies. Ratings have been assigned by using a modification of criteria published by the Guide to Community Preventive Services. No rating was assigned to a recommendation considered standard practice (i.e., a medical or administrative practice conducted routinely by qualified persons experienced in their fields).
Strongly recommended (on the basis of >2 consistent, well-conceived, well-executed studies with control groups or longitudinal measurements).
Recommended (on the basis of >1 well-conceived, well-executed, controlled, or time-series study; or >3 studies with more limited execution).
Indicated (on the basis of previous scientific observation and theoretic rationale, but case-controlled or prospective studies do not exist).
Not recommended (on the basis of published literature recommending against a practice).
