Organized by year, the bibliography lists the article title, authors, journal where the article first appeared, and contributing laboratory. Depending on space and available information, some commentary provided by the respective laboratories is included.
1996: Confirmation of Iron Limitation of Phytoplankton Photosynthesis in the Equatorial Pacific Ocean by M.J. Behrenfeld, A.J. Bale, Z.S. Kolber, J. Aiken, and P.G. Falkowski, Nature 383:508. Cover article of October 10, 1996, issue. (BNL)
1996: Analysis of Lung Tumor Risk in Rats Exposed to Radon by E.S. Gilbert, F.T. Cross, and G.E. Dagle, Radiat. Res.121:28. PNNL was the first to duplicate in experimental animals the lung cancer that had been observed in hard rock and uranium miners in Europe and the United States since the early part of the century. This work allowed studies by Cross at PNNL that defined many parameters of radon exposure related to induction of lung cancer. (PNNL)
1996: Microbes Deep Inside the Earth by J.K. Fredrickson and T.C. Onstott, Sci. Am. 275:68. This article was identified on the journal's cover and discussed in the Editor's column. The article summarizes results of the highly multidisciplinary DOE-OHER Subsurface Science Program to discover and define the origins of microorganisms deep within the earth. (PNNL)
1996: Exploring the Allowed Sequence Space of a Membrane Protein by J. Wen, X. Chen, and J.U. Bowie, Nat. Struct. Biol. 3:141. (UCLA-DOE)
1996: Clastogenic Effects of Defined Numbers of 3.2 MeV Alpha Particles on Individual CHO-K1 Cells by J.M. Nelson, A.L. Brooks, N.F. Metting, M.A. Khan, R.L. Buschbom, A. Duncan, R. Miick, and L.A. Braby, Radiat. Res. 145:568. This paper on the Alpha Particle Microbeam describes a unique experimental procedure using an accelerator for studying the response of living cells to radiation resulting from single alpha particle traversals through their nucleii. Radiation injury to cells from such events is expected to occur as a result of exposure to environmental radon gas or other sources of very low-level radiation. (PNNL)
1995: An Integrated Metric Physical Map of Human Chromosome 19 by L.K. Ashworth, M.A. Batzer, B. Brandriff, E. Branscomb, P. de Jong, E. Garcia, J.A. Garnes, L.A. Gordon, J.E. Lamerdin, G. Lennon, H. Mohrenweiser, A.S. Olsen, T. Slezak, and A.V. Carrano, Nat. Genet. 11:422. This is the first physical map to use a metric scale for positioning genes and other markers. (LLNL)
1995: Lithoautotrophic Microbial Ecosystems in Deep Basalt Aquifers by T.O. Stevens and J.P.McKinley, Science 270:450. This article described a newly discovered microbial ecosystem, which may have served as a first life form on earth and perhaps even in extraterrestrial bodies. (PNNL)
1995: Leaf and Canopy Responses to Elevated CO2 in a Pine Forest Under Free-Air CO2 Enrichment by D.S. Ellsworth, R. Oren, C. Huang, N. Phillips, and G.R. Hendrey, Oecologia 104:139. (BNL)
1995: Portable Blood Irradiator by F.P. Hungate, Radiat. Prot. Dosim. 60:359. This paper describes the development of the first successful portable irradiator for reducing the number of lymphocytes in the blood of organ transplant patients, thereby decreasing the transplanted tissue's risk of rejection. (PNNL)
1995: H2: Lifting the Molecular Cloud by P.M. Dehmer, Phys. World 8:27. Dehmer's article was the cover story of that issue. (ANL)
1995: Cardiac Single Photon Emission Computed Tomography with Iodine-123-Labeled Fatty Acids - Evaluation of Myocardial Viability with BMIPP by F.F. Knapp, Jr., P. Franken, and J. Kropp, J. of Nucl. Med. 36:1022. This classic paper reviews the ORNL development of the BMIPP cardiac imaging and its introduction into clinical use for the evaluation of the degree of reversible damage to the heart muscle after a heart attack. The availability of such an agent is important for therapeutic planning. (ORNL)
1994: The Atmospheric Radiation Measurement (ARM) Program: Programmatic Background and Design of the Cloud and Radiation Test Bed by G.M. Stokes and S.E. Schwartz, Bull. Am. Meteorol. Soc. 75:1201. The ARM Program is a highly collaborative effort among several laboratories. (ANL, BNL, and PNNL)
1994: Alterations of Single Molecule Fluorescence Lifetimes in Near-Field Optical Microscopy by W.P. Ambrose, P.M. Goodwin, J.C. Martin, and R.A. Keller, Science 265:364. (LANL)
1994: Induction of Differentiation in Human Promyelocytic HL-60 Leukemia Cells Activates p21, WAF1/CIP1, Expression in the Absence of p53 by H. Jiang, J. Lin, Z. Su, F.R. Collart, E. Huberman, and P.B. Fisher, Oncogene 9:3397. This paper describes induction of the p21 protein in differentiating cells, which is independent of the p53 gene. Nearly 100 citations. (ANL)
1992: Linkage of Atherogenic Lipoprotein Phenotype to the Low-Density Lipoprotein Receptor Locus on the Short Arm of Chromosome 19 by P.M. Nishina, J.P. Johnson, J.K. Nagert, and R.M. Krauss, Proc. Nat. Acad. Sci. 89:708. 77 citations. (LBNL)
1992: An Unstable Triplet Repeat in a Gene Related to Myotonic Muscular Dystrophy by Y.H. Fu, A. Pizzuti, R.G. Feenwick, J. King, S. Rajnarayan, P.W. Dunne, J. Dubel, G. Nasser, T. Ashizawa, P. de Jong, B. Wieringa, R. Korneluk, M.B. Perryman, H.F. Epstein and C.T. Caskey, Science 255:1256. The myotonic dystrophy gene was discovered by an international team of collaborators including members of the LLNL Human Genome Center. Several papers and a diagnostic tool for the disease resulted from this effort. 332 citations. (LLNL)
1992: Free-Air Carbon Dioxide Enrichment: Development, Progress, Results by G.R. Hendrey, K.F. Lewin, and J. Nagy, Vegetatio 104 105:17. (BNL)
1992: Biodegradation of Metal Citrate Complexes and the Implications for Toxic Metal Mobility by A.J. Francis, C.J. Dodge, and J.B. Gillow, Nature 356:140. (BNL)
1991: Simultaneous Determination of Refractive Index and Density of an Evaporating Aqueous Solution Droplet by I.N. Tang and H.R. Munkelwitz, Aerosol Sci. Technol. 15:201. (BNL)
1991: A Method to Identify Protein Sequences that Fold into a Known Three-Dimensional Structure by J.U. Bowie, R. Lüthy, and D. Eisenberg, Science 253:164. (UCLA-DOE)
1991: Designing Environmental Field Studies by L.L. Eberhardt and J. M. Thomas, Environ. Monogr. Symp. 61:53.This paper describes new techniques for designing environmental studies and offers a new statistical concept, called superpopulation, applicable to ecological studies. It has become a classic in design of community and ecosystem studies. (PNNL)
1990: Detection of Single Fluorescent Molecules by E.B. Shera, N.K. Seitzinger, L.M. Davis, R.A. Keller, and S.A. Soper, Chem. Phys. Lett. 174:553. (LANL)
1990: Modulation of Gene Expression in Syrian Hamster Embryo Cells Following Ionizing Radiation by G.E. Woloschak, C. Chang-Liu, P.S. Jones, and C.A. Jones, Cancer Res. 50:339. This paper, cited over 100 times, describes the modulation of expression of specific genes following low doses of radiation. (ANL)
1989: Behavior of Technetium in Terrestrial and Aquatic Environs: A Symposium by R.E. Wildung, G.M. Desmet, D.A. Cataldo, and S.G. Weiss, Eds., Health Phys. Vol. 57, Special Issue. Earlier publications and this volume initiated major new studies worldwide on the behavior and effects of this important long-lived radionuclide. (PNNL)
1987: Evidence for Increased Somatic Cell Mutations at the Glycophorin A Locus in Atomic Bomb Survivors by R.G. Langlois, W.L. Bigbee, S.K. Kyoizumi, N. Nakamura, M.A. Bean, M. Akiyama, and R.H. Jensen, Science 236:445. This article addresses the application of biological dosimetry to a critical population. (LLNL)
1986: Cytogenetic Analysis Using Quantitative, High-Sensitivity, Fluorescence Hybridization by D. Pinkel, T. Straume, and J.W. Gray, Proc. Nat. Acad. Sci. USA, 83:2934. This paper is the basis for a U.C. patent and an entire new class of biological reagents for research called chromosome paints. 938 citations. (LLNL)
1986: Atmospheric Deposition and Canopy Interactions of Major Ions in a Forest by S.E. Lindberg, G. Lovett, D. Richter, and D. Johnson, Science. In 1995, it was recognized by two magazines, Science Watch and Current Contents as one of the most widely cited papers published since 1981 on ecology and environmental sciences. (ORNL)
1985: Resonance Ionization Mass Spectrometry for High-Resolution, Mass-Resolved Spectra of Rare Isotopes, by C.M. Miller, R. Engleman, Jr., and R.A. Keller, J. Opt. Soc. B2:1503. (LANL)
1984: An Improved Procedure for High-Purity Gaseous Peroxyacyl Nitrate Production: Use of Heavy Lipid Solvents by J.S. Gaffney, R. Fajer, and G.I. Senum, Atmos. Environ. 18:215. (BNL and ANL)
1984: Comparison of Statistical Designs and Experimental Protocols Used to Evaluate Rain Acidity Effects on Field-Grown Soybeans by L.S. Evans, G.R. Hendrey, and K. Thompson, J. Air Pollut.Control Assn. 34:1107. (BNL)
1983: Flow Cytometric Measurement of Total DNA Content and Incorporated Bromodeoxyuridine by F. Dolbeare, H. Gratzner, M.G. Pallavicini, and J.W. Gray, Proc. Nat. Acad. Sci. Biol. 80:5573. 616 citations. (LLNL)
1983: Biological Availability of Trace Metals: Chemical Estimation, Ecological and Health Implications by E.A. Jenne and R.E. Wildung, Eds., Sci.Total Environ., Vol. 27, Special Issue Elsevier Science Publishers, Amsterdam. This publication is the first definitive synthesis of the role of biological availability of metals in defining ecological and health impacts. (PNNL)
1982: How Does the Extracellular Matrix Direct Gene Expression? by M.J. Bissell, H.G. Hall, and G. Parry, J. Theor. Biol. 99:31. 547 citations. (LBNL)
1981: Acid Rain and Gray Snow by G.R. Hendrey, Nat. Hist. 90(2):58. (BNL)
1981: Carcinogenesis Following Prenatal Exposure to Radiationby M. R. Sikov, Int. J. Biol. Res. Pregnancy, 2(4):159. Sikov has led the world in researching the effects of radionuclides on the embryo and fetus, dominating the literature in this field. (PNNL)
1980: Absorption of Actinide Elements from the Gastrointestinal Tract of Rats, Guinea Pigs, and Dogs by M.F. Sullivan, Health Phys. 38:159. This paper reports data extensively used in establishing limits on intake of radionuclides by the International Commission on Radiological Protection. Sullivan's work has dominated the field worldwide. (PNNL)
1978: Two-Dimensional Analysis of Serum and Tissue Proteins: Multiple Isoelectric Focusing by N.G. Anderson and N.L.Anderson, Anal. Biochem. 85:331. This article describes a two-dimensional electrophoresis method used to separate and analyze the gel patterns of proteins in studies of disease states, cell differentiation, and the cellular effects of toxic chemicals. Over 500 citations. (ANL)
1977: Fluorination with F2: A Convenient Synthesis of 2-Deoxy-2-Fluoro-D-Glucose by T. Ido, C.N. Wan, J.S. Fowler, and A.P. Wolf, J. Org. Chem, 42:2341. In terms of worldwide impact some of the most important articles ever published are those on F-18 FDG, such as this one. FDG had an immediate impact and was highlighted in magazine articles and books on PET scanner work. (BNL)
1977: Aerosol Growth Studies III H.R. Ammonium Bisulfate Aerosols in a Moist Atmosphere by I.N. Tang and H.R. Munkelwitz, J. Aerosol Sci. 8:321. (BNL)
1974: Spheroid Chromatin Units (v Bodies) by A.L. and D.E. Olins, Science 183:330. 850 citations of this "Citation Classic." (ORNL)
1974: Plutonium: Biomedical Research by W.J. Bair and R.C. Thompson, Science 183:715. Featured in Science, this paper has been cited extensively and used in university courses in radiation biology. It covers work done at PNNL and elsewhere. (PNNL)
1973: Intracellular Plutonium: Removal by Liposome-Encapsulated Chelating Agent by Y-E. Rahman, M.W. Rosenthal, and E.A. Cerny, Science 180:300. This paper pioneered a new development in treating metal poisonings. It led to accepted methods of treating ingestion of radioactive elements and to novel experimental methods for targeting the delivery of drugs within liposomes and phospholipid prodrugs. (ANL)
1973: Structure of a Gamma-Type Bence-Jones Protein at 3.5-Angstrom Resolution by M. Schiffer, R.L. Girling, L. Rowland, K.R. Ely, and A.B. Edmundson, Biochem.12:4620. This paper reported the first determination of the crystal structure of an antibody protein fragment (Bence- Jones protein) produced as a result of the disease multiple myeloma. This information formed the basis for understanding antibody function, specificity, and diversity. Over 270 citations. (ANL)
1973: Trace Element Analysis with Semi-Conductor Detector X-Ray Spectrometer by R.D. Giauque, F.S. Goulding, J.M. Jaklevic, R.H. Pehl, Anal. Chem. 45:671. (LBNL)
1972: Oogenesis in Xenopus Iaevis (Daudin): Stages of Oocyte Development in Laboratory Maintained Animals by J. Dumont, J. Morph.136:153. A "Citation Classic" cited over 1130 times. (ORNL).
1971: Inelastic Collisions of Fast Charged Particles with Atoms and Molecules the Bethe Theory Revisited by M. Inokuti, Rev. Mod. Phys. 43:297. A "Citation Classic" recognized as the fourth-most-cited paper during the years 1973-1992. (ANL)
1970: Tables for Determining the Statistical Significance of Mutation Frequencies by M.A. Kastenbaum, Mutat. Res. 9:527. 450 citations. (ORNL)
1967: Radiation and the Patterns of Nature by G.M. Woodwell, Science 156(3774):461. A heavily cited, historical article. (BNL)
1965: Electronic Separation of Biological Cells by Volume by M.J. Fulwyler, Science 150 (3698):910. (LANL)
1963: Kinetics of Water Loss from Cells at Subzero Temperatures and the Likelihood of Intercellular Freezing by P. Mazur, J. Gen. Physiol. 47:347. A "Citation Classic." (ORNL)
1960: The First Step in Photosynthesis: Evidence for Its Electronic Nature by W.A. Arnold and R.K. Clayton, Proc. Nat. Acad. Sci. USA 46:769. (ORNL)
1957: Plasma Losses by Fast Electrons in Thin Films by R.H. Ritchie, Phys. Rev. 106:874. A "Citation Classic" cited 430 times. (ORNL)
1956: On the Statistical Nature of Mortality, with Especial Reference to Chronic Radiation Mortality by G.A. Sacher, Radiology 67:250. This is one of the first articles dealing with mathematical treatment of lifespan and radiation injury from which definitive applications to interspecies extrapolation of radiation effects were developed. This paper continues to be cited today, more than 40 years after its publication. (ANL)
1951: X-Ray-Induced Mutations in Mice by W.L. Russell, Cold Spring Harbor Symp. Quant. Biol. 16:327. 292 Citations. (ORNL)
1950: The Role of Lipids and Lipoproteins in Atherosclerosis by J.W. Gofman, F. Lindgren, H. Elliot, H. W. Mantz, J. Hewitt, B. Strisower, and V. Herring, Science, (February 17th issue). Over 530 citations. (LBNL)