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1: HMA1 HMA1 (Heavy metal ATPase 1); copper-exporting ATPase [ Arabidopsis thaliana ]

GeneID: 829881 updated 21-Dec-2008

[Top][Help]Summary

Gene name
HMA1
Primary source
TAIR:AT4G37270
Locus tag
AT4G37270
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis
Also known as
AP22.4; AP22_4; Heavy metal ATPase 1; HMA1

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer




Genomic context[Top][Help]

chromosome: 4See HMA1 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

PubMed 1. that AtHMA1 functions as a Ca(2+)/heavy metal pump. This protein is the first described plant P-type pump specifically inhibited by thapsigargin.
Submit: New GeneRIFCorrection

[Top][Help]General gene information

GeneOntology Provided by TAIR

Function Evidence
ATPase activity
PubMed 16282320		 IMP PubMed
cadmium-transporting ATPase activity
PubMed 18252706		 IGI PubMed
calcium-transporting ATPase activity
PubMed 18252706		 IGI PubMed
copper-exporting ATPase activity ISS
Process Evidence
calcium ion transport
PubMed 18252706		 IGI PubMed
cellular copper ion homeostasis
PubMed 16282320		 IMP PubMed
response to light intensity
PubMed 16282320		 IMP PubMed
response to toxin
PubMed 18252706		 IGI PubMed
Component Evidence
chloroplast envelope
PubMed 16282320		 IDA PubMed

mRNA Comments

NM_119890.3
Supported by ESTs: , Supported by cDNAs:

[Top][Help]General protein information

Names
HMA1 (Heavy metal ATPase 1); copper-exporting ATPase
NP_195444.1
Identical to Putative cadmium/zinc-transporting ATPase HMA1, chloroplast precursor (HMA1) [Arabidopsis Thaliana] (GB:Q9M3H5;GB:Q5JZZ1;GB:Q9SW66); similar to HMA2 (Heavy metal ATPase 2), cadmium-transporting ATPase [Arabidopsis thaliana] (TAIR:AT4G30110.1); similar to hypothetical protein OsI_023399 [Oryza sativa (indica cultivar-group)] (GB:EAZ02167.1); similar to predicted protein [Physcomitrella patens subsp. patens] (GB:EDQ72732.1); similar to unnamed protein product [Vitis vinifera] (GB:CAO71924.1); contains InterPro domain Haloacid dehalogenase-like hydrolase; (InterPro:IPR005834); contains InterPro domain E1-E2 ATPase-associated region; (InterPro:IPR008250); contains InterPro domain Heavy metal translocating P-type ATPase; (InterPro:IPR006416); contains InterPro domain Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; (InterPro:IPR006404); contains InterPro domain ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; (InterPro:IPR001757)

[Top][Help]NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

mRNA and Protein(s)

  1. NM_119890.3→NP_195444.1 HMA1 (Heavy metal ATPase 1); copper-exporting ATPase [Arabidopsis thaliana]

    UniProtKB/Swiss-Prot
    Q9M3H5
    Conserved Domains (2) summary
    pfam00122
    Location:207–443
    Blast Score:396
    E1-E2_ATPase; E1-E2 ATPase
    cl00375
    Location:613–715
    Blast Score:115
    HAD_like; Haloacid Dehalogenase-like Hydrolases