Chemical Sampling Information
	Diisononyl phthalate
Quick Links General Description Health Factors Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 1,2-Benzenedicarboxylic acid, diisononyl ester; DINP OSHA IMIS Code Number: D908 Chemical Abstracts Service (CAS) Registry Number: 28553-12-0 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CZ3850000 Chemical Description and Physical Properties: oily viscous liquid molecular formula: C26H42O4 molecular weight: 418.68 boiling point: 244-252°C flash point: 221°C closed cup melting point: -43°C vapor pressure: <0.01 @ 20°C Pa Health Factors Potential symptoms: No clinical reports of symptoms were found Health Effects: Unknown in humans (no studies found). In animals given high oral doses: liver tumors, kidney lesions and tumors (male rats only); effects on fetal development (rats). Affected organs: In rodents: liver, kidneys Notes: OSHA does not have a PEL for diisononyl phthalate (DINP). The major metabolites of DINP found in the urine of people with no known occupational exposure to DINP are mono-(hydroxyisononyl) phthalate and mono-(carboxyisooctyl) phthalate. Another major urinary metabolite of DINP identified in a volunteer given [2H]-labeled DINP (1.27 mg/kg, oral) was mono-(oxo-isononyl) phthalate. The elimination half-lives were estimated to be approximately 12 hours for the hydroxy and oxo metabolites and about 18 hours for the carboxy metabolite. Adverse effects on liver and kidneys in rodents do not occur in monkeys and are thought to not pose a health hazard for these organs in humans. Date Last Revised: 06/13/2007 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): Diisononyl phthalate. National Toxicology Program: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isononyl Phthalate (DINP). NTP CERHR MON. (2): i-III90, 2003. [6 MB, PDF, 153 pages] Caldwell, D.J., Eldridge, S.R., Lington, A.W. and McKee, R.H.: Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate. Toxicol. Sci. 51(1): 153-160, 1999. Gray, L.E., Jr., Ostby, J., Furr, J., Price, M., Veeramachaneni, D.N.R. and Parks, L.: Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 58(2): 350-365, 2000. Kaufmann, W., Deckardt, K., McKee, R.H., Butala, J.H. and Bahnemann, R.: Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation. Regul. Toxicol. Pharmacol. 36(2): 175-183, 2002. Koch, H.M. and Angerer, J.: Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. Int. J. Hyg. Environ. Health 210(1): 9-19, 2007. Pugh, G., Jr., et al.: Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. Toxicol. Sci. 56(1): 181-188, 2000. Silva, M.J., Reidy, J.A., Preau, J.L., Needham, L.L. and Calafat, A.M.: Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment. Environ. Health Perspect. 114(8): 1158-1161, 2006. All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.