NCI Announces Integrated Implementation Plan to Fight Lung Cancer
The National Cancer Institute (NCI) today announced an integrated effort to
eliminate the suffering and death due to lung cancer by 2015. Each year, 160,000
people in the United States die from lung cancer, making it the
number one cause of cancer deaths in this country. This initiative further
supports the NCI mission to eliminate the suffering and death due to all cancers
by 2015.
The primary cause of lung cancer is tobacco smoke. "If we are going to be
serious about improving health and preventing disease, we must continue to
drive down tobacco use and exposure to second-hand smoke in this country," said
Michael O. Leavitt, Secretary of the Department of Health and Human Services.
However, smoking is not the sole cause of lung cancer. Other environmental
threats and factors play a role in its development. "Reducing the burden of
lung cancer is absolutely essential to achieving our overall 2015 goal," said
NCI Director Andrew von Eschenbach, M.D.
As part of this integrated implementation plan, three critical strategies will
be targeted:
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Reducing the risk for lung cancer by achieving more effective tobacco control
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Improving the likelihood of a cure through earlier detection and treatment of
lung cancer and pre-cancer
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Introduction of novel targeted therapies through cohesive partnerships with
ongoing or planned biology initiatives
Specific recommendations made by NCI's I-2 team, or Integration Implementation
Team, include efforts in these areas:
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Cessation:
Improve the success rates of smoking cessation through a multi-pronged approach
including the development and testing of promising therapies for nicotine
addiction; develop innovative studies to explore the genetics of nicotine
addiction and gene/environment interactions of nicotine dependence; conduct
vaccine research to understand the potential role that the treatment of
addiction may provide; support ongoing studies to better characterize the
impact of nicotine on the developing brain.
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Early Detection:
Maximize detection efforts using proteomic and expression technologies on
tissue and biospecimen samples; utilize tissue from lung cancer cases diagnosed
in the Prostate Lung Colorectal and Ovarian (PLCO) trial to identify markers
expressed in malignancies.
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New Drug Development and Response to Therapy:
Study the early cancer and pre-cancer microenvironment focusing on the effects
of inflammation, infection and injury on the development of lung cancer;
establish a lung cancer-specific Image Response Assessment Team (IRAT) to
initiate standards for image acquisition, quantitative image analysis of
markers of response, and new molecular imaging strategies to assess response;
develop a model that integrates genomic, transcription, proteomic, and clinical
manifestations of lung cancer and provide a global road map of the current
understanding of lung cancer development, sites and mechanisms of drug
interventions; develop drug delivery systems and strategies to stimulate
research in alternative, more effective and less toxic methods such as
aerosolized drug delivery for organ-confined disease or prevention, and
nanoparticle-based drug delivery for systemic disease.
The implementation of this initiative is under way, and progress on these
efforts will be reported in the coming months.
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For more information on lung cancer research, clinical trials, and other
efforts at the NCI, please go to http://www.nci.nih.gov/cancertopics/types/lung.
For information on quitting smoking, please go to http://smokefree.gov/
or call 1-800-QUITNOW.
For information about the Executive Summary of the I2 Lung Cancer business plan, go to
Lung Cancer Integration and Implementation (I2) 1.
For more information about cancer, please visit the NCI Web site at http://www.cancer.gov
or call NCI's Cancer Information Service at 1-800-4 CANCER (1-800-422-6237).
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