HHS Top 50 Grant Programs
| Rank | CFDA | Name | Number | Dollars |
| 1 | 93778 | Medical Assistance Program (Medicaid) | 212 | $157,071,854,021 |
| 2 | 93558 | Temporary Assistance for Needy Families (TANF) | 95 | $17,406,782,830 |
| 3 | 93600 | Head Start | 2,097 | $6,526,182,525 |
| 4 | 93596 | Child Care Mandatory and Matching Funds of the Child Care and Development Fund | 314 | $4,740,670,568 |
| 5 | 93658 | Foster Care: Title IV-E | 74 | $4,561,445,789 |
| 6 | 93563 | Child Support Enforcement (CSE) | 122 | $2,943,198,393 |
| 7 | 93283 | Centers for Disease Control and Prevention_Investigations and Technical Assistance | 1,063 | $2,213,773,754 |
| 8 | 93767 | State Children's Insurance Program (SCHIP) | 72 | $2,179,717,532 |
| 9 | 93568 | Low-Income Home Energy Assistance (LIHEAP) | 219 | $1,988,001,950 |
| 10 | 93667 | Social Services Block Grant (SSBG) | 57 | $1,700,000,000 |
| 11 | 93959 | Block Grants for Prevention and Treatment of Substance Abuse | 60 | $1,666,235,400 |
| 12 | 93856 | Microbiology and Infectious Diseases Research | 3,520 | $1,614,710,634 |
| 13 | 93659 | Adoption Assistance | 66 | $1,481,955,735 |
| 14 | 93268 | Immunization Grants | 65 | $1,369,441,061 |
| 15 | 93224 | Community Health Centers | 1,006 | $1,296,780,503 |
| 16 | 93837 | Heart and Vascular Diseases Research | 3,199 | $1,262,033,642 |
| 17 | 93853 | Extramural Research Programs in the Neurosciences and Neurological Disorders | 3,585 | $1,151,450,541 |
| 18 | 93917 | HIV Care Formula Grants | 59 | $1,020,738,000 |
| 19 | 93242 | Mental Health Research Grants | 2,435 | $850,435,016 |
| 20 | 93210 | Tribal Self-Governance Demonstration Program: Planning and Negotiation Cooperative Agreements and IHS Compacts | 96 | $816,607,343 |
| 21 | 93866 | Aging Research | 1,888 | $768,535,340 |
| 22 | 93389 | Research Infrastructure | 626 | $761,093,565 |
| 23 | 93395 | Cancer Treatment Research | 1,650 | $741,750,206 |
| 24 | 93279 | Drug Abuse Research Programs | 1,652 | $639,859,338 |
| 25 | 93569 | Community Services Block Grant (CSBG) | 124 | $635,561,383 |
| 26 | 93821 | Cell Biology and Biophysics Research | 1,830 | $623,552,839 |
| 27 | 93914 | HIV Emergency Relief Project Grants | 51 | $599,513,000 |
| 28 | 93994 | Maternal and Child Health Services Block Grant to the States | 59 | $593,481,581 |
| 29 | 93393 | Cancer Cause and Prevention Research | 1,471 | $585,969,420 |
| 30 | 93847 | Diabetes, Endocrinology and Metabolism Research | 1,776 | $578,508,668 |
| 31 | 93045 | Special Programs for the Aging_Title III, Part C_Nutrition Services | 108 | $561,747,517 |
| 32 | 93396 | Cancer Biology Research | 1,609 | $549,319,072 |
| 33 | 93838 | Lung Diseases Research | 1,352 | $523,268,080 |
| 34 | 93003 | Public Health and Social Services Emergency Fund | 114 | $511,639,554 |
| 35 | 93867 | Vision Research | 1,608 | $506,447,231 |
| 36 | 93865 | Center for Research for Mothers and Children | 1,470 | $497,293,375 |
| 37 | 93859 | Pharmacology, Physiology, and Biological Chemistry Research | 1,480 | $451,393,796 |
| 38 | 93862 | Genetics and Developmental Biology Research and Research Training | 1,633 | $449,183,455 |
| 39 | 93855 | Allergy, Immunology and Transplantation Research | 1,372 | $433,920,280 |
| 40 | 93958 | Block Grants for Community Mental Health Services | 59 | $415,283,000 |
| 41 | 93839 | Blood Diseases and Resources Research | 971 | $408,178,984 |
| 42 | 93556 | Promoting Safe and Stable Families | 160 | $379,701,855 |
| 43 | 93848 | Digestive Diseases and Nutrition Research | 1,302 | $376,293,118 |
| 44 | 93846 | Arthritis, Musculoskeletal and Skin Diseases Research | 1,304 | $370,802,523 |
| 45 | 93849 | Kidney Diseases, Urology and Hematology Research | 1,243 | $367,352,058 |
| 46 | 93044 | Special Programs for the Aging_Title III, Part B_Grants for Supportive Services and Senior Centers | 56 | $357,318,825 |
| 47 | 93399 | Cancer Control | 565 | $330,524,520 |
| 48 | 93397 | Cancer Centers Support Grants | 179 | $329,187,040 |
| 49 | 93940 | HIV Prevention Activities_Health Department Based | 66 | $318,932,141 |
| 50 | 93173 | Research Related to Deafness and Communication Disorders | 1,205 | $299,298,309 |
