Liess H, Zoller WG, Bogner J, Powitz F, Zietz C, Goebel FD; International Conference on AIDS.

Int Conf AIDS. 1994 Aug 7-12; 10: 171 (abstract no. PB0112).

Medizinische Poliklinik, University of Munich, Germany.

OBJECTIVE: Gastrointestinal involvement of AIDS-associated Kaposi Sarcoma (KS) may be of major prognostic as well as therapeutic relevance. Therefore the incidence of gastrointestinal involvement was retrospectively analysed using data from autopsies performed in an unselected group of patients (pts.) with AIDS. METHODS/PATIENTS: 306 (286 male, 20 female) pts. who died from AIDS were investigated. They had all been treated at the Medizinische Poliklinik (Period of registration: Jan. 1st 1984-May 1st 1993). 257 pts. belonged to the high risk group of homo/bisexuals. 23 pts. had used i.v. drugs, 26 pts. had no apparent risk for HIV-infection. All findings assessed intra vitam as well as autopsy findings were analysed. RESULTS: Investigation of the gastrointestinal tract (GIT) was performed in 228 (74,5%) pts.. This revealed pathological findings (intra vitam or post-mortem) in 145 (63,6%) of these cases. 50 (21,9%) of these were KS. An autopsy was performed in a total of 76 (24,8%) pts.. In 50 (46,3%) of 108 pts. diagnosed with cutaneous KS endoscopy and autopsy together could show GIT involvement. In 39 pts. Kaposi lesions were found intra vitam. In 11 pts. visceral-abdominal involvement was found at time of autopsy. Of these 9 pts. had not had an endoscopy. 2 pts. showed an involvement of the spleen or liver exclusively. All pts. with possibly visible lesions were correctly diagnosed if endoscopy was performed. CONCLUSIONS: Endoscopy detected GIT involvement of KS in almost all patients. Due to high incidence and the potential therapeutic consequences (local versus systemic) we conclude that endoscopy should be performed in all pts. diagnosed with cutaneous AIDS-associated KS.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Autopsy
• Endoscopy
• Female
• HIV Infections
• Humans
• Incidence
• Liver
• Liver Neoplasms
• Male
• Sarcoma, Kaposi
• Skin Neoplasms
• epidemiology

Other ID:

• 94369552

UI: 102208378

From Meeting Abstracts