Acquired factor VIII inhibitor in a patient with d...[Acta Haematol. 2008]

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1: Acta Haematol. 2008;119(1):8-11. Epub 2008 Jan 4. Links

Acquired factor VIII inhibitor in a patient with dermatomyositis--a case study.

Ayoola A, Mohsini W, Aung S.

Department of Medicine, Franklin Square Hospital Center, Baltimore, MD 21237, USA. ayodeleayoola@hotmail.com

BACKGROUND: Acquired factor VIII inhibitor is an antibody formed against FVIII and seen in patients without FVIII replacement therapy. This entity has been associated with both autoimmune disease and infections. CASE STUDY: We report the case of a 65-year-old man with dermatomyositis who presented with a bleeding episode following venipuncture and hematuria. His coagulation parameters were followed as well as the inhibitor level. His acquired FVIII inhibitor was managed successfully with rituximab. CONCLUSION: Our patient's bleeding episodes resolved and the inhibitor level was undetectable after 12 months. This is the first case of acquired FVIII inhibitor in association with dermatomyositis. 2008 S. Karger AG, Basel

PMID: 18176073 [PubMed - indexed for MEDLINE]

ReviewAnti-inhibitor coagulant complex for the rescue therapy of acquired inhibitors to factor VIII: case report and review of the literature. [Haemophilia. 2002]
[Refractory acquired hemophilia A in which factor VIII inhibitor was not detected at onset and thereafter deteriorated after total hip replacement arthroplasty] [Rinsho Ketsueki. 2008]
ReviewAcquired hemophilia: a case report of 2 patients with acquired factor VIII inhibitor treated with rituximab plus a short course of steroid and review of the literature. [Clin Appl Thromb Hemost. 2007]
Rituximab alone or in association with corticosteroids in the treatment of acquired factor VIII inhibitors: report of two cases. [Transfus Med. 2006]
Rituximab in the treatment of acquired factor VIII inhibitors. [Blood. 2002]

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Acquired factor VIII inhibitor in a patient with dermatomyositis--a case study.

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