Samuel NM; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. B10593.
Tn dr Mgr Medical University, Chennai, India
BACKGROUND: HIV/AIDS is an emergency in India. Upto 5 million individuals are infected. ARV if used in public sector will assist in decrease infectiousness, OIs and will be an effective strategy to link care with prevention. OBJECTIVE: The objective of this pilot study is to evaluate the efficacy, tolerance, supervision of drug administration and adherence and monitoring issues in resource constrained settings of rural India. Patients and METHODS: Fifteen seropositive mothers who were exposed to ARV prophylaxis to reduce HIV transmission in infants are offered after extensive counselling and informed consent three AR drugs (AZT, 3TC, Neviraine). RESULTS: Clinical, virological and Immunological monitoring is undertaken before starting therapy and at three monthly intervals. CONCLUSION: All adhered to the biweekly drug supply. Preliminary results indicate that all patients tolerated well the AR drugs with no side effects. The drugs induced changes in CD4/CD8 levels and plasma HIV-1 RNA levels. This study demonstrates that three drug ARV regimen can be supervised and delivered in rural settings in India. The implications of the study go further than the benefits to the individuals influencing public health issues and care linked to prevention.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Clinical Protocols
- Glycoproteins
- HIV Infections
- Health Resources
- Humans
- India
- Infant
- Intercellular Signaling Peptides and Proteins
- Lamivudine
- Pharmaceutical Preparations
- Pilot Projects
- Zidovudine
- amphiregulin
Other ID:
UI: 102255450
From Meeting Abstracts