Tel.: 301-496-7098
Fax: 301-496-0825
E-mail: jaroniec@speck.niddk.nih.gov
RESEARCH INTERESTS
Biophysical solution-state and solid-state NMR. Development of NMR methods
& their application to the study of the structure and dynamics of peptides
and proteins.
EDUCATION
Ph.D., Physical Chemistry, 2003
Massachusetts Institute of Technology, Cambridge, MA
Supervisor: Prof. Robert G. Griffin
Thesis Title: Solid state nuclear magnetic resonance methodology and
applications to structure determination of peptides, proteins, and amyloid
fibrils
B.S. (summa cum laude), Chemistry, 1997
Kent State University, Kent, OH
PROFESSIONAL EXPERIENCE
Postdoctoral Fellow, Supervisor: Dr. Ad Bax
National Institutes of Health, Bethesda, MD, 2003-present
HONORS AND AWARDS
Damon Runyon Cancer Research Foundation Postdoctoral Fellow, 2003-present
Jane Coffin Childs Memorial Fund for Medical Research Fellowship Recipient,
2003
National Science Foundation Predoctoral Fellow, 1997-2000
Teaching Award, Department of Chemistry, Massachusetts Institute of
Technology, 1998
Phi Beta Kappa, 1997
American Chemical Society Award in Analytical Chemistry, Kent State
University, 1996
Merck Award, Department of Chemistry, Kent State University, 1994
PUBLICATIONS
Publications with the Bax Group
Previous Publications:
C.P. Jaroniec, C.E. MacPhee, V.S. Bajaj, M.T. McMahon, C.M. Dobson, R.G. Griffin, High resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy, Proc. Natl. Acad. Sci. USA 2003, submitted.
V. Ladizhansky, C.P. Jaroniec, A. Diehl, H. Oschkinat, R.G. Griffin, Measurement of multiple psi torsion angles in U-13C,15N labeled alpha-spectrin SH3 domain using 3D 15N-13C-13C-15N MAS dipolar-chemical shift correlation spectroscopy, J. Am. Chem. Soc. 2003, 125, 6827-6833.
C.P. Jaroniec, C.E. MacPhee, N.S. Astrof, C.M. Dobson, R.G. Griffin,
Molecular conformation of a peptide fragment of transthyretin in an amyloid
fibril, Proc. Natl. Acad. Sci. USA 2002, 99, 16748-16753.
C.M. Rienstra, M. Hohwy, L.J. Mueller, C.P. Jaroniec, B. Reif, R.G.
Griffin, Determination of multiple torsion-angle constraints in U-13C,15N-labeled
peptides: 3D 1H-15N-13C-1H dipolar-chemical shift NMR spectroscopy in rotating
solids, J. Am. Chem. Soc. 2002, 124, 11908-11922.
C.P. Jaroniec, C. Filip, R.G. Griffin, 3D TEDOR NMR experiments for the simultaneous measurement of multiple carbon-nitrogen distances in uniformly 13C,15N labeled solids, J. Am. Chem. Soc. 2002, 124, 10728-10742.
C.M. Rienstra, L. Tucker-Kellogg, C.P. Jaroniec, M. Hohwy, B. Reif, M.T. McMahon, B. Tidor, T. Lozano-Perez, R.G. Griffin, De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy, Proc. Natl. Acad. Sci. USA 2002, 99, 10260-10265.
A.T. Petkova, M. Hatanaka, C.P. Jaroniec, J.G. Hu, M. Belenky, M. Verhoeven, J. Lugtenburg, R.G. Griffin, J. Herzfeld, Tryptophan interactions in bacteriorhodopsin: A heteronuclear solid-state NMR study, Biochemistry 2002, 41, 2429-2437.
J.C. Lansing, M. Hohwy, C.P. Jaroniec, A.F.L. Creemers, J. Lugtenburg, J. Herzfeld, R.G. Griffin, Chromophore distortions in the bacteriorhodopsin photocycle: Evolution of the H-C14-C15-H dihedral angle measured by solid-state NMR, Biochemistry 2002, 41, 431-438.
C.P. Jaroniec, J.C. Lansing, B.A. Tounge, M. Belenky, J. Herzfeld, R.G. Griffin, Measurement of dipolar couplings in a uniformly 13C,15N labeled membrane protein: Distances between the Schiff base and aspartic acids in the active site of bacteriorhodopsin, J. Am. Chem. Soc. 2001, 123, 12929-12930.
C.P. Jaroniec, B.A. Tounge, J. Herzfeld, R.G. Griffin, Accurate 13C-15N distance measurements in uniformly 13C,15N-labeled peptides, In "Perspectives on Solid State NMR in Biology," S. Kiihne, H.J.M. de Groot, (Eds.), Kluwer, Dordrecht, 2001, 15-21.
B. Reif, C.P. Jaroniec, C.M. Rienstra, M. Hohwy, R.G. Griffin, 1H-1H MAS correlation spectroscopy and distance measurements in a deuterated peptide, J. Magn. Reson. 2001, 151, 320-327.
C.P. Jaroniec, B.A. Tounge, J. Herzfeld, R.G. Griffin, Frequency selective heteronuclear dipolar recoupling in rotating solids: Accurate 13C-15N distance measurements in uniformly 13C,15N-labeled peptides, J. Am. Chem. Soc. 2001, 123, 3507-3519.
C.P. Jaroniec, B.A. Tounge, C.M. Rienstra, J. Herzfeld, R.G. Griffin, Recoupling of heteronuclear dipolar interactions with rotational-echo double-resonanace at high magic-angle spinning frequencies, J. Magn. Reson. 2000, 146, 132-139.
B. Reif, M. Hohwy, C.P. Jaroniec, C.M. Rienstra, R.G. Griffin, NH-NH vector correlation in peptides by solid-state NMR, J. Magn. Reson. 2000, 145, 132-141.
M. Hohwy, C.P. Jaroniec, B. Reif, C.M. Rienstra, R.G. Griffin, Local structure and relaxation in solid-state NMR: Accurate measurement of amide N-H bond lengths and H-N-H bond angles, J. Am. Chem. Soc. 2000, 122, 3218-3219.
C.P. Jaroniec, B.A. Tounge, C.M. Rienstra, J. Herzfeld, R.G. Griffin, Measurement of 13C-15N distances in uniformly 13C labeled biomolecules: J-decoupled REDOR, J. Am. Chem. Soc. 1999, 121, 10237-10238.
M. Hohwy, C.M. Rienstra, C.P. Jaroniec, R.G. Griffin, Fivefold symmetric homonuclear dipolar recoupling in rotating solids: Application to double quantum spectroscopy, J. Chem. Phys. 1999, 110, 7983-7992.
M. Jaroniec, C.P. Jaroniec, M. Kruk, R. Ryoo, Adsorption and thermogravimetric methods for monitoring surface and structural changes in ordered mesoporous silicas induced by their chemical modification, Adsorption 1999, 5, 313-317.
M. Jaroniec, M. Kruk, C.P. Jaroniec, A. Sayari, Modification of surface and structural properties of ordered mesoporous silicates, Adsorption 1999, 5, 39-45.
C.P. Jaroniec, M. Kruk, M. Jaroniec, A. Sayari, Tailoring surface and structural properties of MCM-41 silicas by bonding organosilanes, J. Phys. Chem. B 1998, 102, 5503-5510.
Y.D. Glinka, C.P. Jaroniec, M. Jaroniec, Studies of surface properties of disperse silica and alumina by luminescence measurements and nitrogen adsorption, J. Colloid Interface Sci. 1998, 201, 210-219.
C.P. Jaroniec, R.K. Gilpin, M. Jaroniec, Comparative studies of chromatographic properties of silica-based amide bonded phases under hydro-organic conditions, J. Chromatogr. A 1998, 797, 103-110.
C.P. Jaroniec, M. Jaroniec, M. Kruk, Comparative studies of structural and surface properties of porous inorganic oxides used in liquid chromatography, J. Chromatogr. A 1998, 797, 93-102.
C.P. Jaroniec, R.K. Gilpin, M. Jaroniec, Adsorption and thermogravimetric
studies of silica-based amide bonded phases, J. Phys. Chem. B 1997, 101,
6861-6866.