MTI Recommendations for PMID: 9303406

(Updated: March 14, 2007)

PMID- 9303406
TI - Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004).
AB - HMR 3647 (RU 66647) and HMR 3004 (RU 64004), two ketolides, had MICs at which 50% of the strains are inhibited (MIC50s) of 0.06 to 0.125 microg/ml and MIC90s of 16.0 microg/ml against 352 anaerobes. MIC50s and MIC90s of erythromycin, azithromycin, clarithromycin, and roxithromycin were 0.5 to 2.0 microg/ml and 32.0 to >64.0 microg/ml, respectively. HMR 3647 and HMR 3004 were more active against non-Bacteroides fragilis-group anaerobes (other than Fusobacterium mortiferum, Fusobacterium varium, and Clostridium difficile).

Right	Wrong	Missed	Precision	Recall	F-Measure
9	16	2	0.3600	0.8182	0.5000
Manual			MTI
*Anti-Bacterial Agents [11] Azithromycin [7] *Bacteria, Anaerobic [10] Carbon Dioxide Clarithromycin [8] Erythromycin [4] Hydrogen-Ion Concentration *Ketolides [3] *Macrolides [5] Microbial Sensitivity Tests [9] Roxithromycin [6]			RU 64004 (MM) telithromycin (MM) *Ketolides (MM;RC) Erythromycin (MM;RC) Macrolides (RC) Roxithromycin (MM;RC) Azithromycin (MM;RC) Clarithromycin (MM;RC) Microbial Sensitivity Tests (MM;RC) Bacteria, Anaerobic (MM;RC) Anti-Bacterial Agents (RC) Gram-Positive Bacteria (RC) Drug Resistance, Microbial (RC) Bacterial Infections (RC) Vancomycin (RC) Bacteria, Aerobic (RC) Streptococcus pneumoniae (RC) Lactams (RC) Rifabutin (RC) Penicillin Resistance (RC) Skin Diseases, Bacterial (RC) Methicillin Resistance (RC) Staphylococcus aureus (RC) Soft Tissue Infections (RC) Bites, Human (RC)

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