FELMINGHAM D, ROBBINS MJ, MATHIAS I, BRYSKIER A; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 351 (abstract no. 2154).

GR Micro Ltd, London, UNITED KINGDOM

The in vitro activity of HMR 3562 and HMR 3787, two new ketolides, and clarithromycin (CLAR) was determined against a wide range of clinical bacterial isolates using the NCCLS agar dilution method. HMR 3562 and HMR 3787 (MIC[90] 0.03-0.06mg/L) were 2-4 times more active than CLAR against erythromycin A (ERY) -susceptible isolates of Staphylococcus spp. Both ketolides retained potent activity against inducibly ERY-resistant strains of Staphylococcus spp but not those exhibiting constitutive MLS[B] resistance. HMR 3787 (MIC[90] 0.008-0.015mg/L) was 2-4 times more active than HMR 3562 and CLAR against ERY[S] isolates of haemolytic Streptococcus spp. and retained good activity (MIC[90] 0.03-0.06mg/L) against strains exhibiting efflux-mediated resistance to CLAR. ERY[S] isolates of S. pneumoniae were very susceptible to HMR 3562 (MIC[90] 0.015mg/L) and HMR 3787 (MIC[90] 0.008mg/L) both ketolides retaining good activity against ERY[R] isolates of this species. Both HMR 3562 and HMR 3787 were highly active against other important respiratory tract pathogens including: Moraxella catarrhalis (MIC[90] 0.06 and 0.06mg/L, respectively), Haemophilus influenzae (2 and 1mg/L), Legionella. pneumophila (0.06 and 0.004mg/L), Chlamydia pneumoniae (0.06 and 0.12mg/L) and Mycoplasma pneumoniae (0.0005 and 0.0005mg/L). Generally, when compared with CLAR, HMR 3562 and HMR 3787 exhibited improved activity against a wide range of gram-positive species and other respiratory tract pathogens, activity being retained against inducibly ERY[R] strains and those exhibiting efflux-mediated resistance.

Publication Types:

• Meeting Abstracts

Keywords:

• Chlamydophila pneumoniae
• Clarithromycin
• Erythromycin
• HMR 3562
• HMR 3787
• Haemophilus Infections
• Haemophilus influenzae
• In Vitro
• Ketolides
• Macrolides
• Microbial Sensitivity Tests
• Moraxella (Branhamella) catarrhalis
• Staphylococcus
• Streptococcus

Other ID:

• GWAIDS0009124

UI: 102246621

From Meeting Abstracts