DUBOIS J, ST-PIERRE C; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 257 (abstract no. 1242).

Ctr. Univ. de Sante de l'Estrie and Novabyss, Sherbrooke, Quebec, CANADA.

The in vitro PAE of HMR3647 (HMR), a totally synthetic new ketolides, was compared with those of clarithromycin (CLA), azithromycin (AZI), erythromycin (ERY), cefixime (CEX), cefuroxime (CEF),loracarbef (LOR), cefaclor(CEC), amoxicillin (AMO) and amoxicillin/acid clavulanate (AM/CL) against ATCC culture strains and strains recently obtained from upper and lower respiratory tract infections like S. pneumoniae, H. influenzae, M. catarrhalis, S. aureus and S. pyogenes. The time-kill technique was also performed to assess bactericidal activity of inhibitory concentrations of HMR and comparative agents. Against S. pneumoniae, H. influenzae and S. pyogenes, a significant PAE (>4:00hr) was noted with HMR and AZI. With S. pneumoniae (penicillin-resistant or MLS[b] resistant), the PAE was greater than 9 hours with HMR and most other macrolides and less than 2 hours with Beta-lactam antibiotics. Against S. pneumoniae (penicillin-susceptible, penicillin-resistant or MLS[b] resistant), a significant bactericidal activity (3 log[10] reduction in CFU/ml) was observed after 2 hours only with HMR. Even if no significant PAE was showed with CEX, CEF, LOR,CEC, AMO and AM/CL against H. influenzae (beta-lactamase positive), a significant bactericidal activity was noted after 12 hours with HMR, AZI and CEX. No bactericidal activity was showed with HMR and other tested antibiotics against S. aureus (penicillin-susceptible, methicillin-resistant or MLS[b] constitutive). Against M. catarrhalis (beta-lactamase positive), a bactericidal activity were only observed with HMR, AZI, CEX, CEF, and CEC. The results showed that HMR3647 is an active agent with a bactericidal activity against strains isolated from upper and lower respiratory tract infection.

Publication Types:

• Meeting Abstracts

Keywords:

• Amoxicillin
• Anti-Bacterial Agents
• Anti-Infective Agents
• Cefaclor
• Cefuroxime
• Cephalosporins
• Clavulanic Acid
• Erythromycin
• Ethylamines
• Haemophilus influenzae
• In Vitro
• Ketolides
• Macrolides
• Penicillins
• Respiratory Tract Infections
• loracarbef
• phenyl-2-aminoethyl sulfide
• telithromycin

Other ID:

• GWAIDS0007913

UI: 102245410

From Meeting Abstracts