Takeoka Y, Yashiki S, Maruyama I, Suehiro S, Sonoda S; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 655 (abstract no. C.582).
Dept. of Virology and 3rd Dept. of Internal Medicine Faculty of Medicine, Kagoshima Univ., Kagoshima, Japan
The effect of Neurotropin(R), a non-protein extract from cutaneous tissue of rabbit inoculated with vaccinia virus and contains biologically active substances formed by immuno-inflammatory reaction, on the formation of giant cell in HIV-infected MT-2 cells was investigated. 10-100 mu g/ml of Neurotropin introduced to MT-2 cell culture prior to HIV infection significantly inhibited the giant cell formation. Nonidet P-40 extracts of HIV-infected MT-2 cell membrane proteins were analyzed on 2D gel electrophoresis and the electrophoretic pattern of protein species were compared. One of the HIV-induced MT-2 protein designated as HMP-1 changed its pI from 5.8 to 5.6 upon treatment with Neurotropin. This change was not due to phosphorylation of HMP-1. It seems that HMP-1 is a fusion-associated molecule and specifically influenced by Neurotropin, thereby suppressing the formation of giant cells.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Animals
- Giant Cells
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV Infections
- HIV Seropositivity
- Membrane Proteins
- Polysaccharides
- Proteins
- Rabbits
- Vacuoles
- immunology
- neurotropin
Other ID:
UI: 102179366
From Meeting Abstracts