Durako S, Muenz L, Hittelman J, Nozyce M, Willoughby A; International Conference on AIDS.

Int Conf AIDS. 1991 Jun 16-21; 7: 216 (abstract no. M.B.2137).

Westat, Inc., Rockville, MD, USA

OBJECTIVE: To assess the impact of HIV infection on neurodevelopment by comparing repeated measurements of infected children (I), uninfected children of HIV+ women (U), and controls (C). METHODS: Bayley Scales of Infant Development (MDI/PDI) were administered at 3, 6, 9, 12, 15, 18, and 24 months to children enrolled in a multicenter study of perinatal HIV transmission. One hundred forty children with known infection status (18I, 45U, 77C) are included. Raw MDI/PDI scores were analyzed by two-stage Hierarchical Linear Model, fitting a quadratic equation for each child, and relating the individual estimates to 8 covariates besides infection status: mother's pregnancy use of heroin, cocaine, alcohol, tobacco; mother's age at delivery; mother's education; child's caretaker; and gestational age. RESULTS: MDI: Observed mean MDI scores (cross-sectional) at 3-24 months are fixed 2-3 points lower for I (U=C). The HLM, with covariate adjustment, estimates no difference in mean score among groups at 3 months, with a maximum deficit of 7 points at 15-18 months (I less than U=C), and slow convergence thereafter (est. 5 point deficit at 24 months). HLM indicates significant association between HIV infection and slope (p=.005) and quadratic term (p=.023). PDI: Observed mean PDI is similar to MDI, with fixed deficit of 3-4 points. HLM estimates no difference in mean PDI among groups at 3 months, but slow and continuing divergence thereafter (I less than U=C), with deficit of 5 points at 12 months and 6 points at 24 months. HLM indicates significant association between HIV infection and slope (p=.002) and quadratic term (p=.029). DISCUSSIONS AND CONCLUSIONS: HIV infection appears to have an early effect on neurodevelopment, with a slight decrease in the average MDI and PDI scores of infected children beginning in the first year of life and continuing over the first 24 months. Model suggests that infected children may achieve MDI milestones, but with delay, while PDI deficit may become larger.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Child
• Child Development
• Cocaine
• Dietary Supplements
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Infant
• Mothers
• Pregnancy

Other ID:

• 1213791

UI: 102183060

From Meeting Abstracts