Hetem S, Kanno CM, Silva NI; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: 37 (abstract no. PuA 6159).
School of Dentistry of Aracatuba, Universidade Estadual Paulista, UNESP, SP, Brazil.
OBJECTIVES: To verify possible teratogenic effects on developing structures during foetal life was used the new immunomodulator SB-73, a polymeric anhydride aggregate of magnesium ammonium phospholinoleate (Duran et al., Braz.J.Biol.RES., 23:1303, 1990) already tested in AIDS patients (Nunes, O.D.S.et al., VII Int.Conf, AIDS, Florence, Italy, 1991) and which is being proposed to be tested in clinical trial phase III. METHODS: Female mice were injected intraperitoneally with 30 mg/Kg body weight of SB-73 from the 13th to the 16th days of pregnancy. After the sacrifice of the animals the heads of the foetuses were decalcified for 7 days after MORSE (1945), paraffin embedded and cut at 6 microns thick oriented to furnish frontal sections: the section were stained with hematoxylin and eosin method and analysed with light microscope. RESULTS: The upper and lower molar tooth germs were at the bell stage of development. Mitotic figures were identified in both connective and epithelial tissues. The lower incisor tooth germs showed all its structural components including the presence of mineralized tissues. The palatine processes were fused at the middle line; there was no signal of the epithelial tissue and bony tissue was present on the palate. CONCLUSIONS: The above observations show details of the analysed structures perfectly compatible with the age of the animal and with its supposed stage of development. In spite of the high doses used in this experiment that is, many times the therapeutic doses, the SB-73 did not produce any interference either on the intra-uterine development of the structures analysed of the foetuses or on normal cell proliferation.
Publication Types:
Keywords:
- Animals
- Female
- Hematoxylin
- Humans
- Incisor
- Italy
- Linoleic Acids
- Magnesium
- Mice
- Molar
- Organophosphorus Compounds
- Palate
- Pregnancy
- Tooth Germ
- magnesium ammonium phospholinoleate anhydride
Other ID:
UI: 102201952
From Meeting Abstracts