HOLLINGER KA, SILVERS LE, MARANO N, FEDORKA-CRAY P, ANGULO F, TOLLEFSON L, STAMEY K; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 100 (abstract no. 719).
FDA Ctr. for Vet. Med., Rockville, MD
BACKGROUND: Broilers are a common source of Salmonella. Antibiotics are used in broiler production raising concerns that broiler food products may be a source of resistant salmonella for humans.METHODS: In 1998, National Antimicrobial Resistance Monitoring System (NARMS) isolates were susceptibility tested to 17 antibiotics by Sensititre[TM] microbroth dilution and classified by NCCLS breakpoints, where defined. Comparison of serotypes among all animal species indicated that Salmonella Heidelberg(H), Kentucky(K) and Thompson(T) were most often isolated from broilers, accounting for 55.0% of broiler and 8.0% of human isolates. Human serotypes were separated into two groups: HKT (n=107), and another group composed of the remaining serotypes, non-HKT (n=1330).RESULTS: Comparison between the two human groups indicated similar prevalence of resistance for all antibiotics tested except for: chloramphenicol, gentamicin, kanamycin, and streptomycin. The largest difference between human groups was observed for gentamicin where 15.9% of the HKT group and 1.8% of the non-HKT group were resistant; the HKT group was more similar to the broiler isolates, (15.5%). Comparison of human HKT and broiler groups indicated similarity in prevalence of resistance for all antibiotics except kanamycin where broiler prevalence (3.2%) was more similar to the human non-HKT (5.2%). DISCUSSION: The higher prevalence of gentamicin resistance between human groups was a discrepancy not seen with other antibiotics. In the broiler industry there is injection of broiler eggs with gentamicin prior to hatch.CONCLUSIONS: The greater proportion of gentamicin resistance in persons ill with salmonella and submitting isolates to NARMS occurred in serotypes that were predominantly isolated from broilers.
Publication Types:
Keywords:
- Animals
- Anti-Bacterial Agents
- Chickens
- Chloramphenicol
- Gentamicins
- Humans
- Kanamycin
- Kentucky
- Meat
- Salmonella
- Salmonella Infections
- Salmonella enterica
Other ID:
UI: 102244843
From Meeting Abstracts