Zhou SY, Wagner K, Hawkes C, Rusnak J, Mayers D; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 155 (abstract no. Mo.C.1583).
Henry M. Jackson Foundation, Rockville, MD, USA. Fax 301-762-7460. E-mail: zhou6017@hjfhiv.hjf.org.
Objectives: (1) To describe the temporal trends in the percentage of CD4 lymphocyte count; (2) to assess whether subgroups of CD4% are associated with demographic characteristics and HIV-1 progression diseases. Methods: We did a longitudinal analysis of CD4% data from 2526 volunteers who enrolled in the RV-1 study of the HIV-1 Natural History Protocol of the MMCARR during 1984-1995. We grouped the study participants into four subgroups: CD4% (less than or greater than or equal to 14) at entry and CD4% linear trends over time (decline or not). Results: At entry, 12% of the study population had CD4% of less than 14%. The levels of CD4% at entry are associated with race, age, and CD4+ at entry, not with sex, service, HIV status, or Walter Reed stage. In this cohort, 58% has decline in CD4%. The temporal trend of CD4% (decline or not) is associated with race, age and CD4+ count at entry, not with sex, HIV status, service or Walter Reed stage. The decline in CD4% prior and post to the initiation of ZDV treatment is estimated to be 1.27% (se=0.28%) per year using the unbalanced repeated mearsurement model. Survival time or time to AIDS outcomes (Anergy, Thresh, PCP, New OI, CD4+ less than 200) are all significantly different for these four groups. Conclusion: This study confirms that CD4% is a significant surrogate marker for HIV-1/AIDS progression.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- CD4 Lymphocyte Count
- Disease Progression
- HIV Infections
- HIV-1
- Longitudinal Studies
- Military Personnel
- Zidovudine
- immunology
- trends
Other ID:
UI: 102217529
From Meeting Abstracts