SATO Y, NONOYAMA M, TOYONAGA Y, SUNAKAWA K; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. G-843.

Japanese Study Group on Resistant Infections in Pediatrics, Gunma, Japan

BACKGROUND:A nationwide surveillance of resistant infections in pediatrics has been conducted under the participation of 19 institutions throughout Japan during October 2000 to July 2001. The antibiotic susceptibilities of two major respiratory pathogens, S.pneumoniae (Spn) and H.influenzae (Hin), to various antibacterial agents and the backgrounds of the patients suffered by PRSP and BLNAR were investigated. METHODS:A total of 361 Spn and 448 Hin isolated among 807 children (aged 0-week - 15-years old) were subjected to the NCCLS susceptibility testing using 12 oral agents and 6 injectable agents. The backgrounds of the children suffering by PRSP and BLNAR were analyzed for age, previous use of antibacterial agents. RESULTS: In Spn, 126 strains (35%) were found to be PISP and 108 (30%) to be PRSP. Against PRSP, faropenem(FRPM) showed the most favorite activity MIC90; 0.5microg/mL) followed by cefditoren(CDTR) (1microg/mL) among the oral agents tested, and panipenem(PAPM) (0.25microg/mL) followed by vancomycin(VCM) (0.25microg/mL) among the injectable agents. In Hin, 215 strains (48%) were found to be BLNAR and 37 (8%) to be beta-lactamase producing. Against BLNAR, CDTR (0.125microg/mL) followed by cefcapen(CFPN) (0.125microg/mL) were found to be effective and ceftriaxone(CTRX) (0.03microg/mL) followed by cefotaxime(CTX) (0.063microg/mL). From the analyses of the backgrounds, the age, up to 6-year old, was fond to be important factor in both PRSP and BLNAR infections, the younger the more frequent. In PRSP infections, the previous use of antibacterial agents was found to be another important factor (p=0.0021). CONCLUSIONS: It should be noticed that Spn and Hin tend to be less susceptible in pediatric infections as exemplified that PISP+PRSP=65% and that BLNAR=48%. One should carefully choose an appropriate antibacterial agent in pediatrics, particularly for Spn and Hin infections among children below 6-year old.

Publication Types:

• Meeting Abstracts

Keywords:

• Ampicillin
• Ampicillin Resistance
• Anti-Bacterial Agents
• Bacteria
• Cefotaxime
• Ceftriaxone
• Cephalosporins
• Child
• Haemophilus Infections
• Haemophilus influenzae
• Humans
• Japan
• Lactams
• Streptococcus pneumoniae
• Thienamycins
• beta-Lactamases
• cefditoren
• fropenem
• panipenem

Other ID:

• GWAIDS0028488

UI: 102268112

From Meeting Abstracts