US 7,378,569 B2
	Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
Ching-Fu Tu, Miaoli Hsien (Taiwan); Chi-Kai Yang, Miaoli Hsien (Taiwan); Ming-Shing Liu, Miaoli Hsien (Taiwan); Lin-Lin Ho, Miaoli Hsien (Taiwan); Kuei-Feng Huang, Miaoli Hsien (Taiwan); Chun-Jean Lee, Miaoli Hsien (Taiwan); and Hao-Chih Tai, Miaoli Hsien (Taiwan)
Assigned to Animal Technology Institute Taiwan, (Taiwan)
Filed on Jun. 01, 2004, as Appl. No. 10/857,613.
Prior Publication US 2005/0268347 A1, Dec. 01, 2005
Int. Cl. A01K 67/27 (2006.01); A01K 67/033 (2006.01); C12N 5/00 (2006.01)

U.S. Cl. 800—17  [800/14; 424/93.2]

5 Claims

1. A transgenic pig having a genome including a human decay accelerating factor (hDAF) transgene having the sequence of SEQ ID NO:1 and a human heme oxygenase (hHO)-1 transgene having the sequence of SEQ ID NO:2 wherein the hDAF and hHO-1 transgenes are operably and independently linked to a chicken beta-Actin promoter, and wherein expression of the hDAF and hHO-1 transgenes results in protection of endothelial cells of blood vessels or hepatocytes of said transgenic pig from apoptosis, oxidation and inflammation.