disease:Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) [MIM:312863]. XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.,
disease:Defects in IL2RG are the cause of X-linked severe combined immunodeficiency (XSCID) [MIM:300400]; also known as agammaglobulinemia, Swiss type.,
domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,
domain:The box 1 motif is required for JAK interaction and/or activation.,
function:Common subunit for the receptors for a variety of interleukins.,
similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,
similarity:Contains 1 fibronectin type-III domain.,
subcellular location:Membrane; Single-pass type I membrane protein.,
subunit:The gamma chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.,
The interleukin 2 (IL2) receptor gamma chain (IL2RG), an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID).,
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