Mitochondrial DNA and Cancer Epidemiology Workshop:
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Mitochondrial DNA and Cancer Epidemiology Workshop
Agenda
| Day 1 - Thursday, September 7, 2006 |
| 8:30 a.m. – 9:00 a.m. |
Registration |
| 9:00 a.m. – 9:10 a.m. |
Welcome Address
Deborah Winn, Ph.D.
Acting Associate Director of the Epidemiology and Genetics Research
Program (EGRP), Division of Cancer Control and Population Sciences
(DCCPS), National Cancer Institute (NCI), National Institutes of Health
(NIH) |
| 9:10 a.m. – 9:30 a.m. |
Charges to the Participants
Mukesh Verma, Ph.D.
Acting Branch Chief, Analytic Epidemiology Research
Branch and Program Director, EGRP, DCCPS, NCI, NIH |
| 9:30 a.m. – 10:00 a.m. |
Overview
Keshav K. Singh, Ph.D. (Chair of the Meeting)
Associate Professor, Department of Cancer Genetics, Roswell Park
Cancer Institute |
| 10:00 a.m. – 10:20 a.m. |
Breast Cancer Population Studies
Jeffrey A. Canter, M.D., M.P.H.
Investigator, Center for Human Genetics Research, Department of
Molecular Physiology and Biophysics, Vanderbilt University Medical
Center |
| 10:20 a.m. – 10:40 a.m. |
Break |
| 10:40 a.m. – 11:00 a.m. |
Mitochondrial Haplogroups and Cancer and Metabolic Diseases
Masashi Tanaka , M.D., Ph.D.
Research Director, Genomics for Longevity and Health, Tokyo
Metropolitan Institute of Gerontology |
| 11:00 a.m. – 11:20 a.m. |
Cytochrome C Oxidase Subunit I Mutations and Haplotype Predisposition in Prostate and Renal Cancer
John Petros, M.D.
Associate Professor, Department of Urology, Pathology and Laboratory
Medicine and the Winship Cancer Institute, Emory University and the
Atlanta VA Medical Center |
| 11:20 a.m. – 11:40 a.m. |
Mitochondrial Correlation Microscopy in Single Cell Cancer Diagnosis
Paul L. Gourley, Ph.D.
Distinguished Member of Science Staff, Biomolecular Materials and
Systems, Sandia National Laboratories |
| 11:40 a.m. – 12:00 noon |
Biocavity Laser Spectroscopy of Cancer Cells and Genetic Forms of Mitochondrial Disease
Robert K. Naviaux, M.D., Ph.D. (Co-Chair of the Meeting)
Associate Professor, Department of Medicine, University of California, San Diego |
| 12:00 noon – 1:30 p.m. |
Lunch |
| 1:30 p.m. – 1:50 p.m. |
Skin Cancer mtDNA Mutation
James E. Sligh, M.D., Ph.D.
Assistant Professor, Division of Dermatology, Vanderbilt University
Medical Center |
| 1:50 p.m. – 2:10 p.m. |
The Role of mtDNA Alterations in Body Fluids in Diagnosing
Cancer
Edward R. Sauter, M.D., Ph.D.
Professor, Department of Surgery, University of Missouri, Columbia |
| 2:10 p.m. – 2:20 p.m. |
hMitChip3 and Mitochondrial Transcriptome in Melanoma
Yan Su, M.D., Ph.D.
Associate Professor of Biochemistry and Molecular Biology, Associate Director of Catherine Birch McCormick Genomics Center, The George Washington University Medical Center |
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Depletion of mtDNA in Prostate Cancer
Masahiro Higuchi, Ph.D.
Assistant Professor, Department of Biochemistry and Molecular Biology,
University of Arkansas for Medical Sciences |
| 2:40 p.m. – 3:00 p.m. |
Mitochondrial DNA Mutations and Reactive Oxygen Species Stress in Cancer Cells: Molecular Players and Clinical Implications
Peng Huang, M.D., Ph.D.
Associate Professor, Department of
Molecular Pathology, The University of Texas M.D. Anderson
Cancer Center |
| 3:00 p.m. – 3:20 p.m. |
Break |
| 3:20 p.m. – 5:30 p.m. |
Discussion Panel Leaders
Konstantin Khrapko, Ph.D.
Assistant Professor, Department of
Medicine, Beth Israel Medical Center, Harvard Medical School
Laurence N. Kolonel, M.D., Ph.D.
Director, Epidemiology
Program, Cancer Research Center, University of Hawaii
Roberta B. Ness, M.D., Ph.D.
Professor and Chair, Department
of Epidemiology, Graduate School of Public Health, University
of Pittsburgh
Alexander S. Parker, Ph.D., M.S.
Assistant Professor of
Epidemiology, Department of Urology, Mayo Clinic College
of Medicine
Peter G. Shields, M.D., Ph.D.
Georgetown University Lombardi
Comprehensive Cancer Center
Mukesh Verma, Ph.D.
Acting Branch Chief, Analytic Epidemiology
Research Branch and Program Director, EGRP, DCCPS, NCI, NIH
Discussion Questions
- Are we ready to utilize mitochondrial DNA information
in studying cancer epidemiology?
- If not, what are the issues?
- How will mitochondrial proteomic knowledge contribute
toward understanding cancer etiology in the population
sciences?
- MitoChip (high-throughput).
- Sensitivity, specificity of the assays to detect mutation.
- Mitochondrial DNA: sample preparation.
- How much sample is needed? Which samples are best for
mutation analysis?
- Origin of mitochondrial mutation: stem cells?
- Do somatic mtDNA mutations actually provoke pathological
states, or should they be considered epiphenomena? (Somatic
mtDNA mutations: the chicken or the egg?)
- Are we there yet? Use in clinic.
- Identifying a cohort of patients with suspected mitochondrial
disorders is a challenge.
- Founder effects?
- Are mutations causative or merely a reflection of nuclear
instability?
- Are these processes independent events?
- Mitochondrial haplotypes.
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| 5:30 p.m. |
Adjourn |
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| Day 2 – Friday, September 8, 2006 |
| 8:30 a.m. – 9:00 a.m. |
Registration |
| 9:00 a.m. – 9:20 a.m. |
The Origins of mtDNA Mutations
William Copeland, Ph.D.
Senior Investigator, Laboratory of Molecular Genetics, National
Institute of Environmental Health Sciences, NIH |
| 9:20 a.m. – 9:40 a.m. |
mtDNA Involvement in Aging/Longevity and Age-Related Diseases
Claudio Franceschi, M.D., Ph.D.
Professor, Department of Experimental Pathology, University of
Bologna, Italy |
| 9:40 a.m. – 10:00 a.m. |
Somatic mtDNA Mutations and Germline mtDNA Polymorphisms in Cancer
Lee-Jun C. Wong, Ph.D.
Professor, Department of Molecular and Human Genetics and Director,
Mitochondrial Diagnostic Laboratory, Baylor College of Medicine |
| 10:00 a.m. – 10:20 a.m. |
Break |
| 10:20 a.m. – 12:30 p.m. |
Recommendations
Presented to the Group by the Chair and Co-Chair |
| 12:30 p.m. |
Adjourn |
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