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PUMA2 -- Evolutionary Analysis of Metabolism | |
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PUMA2 is not being maintained or updated by Argonne National Laboratory and will be taken down in the near future. If there is any data here that you wish to preserve, you are responsible for downloading it. An overview of the bioinformatics research being conducted at the Mathematics and Computer Science Division is available at this page. |
| EC-number: 3.4.25.1 ----- proteasome endopeptidase complex |
| EC-NUMBER | 3.4.25.1 | |
| ENZYME-NAME | proteasome endopeptidase complex | |
| ENZYME-SYSNAME | A 20-S protein composed of 28 subunits arranged in four rings of seven. The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. The molecule is barrel-shaped, and the active sites are on the inner surfaces. Terminal apertures restrict access of substrates to the active sites. There is evidence that catalytic subunits are replaced by others under some conditions so as to alter the specificity of proteolysis, perhaps optimizing it for the formation of antigenic peptides. A complex of the 20-S proteasome endopeptidase complex with a 19-S regulatory unit is the 26-S proteasome that degrades ubiquitin-protein conjugates. Type example of peptidase family T1. Formerly EC 3.4.24.5, EC 3.4.22.21 and EC 3.4.99.46 | |
| ENZYME-CLASS | Hydrolases Acting on peptide bonds (peptidases) Threonine endopeptidases | |
| SYNONYMS | 26S protease;; MCP;; alkaline protease;; ingensin;; >>more synonyms | |
| REACTION | Cleavage of peptide bonds with very broad specificityINHIBITOR Mercurial reagent [CPD:C02556] | Inhibitor of serine endopeptidase [CPD:C04198] |
| PATHWAY | EMP-PATHWAYS: Target_protein--Small_oligopeptides_catabolism_(ubiquitin,_ATP); >>more EMP pathways | |
| KEGG-PATHWAYS: Proteasome; >>more KEGG pathways | ||
| GO_TERM | GO: : | |
| ENZYME-COMMENT | NULL | |
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To perform phylogenetic analysis:
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